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mutLBSgeneDB |
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| Gene summary for RHOB |
 Gene summary |
| Basic gene Info. | Gene symbol | RHOB |
| Gene name | ras homolog family member B | |
| Synonyms | ARH6|ARHB|MST081|MSTP081|RHOH6 | |
| Cytomap | UCSC genome browser: 2p24 | |
| Type of gene | protein-coding | |
| RefGenes | NM_004040.2, | |
| Description | Aplysia RAS-related homolog 6h6oncogene RHO H6ras homolog gene family, member Brho cDNA clone 6rho-related GTP-binding protein RhoB | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 165370 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000143878 | ||
| HPRD : 01321 | ||
| Vega : OTTHUMG00000090755 | ||
| Protein | UniProt: P62745 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_RHOB | |
| BioGPS: 388 | ||
| Pathway | NCI Pathway Interaction Database: RHOB | |
| KEGG: RHOB | ||
| REACTOME: RHOB | ||
| Pathway Commons: RHOB | ||
| Context | iHOP: RHOB | |
| ligand binding site mutation search in PubMed: RHOB | ||
| UCL Cancer Institute: RHOB | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0008333 | endosome to lysosome transport | 10508588 | GO:0070301 | cellular response to hydrogen peroxide | 21373644 | GO:0071479 | cellular response to ionizing radiation | 21373644 |
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| Ligand binding site mutations for RHOB |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | A15 | G14S | BLCA | 1 | K162 | K162N | BLCA | 1 | A15 | D13Y | BRCA | 1 | A61 | Q63P | SKCM | 1 | K118 | K118I | SKCM | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for RHOB |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | K162 | K162N | -1.3226513 | A15 | G14S | -0.59462596 | A15 | D13Y | -0.34892107 | A61 | Q63P | -0.23258449 | K118 | K118I | -0.032222028 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for RHOB from PDB |
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| Differential gene expression and gene-gene network for RHOB |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for RHOB |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0036421 | Scleroderma, Systemic | 2 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for RHOB |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved|investigational | DB00083 | Botulinum Toxin Type A | Biotech |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of RHOB go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | GDP | GUANOSINE-5'-DIPHOSPHATE | 2fv8 | A | A15 A61 K118 K162 |
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| Conservation information for LBS of RHOB |
| Multiple alignments for P62745 in multiple species |
| LBS | AA sequence | # species | Species | A15 | VVGDGACGKTC | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | A161 | YLECSAKTKEG | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | A61 | ALWDTAGQEDY | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | C16 | VGDGACGKTCL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | C20 | ACGKTCLLIVF | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | D120 | VANKKDLRSDE | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G17 | GDGACGKTCLL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | K118 | ILVANKKDLRS | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | K162 | LECSAKTKEGV | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | K18 | DGACGKTCLLI | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | L121 | ANKKDLRSDEH | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | S160 | DYLECSAKTKE | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | T19 | GACGKTCLLIV | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus |
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