mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for KRAS
Gene summary
Basic gene Info.Gene symbolKRAS
Gene nameKirsten rat sarcoma viral oncogene homolog
SynonymsC-K-RAS|CFC2|K-RAS2A|K-RAS2B|K-RAS4A|K-RAS4B|KI-RAS|KRAS1|KRAS2|NS|NS3|RASK2
CytomapUCSC genome browser: 12p12.1
Type of geneprotein-coding
RefGenesNM_004985.4,
NM_033360.3,
DescriptionGTPase KRasK-Ras 2K-ras p21 proteinPR310 c-K-ras oncogenec-Ki-rasc-Kirsten-ras proteincellular c-Ki-ras2 proto-oncogeneoncogene KRAS2transforming protein p21v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog
Modification date20141222
dbXrefs MIM : 190070
HGNC : HGNC
Ensembl : ENSG00000133703
HPRD : 01817
Vega : OTTHUMG00000171193
ProteinUniProt: P01116
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_KRAS
BioGPS: 3845
PathwayNCI Pathway Interaction Database: KRAS
KEGG: KRAS
REACTOME: KRAS
Pathway Commons: KRAS
ContextiHOP: KRAS
ligand binding site mutation search in PubMed: KRAS
UCL Cancer Institute: KRAS
Assigned class in mutLBSgeneDBA: This gene has a literature evidence and it belongs to targetable_mutLBSgenes.
References showing study about ligand binding site mutation for KRAS.1. Maurer, T., Garrenton, L. S., Oh, A., Pitts, K., Anderson, D. J., Skelton, N. J., ... & Ludlam, M. J. (2012). Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity.Proceedings of the National Academy of Sciences, 109(14), 5299-5304. 22431598

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for KRAS

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
G12G12DCOAD31
G12G12CLUAD30
G12G12VCOAD23
G12G12DUCEC16
G12G12VLUAD15
G12G12VUCEC12
G13G13DCOAD10
G13G13DSTAD9
A146A146TCOAD8
G12G12DSTAD7
G13G13DUCEC7
G12G12CCOAD6
K117K117NCOAD5
G12G12ALUAD5
G12G12AUCEC5
G12G12VBRCA3
G12G12SCOAD3
G12G12ACOAD3
Q61Q61LLUAD3
G12G12DLUAD3
Q61Q61HSTAD3
Q70,R68D69GCOAD2
Q61Q61LCOAD2
K5K5RCOAD2
Q61Q61KCOAD2
A146A146VCOAD2
M72M72TCOAD2
S17S17GCOAD2
M72M72VCOAD2
G12G12DGBM2
G12G12DLAML2
G12G12VOV2
A146A146TSTAD2
G12G12SSTAD2
Q61Q61HUCEC2
G12G12CUCEC2
G12G12CBRCA1
G12G12DBRCA1
T35T35ACOAD1
G13G13CCOAD1
G12G12RCOAD1
R68R68SCOAD1
A18T20ACOAD1
E62E63KCOAD1
G12G10RCOAD1
V7V9FCOAD1
F28H27NCOAD1
E62E62GCOAD1
P34P34LCOAD1
V14V14ACOAD1
R68R68GCOAD1
A146A146GCOAD1
V7V8ACOAD1
V14V14GCOAD1
Y71Y71CCOAD1
V7V9ICOAD1
K117K117ECOAD1
Q61Q61HKIRC1
A59A59GKIRC1
G12G12DKIRC1
Q61Q61HLAML1
G12G12VLAML1
A59A59ELAML1
E37,T35I36MLAML1
A146A146TLAML1
G13G13DLAML1
G13G13CLUAD1
A146A146PLUAD1
G13G13DLUAD1
P34,Y32D33ELUAD1
D119,K117C118SLUSC1
Q61Q61HLUSC1
E62E62KSKCM1
Q61Q61RSKCM1
K117K117NSKCM1
G12G12DSKCM1
G12G12CSTAD1
Q61Q61RTHCA1
G12G12VTHCA1
Q61Q61LUCEC1
G12G12SUCEC1
A18T20RUCEC1
G13G13CUCEC1
G13G13VUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Clinical information for KRAS from My Cancer Genome.
The G12V mutation results in an amino acid substitution at position 12 in KRAS, from a glycine (G) to a valine (V). The role of KRAS mutations for selecting/prioritizing anti-cancer treatment, including cytotoxic chemotherapy and targeted agents, is unknown at this time.A clinical trial showed that the MEK inhibitor selumetinib increased responses to radioactive iodine in patients with radioactive iodine–refractory metastatic thyroid cancer, particularly in RAS-mutated tumors (Ho et al. 2013). In this trial, 5 of 5 patients with NRAS-mutated tumors achieved greater radioiodine incorporation into metastatic sites after selumetinib. Partial responses to therapeutic radioiodine were observed in 4 of the patients, and stable disease was observed in the 5th (Ho et al. 2013).While sorafenib has had beneficial effects for patients with metastatic MTC and DTC, it is unknown whether mutation status affects sensitivity to sorafenib (Hoftijzer et al. 2009, Kloos et al. 2009).Espinosa, A., J. Gilbert, J. Fagin. 2015. KRAS c.35G>T (G12V) Mutation in Thyroid Cancer.My Cancer Genome https://www.mycancergenome.org/content/disease/thyroid-cancer/kras/37/ (Updated February 17).

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Protein structure related information for KRAS
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
Q61Q61L0.20187714
A146A146G-1.3117704
T35T35A-1.2573672
Y71Y71C-1.2424236
V7V8A-1.1989265
R68R68G-1.1622646
A146A146T-1.088413
R68R68S-1.0536319
K117C118S-1.0031905
D119C118S-1.0031905
E62E63K-1.0024674
V14V14G-0.96035751
V14V14A-0.95507363
A146A146P-0.92400051
M72M72T-0.87178184
A146A146V-0.85941844
F28H27N-0.82038307
K5K5R-0.75930727
A59A59G-0.73978146
E37I36M-0.70963745
T35I36M-0.70963745
M72M72V-0.61665747
Y32D33E-0.58652925
P34D33E-0.58652925
G12G12A-0.52787992
V7V9F-0.51801687
P34P34L-0.4825546
E62E62G-0.47181156
V7V9I-0.46520295
R68D69G-0.4449611
Q70D69G-0.4449611
A18T20A-0.4423276
G12G12S-0.4398267
Q61Q61H-0.43826644
A59A59E-0.4224792
K117K117N-0.3926214
Q61Q61K-0.36102568
G13G13D-0.3556049
G12G12D-0.35182111
G13G13C-0.30121522
G13G13V-0.21411651
G12G10R-0.20449613
G12G12C-0.19725542
S17S17G-0.19035903
E62E62K-0.15511236
G12G12R-0.13974981
Q61Q61R-0.11317789
G12G12V-0.091303772
A18T20R-0.059715487
K117K117E-0.056241973
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for KRAS from PDB
PDB IDPDB titlePDB structure
4TQ9Crystal Structure of a GDP-bound G12V Oncogenic Mutant of Human GTPase Kras

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Differential gene expression and gene-gene network for KRAS
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types
KRAS_COAD_DE
KRAS_LUAD_DE

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of KRAS and the right PPI network was created from samples without mutations in the LBS of KRAS. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

* In COAD

* In LUAD


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Phenotype information for KRAS
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0001418Adenocarcinoma228AlteredExpression, Biomarker, GeneticVariation, PostTranslationalModification
umls:C0007131Carcinoma, Non-Small-Cell Lung178Biomarker, GeneticVariation
umls:C0007097Carcinoma117AlteredExpression, Biomarker, GeneticVariation
umls:C0027627Neoplasm Metastasis100Biomarker, GeneticVariation
umls:C0024121Lung Neoplasms94AlteredExpression, Biomarker, GeneticVariation
umls:C0009404Colorectal Neoplasms92AlteredExpression, Biomarker, GeneticVariation, PostTranslationalModification
umls:C0152013Adenocarcinoma of lung73Biomarker, GeneticVariation
umls:C0001430Adenoma69Biomarker, GeneticVariation
umls:C0027651Neoplasms52Biomarker, GeneticVariation
umls:C0009375Colonic Neoplasms38Biomarker, GeneticVariation
umls:C0007137Carcinoma, Squamous Cell36AlteredExpression, Biomarker, GeneticVariation
umls:C0030297Pancreatic Neoplasms35Biomarker, GeneticVariation
umls:C0028326Noonan Syndrome32Biomarker, GeneticVariation
umls:C0919267Ovarian Neoplasms20Biomarker, GeneticVariation
umls:C0699791STOMACH CARCINOMA19Biomarker, GeneticVariation
umls:C0206698Cholangiocarcinoma18Biomarker, GeneticVariation
umls:C1275081Cardiofaciocutaneous syndrome15Biomarker
umls:C2239176Carcinoma, Hepatocellular12Biomarker
umls:C0040136Thyroid Neoplasms9Biomarker, GeneticVariation
umls:C0038356Stomach Neoplasms9Biomarker, GeneticVariation
umls:C0587248Costello Syndrome9Biomarker, GeneticVariation
umls:C0023467Leukemia, Myeloid, Acute8AlteredExpression, Biomarker, GeneticVariation
umls:C0014175Endometriosis7Biomarker, GeneticVariation
umls:C0023903Liver Neoplasms7Biomarker, GeneticVariation
umls:C0018923Hemangiosarcoma7Biomarker
umls:C1458155Breast Neoplasms4Biomarker
umls:C0005684Malignant neoplasm of bladder4Biomarker, GeneticVariation
umls:C0026640Mouth Neoplasms3Biomarker, GeneticVariation
umls:C0024299Lymphoma3Biomarker
umls:C0027659Neoplasms, Experimental3Biomarker
umls:C0005695Urinary Bladder Neoplasms2Biomarker, GeneticVariation
umls:C0004114Astrocytoma2Biomarker, GeneticVariation
umls:C2931822Nasopharyngeal carcinoma2Biomarker
umls:C0265318Nevus, Sebaceous of Jadassohn1Biomarker
umls:C0007528Cecal Neoplasms1Biomarker
umls:C0016978Gallbladder Neoplasms1Biomarker
umls:C0023897Liver Diseases, Parasitic1Biomarker
umls:C0023904Liver Neoplasms, Experimental1Biomarker
umls:C0030849Penile Neoplasms1Biomarker
umls:C0042138Uterine Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs
27617G12CPathogenic;drug responseSomaticMedGen:C0007131
SNOMED CT:254637007
MedGen:C0476089
OMIM:608089
SNOMED CT:254878006
MedGen:C0684249
OMIM:211980
SNOMED CT:187875007
27618G12RPathogenic;drug responseSomaticMedGen:C0005684
OMIM:109800
SNOMED CT:399326009
MedGen:C0007131
SNOMED CT:254637007
MedGen:C0149782
27619G13DPathogenic;drug responseSomaticMedGen:C0007131
SNOMED CT:254637007
MedGen:C0349639
OMIM:607785
Orphanet:ORPHA86834
MedGen:C0858252
MedGen:C2674723
OMIM:614470
Orphanet:ORPHA268114
27621G12DPathogenic;drug responseSomaticMedGen:C0007131
SNOMED CT:254637007
MedGen:C0038356
OMIM:613659
SNOMED CT:126824007
MedGen:C0235974
OMIM:260350
Orphanet:ORPHA1333
SNOMED CT:372142002
MedGen:C0265318
OMIM:163200
Orphanet:ORPHA2612
SNOMED CT:239112008
MedGen:C0334082
OMIM:162900
Orphanet:
27622G12VPathogenic;drug responseGermline;somaticMedGen:C0007131
SNOMED CT:254637007
MedGen:C0235974
OMIM:260350
Orphanet:ORPHA1333
SNOMED CT:372142002
MedGen:C0349639
OMIM:607785
Orphanet:ORPHA86834
MedGen:C0853032
MedGen:CN166718
27623G12SPathogenic;drug responseSomaticMedGen:C0007131
SNOMED CT:254637007
MedGen:C0038356
OMIM:613659
SNOMED CT:126824007
MedGen:C0349639
OMIM:607785
Orphanet:ORPHA86834
MedGen:C0919267
OMIM:167000
SNOMED CT:123843001
48924P34LPathogenicGermlineGeneReviews:NBK1124
MedGen:C1860991
OMIM:609942
Orphanet:ORPHA648
MedGen:CN166718
MedGen:CN221809
54282Q61RPathogenicGermlineGeneReviews:NBK1124
MedGen:C1860991
OMIM:609942
Orphanet:ORPHA648
54283Q61LLikely pathogenic;PathogenicSomaticMedGen:C0007131
SNOMED CT:254637007
MedGen:C0238462
SNOMED CT:255032005
54284Q61HPathogenicSomaticMedGen:C0007131
SNOMED CT:254637007
54289G12APathogenic;drug responseSomaticMedGen:C0007131
SNOMED CT:254637007
54290G13CPathogenicSomaticMedGen:C0007131
SNOMED CT:254637007
MedGen:C2674723
OMIM:614470
Orphanet:ORPHA268114
54291G13VPathogenicSomaticMedGen:C0007131
SNOMED CT:254637007
175715Q61KPathogenicSomaticMedGen:C0007131
SNOMED CT:254637007
175716I36MLikely pathogenicGermlineGeneReviews:NBK1124
MedGen:C1860991
OMIM:609942
Orphanet:ORPHA648
175854Q61HPathogenicSomaticMedGen:C0007131
SNOMED CT:254637007
194404A146TUncertain significanceGermlineMedGen:CN221809

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Pharmacological information for KRAS
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB07771[(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACIDSmall molecule
ExperimentalDB07780FARNESYL DIPHOSPHATESmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of KRAS go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
MGMAGNESIUM(2+)4dsnAA59
MGMAGNESIUM(2+)4dstAA59
21FN-{1-[N-(4-CHLORO-5-IODO-2-METHOXYPHENYL) GLYCYL]PIPERIDIN-4-YL}ETHANESULFONAMIDE4lyhCA59 R68 Y71 M72
21CN-{1-[N-(4,5-DICHLORO-2-HYDROXYPHENYL)GLYCYL]PIPERIDIN- 4-YL}ETHANESULFONAMIDE4lyfBE62 R68 Y71 M72
21FN-{1-[N-(4-CHLORO-5-IODO-2-METHOXYPHENYL) GLYCYL]PIPERIDIN-4-YL}ETHANESULFONAMIDE4lyjAE62 R68 Y71 M72
21JN-(1-{[(5,7-DICHLORO-2,2-DIMETHYL-1,3-BENZODIOXOL-4- YL)OXY]ACETYL}PIPERIDIN-4-YL)ETHANESULFONAMIDE4m1oBE62 R68 Y71 M72
21RN-{1-[N-(4,5-DICHLORO-2-ETHYLPHENYL)GLYCYL]PIPERIDIN-4- YL}ETHANESULFONAMIDE4m1wBE62 R68 Y71 M72
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER3gftFG12 G13 V14 S17 A18 F28 A59 K117 D119 A146
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER3gftDG12 G13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4epwAG12 G13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4lpkBG12 G13 V14 S17 A18 F28 K117 D119 A146
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER3gftCG12 G13 V14 S17 A18 F28 T35 K117 D119 A146
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER3gftAG12 G13 V14 S17 A18 F28 Y32 P34 T35 K117 D119 A146
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER3gftBG12 G13 V14 S17 A18 F28 Y32 P34 T35 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4lyfCG13 V14 S17 A18 F28 A59 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4lyhCG13 V14 S17 A18 F28 A59 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4m1sCG13 V14 S17 A18 F28 A59 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4m1wCG13 V14 S17 A18 F28 A59 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4m1yCG13 V14 S17 A18 F28 A59 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4m21CG13 V14 S17 A18 F28 A59 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4dsuAG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4eprAG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4eptAG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4epvAG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4epxAG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4epyAG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4l8gAG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4lpkAG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4lrwAG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4lucAG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4lucBG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4lv6AG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4lv6BG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4lyfAG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4lyfBG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4lyhAG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4lyhBG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4m1oAG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4m1oBG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4m1oCG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4m1sAG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4m1sBG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4m1tAG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4m1tBG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4m1tCG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4m1wAG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4m1wBG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4m1yAG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4m1yBG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4m21AG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4m21BG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4m22AG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4m22BG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4m22CG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4ldjAG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4obeAG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4obeBG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4pzyAG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4pzyBG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4pzzAG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4q01AG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4q01BG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4q02AG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4q03AG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4ql3AG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4tq9AG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4tq9BG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4wa7AG13 V14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE5f2eAG13 V14 S17 A18 F28 K117 D119 A146
Y9Z5'-O-[(S)-{[(S)-[2-(ACETYLAMINO)ETHOXY](HYDROXY) PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]GUANOSINE4nmmAG13 V14 S17 A18 F28 P34 A59 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4lrwBG13 V14 S17 A18 F28 Y32 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4lyjAG13 V14 S17 A18 F28 Y32 K117 D119 A146
GSPGUANOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE4dsoAG13 V14 S17 A18 F28 Y32 P34 T35 K117 D119 A146
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER3gftEG13 V14 S17 A18 F28 Y32 T35 K117 D119 A146
9LI2-(4,6-DICHLORO-2-METHYL-1H-INDOL-3-YL)ETHANAMINE4dstAK5 V7
BZIBENZIMIDAZOLE4dsuAK5 V7
2XR2-CHLORO-1-(1H-INDOL-3-YL)ETHANONE4pzyAK5 V7
0QX2-(1H-INDOL-3-YLMETHYL)-1H-IMIDAZO[4,5-C]PYRIDINE4epvAK5 V7 E37 Y71
0QV(4-HYDROXYPIPERIDIN-1-YL)(1H-INDOL-3-YL)METHANETHIONE4epwAK5 V7 E37 Y71
0QYN-[2-(1H-INDOL-3-YLMETHYL)-1H-BENZIMIDAZOL-5-YL]-L- PROLINAMIDE4epyAK5 V7 E37 Y71
0QW(2-HYDROXYPHENYL)(PYRROLIDIN-1-YL)METHANETHIONE4eptAK5 V7 Y71
2XR2-CHLORO-1-(1H-INDOL-3-YL)ETHANONE4pzyBK5 V7 Y71
2XO1H-BENZIMIDAZOL-2-YLMETHANETHIOL4pzzAK5 V7 Y71
2XHNAPHTHALENE-1-THIOL4q01AK5 V7 Y71
2XHNAPHTHALENE-1-THIOL4q01BK5 V7 Y71
2XG3,4-DIFLUOROBENZENETHIOL4q02AK5 V7 Y71
5UT1-[3-[4-[2-[[4-CHLORANYL-5-(1-METHYLCYCLOPROPYL)-2- OXIDANYL-PHENYL]AMINO]ETHANOYL]PIPERAZIN-1- YL]AZETIDIN-1-YL]PROP-2-EN-1-ONE5f2eAP34 A59 E62 R68 M72
22C1-{4-[(2,4-DICHLOROPHENOXY)ACETYL]PIPERAZIN-1- YL}PROPAN-1-ONE4m22BP34 A59 R68 Y71 M72
22C1-{4-[(2,4-DICHLOROPHENOXY)ACETYL]PIPERAZIN-1- YL}PROPAN-1-ONE4m22CP34 A59 Y71 M72
21Y1-(4-{[(4,5-DICHLORO-2-METHOXYPHENYL) AMINO]ACETYL}PIPERAZIN-1-YL)PROPAN-1-ONE4m21BR68 Y71 M72
MGMAGNESIUM(2+)3gftDS17
MGMAGNESIUM(2+)3gftAS17 T35
MGMAGNESIUM(2+)3gftBS17 T35
MGMAGNESIUM(2+)3gftCS17 T35
MGMAGNESIUM(2+)3gftES17 T35
MGMAGNESIUM(2+)4dsnAS17 T35
MGMAGNESIUM(2+)4dsoAS17 T35
MGMAGNESIUM(2+)4dstAS17 T35
CACALCIUM(2+)4lpkBS17 Y32
MGMAGNESIUM(2+)4lyjAS17 Y32
MGMAGNESIUM(2+)4nmmAS17 Y32
GDPGUANOSINE-5'-DIPHOSPHATE4tqaAV14 S17 A18 F28 K117 D119 A146
GDPGUANOSINE-5'-DIPHOSPHATE4tqaBV14 S17 A18 F28 K117 D119 A146
21RN-{1-[N-(4,5-DICHLORO-2-ETHYLPHENYL)GLYCYL]PIPERIDIN-4- YL}ETHANESULFONAMIDE4m1wCV7 A59 Q61 Y71 M72
0QRN-(6-AMINOPYRIDIN-2-YL)-4-FLUOROBENZENESULFONAMIDE4epxAV7 E37 E62 Q70 Y71
21FN-{1-[N-(4-CHLORO-5-IODO-2-METHOXYPHENYL) GLYCYL]PIPERIDIN-4-YL}ETHANESULFONAMIDE4lyhBV7 E62 R68 Y71 M72
21MN-{1-[(2,4-DICHLOROPHENOXY)ACETYL]PIPERIDIN-4- YL}ETHANESULFONAMIDE4m1tBV7 E62 R68 Y71 M72
21SN-{1-[N-(5,7-DICHLORO-2,1,3-BENZOTHIADIAZOL-4-YL) GLYCYL]PIPERIDIN-4-YL}ETHANESULFONAMIDE4m1yBV7 E62 R68 Y71 M72
20GN-{1-[(2,4-DICHLOROPHENOXY)ACETYL]PIPERIDIN-4-YL}-4- SULFANYLBUTANAMIDE4lucAV7 G13 P34 Q61 E62 R68 Y71 M72
20H1-[(2,4-DICHLOROPHENOXY)ACETYL]-N-(2-SULFANYLETHYL) PIPERIDINE-4-CARBOXAMIDE4lv6AV7 P34 A59 Q61 E62 R68 Y71 M72
20H1-[(2,4-DICHLOROPHENOXY)ACETYL]-N-(2-SULFANYLETHYL) PIPERIDINE-4-CARBOXAMIDE4lv6BV7 P34 A59 Q61 E62 R68 Y71 M72
20GN-{1-[(2,4-DICHLOROPHENOXY)ACETYL]PIPERIDIN-4-YL}-4- SULFANYLBUTANAMIDE4lucBV7 Q61 E62 R68 Y71 M72
21KN-{1-[N-(2,4-DICHLOROPHENYL)GLYCYL]PIPERIDIN-4- YL}ETHANESULFONAMIDE4m1sBV7 Q61 R68 Y71 M72
2XE4-BROMOBENZENETHIOL4q03AV7 Y71


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Conservation information for LBS of KRAS
Multiple alignments for P01116 in multiple species
LBSAA sequence# speciesSpecies
A146FIETSAKTRQR3Homo sapiens, Mus musculus, Rattus norvegicus
A146YIETSAKTRMG1Drosophila melanogaster
A146NVDTSAKTRMG1Caenorhabditis elegans
A18GVGKSALTIQL5Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Caenorhabditis elegans
A59DILDTAGQEEY5Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Caenorhabditis elegans
D119VGNKCDLPSRT3Homo sapiens, Mus musculus, Rattus norvegicus
D119VGNKCDLASWN1Drosophila melanogaster
D119VGNKCDLSSRS1Caenorhabditis elegans
D30QNHFVDEYDPT4Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster
D30QNHFVEEYDPT1Caenorhabditis elegans
D38DPTIEDSYRKQ5Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Caenorhabditis elegans
D54ETCLLDILDTA5Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Caenorhabditis elegans
E31NHFVDEYDPTI4Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster
E31NHFVEEYDPTI1Caenorhabditis elegans
E37YDPTIEDSYRK5Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Caenorhabditis elegans
E62DTAGQEEYSAM5Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Caenorhabditis elegans
F28LIQNHFVDEYD4Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster
F28LIQNHFVEEYD1Caenorhabditis elegans
G12VVVGAGGVGKS4Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster
G12VVVGDGGVGKS1Caenorhabditis elegans
G13VVGAGGVGKSA4Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster
G13VVGDGGVGKSA1Caenorhabditis elegans
G15GAGGVGKSALT4Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster
G15GDGGVGKSALT1Caenorhabditis elegans
G60ILDTAGQEEYS5Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Caenorhabditis elegans
G75QYMRTGEGFLC3Homo sapiens, Mus musculus, Rattus norvegicus
G75QYMRTGEGFLL2Drosophila melanogaster, Caenorhabditis elegans
I100HYREQIKRVKD3Homo sapiens, Mus musculus, Rattus norvegicus
I100TYREQIKRVKD1Drosophila melanogaster
I100NYREQIRRVKD1Caenorhabditis elegans
I55TCLLDILDTAG5Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Caenorhabditis elegans
K117VLVGNKCDLPS3Homo sapiens, Mus musculus, Rattus norvegicus
K117VLVGNKCDLAS1Drosophila melanogaster
K117VLVGNKCDLSS1Caenorhabditis elegans
K16AGGVGKSALTI4Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster
K16DGGVGKSALTI1Caenorhabditis elegans
K55Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Caenorhabditis elegans
L120GNKCDLPSRTV3Homo sapiens, Mus musculus, Rattus norvegicus
L120GNKCDLASWNV1Drosophila melanogaster
L120GNKCDLSSRSV1Caenorhabditis elegans
L56CLLDILDTAGQ5Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Caenorhabditis elegans
L6MTEYKLVVVGA4Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster
L6MTEYKLVVVGD1Caenorhabditis elegans
M67EEYSAMRDQYM5Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Caenorhabditis elegans
M72MRDQYMRTGEG5Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Caenorhabditis elegans
N116MVLVGNKCDLP3Homo sapiens, Mus musculus, Rattus norvegicus
N116MVLVGNKCDLA1Drosophila melanogaster
N116MVLVGNKCDLS1Caenorhabditis elegans
P34VDEYDPTIEDS4Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster
P34VEEYDPTIEDS1Caenorhabditis elegans
Q61LDTAGQEEYSA5Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Caenorhabditis elegans
Q70SAMRDQYMRTG5Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Caenorhabditis elegans
Q99HHYREQIKRVK3Homo sapiens, Mus musculus, Rattus norvegicus
Q99GTYREQIKRVK1Drosophila melanogaster
Q99ANYREQIRRVK1Caenorhabditis elegans
R68EYSAMRDQYMR5Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Caenorhabditis elegans
R73RDQYMRTGEGF5Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Caenorhabditis elegans
S145PFIETSAKTRQ3Homo sapiens, Mus musculus, Rattus norvegicus
S145PYIETSAKTRM1Drosophila melanogaster
S145PNVDTSAKTRM1Caenorhabditis elegans
S17GGVGKSALTIQ5Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Caenorhabditis elegans
S39PTIEDSYRKQV5Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Caenorhabditis elegans
T35DEYDPTIEDSY4Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster
T35EEYDPTIEDSY1Caenorhabditis elegans
T58LDILDTAGQEE5Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Caenorhabditis elegans
T74DQYMRTGEGFL5Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Caenorhabditis elegans
V14VGAGGVGKSAL4Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster
V14VGDGGVGKSAL1Caenorhabditis elegans
V29IQNHFVDEYDP4Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster
V29IQNHFVEEYDP1Caenorhabditis elegans
V7TEYKLVVVGAG4Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster
V7TEYKLVVVGDG1Caenorhabditis elegans
Y32HFVDEYDPTIE4Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster
Y32HFVEEYDPTIE1Caenorhabditis elegans
Y40TIEDSYRKQVV5Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Caenorhabditis elegans
Y71AMRDQYMRTGE5Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Caenorhabditis elegans
Y96EDIHHYREQIK3Homo sapiens, Mus musculus, Rattus norvegicus
Y96EDIGTYREQIK1Drosophila melanogaster
Y96ENVANYREQIR1Caenorhabditis elegans


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