mutLBSgeneDB |
Gene summary for LGALS1 |
Gene summary |
Basic gene Info. | Gene symbol | LGALS1 |
Gene name | lectin, galactoside-binding, soluble, 1 | |
Synonyms | GAL1|GBP | |
Cytomap | UCSC genome browser: 22q13.1 | |
Type of gene | protein-coding | |
RefGenes | NM_002305.3, | |
Description | 14 kDa laminin-binding protein14 kDa lectinHBLHLBP14HPLS-Lac lectin 1beta-galactoside-binding lectin L-14-Ibeta-galactoside-binding protein 14kDagal-1galaptingalectin 1galectin-1lactose-binding lectin 1putative MAPK-activating protein PM12 | |
Modification date | 20141222 | |
dbXrefs | MIM : 150570 | |
HGNC : HGNC | ||
Ensembl : ENSG00000100097 | ||
HPRD : 01040 | ||
Vega : OTTHUMG00000150661 | ||
Protein | UniProt: P09382 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_LGALS1 | |
BioGPS: 3956 | ||
Pathway | NCI Pathway Interaction Database: LGALS1 | |
KEGG: LGALS1 | ||
REACTOME: LGALS1 | ||
Pathway Commons: LGALS1 | ||
Context | iHOP: LGALS1 | |
ligand binding site mutation search in PubMed: LGALS1 | ||
UCL Cancer Institute: LGALS1 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
Top |
Ligand binding site mutations for LGALS1 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | S30 | K29N | HNSC | 1 | H45 | C43Y | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
Top |
Protein structure related information for LGALS1 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | S30 | K29N | -1.52886 | H45 | C43Y | -0.90956521 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for LGALS1 from PDB |
Top |
Differential gene expression and gene-gene network for LGALS1 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
Top |
Top |
Phenotype information for LGALS1 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0007131 | Carcinoma, Non-Small-Cell Lung | 3 | Biomarker |
umls:C0022548 | Keloid | 1 | Biomarker |
umls:C0027697 | Nephritis | 1 | Therapeutic |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
Top |
Pharmacological information for LGALS1 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Experimental | DB03345 | Beta-Mercaptoethanol | Small molecule | |
Experimental | DB04396 | Thiodigalactoside | Small molecule | |
Experimental | DB04447 | 1,4-Dithiothreitol | Small molecule |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of LGALS1 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
Top |
Conservation information for LBS of LGALS1 |
Multiple alignments for P09382 in multiple species |
LBS | AA sequence | # species | Species | D124 | NYMAADGDFKI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D124 | NYLSAGGDFKI | 1 | Bos taurus | D126 | MAADGDFKIKC | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D126 | LSAGGDFKIKC | 1 | Bos taurus | D55 | FNAHGDANTIV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D55 | FNAHGDVNTIV | 1 | Bos taurus | E72 | GAWGTEQREAV | 1 | Homo sapiens | E72 | GAWGAEQRESA | 1 | Bos taurus | E72 | GTWGTEHREPA | 1 | Mus musculus | E72 | GTWGTEQRETA | 1 | Rattus norvegicus | F31 | PDAKSFVLNLG | 2 | Homo sapiens, Rattus norvegicus | F31 | ADAKSFLLNLG | 1 | Bos taurus | F31 | SDAKSFVLNLG | 1 | Mus musculus | G125 | YMAADGDFKIK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G125 | YLSAGGDFKIK | 1 | Bos taurus | H45 | NNLCLHFNPRF | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | H53 | PRFNAHGDANT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H53 | PRFNAHGDVNT | 1 | Bos taurus | N47 | LCLHFNPRFNA | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | N62 | NTIVCNSKDGG | 1 | Homo sapiens | N62 | NTIVCNSKDAG | 1 | Bos taurus | N62 | NTIVCNTKEDG | 1 | Mus musculus | N62 | NTIVCNSKDDG | 1 | Rattus norvegicus | R49 | LHFNPRFNAHG | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | R74 | WGTEQREAVFP | 1 | Homo sapiens | R74 | WGAEQRESAFP | 1 | Bos taurus | R74 | WGTEHREPAFP | 1 | Mus musculus | R74 | WGTEQRETAFP | 1 | Rattus norvegicus | S30 | APDAKSFVLNL | 2 | Homo sapiens, Rattus norvegicus | S30 | AADAKSFLLNL | 1 | Bos taurus | S30 | ASDAKSFVLNL | 1 | Mus musculus | V32 | DAKSFVLNLGK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V32 | DAKSFLLNLGK | 1 | Bos taurus | V60 | DANTIVCNSKD | 2 | Homo sapiens, Rattus norvegicus | V60 | DVNTIVCNSKD | 1 | Bos taurus | V60 | DANTIVCNTKE | 1 | Mus musculus | W69 | KDGGAWGTEQR | 1 | Homo sapiens | W69 | KDAGAWGAEQR | 1 | Bos taurus | W69 | KEDGTWGTEHR | 1 | Mus musculus | W69 | KDDGTWGTEQR | 1 | Rattus norvegicus |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |