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mutLBSgeneDB |
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| Gene summary for RND3 |
 Gene summary |
| Basic gene Info. | Gene symbol | RND3 |
| Gene name | Rho family GTPase 3 | |
| Synonyms | ARHE|Rho8|RhoE|memB | |
| Cytomap | UCSC genome browser: 2q23.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001254738.1, NM_005168.4, | |
| Description | protein MemBras homolog gene family, member Erho-related GTP-binding protein Rho8rho-related GTP-binding protein RhoEsmall GTP binding protein Rho8 | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 602924 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000115963 | ||
| HPRD : 04233 | ||
| Vega : OTTHUMG00000131859 | ||
| Protein | UniProt: P61587 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_RND3 | |
| BioGPS: 390 | ||
| Pathway | NCI Pathway Interaction Database: RND3 | |
| KEGG: RND3 | ||
| REACTOME: RND3 | ||
| Pathway Commons: RND3 | ||
| Context | iHOP: RND3 | |
| ligand binding site mutation search in PubMed: RND3 | ||
| UCL Cancer Institute: RND3 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for RND3 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | G80 | S81Y | COAD | 1 | L139 | L139M | LUAD | 1 | L139 | R140Q | LUSC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for RND3 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | L139 | L139M | -1.668549 | L139 | R140Q | -1.2507218 | G80 | S81Y | -0.76215581 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for RND3 from PDB |
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| Differential gene expression and gene-gene network for RND3 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for RND3 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for RND3 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB04137 | Guanosine-5'-Triphosphate | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of RND3 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | GTP | GTP | 1m7b | A | G80 L139 | GTP | GTP | 2v55 | B | G80 L139 | GTP | GTP | 2v55 | D | G80 L139 |
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| Conservation information for LBS of RND3 |
| Multiple alignments for P61587 in multiple species |
| LBS | AA sequence | # species | Species | A179 | YIECSALQSEN | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A38 | QCGKTALLHVF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C34 | VGDSQCGKTAL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D138 | VGCKSDLRTDV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G35 | GDSQCGKTALL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G80 | LWDTSGSPYYD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K136 | LLVGCKSDLRT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K36 | DSQCGKTALLH | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L139 | GCKSDLRTDVS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L180 | IECSALQSENS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P54 | PENYVPTVFEN | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Q33 | VVGDSQCGKTA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S32 | VVVGDSQCGKT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T37 | SQCGKTALLHV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T55 | ENYVPTVFENY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T78 | LSLWDTSGSPY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V53 | FPENYVPTVFE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y52 | CFPENYVPTVF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus |
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