mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PRSS57
Gene summary
Basic gene Info.Gene symbolPRSS57
Gene nameprotease, serine, 57
CytomapUCSC genome browser: 19p13.3
Type of geneprotein-coding
DescriptionGLGL782protease, serine-like 1serine protease 1-like protein 1serine protease 57
Modification date20141207
dbXrefs HGNC : HGNC
Ensembl : ENSG00000185198
HPRD : 17916
Vega : OTTHUMG00000180662
ProteinUniProt: Q6UWY2
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PRSS57
BioGPS: 400668
PathwayNCI Pathway Interaction Database: PRSS57
Pathway Commons: PRSS57
ContextiHOP: PRSS57
ligand binding site mutation search in PubMed: PRSS57
UCL Cancer Institute: PRSS57
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for PRSS57

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for PRSS57
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PRSS57 from PDB

Differential gene expression and gene-gene network for PRSS57
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PRSS57 and the right PPI network was created from samples without mutations in the LBS of PRSS57. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for PRSS57
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for PRSS57
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PRSS57 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of PRSS57
Multiple alignments for Q6UWY2 in multiple species
LBSAA sequence# speciesSpecies
A216RGFCSADSGGP3Homo sapiens, Mus musculus, Rattus norvegicus
C214RRRGFCSADSG2Mus musculus, Rattus norvegicus
C214HRRGFCSADSG1Homo sapiens
C239FSGLWCGDPKT3Homo sapiens, Mus musculus, Rattus norvegicus
D122MTHANDICLLR1Homo sapiens
D122ATQANDICLLR1Mus musculus
D122TTQANDICLLR1Rattus norvegicus
F213RRRRGFCSADS2Mus musculus, Rattus norvegicus
F213SHRRGFCSADS1Homo sapiens
F234HGLVSFSGLWC3Homo sapiens, Mus musculus, Rattus norvegicus
G236LVSFSGLWCGD3Homo sapiens, Mus musculus, Rattus norvegicus
H119YHPMTHANDIC1Homo sapiens
H119FQPATQANDIC1Mus musculus
H119FEPTTQANDIC1Rattus norvegicus
H74VVSAAHCFSHR1Homo sapiens
H74VVSAAHCFSDR1Mus musculus
H74VLSAAHCFSDR1Rattus norvegicus
K193CNSSWKGHLTL1Homo sapiens
K193CNSSWQGQLNP1Mus musculus
K193CNSSWQGQLSP1Rattus norvegicus
S190LSVCNSSWQGQ2Mus musculus, Rattus norvegicus
S190PDVCNSSWKGH1Homo sapiens
S215RRGFCSADSGG3Homo sapiens, Mus musculus, Rattus norvegicus
S218FCSADSGGPLV3Homo sapiens, Mus musculus, Rattus norvegicus
S233AHGLVSFSGLW3Homo sapiens, Mus musculus, Rattus norvegicus
S235GLVSFSGLWCG3Homo sapiens, Mus musculus, Rattus norvegicus
Y114TTHPDYHPMTH1Homo sapiens
Y114VSHPDFQPATQ1Mus musculus
Y114VSHPDFEPTTQ1Rattus norvegicus

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