mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for LALBA
Gene summary
Basic gene Info.Gene symbolLALBA
Gene namelactalbumin, alpha-
CytomapUCSC genome browser: 12q13
Type of geneprotein-coding
Descriptionalpha-lactalbuminlactose synthase B proteinlysozyme-like protein 7
Modification date20141207
dbXrefs MIM : 149750
Ensembl : ENSG00000167531
HPRD : 01024
Vega : OTTHUMG00000170391
ProteinUniProt: P00709
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_LALBA
BioGPS: 3906
PathwayNCI Pathway Interaction Database: LALBA
Pathway Commons: LALBA
ContextiHOP: LALBA
ligand binding site mutation search in PubMed: LALBA
UCL Cancer Institute: LALBA
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for LALBA
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for LALBA
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for LALBA from PDB

Differential gene expression and gene-gene network for LALBA
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of LALBA and the right PPI network was created from samples without mutations in the LBS of LALBA. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for LALBA
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for LALBA
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB03796Palmitic AcidSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of LALBA go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of LALBA
Multiple alignments for P00709 in multiple species
LBSAA sequence# speciesSpecies
D101CDKFLDDDLTD2Bos taurus, Canis lupus familiaris
D101CDKFLDDDITD1Homo sapiens
D101CDKLLDDELDD1Mus musculus
D101CDKFLDDELAD1Rattus norvegicus
D102DKFLDDDLTDD2Bos taurus, Canis lupus familiaris
D102DKFLDDDITDD1Homo sapiens
D102DKLLDDELDDD1Mus musculus
D102DKFLDDELADD1Rattus norvegicus
D103KFLDDDITDDI1Homo sapiens
D103KLLDDELDDDI1Mus musculus
D103KFLDDELADDI1Rattus norvegicus
D103KFLDDDLTDDI1Bos taurus
D103KFLDDDLTDDM1Canis lupus familiaris
D106DDDITDDIMCA1Homo sapiens
D106DDELDDDIACA1Mus musculus
D106DDELADDIVCA1Rattus norvegicus
D106DDDLTDDIMCV1Bos taurus
D106DDDLTDDMICA1Canis lupus familiaris
D107DDITDDIMCAK1Homo sapiens
D107DELDDDIACAK1Mus musculus
D107DELADDIVCAK1Rattus norvegicus
D107DDLTDDIMCVK1Bos taurus
D107DDLTDDMICAK1Canis lupus familiaris
F99ISCDKFLDDDL2Bos taurus, Canis lupus familiaris
F99ISCDKFLDDDI1Homo sapiens
F99ISCDKLLDDEL1Mus musculus
F99ISCDKFLDDEL1Rattus norvegicus
I104FLDDDITDDIM1Homo sapiens
I104LLDDELDDDIA1Mus musculus
I104FLDDELADDIV1Rattus norvegicus
I104FLDDDLTDDIM1Bos taurus
I104FLDDDLTDDMI1Canis lupus familiaris
K98DISCDKFLDDD2Homo sapiens, Canis lupus familiaris
K98GISCDKLLDDE1Mus musculus
K98DISCDKFLDDE1Rattus norvegicus
L100SCDKFLDDDLT2Bos taurus, Canis lupus familiaris
L100SCDKFLDDDIT1Homo sapiens
L100SCDKLLDDELD1Mus musculus
L100SCDKFLDDELA1Rattus norvegicus
Q58SGYDTQAIVEN1Homo sapiens
Q58SGYDTQAVVND1Mus musculus
Q58SGYDSQAIVKN1Rattus norvegicus
Q58SGYDTQTIVNN1Canis lupus familiaris
T57TSGYDTQAIVE1Homo sapiens
T57TSGYDTQAVVN1Mus musculus
T57TSGYDSQAIVK1Rattus norvegicus
T57TSGYDTQTIVN1Canis lupus familiaris

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