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mutLBSgeneDB |
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| Gene summary for LCN1 |
 Gene summary |
| Basic gene Info. | Gene symbol | LCN1 |
| Gene name | lipocalin 1 | |
| Synonyms | PMFA|TLC|TP|VEGP | |
| Cytomap | UCSC genome browser: 9q34 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001252617.1, NM_001252618.1,NM_001252619.1,NM_002297.3, | |
| Description | VEG proteinVon Ebner gland proteinlipocalin 1 (tear prealbumin)lipocalin-1protein migrating faster than albumintear prealbumin | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 151675 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000160349 | ||
| HPRD : 01059 | ||
| Vega : OTTHUMG00000020908 | ||
| Protein | UniProt: P31025 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_LCN1 | |
| BioGPS: 3933 | ||
| Pathway | NCI Pathway Interaction Database: LCN1 | |
| KEGG: LCN1 | ||
| REACTOME: LCN1 | ||
| Pathway Commons: LCN1 | ||
| Context | iHOP: LCN1 | |
| ligand binding site mutation search in PubMed: LCN1 | ||
| UCL Cancer Institute: LCN1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for LCN1 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | K94 | G93E | HNSC | 1 | D147 | E146G | KIRC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for LCN1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | D147 | E146G | -1.0580552 | K94 | G93E | -0.25636232 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for LCN1 from PDB |
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| Differential gene expression and gene-gene network for LCN1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for LCN1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for LCN1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of LCN1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of LCN1 |
| Multiple alignments for P31025 in multiple species |
| LBS | AA sequence | # species | Species | D147 | LEALEDFEKAA | 1 | Homo sapiens | D147 | QEALEDFQNAV | 1 | Rattus norvegicus | D147 | QEALEDFQSVV | 1 | Rattus norvegicus | E143 | PEINQEALEDF | 2 | Rattus norvegicus, Rattus norvegicus | E143 | PKNNLEALEDF | 1 | Homo sapiens | E91 | LEKTDEPGKYT | 2 | Homo sapiens, Rattus norvegicus | E91 | LEKTDEPAKYT | 1 | Rattus norvegicus | H110 | YIIRSHVKDHY | 1 | Homo sapiens | H110 | YSIPSAVEDHY | 1 | Rattus norvegicus | H110 | YIIPSSVEDHY | 1 | Rattus norvegicus | H114 | SHVKDHYIFYC | 1 | Homo sapiens | H114 | SAVEDHYIFYY | 1 | Rattus norvegicus | H114 | SSVEDHYIFYY | 1 | Rattus norvegicus | I106 | KHVAYIIRSHV | 1 | Homo sapiens | I106 | KQVVYSIPSAV | 1 | Rattus norvegicus | I106 | KQVLYIIPSSV | 1 | Rattus norvegicus | K94 | TDEPGKYTADG | 1 | Homo sapiens | K94 | TDEPGKYTAYS | 1 | Rattus norvegicus | K94 | TDEPAKYTAYS | 1 | Rattus norvegicus | L133 | VRGVKLVGRDP | 1 | Homo sapiens | L133 | FQIAKLVGRNP | 1 | Rattus norvegicus | L133 | FQIAKLVGRDP | 1 | Rattus norvegicus | L59 | VTPMKIKTLEG | 2 | Rattus norvegicus, Rattus norvegicus | L59 | VTPMTLTTLEG | 1 | Homo sapiens | M57 | VSVTPMKIKTL | 2 | Rattus norvegicus, Rattus norvegicus | M57 | -SVTPMTLTTL | 1 | Homo sapiens | V31 | EN-QDVSGTWY | 2 | Rattus norvegicus, Rattus norvegicus | V31 | EEIQDVSGTWY | 1 | Homo sapiens |
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