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mutLBSgeneDB |
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| Gene summary for PRSS57 |
 Gene summary |
| Basic gene Info. | Gene symbol | PRSS57 |
| Gene name | protease, serine, 57 | |
| Synonyms | PRSSL1|UNQ782 | |
| Cytomap | UCSC genome browser: 19p13.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_214710.3, | |
| Description | GLGL782protease, serine-like 1serine protease 1-like protein 1serine protease 57 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000185198 | ||
| HPRD : 17916 | ||
| Vega : OTTHUMG00000180662 | ||
| Protein | UniProt: Q6UWY2 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PRSS57 | |
| BioGPS: 400668 | ||
| Pathway | NCI Pathway Interaction Database: PRSS57 | |
| KEGG: PRSS57 | ||
| REACTOME: PRSS57 | ||
| Pathway Commons: PRSS57 | ||
| Context | iHOP: PRSS57 | |
| ligand binding site mutation search in PubMed: PRSS57 | ||
| UCL Cancer Institute: PRSS57 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for PRSS57 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | H119 | A120T | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for PRSS57 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | H119 | A120T | -0.63312294 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PRSS57 from PDB |
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| Differential gene expression and gene-gene network for PRSS57 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for PRSS57 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for PRSS57 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of PRSS57 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of PRSS57 |
| Multiple alignments for Q6UWY2 in multiple species |
| LBS | AA sequence | # species | Species | A216 | RGFCSADSGGP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C214 | RRRGFCSADSG | 2 | Mus musculus, Rattus norvegicus | C214 | HRRGFCSADSG | 1 | Homo sapiens | C239 | FSGLWCGDPKT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D122 | MTHANDICLLR | 1 | Homo sapiens | D122 | ATQANDICLLR | 1 | Mus musculus | D122 | TTQANDICLLR | 1 | Rattus norvegicus | F213 | RRRRGFCSADS | 2 | Mus musculus, Rattus norvegicus | F213 | SHRRGFCSADS | 1 | Homo sapiens | F234 | HGLVSFSGLWC | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G236 | LVSFSGLWCGD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H119 | YHPMTHANDIC | 1 | Homo sapiens | H119 | FQPATQANDIC | 1 | Mus musculus | H119 | FEPTTQANDIC | 1 | Rattus norvegicus | H74 | VVSAAHCFSHR | 1 | Homo sapiens | H74 | VVSAAHCFSDR | 1 | Mus musculus | H74 | VLSAAHCFSDR | 1 | Rattus norvegicus | K193 | CNSSWKGHLTL | 1 | Homo sapiens | K193 | CNSSWQGQLNP | 1 | Mus musculus | K193 | CNSSWQGQLSP | 1 | Rattus norvegicus | S190 | LSVCNSSWQGQ | 2 | Mus musculus, Rattus norvegicus | S190 | PDVCNSSWKGH | 1 | Homo sapiens | S215 | RRGFCSADSGG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S218 | FCSADSGGPLV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S233 | AHGLVSFSGLW | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S235 | GLVSFSGLWCG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y114 | TTHPDYHPMTH | 1 | Homo sapiens | Y114 | VSHPDFQPATQ | 1 | Mus musculus | Y114 | VSHPDFEPTTQ | 1 | Rattus norvegicus |
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