mutLBSgeneDB |
Gene summary for KDM4E |
Gene summary |
Basic gene Info. | Gene symbol | KDM4E |
Gene name | lysine (K)-specific demethylase 4E | |
Synonyms | JMJD2E|KDM4DL | |
Cytomap | UCSC genome browser: 11q21 | |
Type of gene | protein-coding | |
RefGenes | NM_001161630.1, | |
Description | KDM4D-like proteinlysine-specific demethylase 4E | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000235268 | ||
Vega : OTTHUMG00000167858 | ||
Protein | UniProt: B2RXH2 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KDM4E | |
BioGPS: 390245 | ||
Pathway | NCI Pathway Interaction Database: KDM4E | |
KEGG: KDM4E | ||
REACTOME: KDM4E | ||
Pathway Commons: KDM4E | ||
Context | iHOP: KDM4E | |
ligand binding site mutation search in PubMed: KDM4E | ||
UCL Cancer Institute: KDM4E | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for KDM4E |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | K207 | P206H | KIRC | 1 | Y178 | G180V | LUAD | 1 | Y178 | Y176C | STAD | 1 | Y133 | I132S | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for KDM4E |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | Y133 | I132S | -1.8774095 | K207 | P206H | -1.3195423 | Y178 | Y176C | -0.82565386 | Y178 | G180V | -0.81540979 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for KDM4E from PDB |
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Differential gene expression and gene-gene network for KDM4E |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for KDM4E |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for KDM4E |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of KDM4E go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | PD2 | LUTIDINIC ACID | 2w2i | B | Y133 K207 | PD2 | LUTIDINIC ACID | 2w2i | A | Y133 Y178 K207 | PD2 | LUTIDINIC ACID | 2w2i | C | Y133 Y178 K207 |
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Conservation information for LBS of KDM4E |
Multiple alignments for B2RXH2 in multiple species |
LBS | AA sequence | # species | Species |
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