mutLBSgeneDB |
Gene summary for NSUN4 |
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Basic gene Info. | Gene symbol | NSUN4 |
Gene name | NOP2/Sun domain family, member 4 | |
Synonyms | SHTAP | |
Cytomap | UCSC genome browser: 1p34 | |
Type of gene | protein-coding | |
RefGenes | NM_001256127.1, NM_001256128.1,NM_199044.3,NR_045789.1,NR_045790.1, NR_045791.1, | |
Description | 5-methylcytosine rRNA methyltransferase NSUN4NOL1/NOP2/Sun domain family member 4putative methyltransferase NSUN4sperm head and tail associated protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 615394 | |
HGNC : HGNC | ||
HPRD : 14842 | ||
Protein | UniProt: Q96CB9 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_NSUN4 | |
BioGPS: 387338 | ||
Pathway | NCI Pathway Interaction Database: NSUN4 | |
KEGG: NSUN4 | ||
REACTOME: NSUN4 | ||
Pathway Commons: NSUN4 | ||
Context | iHOP: NSUN4 | |
ligand binding site mutation search in PubMed: NSUN4 | ||
UCL Cancer Institute: NSUN4 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID | GO:0031167 | rRNA methylation | 23022348 |
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Ligand binding site mutations for NSUN4 |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | P184 | P184S | LUSC | 1 | V256 | V256A | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for NSUN4 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | V256 | V256A | -2.0070709 | P184 | P184S | -0.94431425 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for NSUN4 |
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Phenotype information for NSUN4 |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for NSUN4 |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | SAM | S-ADENOSYL-L-METHIONINE | 4fp9 | A | P184 V256 | SAM | S-ADENOSYL-L-METHIONINE | 4fp9 | C | P184 V256 | SAM | S-ADENOSYL-L-METHIONINE | 4fp9 | D | P184 V256 | SAM | S-ADENOSYL-L-METHIONINE | 4fp9 | F | P184 V256 | SAM | S-ADENOSYL-L-METHIONINE | 4fzv | A | V256 |
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Conservation information for LBS of NSUN4 |
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LBS | AA sequence | # species | Species | A182 | VLDLCAAPGGK | 4 | Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus | A183 | LDLCAAPGGKT | 4 | Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus | C181 | TVLDLCAAPGG | 2 | Bos taurus, Mus musculus | C181 | IVLDLCAAPGG | 1 | Homo sapiens | C181 | SVLDLCAAPGG | 1 | Xenopus tropicalis | D204 | NLAANDLSTSR | 2 | Bos taurus, Mus musculus | D204 | NLAANDLSPSR | 1 | Homo sapiens | D204 | YLAANDLSTSR | 1 | Xenopus tropicalis | D237 | RVTSWDGRKWG | 3 | Homo sapiens, Bos taurus, Mus musculus | D237 | CITSQDGRLWG | 1 | Xenopus tropicalis | D255 | DRVLVDVPCTT | 4 | Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus | G185 | LCAAPGGKTLA | 4 | Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus | G186 | CAAPGGKTLAL | 4 | Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus | G238 | VTSWDGRKWGE | 3 | Homo sapiens, Bos taurus, Mus musculus | G238 | ITSQDGRLWGD | 1 | Xenopus tropicalis | K187 | AAPGGKTLALL | 4 | Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus | L180 | DTVLDLCAAPG | 2 | Bos taurus, Mus musculus | L180 | DIVLDLCAAPG | 1 | Homo sapiens | L180 | HSVLDLCAAPG | 1 | Xenopus tropicalis | L205 | LAANDLSTSRT | 2 | Bos taurus, Mus musculus | L205 | LAANDLSPSRI | 1 | Homo sapiens | L205 | LAANDLSTSRS | 1 | Xenopus tropicalis | L291 | VLQVQLLAAGL | 2 | Homo sapiens, Bos taurus | L291 | LLQAELLVAGL | 1 | Xenopus tropicalis | L291 | MLQVQLLAAGL | 1 | Mus musculus | N203 | RNLAANDLSTS | 2 | Bos taurus, Mus musculus | N203 | RNLAANDLSPS | 1 | Homo sapiens | N203 | QYLAANDLSTS | 1 | Xenopus tropicalis | P184 | DLCAAPGGKTL | 4 | Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus | P257 | VLVDVPCTTDR | 4 | Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus | R209 | DLSPSRIARLQ | 1 | Homo sapiens | R209 | DLSTSRSSRLH | 1 | Xenopus tropicalis | R209 | DLSTSRTSRLQ | 1 | Bos taurus | R209 | DLSTSRTGRLQ | 1 | Mus musculus | S206 | AANDLSPSRIA | 1 | Homo sapiens | S206 | AANDLSTSRSS | 1 | Xenopus tropicalis | S206 | AANDLSTSRTS | 1 | Bos taurus | S206 | AANDLSTSRTG | 1 | Mus musculus | V256 | RVLVDVPCTTD | 4 | Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus |
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