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mutLBSgeneDB |
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| Gene summary for LGALS8 |
 Gene summary |
| Basic gene Info. | Gene symbol | LGALS8 |
| Gene name | lectin, galactoside-binding, soluble, 8 | |
| Synonyms | Gal-8|PCTA-1|PCTA1|Po66-CBP | |
| Cytomap | UCSC genome browser: 1q43 | |
| Type of gene | protein-coding | |
| RefGenes | NM_006499.4, NM_201543.2,NM_201544.2,NM_201545.2, | |
| Description | Po66 carbohydrate binding proteingalectin 8galectin-8galectin-8gpo66 carbohydrate-binding proteinprostate carcinoma tumor antigen 1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 606099 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000116977 | ||
| HPRD : 09356 | ||
| Vega : OTTHUMG00000039953 | ||
| Protein | UniProt: O00214 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_LGALS8 | |
| BioGPS: 3964 | ||
| Pathway | NCI Pathway Interaction Database: LGALS8 | |
| KEGG: LGALS8 | ||
| REACTOME: LGALS8 | ||
| Pathway Commons: LGALS8 | ||
| Context | iHOP: LGALS8 | |
| ligand binding site mutation search in PubMed: LGALS8 | ||
| UCL Cancer Institute: LGALS8 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for LGALS8 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | K204,V202 | V203I | COAD | 1 | R59 | R59Q | COAD | 1 | I270,E268 | M269V | COAD | 1 | N283 | N283H | KIRC | 1 | H65 | H65N | LUSC | 1 | H38 | G37E | OV | 1 | R129 | G131S | STAD | 1 | N231 | N231I | STAD | 1 | Y272 | D274G | UCEC | 1 | R69 | R69H | UCEC | 1 | R233 | R233H | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for LGALS8 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | R233 | R233H | -1.8103524 | R69 | R69H | -1.4531846 | K204 | V203I | -1.053888 | V202 | V203I | -1.053888 | R129 | G131S | -1.0001393 | H38 | G37E | -0.93478589 | E268 | M269V | -0.89695248 | I270 | M269V | -0.89695248 | H65 | H65N | -0.88033574 | R59 | R59Q | -0.87553083 | Y272 | D274G | -0.53335944 | N231 | N231I | -0.23240303 | N283 | N283H | -0.14763747 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for LGALS8 from PDB |
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| Differential gene expression and gene-gene network for LGALS8 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for LGALS8 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for LGALS8 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of LGALS8 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | IOD | IODIDE | 3apb | B | H38 | ZN | ZINC(2+) | 4bmb | A | H38 | LBT | ALPHA-LACTOSE | 3ap4 | A | H65 R69 | LBT | ALPHA-LACTOSE | 3ap4 | B | H65 R69 | LBT | ALPHA-LACTOSE | 3ap4 | C | H65 R69 | LBT | ALPHA-LACTOSE | 3ap4 | D | H65 R69 | LAT | BETA-LACTOSE | 3ap6 | A | H65 R69 | LAT | BETA-LACTOSE | 3ap6 | B | H65 R69 | LAT | BETA-LACTOSE | 3ap6 | C | H65 R69 | LAT | BETA-LACTOSE | 3ap6 | D | H65 R69 | LAT | BETA-LACTOSE | 3ap7 | A | H65 R69 | GAL | BETA-D-GALACTOSE | 3ap9 | A | H65 R69 | GAL | BETA-D-GALACTOSE | 3vkl | A | H65 R69 | GAL | BETA-D-GALACTOSE | 3vkl | B | H65 R69 | GAL | BETA-D-GALACTOSE | 3vkm | A | H65 R69 | GAL | BETA-D-GALACTOSE | 3vkm | B | H65 R69 | GAL | BETA-D-GALACTOSE | 3vko | A | H65 R69 | GAL | BETA-D-GALACTOSE | 3vko | B | H65 R69 | GAL | BETA-D-GALACTOSE | 4fqz | A | H65 R69 | LAT | BETA-LACTOSE | 4bmb | A | H65 R69 | LBT | ALPHA-LACTOSE | 4bme | A | H65 R69 | LBT | ALPHA-LACTOSE | 4bme | B | H65 R69 | III | Peptide ligand (PRO,GLY,LEU,ALA,TYR,GLY,ASN,PRO,TYR) | 4han | A | K204 E268 I270 Y272 N283 | III | Peptide ligand (PRO,GLY,LEU,ALA,TYR,GLY,ASN,PRO,TYR) | 4han | B | K204 E268 I270 Y272 N283 | GAL | BETA-D-GALACTOSE | 3vkm | B | N231 | GAL | BETA-D-GALACTOSE | 3vkl | A | N231 R233 | GAL | BETA-D-GALACTOSE | 3vkl | B | N231 R233 | GAL | BETA-D-GALACTOSE | 3vkm | A | N231 R233 | IOD | IODIDE | 3apb | A | R129 | BGC | BETA-D-GLUCOSE | 3vkl | A | R233 | BGC | BETA-D-GLUCOSE | 3vkl | B | R233 | BGC | BETA-D-GLUCOSE | 3vkm | A | R233 | BGC | BETA-D-GLUCOSE | 3vkm | B | R233 | SIA | N-ACETYLNEURAMINIC ACID | 3ap7 | A | R59 | GAL | BETA-D-GALACTOSE | 3ap9 | A | R59 | SIA | N-ACETYLNEURAMINIC ACID | 3vkm | A | R59 | SIA | N-ACETYLNEURAMINIC ACID | 3vkm | B | R59 | SIA | N-ACETYLNEURAMINIC ACID | 3vko | A | R59 | SIA | N-ACETYLNEURAMINIC ACID | 3vko | B | R59 | SO4 | SULFATE | 3ap6 | A | R59 H65 | SO4 | SULFATE | 3ap6 | B | R59 H65 | SO4 | SULFATE | 3ap6 | C | R59 H65 | SO4 | SULFATE | 3ap6 | D | R59 H65 | NAD | NAD ZWITTERION | 4han | A | R59 H65 R69 | NAD | NAD ZWITTERION | 4han | B | R59 H65 R69 | BGC | BETA-D-GLUCOSE | 3ap9 | A | R69 | BGC | BETA-D-GLUCOSE | 3vkl | A | R69 | BGC | BETA-D-GLUCOSE | 3vkl | B | R69 | BGC | BETA-D-GLUCOSE | 3vkm | A | R69 | BGC | BETA-D-GLUCOSE | 3vkm | B | R69 | BGC | BETA-D-GLUCOSE | 4fqz | A | R69 |
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| Conservation information for LBS of LGALS8 |
| Multiple alignments for O00214 in multiple species |
| LBS | AA sequence | # species | Species |
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