mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ARHGDIA
Gene summary
Basic gene Info.Gene symbolARHGDIA
Gene nameRho GDP dissociation inhibitor (GDI) alpha
CytomapUCSC genome browser: 17q25.3
Type of geneprotein-coding
DescriptionGDP-dissociation inhibitor, aplysia RAS-related 1epididymis secretory sperm binding protein Li 47erho GDP-dissociation inhibitor 1
Modification date20141222
dbXrefs MIM : 601925
Ensembl : ENSG00000141522
HPRD : 03565
Vega : OTTHUMG00000178352
ProteinUniProt: P52565
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ARHGDIA
BioGPS: 396
PathwayNCI Pathway Interaction Database: ARHGDIA
Pathway Commons: ARHGDIA
ligand binding site mutation search in PubMed: ARHGDIA
UCL Cancer Institute: ARHGDIA
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for ARHGDIA

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for ARHGDIA
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ARHGDIA from PDB

Differential gene expression and gene-gene network for ARHGDIA
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ARHGDIA and the right PPI network was created from samples without mutations in the LBS of ARHGDIA. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for ARHGDIA
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0027627Neoplasm Metastasis3Biomarker
umls:C1458155Breast Neoplasms1Biomarker
umls:C0019693HIV Infections1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for ARHGDIA
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ARHGDIA go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of ARHGDIA
Multiple alignments for P52565 in multiple species
LBSAA sequence# speciesSpecies
A171PKGMLARGSYN3Bos taurus, Mus musculus, Rattus norvegicus
A171PKGMLARGSYS1Homo sapiens
A171PSGMFARGSYS1Arabidopsis thaliana
A171PSGMMHRGKYK1Caenorhabditis elegans
A171PSGFLARGNYS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A171PTGMLARGHYE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I112GVEYRIKISFR4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
I112GSKYNLKFTFH1Arabidopsis thaliana
I112GSNYRLSFAFH1Caenorhabditis elegans
I112NSIYKLKIVFK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I112GSEFKIGVKFR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I139RKGVKIDKTDY4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
I139KTGVKVDRAKE1Arabidopsis thaliana
I139RSGITVENEKY1Caenorhabditis elegans
I139KAGIAVDKIDD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I139RRGFVVDKTST1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L196SWEWNLTIKKE3Bos taurus, Mus musculus, Rattus norvegicus
L196SWEWNLTIKKD1Homo sapiens
L196EINYSFDIRKE1Arabidopsis thaliana
L196DWQWTLHITKE1Caenorhabditis elegans
L196TLNWGVEIVKK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L196EFVWAFDVAKS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L75VIVTRLTLVCS2Mus musculus, Rattus norvegicus
L75VVVTGLTLVCS1Homo sapiens
L75VRIDSLAIISP1Arabidopsis thaliana
L75VIVRSVELLIN1Caenorhabditis elegans
L75VVVQKIQLLVN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L75VVILKLSLLVD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L77VTRLTLVCSTA3Bos taurus, Mus musculus, Rattus norvegicus
L77VTGLTLVCSSA1Homo sapiens
L77IDSLAIISPGR1Arabidopsis thaliana
L77VRSVELLINGK1Caenorhabditis elegans
L77VQKIQLLVNTE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L77ILKLSLLVDGR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L88PGPLELDLTGD4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
L88PDIVLLVPENG1Arabidopsis thaliana
L88-TAQSFDLSDP1Caenorhabditis elegans
L88PNPITFDLTNE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L88-DPVDVNMEDA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P166PMEEAPKGMLA3Bos taurus, Mus musculus, Rattus norvegicus
P166PVEEAPKGMLA1Homo sapiens
P166PEETTPSGMFA1Arabidopsis thaliana
P166PNEEAPSGMMH1Caenorhabditis elegans
P166PESEAPSGFLA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P166EPDEAPTGMLA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q130GMKYIQHTYRK4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Q130GLRYTNTVWKT1Arabidopsis thaliana
Q130GLHYKHKVKRS1Caenorhabditis elegans
Q130GLRYVQYIKKA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q130GLRYVQTVRRR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T132KYIQHTYRKGV4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
T132RYTNTVWKTGV1Arabidopsis thaliana
T132HYKHKVKRSGI1Caenorhabditis elegans
T132RYVQYIKKAGI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T132RYVQTVRRRGF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W194HLSWEWNLTIK4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
W194YLEINYSFDIR1Arabidopsis thaliana
W194YLDWQWTLHIT1Caenorhabditis elegans
W194HLTLNWGVEIV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W194HHEFVWAFDVA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y110KEGVEYRIKIS4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Y110KEGSKYNLKFT1Arabidopsis thaliana
Y110KEGSNYRLSFA1Caenorhabditis elegans
Y110KENSIYKLKIV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y110KEGSEFKIGVK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)

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