mutLBSgeneDB |
Gene summary for LGALS9 |
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Basic gene Info. | Gene symbol | LGALS9 |
Gene name | lectin, galactoside-binding, soluble, 9 | |
Synonyms | HUAT|LGALS9A | |
Cytomap | UCSC genome browser: 17q11.2 | |
Type of gene | protein-coding | |
RefGenes | NM_002308.3, NM_009587.2,NR_024043.1, | |
Description | ecalectingal-9galectin 9galectin-9tumor antigen HOM-HD-21urate transporter/channel protein | |
Modification date | 20141222 | |
dbXrefs | MIM : 601879 | |
HGNC : HGNC | ||
Ensembl : ENSG00000168961 | ||
HPRD : 03528 | ||
Vega : OTTHUMG00000179831 | ||
Protein | UniProt: O00182 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_LGALS9 | |
BioGPS: 3965 | ||
Pathway | NCI Pathway Interaction Database: LGALS9 | |
KEGG: LGALS9 | ||
REACTOME: LGALS9 | ||
Pathway Commons: LGALS9 | ||
Context | iHOP: LGALS9 | |
ligand binding site mutation search in PubMed: LGALS9 | ||
UCL Cancer Institute: LGALS9 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for LGALS9 |
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LBS | AAchange of nsSNV | Cancer type | # samples | R65 | R65W | BLCA | 1 | R271 | R271H | COAD | 1 | N280 | R279H | GBM | 1 | N63,R65 | P64L | LUAD | 1 | W82 | G83V | LUAD | 1 | R292 | R292Q | SKCM | 1 | W82 | G80E | SKCM | 1 | R271,N269 | P270S | SKCM | 1 | E85 | P84L | SKCM | 1 | N137 | S135F | SKCM | 1 | N137 | G138D | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for LGALS9 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | R271 | P270S | -1.4700243 | N269 | P270S | -1.4700243 | R271 | R271H | -1.2943698 | R65 | R65W | -1.0532841 | R292 | R292Q | -0.78706457 | N280 | R279H | -0.7710568 | N137 | S135F | -0.65348864 | W82 | G83V | -0.48708285 | N137 | G138D | -0.41694456 | R65 | P64L | -0.35852927 | N63 | P64L | -0.35852927 | E85 | P84L | -0.26541965 | W82 | G80E | -0.075118792 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for LGALS9 |
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Phenotype information for LGALS9 |
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Disease ID | Disease name | # PubMed | Association type |
umls:C0027697 | Nephritis | 1 | Therapeutic |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for LGALS9 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
Experimental | DB04472 | (R)-1-Para-Nitro-Phenyl-2-Azido-Ethanol | Small molecule | ![]() |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | GAL | BETA-D-GALACTOSE | 2zhk | A | N137 | GAL | BETA-D-GALACTOSE | 2zhl | B | N137 | GAL | BETA-D-GALACTOSE | 2zhl | C | N137 | GAL | BETA-D-GALACTOSE | 2zhm | B | N137 | GAL | BETA-D-GALACTOSE | 2zhm | D | N137 | LBT | ALPHA-LACTOSE | 2eak | A | N63 R65 W82 E85 | LBT | ALPHA-LACTOSE | 2eak | C | N63 R65 W82 E85 | GAL | BETA-D-GALACTOSE | 2zhk | A | N63 R65 W82 E85 | GAL | BETA-D-GALACTOSE | 2zhk | B | N63 R65 W82 E85 | GAL | BETA-D-GALACTOSE | 2zhl | A | N63 R65 W82 E85 | GAL | BETA-D-GALACTOSE | 2zhl | B | N63 R65 W82 E85 | GAL | BETA-D-GALACTOSE | 2zhl | C | N63 R65 W82 E85 | GAL | BETA-D-GALACTOSE | 2zhl | D | N63 R65 W82 E85 | GAL | BETA-D-GALACTOSE | 2zhm | A | N63 R65 W82 E85 | GAL | BETA-D-GALACTOSE | 2zhm | B | N63 R65 W82 E85 | GAL | BETA-D-GALACTOSE | 2zhm | C | N63 R65 W82 E85 | GAL | BETA-D-GALACTOSE | 2zhm | D | N63 R65 W82 E85 | GAL | BETA-D-GALACTOSE | 2zhn | A | N63 R65 W82 E85 | LAT | BETA-LACTOSE | 3lse | A | N63 R65 W82 E85 | LSE | 2-(TRIMETHYLSILYL)ETHYL 4-O-BETA-D-GALACTOPYRANOSYL-6- SE-METHYL-6-SELENO-BETA-D-GLUCOPYRANOSIDE | 3wlu | A | N63 R65 W82 E85 | LSE | 2-(TRIMETHYLSILYL)ETHYL 4-O-BETA-D-GALACTOPYRANOSYL-6- SE-METHYL-6-SELENO-BETA-D-GLUCOPYRANOSIDE | 3wlu | B | N63 R65 W82 E85 | LSE | 2-(TRIMETHYLSILYL)ETHYL 4-O-BETA-D-GALACTOPYRANOSYL-6- SE-METHYL-6-SELENO-BETA-D-GLUCOPYRANOSIDE | 3wlu | C | N63 R65 W82 E85 | LSE | 2-(TRIMETHYLSILYL)ETHYL 4-O-BETA-D-GALACTOPYRANOSYL-6- SE-METHYL-6-SELENO-BETA-D-GLUCOPYRANOSIDE | 3wlu | D | N63 R65 W82 E85 | GAL | BETA-D-GALACTOSE | 3wv6 | A | N63 R65 W82 E85 | GAL | BETA-D-GALACTOSE | 3wv6 | B | N63 R65 W82 E85 | GAL | BETA-D-GALACTOSE | 2eal | A | R65 E85 | GAL | BETA-D-GALACTOSE | 2eal | B | R65 E85 | BGC | BETA-D-GLUCOSE | 3wv6 | A | R65 E85 | BGC | BETA-D-GLUCOSE | 3wv6 | B | R65 E85 |
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Conservation information for LBS of LGALS9 |
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LBS | AA sequence | # species | Species |
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