mutLBSgeneDB |
Gene summary for LCN2 |
Gene summary |
Basic gene Info. | Gene symbol | LCN2 |
Gene name | lipocalin 2 | |
Synonyms | 24p3|MSFI|NGAL | |
Cytomap | UCSC genome browser: 9q34 | |
Type of gene | protein-coding | |
RefGenes | NM_005564.3, | |
Description | 25 kDa alpha-2-microglobulin-related subunit of MMP-9lipocalin-2migration-stimulating factor inhibitorneutrophil gelatinase-associated lipocalinoncogene 24p3p25siderocalin LCN2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 600181 | |
HGNC : HGNC | ||
Ensembl : ENSG00000148346 | ||
HPRD : 02551 | ||
Vega : OTTHUMG00000020734 | ||
Protein | UniProt: P80188 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_LCN2 | |
BioGPS: 3934 | ||
Pathway | NCI Pathway Interaction Database: LCN2 | |
KEGG: LCN2 | ||
REACTOME: LCN2 | ||
Pathway Commons: LCN2 | ||
Context | iHOP: LCN2 | |
ligand binding site mutation search in PubMed: LCN2 | ||
UCL Cancer Institute: LCN2 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for LCN2 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | F153 | F153L | BLCA | 1 | K154 | K154Q | HNSC | 1 | T156,Y158 | L157I | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for LCN2 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | T156 | L157I | -1.5219365 | Y158 | L157I | -1.5219365 | K154 | K154Q | -0.68939564 | F153 | F153L | -0.60242712 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for LCN2 from PDB |
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Differential gene expression and gene-gene network for LCN2 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for LCN2 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0027627 | Neoplasm Metastasis | 16 | Biomarker, GeneticVariation |
umls:C0022658 | Kidney Diseases | 9 | AlteredExpression, Biomarker |
umls:C0027651 | Neoplasms | 6 | Biomarker, Therapeutic |
umls:C2609414 | Acute Kidney Injury | 4 | Biomarker |
umls:C0005283 | beta-Thalassemia | 2 | AlteredExpression, Biomarker |
umls:C0021368 | Inflammation | 2 | Biomarker |
umls:C0860207 | Drug-Induced Liver Injury | 2 | Biomarker |
umls:C0003873 | Arthritis, Rheumatoid | 1 | Biomarker |
umls:C0006663 | Calcinosis | 1 | Biomarker |
umls:C0018824 | Heart Valve Diseases | 1 | Biomarker |
umls:C0019188 | Hepatitis, Animal | 1 | Biomarker |
umls:C0023893 | Liver Cirrhosis, Experimental | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for LCN2 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Experimental | DB01631 | Methyl Nonanoate (Ester) | Small molecule | |
Experimental | DB01672 | 2,3-Dihydroxy-Benzoic Acid | Small molecule | |
Experimental | DB01926 | Carboxymycobactin S | Small molecule | |
Experimental | DB02710 | 2,3,-Dihydroxybenzoylserine | Small molecule | |
Experimental | DB04043 | Carboxymycobactin T | Small molecule | |
Experimental | DB04476 | Trencam-3,2-Hopo | Small molecule |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of LCN2 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of LCN2 |
Multiple alignments for P80188 in multiple species |
LBS | AA sequence | # species | Species | A60 | GLAGNAILRED | 1 | Homo sapiens | A60 | GLAGNAVQKKT | 1 | Mus musculus | A60 | GLAGNAVQKER | 1 | Rattus norvegicus | D81 | YELKEDKSYNV | 1 | Homo sapiens | D81 | YELQENNSYNV | 1 | Mus musculus | D81 | YELQEDNSYNV | 1 | Rattus norvegicus | E64 | NAILREDKDPQ | 1 | Homo sapiens | E64 | NAVQKKTEGSF | 1 | Mus musculus | E64 | NAVQKERQSRF | 1 | Rattus norvegicus | F143 | HAMVFFKKVSQ | 1 | Homo sapiens | F143 | FAMVFFRKTSE | 1 | Mus musculus | F143 | FAMVFFQKTSE | 1 | Rattus norvegicus | F153 | QNREYFKITLY | 1 | Homo sapiens | F153 | ENKQYFKITLY | 1 | Mus musculus | F153 | ENKQYFKVTLY | 1 | Rattus norvegicus | I61 | LAGNAILREDK | 1 | Homo sapiens | I61 | LAGNAVQKKTE | 1 | Mus musculus | I61 | LAGNAVQKERQ | 1 | Rattus norvegicus | K145 | MVFFKKVSQNR | 1 | Homo sapiens | K145 | MVFFRKTSENK | 1 | Mus musculus | K145 | MVFFQKTSENK | 1 | Rattus norvegicus | K154 | NREYFKITLYG | 1 | Homo sapiens | K154 | NKQYFKITLYG | 1 | Mus musculus | K154 | NKQYFKVTLYG | 1 | Rattus norvegicus | K70 | DKDPQKMYATI | 1 | Homo sapiens | K70 | TEGSFTMYSTI | 1 | Mus musculus | K70 | RQSRFTMYSTI | 1 | Rattus norvegicus | L114 | PGEFTLGNIKS | 1 | Homo sapiens | L114 | AGQFTLGNMHR | 1 | Mus musculus | L114 | PGQFTLGNIHS | 1 | Rattus norvegicus | L123 | KSYPGLTSYLV | 1 | Homo sapiens | L123 | HRYPQVQSYNV | 1 | Mus musculus | L123 | HSYPQIQSYDV | 1 | Rattus norvegicus | L56 | WYVVGLAGNAI | 1 | Homo sapiens | L56 | WYVVGLAGNAV | 1 | Mus musculus | L56 | WFVVGLAGNAV | 1 | Rattus norvegicus | L62 | AGNAILREDKD | 1 | Homo sapiens | L62 | AGNAVQKKTEG | 1 | Mus musculus | L62 | AGNAVQKERQS | 1 | Rattus norvegicus | L90 | NVTSVLFR--K | 1 | Homo sapiens | L90 | NVTSILVRDQD | 1 | Mus musculus | L90 | NVTSILVR--G | 1 | Rattus norvegicus | N136 | VSTNYNQHAMV | 1 | Homo sapiens | N136 | ATTDYNQFAMV | 1 | Mus musculus | N136 | ADTDYDQFAMV | 1 | Rattus norvegicus | P189 | NHIVFPVPIDQ | 1 | Homo sapiens | P189 | DNIIFSVPTDQ | 1 | Mus musculus | P189 | NNIVFSVPTDQ | 1 | Rattus norvegicus | Q43 | LQQNFQDNQFQ | 1 | Homo sapiens | Q43 | LQPDFRSDQFR | 1 | Mus musculus | Q43 | LQPGFWTERFQ | 1 | Rattus norvegicus | Q46 | NFQDNQFQGKW | 1 | Homo sapiens | Q46 | DFRSDQFRGRW | 1 | Mus musculus | Q46 | GFWTERFQGRW | 1 | Rattus norvegicus | Q69 | EDKDPQKMYAT | 1 | Homo sapiens | Q69 | KTEGSFTMYST | 1 | Mus musculus | Q69 | ERQSRFTMYST | 1 | Rattus norvegicus | R101 | CRYWIRTFVPS | 2 | Mus musculus, Rattus norvegicus | R101 | CDYWIRTFVPG | 1 | Homo sapiens | R160 | ITLYGRTKELT | 1 | Homo sapiens | R160 | ITLYGRTKELS | 1 | Mus musculus | R160 | VTLYGRTKGLS | 1 | Rattus norvegicus | R63 | GNAILREDKDP | 1 | Homo sapiens | R63 | GNAVQKKTEGS | 1 | Mus musculus | R63 | GNAVQKERQSR | 1 | Rattus norvegicus | R92 | TSVLFR--KKK | 1 | Homo sapiens | R92 | TSILVRDQDQG | 1 | Mus musculus | R92 | TSILVR--GQG | 1 | Rattus norvegicus | S147 | FFKKVSQNREY | 1 | Homo sapiens | S147 | FFRKTSENKQY | 1 | Mus musculus | S147 | FFQKTSENKQY | 1 | Rattus norvegicus | S83 | LKEDKSYNVTS | 1 | Homo sapiens | S83 | LQENNSYNVTS | 1 | Mus musculus | S83 | LQEDNSYNVTS | 1 | Rattus norvegicus | S88 | SYNVTSVLFR- | 1 | Homo sapiens | S88 | SYNVTSILVRD | 1 | Mus musculus | S88 | SYNVTSILVR- | 1 | Rattus norvegicus | T102 | RYWIRTFVPSS | 2 | Mus musculus, Rattus norvegicus | T102 | DYWIRTFVPGC | 1 | Homo sapiens | T156 | EYFKITLYGRT | 1 | Homo sapiens | T156 | QYFKITLYGRT | 1 | Mus musculus | T156 | QYFKVTLYGRT | 1 | Rattus norvegicus | T74 | FTMYSTIYELQ | 2 | Mus musculus, Rattus norvegicus | T74 | QKMYATIYELK | 1 | Homo sapiens | V104 | WIRTFVPGCQP | 1 | Homo sapiens | V104 | WIRTFVPSSRA | 1 | Mus musculus | V104 | WIRTFVPSSRP | 1 | Rattus norvegicus | V86 | DKSYNVTSVLF | 1 | Homo sapiens | V86 | NNSYNVTSILV | 1 | Mus musculus | V86 | DNSYNVTSILV | 1 | Rattus norvegicus | W99 | QGCRYWIRTFV | 2 | Mus musculus, Rattus norvegicus | W99 | KKCDYWIRTFV | 1 | Homo sapiens | Y120 | GNIKSYPGLTS | 1 | Homo sapiens | Y120 | GNMHRYPQVQS | 1 | Mus musculus | Y120 | GNIHSYPQIQS | 1 | Rattus norvegicus | Y126 | PGLTSYLVRVV | 1 | Homo sapiens | Y126 | PQVQSYNVQVA | 1 | Mus musculus | Y126 | PQIQSYDVQVA | 1 | Rattus norvegicus | Y135 | VVSTNYNQHAM | 1 | Homo sapiens | Y135 | VATTDYNQFAM | 1 | Mus musculus | Y135 | VADTDYDQFAM | 1 | Rattus norvegicus | Y152 | SQNREYFKITL | 1 | Homo sapiens | Y152 | SENKQYFKITL | 1 | Mus musculus | Y152 | SENKQYFKVTL | 1 | Rattus norvegicus | Y158 | FKITLYGRTKE | 2 | Homo sapiens, Mus musculus | Y158 | FKVTLYGRTKG | 1 | Rattus norvegicus | Y72 | DPQKMYATIYE | 1 | Homo sapiens | Y72 | GSFTMYSTIYE | 1 | Mus musculus | Y72 | SRFTMYSTIYE | 1 | Rattus norvegicus |
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