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mutLBSgeneDB |
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| Gene summary for LIMK2 |
 Gene summary |
| Basic gene Info. | Gene symbol | LIMK2 |
| Gene name | LIM domain kinase 2 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 22q12.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001031801.1, NM_005569.3,NM_016733.2, | |
| Description | - | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 601988 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000182541 | ||
| HPRD : 03585 | ||
| Vega : OTTHUMG00000151251 | ||
| Protein | UniProt: P53671 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_LIMK2 | |
| BioGPS: 3985 | ||
| Pathway | NCI Pathway Interaction Database: LIMK2 | |
| KEGG: LIMK2 | ||
| REACTOME: LIMK2 | ||
| Pathway Commons: LIMK2 | ||
| Context | iHOP: LIMK2 | |
| ligand binding site mutation search in PubMed: LIMK2 | ||
| UCL Cancer Institute: LIMK2 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for LIMK2 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | C72 | F71L | COAD | 1 | T405 | Y407C | COAD | 1 | C72 | E70K | HNSC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for LIMK2 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | C72 | E70K | -1.1668061 | T405 | Y407C | -1.0656403 | C72 | F71L | -0.44266457 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for LIMK2 from PDB |
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| Differential gene expression and gene-gene network for LIMK2 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for LIMK2 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for LIMK2 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of LIMK2 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | 35H | N-{4-[(1S)-1,2-DIHYDROXYETHYL]BENZYL}-N-METHYL-4- (PHENYLSULFAMOYL)BENZAMIDE | 4tpt | A | T405 | 35H | N-{4-[(1S)-1,2-DIHYDROXYETHYL]BENZYL}-N-METHYL-4- (PHENYLSULFAMOYL)BENZAMIDE | 4tpt | B | T405 |
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| Conservation information for LBS of LIMK2 |
| Multiple alignments for P53671 in multiple species |
| LBS | AA sequence | # species | Species | A468 | KTVVVADFGLS | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | C101 | FACMSCKVIIE | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | C121 | HATLYCGKCHN | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | C121 | HSTLYCGKCHN | 1 | Gallus gallus | C124 | LYCGKCHNEVV | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | C124 | LYCGKCHNQIV | 1 | Gallus gallus | C72 | KFGEFCHGCSL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | C72 | KFGESCHGCSL | 1 | Gallus gallus | C75 | EFCHGCSLLMT | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | C75 | ESCHGCSLLMT | 1 | Gallus gallus | C95 | KYHPECFACMS | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | C98 | PECFACMSCKV | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | D469 | TVVVADFGLSR | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | E361 | VMVMKELIRCD | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | E361 | VMVMNELIRCD | 1 | Bos taurus | F391 | PNVLKFIGVLY | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | F470 | VVVADFGLSRL | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | H449 | SMCIIHRDLNS | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | H92 | GEFKYHPECFA | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | H92 | GEYKYHPECFA | 1 | Gallus gallus | I363 | VMKELIRCDEE | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | I363 | VMNELIRCDEE | 1 | Bos taurus | K360 | KVMVMKELIRC | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | K360 | KVMVMNELIRC | 1 | Bos taurus | L383 | KVMRSLDHPNV | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | L389 | DHPNVLKFIGV | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | L403 | DKKLNLLTEYI | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | L442 | SGMAYLHSMCI | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | L472 | VADFGLSRLIV | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | M380 | TEVKVMRSLDH | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | T405 | KLNLLTEYIEG | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | V388 | LDHPNVLKFIG | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | V467 | DKTVVVADFGL | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus |
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