mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for RHOA

Gene summary

Basic gene Info.	Gene symbol	RHOA
	Gene name	ras homolog family member A
	Synonyms	ARH12\|ARHA\|RHO12\|RHOH12
	Cytomap	UCSC genome browser: 3p21.3
	Type of gene	protein-coding
	RefGenes	NM_001664.2,
	Description	Aplysia ras-related homolog 12h12oncogene RHO H12ras homolog gene family, member Arho cDNA clone 12small GTP binding protein RhoAtransforming protein RhoA
	Modification date	20141222
dbXrefs	MIM : 165390
	HGNC : HGNC
	Ensembl : ENSG00000067560
	HPRD : 01323
	Vega : OTTHUMG00000156838
Protein	UniProt: P61586 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_RHOA
	BioGPS: 387
Pathway	NCI Pathway Interaction Database: RHOA
	KEGG: RHOA
	REACTOME: RHOA
	Pathway Commons: RHOA
Context	iHOP: RHOA
	ligand binding site mutation search in PubMed: RHOA
	UCL Cancer Institute: RHOA
Assigned class in mutLBSgeneDB	C: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0036089	cleavage furrow formation	16103226
GO:0051496	positive regulation of stress fiber assembly	15467718

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Ligand binding site mutations for RHOA

Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)

: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
E40	E40Q	HNSC	4
N41	Y42C	STAD	3
N41	Y42S	STAD	2
C20	L22P	BLCA	1
Q63	Q63K	BLCA	1
E40	E40Q	BRCA	1
A61	A61V	COAD	1
G17	G17R	COAD	1
D59	D59N	LUAD	1
G17	G17V	OV	1
D59	L57V	STAD	1
Y34	Y34C	STAD	1
E40	F39C	STAD	1
T60	T60I	STAD	1
G62	G62E	STAD	1
D59	D59Y	STAD	1
A61	A61D	STAD	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Clinical information for RHOA from My Cancer Genome.

Ras homolog family member A (RHOA) is a gene that encodes a protein that functions in the regulation of a cell signaling pathway that links plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as esophageal cancer, intestinal cancer, and stomach cancer.Modified: July 1, 2015

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Protein structure related information for RHOA

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
A61	A61V	0.075380325
D59	L57V	-1.5871361
C20	L22P	-1.2221757
N41	Y42S	-1.2110864
E40	E40Q	-1.1280652
N41	Y42C	-0.85751493
E40	F39C	-0.7046367
Y34	Y34C	-0.64667728
T60	T60I	-0.57634612
D59	D59N	-0.57189695
G62	G62E	-0.48813778
Q63	Q63K	-0.42761971
A61	A61D	-0.38949306
G17	G17R	-0.21501414
G17	G17V	-0.21470308
D59	D59Y	-0.15343055

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for RHOA from PDB

PDB ID	PDB title	PDB structure
1DPF	CRYSTAL STRUCTURE OF A MG-FREE FORM OF RHOA COMPLEXED WITH GDP

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Differential gene expression and gene-gene network for RHOA

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of RHOA and the right PPI network was created from samples without mutations in the LBS of RHOA. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for RHOA

Gene level disease information (DisGeNet)

Disease ID	Disease name	# PubMed	Association type
umls:C0038356	Stomach Neoplasms	4	Biomarker
umls:C0020981	Immunoblastic Lymphadenopathy	4	Biomarker, GeneticVariation
umls:C0079774	Lymphoma, T-Cell, Peripheral	4	Biomarker, GeneticVariation
umls:C0007097	Carcinoma	3	AlteredExpression, Biomarker
umls:C0017661	Glomerulonephritis, IGA	2	Biomarker
umls:C0079772	Lymphoma, T-Cell	1	Biomarker, GeneticVariation
umls:C0027626	Neoplasm Invasiveness	1	Biomarker
umls:C0033687	Proteinuria	1	Biomarker
umls:C0005695	Urinary Bladder Neoplasms	1	Biomarker

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for RHOA

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network

Drug information targeting mutLBSgene (Approved drugs only)

Drug status	DrugBank ID	Name	Type	Drug structure
Experimental	DB04315	Guanosine-5'-Diphosphate	Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of RHOA go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
MG		MAGNESIUM(2+)	3kz1	E	D59
MG		MAGNESIUM(2+)	3kz1	F	D59 T60
NAI		NADH	5bwm	A	E40 N41
GDP		GUANOSINE-5'-DIPHOSPHATE	1cc0	A	G17 C20
GDP		GUANOSINE-5'-DIPHOSPHATE	1cc0	C	G17 C20
GDP		GUANOSINE-5'-DIPHOSPHATE	1ftn	A	G17 C20
GDP		GUANOSINE-5'-DIPHOSPHATE	3lw8	A	G17 C20
GDP		GUANOSINE-5'-DIPHOSPHATE	3lw8	B	G17 C20
GDP		GUANOSINE-5'-DIPHOSPHATE	3lw8	C	G17 C20
GDP		GUANOSINE-5'-DIPHOSPHATE	3lw8	D	G17 C20
GDP		GUANOSINE-5'-DIPHOSPHATE	3lxr	A	G17 C20
GDP		GUANOSINE-5'-DIPHOSPHATE	5bwm	A	G17 C20
GDP		GUANOSINE-5'-DIPHOSPHATE	5fr1	A	G17 C20
GDP		GUANOSINE-5'-DIPHOSPHATE	5fr2	A	G17 C20
GDP		GUANOSINE-5'-DIPHOSPHATE	1dpf	A	G17 C20 A61
GDP		GUANOSINE-5'-DIPHOSPHATE	3lwn	A	G17 C20 A61
GDP		GUANOSINE-5'-DIPHOSPHATE	3lwn	B	G17 C20 A61
GDP		GUANOSINE-5'-DIPHOSPHATE	4d0n	A	G17 C20 A61
GDP		GUANOSINE-5'-DIPHOSPHATE	5a0f	A	G17 C20 A61
GSP		GUANOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE	4xsg	A	G17 C20 G62
GSP		GUANOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE	4xsh	A	G17 C20 G62 Q63
GDP		GUANOSINE-5'-DIPHOSPHATE	1ow3	B	G17 C20 Y34
GDP		GUANOSINE-5'-DIPHOSPHATE	1tx4	B	G17 C20 Y34
GDP		GUANOSINE-5'-DIPHOSPHATE	3msx	A	G17 C20 Y34
GSP		GUANOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE	1a2b	A	G17 C20 Y34 G62
GSP		GUANOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE	1cxz	A	G17 C20 Y34 G62
GNP		PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER	1kmq	A	G17 C20 Y34 G62
GNP		PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER	1s1c	A	G17 C20 Y34 G62
GNP		PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER	1s1c	B	G17 C20 Y34 G62
GSP		GUANOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE	3kz1	E	G17 C20 Y34 G62
GSP		GUANOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE	3kz1	F	G17 C20 Y34 G62
GTP		GTP	4xoi	A	G17 C20 Y34 G62
GTP		GTP	4xoi	C	G17 C20 Y34 G62
MGF		TRIFLUOROMAGNESATE(1-)	1ow3	B	G62 Q63
MGF		TRIFLUOROMAGNESATE(1-)	3msx	A	G62 Q63
ALF		TETRAFLUOROALUMINATE(1-)	1tx4	B	T60 G62 Q63

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Conservation information for LBS of RHOA

Multiple alignments for P61586 in multiple species

LBS	AA sequence	# species	Species
A15	IVGDGACGKTC	10	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (
A161	YMECSAKTKDG	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio
A161	YLECSAKLNEG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A161	YLECSAKTNEG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A161	YYECSAKTGYG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A161	YIECSAKTGYG	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
A161	YIECSAKTGFG	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
A61	ALWDTAGQEDY	10	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (
C16	VGDGACGKTCL	10	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (
C20	ACGKTCLLIVF	10	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (
D120	VGNKKDLRNDE	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio
D120	VGCKVDLRNDP	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D120	VGCKADLRNDP	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D120	VACKADLRNDP	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D59	ELALWDTAGQE	10	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (
E40	VPTVFENYVAD	8	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E40	VPTVFDNYVAD	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E97	LENIPEKWTPE	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio
E97	LDNVQEKWISE	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E97	LENVMEKWISE	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E97	LENVQEKWIAE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F30	FSKDQFPEVYV	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio
F30	FSKGTFPEVYV	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F30	FAKGKFPQVYV	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F30	FSKGQFPEVYV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G14	VIVGDGACGKT	10	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (
G17	GDGACGKTCLL	10	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (
G62	LWDTAGQEDYD	10	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (
K118	ILVGNKKDLRN	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio
K118	ILVGCKADLRN	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
K118	LLVGCKVDLRN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K118	LLVACKADLRN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K118	ILVGCKVDLRN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K162	MECSAKTKDGV	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio
K162	LECSAKLNEGV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K162	LECSAKTNEGV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K162	YECSAKTGYGV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K162	IECSAKTGYGV	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
K162	IECSAKTGFGV	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
K18	DGACGKTCLLI	10	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (
L121	GNKKDLRNDEH	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio
L121	GCKADLRNDPQ	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L121	GCKVDLRNDPK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L121	ACKADLRNDPK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L121	GCKVDLRNDPQ	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N41	PTVFENYVADI	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio
N41	PTVFENYVADV	3	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N41	PTVFDNYVADV	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
N94	PDSLENIPEKW	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio
N94	PDSLENVMEKW	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
N94	PESLDNVQEKW	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N94	PDSLDNVQEKW	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N94	PDSLENVQEKW	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P36	PEVYVPTVFEN	8	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P36	PQVYVPTVFDN	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Q63	WDTAGQEDYDR	10	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (
S160	GYMECSAKTKD	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio
S160	KYLECSAKLNE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S160	KYLECSAKTNE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S160	GYYECSAKTGY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S160	DYIECSAKTGY	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
S160	EYIECSAKTGF	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
T19	GACGKTCLLIV	10	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (
T37	EVYVPTVFENY	8	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T37	QVYVPTVFDNY	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
T60	LALWDTAGQED	10	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (
V35	FPEVYVPTVFE	8	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V35	FPQVYVPTVFD	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Y34	QFPEVYVPTVF	6	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y34	TFPEVYVPTVF	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y34	KFPQVYVPTVF	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)