mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for LGALS9
Gene summary
Basic gene Info.Gene symbolLGALS9
Gene namelectin, galactoside-binding, soluble, 9
SynonymsHUAT|LGALS9A
CytomapUCSC genome browser: 17q11.2
Type of geneprotein-coding
RefGenesNM_002308.3,
NM_009587.2,NR_024043.1,
Descriptionecalectingal-9galectin 9galectin-9tumor antigen HOM-HD-21urate transporter/channel protein
Modification date20141222
dbXrefs MIM : 601879
HGNC : HGNC
Ensembl : ENSG00000168961
HPRD : 03528
Vega : OTTHUMG00000179831
ProteinUniProt: O00182
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_LGALS9
BioGPS: 3965
PathwayNCI Pathway Interaction Database: LGALS9
KEGG: LGALS9
REACTOME: LGALS9
Pathway Commons: LGALS9
ContextiHOP: LGALS9
ligand binding site mutation search in PubMed: LGALS9
UCL Cancer Institute: LGALS9
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for LGALS9

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R65R65WBLCA1
R271R271HCOAD1
N280R279HGBM1
N63,R65P64LLUAD1
W82G83VLUAD1
R292R292QSKCM1
W82G80ESKCM1
R271,N269P270SSKCM1
E85P84LSKCM1
N137S135FSKCM1
N137G138DUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for LGALS9
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
R271P270S-1.4700243
N269P270S-1.4700243
R271R271H-1.2943698
R65R65W-1.0532841
R292R292Q-0.78706457
N280R279H-0.7710568
N137S135F-0.65348864
W82G83V-0.48708285
N137G138D-0.41694456
R65P64L-0.35852927
N63P64L-0.35852927
E85P84L-0.26541965
W82G80E-0.075118792
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for LGALS9 from PDB

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Differential gene expression and gene-gene network for LGALS9
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of LGALS9 and the right PPI network was created from samples without mutations in the LBS of LGALS9. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for LGALS9
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0027697Nephritis1Therapeutic

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for LGALS9
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB04472(R)-1-Para-Nitro-Phenyl-2-Azido-EthanolSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of LGALS9 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
GALBETA-D-GALACTOSE2zhkAN137
GALBETA-D-GALACTOSE2zhlBN137
GALBETA-D-GALACTOSE2zhlCN137
GALBETA-D-GALACTOSE2zhmBN137
GALBETA-D-GALACTOSE2zhmDN137
LBTALPHA-LACTOSE2eakAN63 R65 W82 E85
LBTALPHA-LACTOSE2eakCN63 R65 W82 E85
GALBETA-D-GALACTOSE2zhkAN63 R65 W82 E85
GALBETA-D-GALACTOSE2zhkBN63 R65 W82 E85
GALBETA-D-GALACTOSE2zhlAN63 R65 W82 E85
GALBETA-D-GALACTOSE2zhlBN63 R65 W82 E85
GALBETA-D-GALACTOSE2zhlCN63 R65 W82 E85
GALBETA-D-GALACTOSE2zhlDN63 R65 W82 E85
GALBETA-D-GALACTOSE2zhmAN63 R65 W82 E85
GALBETA-D-GALACTOSE2zhmBN63 R65 W82 E85
GALBETA-D-GALACTOSE2zhmCN63 R65 W82 E85
GALBETA-D-GALACTOSE2zhmDN63 R65 W82 E85
GALBETA-D-GALACTOSE2zhnAN63 R65 W82 E85
LATBETA-LACTOSE3lseAN63 R65 W82 E85
LSE2-(TRIMETHYLSILYL)ETHYL 4-O-BETA-D-GALACTOPYRANOSYL-6- SE-METHYL-6-SELENO-BETA-D-GLUCOPYRANOSIDE3wluAN63 R65 W82 E85
LSE2-(TRIMETHYLSILYL)ETHYL 4-O-BETA-D-GALACTOPYRANOSYL-6- SE-METHYL-6-SELENO-BETA-D-GLUCOPYRANOSIDE3wluBN63 R65 W82 E85
LSE2-(TRIMETHYLSILYL)ETHYL 4-O-BETA-D-GALACTOPYRANOSYL-6- SE-METHYL-6-SELENO-BETA-D-GLUCOPYRANOSIDE3wluCN63 R65 W82 E85
LSE2-(TRIMETHYLSILYL)ETHYL 4-O-BETA-D-GALACTOPYRANOSYL-6- SE-METHYL-6-SELENO-BETA-D-GLUCOPYRANOSIDE3wluDN63 R65 W82 E85
GALBETA-D-GALACTOSE3wv6AN63 R65 W82 E85
GALBETA-D-GALACTOSE3wv6BN63 R65 W82 E85
GALBETA-D-GALACTOSE2ealAR65 E85
GALBETA-D-GALACTOSE2ealBR65 E85
BGCBETA-D-GLUCOSE3wv6AR65 E85
BGCBETA-D-GLUCOSE3wv6BR65 E85


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Conservation information for LBS of LGALS9
Multiple alignments for O00182 in multiple species
LBSAA sequence# speciesSpecies


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