mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

Home

Download

 Statistics

Help

About Us
Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for LIG4
Gene summary
Basic gene Info.Gene symbolLIG4
Gene nameligase IV, DNA, ATP-dependent
SynonymsLIG4S
CytomapUCSC genome browser: 13q33-q34
Type of geneprotein-coding
RefGenesNM_001098268.1,
NM_002312.3,NM_206937.1,
DescriptionDNA joinaseDNA ligase 4DNA ligase IVDNA repair enzymepolydeoxyribonucleotide synthase [ATP] 4polynucleotide ligasesealase
Modification date20141221
dbXrefs MIM : 601837
HGNC : HGNC
Ensembl : ENSG00000174405
HPRD : 03500
Vega : OTTHUMG00000017328
ProteinUniProt: P49917
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_LIG4
BioGPS: 3981
PathwayNCI Pathway Interaction Database: LIG4
KEGG: LIG4
REACTOME: LIG4
Pathway Commons: LIG4
ContextiHOP: LIG4
ligand binding site mutation search in PubMed: LIG4
UCL Cancer Institute: LIG4
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0000012single strand break repair8798671
GO:0006266DNA ligation12517771
GO:0006297nucleotide-excision repair, DNA gap filling12517771
GO:0006302double-strand break repair9242410
GO:0006303double-strand break repair via nonhomologous end joining12517771
GO:0033151V(D)J recombination9809069
GO:0051103DNA ligation involved in DNA repair12517771


Top
Ligand binding site mutations for LIG4

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
M68A67TCOAD1
L515Y516CCOAD1
H13S12CHNSC1
K432P434HLUAD1
L599D597YOV1
R603G604RSTAD1
S45S45YUCEC1
R603L602RUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


Top
Protein structure related information for LIG4
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
K432P434H-1.514265
R603L602R-1.3149085
H13S12C-0.91129329
R603G604R-0.90030729
L515Y516C-0.66578954
M68A67T-0.52615289
S45S45Y-0.46075922
L599D597Y-0.083849089
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for LIG4 from PDB

Top
Differential gene expression and gene-gene network for LIG4
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of LIG4 and the right PPI network was created from samples without mutations in the LBS of LIG4. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Top

Top
Phenotype information for LIG4
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C1847827LIG4 Syndrome8Biomarker, GeneticVariation
umls:C0026764Multiple Myeloma2Biomarker, GeneticVariation

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Top
Pharmacological information for LIG4
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of LIG4 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (ASP,VAL,PRO,GLN,TRP,GLU,VAL,PHE,PHE,LYS)4htpAH13 S45
IIIPeptide ligand (PRO,GLN,TRP,GLU)4htpBH13 S45
IIIPeptide ligand (VAL,PRO,GLN,TRP,GLU,VAL,PHE,PHE,LYS,ARG)3w1gAH13 S45
ATPATP3w1gAK432
ATPATP3w5oAK432
ATPATP3w5oBK432
HGMERCURY(2+)3w1bAL515
HGMERCURY(2+)3w1bAL599 R603
HGMERCURY(2+)3w1bAM68
IIIPeptide ligand (VAL,PRO,GLN,TRP,GLU,VAL,PHE,PHE,LYS,ARG)3w1bAS45


Top
Conservation information for LBS of LIG4
Multiple alignments for P49917 in multiple species
LBSAA sequence# speciesSpecies
A52RKFHDALHKNH1Homo sapiens
A52EIITNFIKLWR1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
A52EIISNFVEMWR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A52EITSNFVSLWR1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
A52KILLDYFNKWR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A52CKPSDYF----1Arabidopsis thaliana
A52RKFHSALHQKE1Gallus gallus
A52RKFHDALHKNR1Mus musculus
C225DLEKVCRQLHD3Homo sapiens, Gallus gallus, Mus musculus
C225DLDVLSQRLYN1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
C225DLKVVTSKLYD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C225DLRIVAHTLYD1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
C225SLKRICWELYD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C225DLKLVCEKLRD1Arabidopsis thaliana
C363SDLQTCYCVFD1Homo sapiens
C363ESYKPLFVAFD1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
C363VDFHPLYMVFD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C363PTYRPLYAVFD1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
C363SSYSPYYVVFD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C363SHKQLCYVAFD1Arabidopsis thaliana
C363SDLQTCFCVFD1Gallus gallus
C363SGLQTCYSVFD1Mus musculus
C365LQTCYCVFDVL1Homo sapiens
C365YKPLFVAFDLV1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
C365FHPLYMVFDLL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C365YRPLYAVFDLL1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
C365YSPYYVVFDIL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C365KQLCYVAFDVL1Arabidopsis thaliana
C365LQTCFCVFDVL1Gallus gallus
C365LQTCYSVFDVL1Mus musculus
C510RVGSGYTMKEL2Gallus gallus, Mus musculus
C510RVGSGCTMKEL1Homo sapiens
C510TIANGLSNEEF1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
C510SIANGISQEEF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C510SIANGISNEEF1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
C510RVGGGFTYFDR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C510RVGTGLSDDEL1Arabidopsis thaliana
C540PSSILC---GT2Homo sapiens, Mus musculus
C540SPNLLG--FGT1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
C540PASILE--FGS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C540PTDWVE--FGT1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
C540EYMELA---GT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C540PSFYQVTNHSK1Arabidopsis thaliana
C540PCNILC---GT1Gallus gallus
C574MYKTGCTLRFP1Homo sapiens
C574KYRSGCTLHFG1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
C574KYATNCTLYGG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C574LYKTGSTLYNA1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
C574RFKTNYTLRFP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C574VFVAPYSLRFP1Arabidopsis thaliana
C574MYKTDCTLRFP1Gallus gallus
C574MYKTGSTLRFP1Mus musculus
D18HVPFADLCSTL3Homo sapiens, Gallus gallus, Mus musculus
D18SPEFKWLCDEL1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D18SPDFKWLCEEL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D18SPDFCWLCDEL1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D18TLEFYDFVTTL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D18EIKFSVLVS-L1Arabidopsis thaliana
D275IETKLDGERMQ3Homo sapiens, Gallus gallus, Mus musculus
D275IEEKMDGERLQ1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D275VEEKMDGERIQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D275VEEKMDGDRIQ1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D275IEEKLDGERIQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D275AECKFDGDRIQ1Arabidopsis thaliana
E271QSFYIETKLDG2Homo sapiens, Mus musculus
E271-DFIIEEKMDG1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
E271-DFLVEEKMDG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E271-DFYVEEKMDG1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E271KPFWIEEKLDG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E271KDVVAECKFDG1Arabidopsis thaliana
E271QVFYIETKLDG1Gallus gallus
E331CILDGEMMAYN3Homo sapiens, Gallus gallus, Mus musculus
E331CILDGEMITYD1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
E331CVLDGEMVTFD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E331CILDGEMVSYD1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E331IILDGEMVTWD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E331CILDGEMLVWD1Arabidopsis thaliana
E427IDKREEGIMVK2Homo sapiens, Mus musculus
E427ISMGSEGIVLK1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
E427ISLGSEGVVLK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E427VAHGSEGIVLK1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E427IQEGSEGLVIK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E427VENRDEGIVLK1Arabidopsis thaliana
E427IDNREEGIMVK1Gallus gallus
F342PNTQTFMQKGT1Homo sapiens
F342TEKDIVLPFGL1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
F342AKRRVILPFGL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F342KEMQCILPFGL1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F342PVLETVIPYGS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F342TSLNRFAEFGS1Arabidopsis thaliana
F342PETQTFMQKGN1Gallus gallus
F342PTTQTFMQKGV1Mus musculus
F367TCYCVFDVLMV1Homo sapiens
F367PLFVAFDLVYL1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
F367PLYMVFDLLYL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F367PLYAVFDLLYL1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F367PYYVVFDILYL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F367LCYVAFDVLYV1Arabidopsis thaliana
F367TCFCVFDVLMI1Gallus gallus
F367TCYSVFDVLMV1Mus musculus
F42RHFREFLDSWR1Homo sapiens
F42GKPVTV-RYLE1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
F42GKSRSF-KYYE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F42GKPRKV-RNLE1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F42SNLDPYELKRK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F42SKFRKFLDTYC1Arabidopsis thaliana
F42KYFKDFLDSWR1Gallus gallus
F42RHFKEFLDSWR1Mus musculus
F49DSWRKFHDALH2Homo sapiens, Mus musculus
F49RYLEIITNFIK1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
F49KYYEIISNFVE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F49RNLEITSNFVS1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F49LKRKILLDYFN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F49DTYCKPSDYF-1Arabidopsis thaliana
F49DSWRKFHSALH1Gallus gallus
F529WKP--FHRKAP1Homo sapiens
F529WHI--FSEDPP1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
F529WKR--TSEVAP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F529WFP--YDERKP1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F529WLP--WSSDAL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F529FRKNEHPKKAP1Arabidopsis thaliana
F529WKP--YNRKDP1Gallus gallus
F529WKP--FHKKSP1Mus musculus
H13-TVASHVPFAD2Homo sapiens, Gallus gallus
H13-NFSPSPEFKW1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
H13-NFAPSPDFKW1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H13INFSPSPDFCW1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
H13-NHSSTLEFYD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H13--MTEEIKFSV1Arabidopsis thaliana
H13-TVAAHVPFAD1Mus musculus
I538APPSSILC---1Homo sapiens
I538PPSPNLLG--F1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
I538APPASILE--F1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I538KPPTDWVE--F1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
I538ALEYMELA---1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I538APPSFYQVTNH1Arabidopsis thaliana
I538DPPCNILC---1Gallus gallus
I538SPPSSILC---1Mus musculus
K273FYIETKLDGER3Homo sapiens, Gallus gallus, Mus musculus
K273FIIEEKMDGER1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
K273FLVEEKMDGER1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K273FYVEEKMDGDR1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
K273FWIEEKLDGER1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K273VVAECKFDGDR1Arabidopsis thaliana
K345QTFMQKGT---1Homo sapiens
K345DIVLPFGLVKS1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
K345RVILPFGLVKG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K345QCILPFGLTKS1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
K345ETVIPYGSLRS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K345NRFAEFGSNQE1Arabidopsis thaliana
K345QTFMQKGN---1Gallus gallus
K345QTFMQKGV---1Mus musculus
K432EGIMVKQPLSI1Homo sapiens
K432EGIVLKHLHSK1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
K432EGVVLKYYNSS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K432EGIVLKKARSK1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
K432EGLVIKKPSGS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K432EGIVLKDLESK1Arabidopsis thaliana
K432EGIMVKDPMST1Gallus gallus
K432EGIMVKHPLSI1Mus musculus
K449GEGWLKIKPEY3Homo sapiens, Gallus gallus, Mus musculus
K449NTDWIKIKPEY1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
K449NNNWIKVKPEY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K449DDSWIKIKPEY1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
K449MDDWIKVKPYY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K449SGKWMKLKPEY1Arabidopsis thaliana
K451GWLKIKPEYVS2Homo sapiens, Mus musculus
K451DWIKIKPEYLE1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
K451NWIKVKPEYLE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K451SWIKIKPEYLE1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
K451DWIKVKPYYLQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K451KWMKLKPEYIR1Arabidopsis thaliana
K451GWLKIKPEYVN1Gallus gallus
K48LDSWRKFHDAL2Homo sapiens, Mus musculus
K48-RYLEIITNFI1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
K48-KYYEIISNFV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K48-RNLEITSNFV1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
K48ELKRKILLDYF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K48LDTYCKPSDYF1Arabidopsis thaliana
K48LDSWRKFHSAL1Gallus gallus
L221NVTTDLEKVCR3Homo sapiens, Gallus gallus, Mus musculus
L221SVVSDLDVLSQ1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
L221SVISDLKVVTS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L221KVVSDLRIVAH1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L221RLCSSLKRICW1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L221NVTCDLKLVCE1Arabidopsis thaliana
L274YIETKLDGERM3Homo sapiens, Gallus gallus, Mus musculus
L274IIEEKMDGERL1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
L274LVEEKMDGERI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L274YVEEKMDGDRI1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L274WIEEKLDGERI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L274VAECKFDGDRI1Arabidopsis thaliana
L515YTMKELYDLGL2Gallus gallus, Mus musculus
L515CTMKELYDLGL1Homo sapiens
L515LSNEEFKDIER1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
L515ISQEEFKEIDR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L515ISNEEFKEIDR1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L515FTYFDRDIIRK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L515LSDDELNTVVS1Arabidopsis thaliana
L53KFHDALHKNHK1Homo sapiens
L53IITNFIKLWRS1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
L53IISNFVEMWRK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L53ITSNFVSLWRK1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L53ILLDYFNKWRQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L53KPSDYF-----1Arabidopsis thaliana
L53KFHSALHQKEK1Gallus gallus
L53KFHDALHKNRK1Mus musculus
L599MTLDDLEQLRG1Homo sapiens
L599ASFSEFEDMKD1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
L599YTLNDLYESRT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L599STVAEYDTARE1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L599LTINEFFTLKN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L599LDVQAFVELVN1Arabidopsis thaliana
L599MTLDMLEHLRS1Gallus gallus
L599MTLGDLEQLRG1Mus musculus
M430REEGIMVKQPL1Homo sapiens
M430GSEGIVLKHLH1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
M430GSEGVVLKYYN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M430GSEGIVLKKAR1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
M430GSEGLVIKKPS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M430RDEGIVLKDLE1Arabidopsis thaliana
M430REEGIMVKDPM1Gallus gallus
M430REEGIMVKHPL1Mus musculus
M68SFYPAMRLILP3Homo sapiens, Gallus gallus, Mus musculus
M68YIYPALRLIVP1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
M68NIYPALVLALP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M68DIYPALVLSLP1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
M68DLYPLLRLMLP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M68---VAVRLIIP1Arabidopsis thaliana
P15VASHVPFADLC2Homo sapiens, Gallus gallus
P15FSPSPEFKWLC1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
P15FAPSPDFKWLC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P15FSPSPDFCWLC1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
P15HSSTLEFYDFV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P15MTEEIKFSVLV1Arabidopsis thaliana
P15VAAHVPFADLC1Mus musculus
R25STL-ERIQKSK1Homo sapiens
R25DELLGKIYETS1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
R25EELFVKIHEVQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R25DELFIKLEEVA1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R25TTLLEPLSRIG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R25S-LFNWIQKSK1Arabidopsis thaliana
R25STL-ERIQTCK1Gallus gallus
R25STL-ERIQKGK1Mus musculus
R278KLDGERMQMH-3Homo sapiens, Gallus gallus, Mus musculus
R278KMDGERLQIHY1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
R278KMDGERIQVHY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R278KMDGDRIQVHY1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R278KLDGERIQLH-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R278KFDGDRIQIH-1Arabidopsis thaliana
R603DLEQLRGKASG2Homo sapiens, Mus musculus
R603EFEDMKDARN-1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
R603DLYESRTVKS-1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R603EYDTAREARS-1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R603EFFTLKNAVE-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R603AFVELVNSSNG1Arabidopsis thaliana
R603MLEHLRSRAEG1Gallus gallus
S45REFLDSWRKFH1Homo sapiens
S45VTV-RYLEIIT1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
S45RSF-KYYEIIS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S45RKV-RNLEITS1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S45DPYELKRKILL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S45RKFLDTYCKPS1Arabidopsis thaliana
S45KDFLDSWRKFH1Gallus gallus
S45KEFLDSWRKFH1Mus musculus
S508LSRVGSGCTMK1Homo sapiens
S508FCTIANGLSNE1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
S508FCSIANGISQE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S508FCSIANGISNE1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S508FVRVGGGFTYF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S508FCRVGTGLSDD1Arabidopsis thaliana
S508ICRVGSGYTMK1Gallus gallus
S508LCRVGSGYTMK1Mus musculus
T22ADLCSTL-ERI3Homo sapiens, Gallus gallus, Mus musculus
T22KWLCDELLGKI1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
T22KWLCEELFVKI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T22CWLCDELFIKL1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
T22YDFVTTLLEPL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T22SVLVS-LFNWI1Arabidopsis thaliana
T272SFYIETKLDGE2Homo sapiens, Mus musculus
T272DFIIEEKMDGE1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
T272DFLVEEKMDGE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T272DFYVEEKMDGD1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
T272PFWIEEKLDGE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T272DVVAECKFDGD1Arabidopsis thaliana
T272VFYIETKLDGE1Gallus gallus
V14TVASHVPFADL2Homo sapiens, Gallus gallus
V14NFSPSPEFKWL1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
V14NFAPSPDFKWL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V14NFSPSPDFCWL1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
V14NHSSTLEFYDF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V14-MTEEIKFSVL1Arabidopsis thaliana
V14TVAAHVPFADL1Mus musculus
W447KRGEGWLKIKP3Homo sapiens, Gallus gallus, Mus musculus
W447SRNTDWIKIKP1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
W447SRNNNWIKVKP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W447KRDDSWIKIKP1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
W447ERMDDWIKVKP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W447DRSGKWMKLKP1Arabidopsis thaliana
W46EFLDSWRKFHD2Homo sapiens, Mus musculus
W46TV-RYLEIITN1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
W46SF-KYYEIISN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W46KV-RNLEITSN1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
W46PYELKRKILLD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W46KFLDTYCKPSD1Arabidopsis thaliana
W46DFLDSWRKFHS1Gallus gallus
Y364DLQTCYCVFDV1Homo sapiens
Y364SYKPLFVAFDL1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Y364DFHPLYMVFDL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y364TYRPLYAVFDL1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Y364SYSPYYVVFDI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y364HKQLCYVAFDV1Arabidopsis thaliana
Y364DLQTCFCVFDV1Gallus gallus
Y364GLQTCYSVFDV1Mus musculus


Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas