mutLBSgeneDB |
Gene summary for LDHB |
Gene summary |
Basic gene Info. | Gene symbol | LDHB |
Gene name | lactate dehydrogenase B | |
Synonyms | HEL-S-281|LDH-B|LDH-H|LDHBD|TRG-5 | |
Cytomap | UCSC genome browser: 12p12.2-p12.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001174097.1, NM_002300.6, | |
Description | L-lactate dehydrogenase B chainLDH heart subunitepididymis secretory protein Li 281lactate dehydrogenase H chainrenal carcinoma antigen NY-REN-46 | |
Modification date | 20141222 | |
dbXrefs | MIM : 150100 | |
HGNC : HGNC | ||
Ensembl : ENSG00000111716 | ||
HPRD : 01026 | ||
Vega : OTTHUMG00000133760 | ||
Protein | UniProt: P07195 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_LDHB | |
BioGPS: 3945 | ||
Pathway | NCI Pathway Interaction Database: LDHB | |
KEGG: LDHB | ||
REACTOME: LDHB | ||
Pathway Commons: LDHB | ||
Context | iHOP: LDHB | |
ligand binding site mutation search in PubMed: LDHB | ||
UCL Cancer Institute: LDHB | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for LDHB |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | R100 | R100C | COAD | 1 | R170,L166 | S168Y | COAD | 1 | R107 | R107P | LUSC | 1 | I253 | I253V | LUSC | 1 | Y84 | S85F | SKCM | 1 | V29 | V27L | STAD | 1 | I253 | A252T | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for LDHB |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | R100 | R100C | 0.21680926 | I253 | A252T | -1.1244348 | Y84 | S85F | -0.74956074 | I253 | I253V | -0.7474699 | R107 | R107P | -0.45268087 | L166 | S168Y | -0.30577461 | R170 | S168Y | -0.30577461 | V29 | V27L | -0.17596945 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for LDHB from PDB |
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Differential gene expression and gene-gene network for LDHB |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for LDHB |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0007124 | Carcinoma, Intraductal, Noninfiltrating | 1 | Biomarker |
umls:C0948089 | Acute Coronary Syndrome | 1 | Biomarker |
umls:C1458155 | Breast Neoplasms | 1 | Biomarker |
umls:C0007134 | Carcinoma, Renal Cell | 1 | Biomarker |
umls:C0025521 | Metabolism, Inborn Errors | 1 | Biomarker |
umls:C0027626 | Neoplasm Invasiveness | 1 | Biomarker |
umls:C0033578 | Prostatic Neoplasms | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for LDHB |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Nutraceutical | DB00157 | NADH | Small molecule | |
Experimental | DB02401 | 4-Hydroxy-1,2,5-Oxadiazole-3-Carboxylic Acid | Small molecule | |
Experimental | DB03940 | Oxamic Acid | Small molecule |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of LDHB go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of LDHB |
Multiple alignments for P07195 in multiple species |
LBS | AA sequence | # species | Species | A239 | MVVDSAYEVIK | 3 | Danio rerio, Mus musculus, Rattus norvegicus | A239 | MVVESAYEVIK | 2 | Homo sapiens, Pan troglodytes | A239 | KVVDSAYEVIR | 1 | Danio rerio | A239 | QVVESAYEVIR | 1 | Gallus gallus | A97 | IVVVTAGVRQQ | 7 | Homo sapiens, Danio rerio, Danio rerio, Gallus gallus, Pan troglodytes, Mus musculus, Rattus norvegicus | D53 | ELALVDVLEDK | 5 | Homo sapiens, Gallus gallus, Pan troglodytes, Mus musculus, Rattus norvegicus | D53 | ELALVDVVEDK | 1 | Danio rerio | D53 | ELALVDVVEDR | 1 | Danio rerio | G30 | TVVGVGQVGMA | 6 | Homo sapiens, Danio rerio, Gallus gallus, Pan troglodytes, Mus musculus, Rattus norvegicus | G30 | TIVGVGQVGMA | 1 | Danio rerio | G98 | VVVTAGVRQQE | 7 | Homo sapiens, Danio rerio, Danio rerio, Gallus gallus, Pan troglodytes, Mus musculus, Rattus norvegicus | H194 | WILGEHGDSSV | 6 | Homo sapiens, Danio rerio, Gallus gallus, Pan troglodytes, Mus musculus, Rattus norvegicus | H194 | YILGEHGDTSV | 1 | Danio rerio | I121 | NVFKFIIPQIV | 5 | Homo sapiens, Gallus gallus, Pan troglodytes, Mus musculus, Rattus norvegicus | I121 | NIFKHIIPQIV | 2 | Danio rerio, Danio rerio | I253 | YTNWAIGLSVA | 7 | Homo sapiens, Danio rerio, Danio rerio, Gallus gallus, Pan troglodytes, Mus musculus, Rattus norvegicus | L166 | GSGCNLDSARF | 4 | Homo sapiens, Pan troglodytes, Mus musculus, Rattus norvegicus | L166 | GSGTNLDSARF | 2 | Danio rerio, Danio rerio | L166 | GSGCNLDTARF | 1 | Gallus gallus | L55 | ALVDVLEDKLK | 5 | Homo sapiens, Gallus gallus, Pan troglodytes, Mus musculus, Rattus norvegicus | L55 | ALVDVVEDKLK | 1 | Danio rerio | L55 | ALVDVVEDRLK | 1 | Danio rerio | N139 | IIVVSNPVDIL | 4 | Homo sapiens, Pan troglodytes, Mus musculus, Rattus norvegicus | N139 | LIVVSNPVDVL | 1 | Danio rerio | N139 | LVVVSNPVDVL | 1 | Danio rerio | N139 | ILVVSNPVDIL | 1 | Gallus gallus | Q101 | TAGVRQQEGES | 7 | Homo sapiens, Danio rerio, Danio rerio, Gallus gallus, Pan troglodytes, Mus musculus, Rattus norvegicus | Q31 | VVGVGQVGMAC | 6 | Homo sapiens, Danio rerio, Gallus gallus, Pan troglodytes, Mus musculus, Rattus norvegicus | Q31 | IVGVGQVGMAC | 1 | Danio rerio | R100 | VTAGVRQQEGE | 7 | Homo sapiens, Danio rerio, Danio rerio, Gallus gallus, Pan troglodytes, Mus musculus, Rattus norvegicus | R107 | QEGESRLNLVQ | 7 | Homo sapiens, Danio rerio, Danio rerio, Gallus gallus, Pan troglodytes, Mus musculus, Rattus norvegicus | R170 | NLDSARFRYLM | 5 | Homo sapiens, Danio rerio, Pan troglodytes, Mus musculus, Rattus norvegicus | R170 | NLDSARFRYIM | 1 | Danio rerio | R170 | NLDTARFRYLM | 1 | Gallus gallus | S138 | IIIVVSNPVDI | 2 | Homo sapiens, Pan troglodytes | S138 | TIIVVSNPVDI | 2 | Mus musculus, Rattus norvegicus | S138 | ILIVVSNPVDV | 1 | Danio rerio | S138 | ILVVVSNPVDV | 1 | Danio rerio | S138 | TILVVSNPVDI | 1 | Gallus gallus | S162 | HRVIGSGCNLD | 5 | Homo sapiens, Gallus gallus, Pan troglodytes, Mus musculus, Rattus norvegicus | S162 | HRVIGSGTNLD | 2 | Danio rerio, Danio rerio | T249 | KLKGYTNWAIG | 5 | Homo sapiens, Danio rerio, Pan troglodytes, Mus musculus, Rattus norvegicus | T249 | RLKGYTNWAIG | 2 | Danio rerio, Gallus gallus | T96 | KIVVVTAGVRQ | 5 | Homo sapiens, Gallus gallus, Pan troglodytes, Mus musculus, Rattus norvegicus | T96 | RIVVVTAGVRQ | 2 | Danio rerio, Danio rerio | V117 | QRNVNVFKFII | 5 | Homo sapiens, Gallus gallus, Pan troglodytes, Mus musculus, Rattus norvegicus | V117 | QRNVNIFKHII | 2 | Danio rerio, Danio rerio | V137 | CIIIVVSNPVD | 2 | Homo sapiens, Pan troglodytes | V137 | CTIIVVSNPVD | 2 | Mus musculus, Rattus norvegicus | V137 | CILIVVSNPVD | 1 | Danio rerio | V137 | CILVVVSNPVD | 1 | Danio rerio | V137 | CTILVVSNPVD | 1 | Gallus gallus | V141 | VVSNPVDILTY | 5 | Homo sapiens, Gallus gallus, Pan troglodytes, Mus musculus, Rattus norvegicus | V141 | VVSNPVDVLTY | 2 | Danio rerio, Danio rerio | V29 | ITVVGVGQVGM | 5 | Homo sapiens, Gallus gallus, Pan troglodytes, Mus musculus, Rattus norvegicus | V29 | VTVVGVGQVGM | 1 | Danio rerio | V29 | VTIVGVGQVGM | 1 | Danio rerio | V32 | VGVGQVGMACA | 7 | Homo sapiens, Danio rerio, Danio rerio, Gallus gallus, Pan troglodytes, Mus musculus, Rattus norvegicus | V54 | LALVDVLEDKL | 5 | Homo sapiens, Gallus gallus, Pan troglodytes, Mus musculus, Rattus norvegicus | V54 | LALVDVVEDKL | 1 | Danio rerio | V54 | LALVDVVEDRL | 1 | Danio rerio | V99 | VVTAGVRQQEG | 7 | Homo sapiens, Danio rerio, Danio rerio, Gallus gallus, Pan troglodytes, Mus musculus, Rattus norvegicus | Y84 | VADKDYSVTAN | 5 | Homo sapiens, Danio rerio, Pan troglodytes, Mus musculus, Rattus norvegicus | Y84 | VSGKDYSVTAN | 1 | Danio rerio | Y84 | VADKDYAVTAN | 1 | Gallus gallus |
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