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mutLBSgeneDB |
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| Gene summary for LYZ |
 Gene summary |
| Basic gene Info. | Gene symbol | LYZ |
| Gene name | lysozyme | |
| Synonyms | LZM | |
| Cytomap | UCSC genome browser: 12q15 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000239.2, | |
| Description | 1,4-beta-N-acetylmuramidase Cc-type lysozymelysozyme C | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 153450 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000090382 | ||
| HPRD : 01085 | ||
| Vega : OTTHUMG00000169342 | ||
| Protein | UniProt: P61626 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_LYZ | |
| BioGPS: 4069 | ||
| Pathway | NCI Pathway Interaction Database: LYZ | |
| KEGG: LYZ | ||
| REACTOME: LYZ | ||
| Pathway Commons: LYZ | ||
| Context | iHOP: LYZ | |
| ligand binding site mutation search in PubMed: LYZ | ||
| UCL Cancer Institute: LYZ | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for LYZ |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | A129 | R131I | COAD | 1 | E53 | E53K | SKCM | 1 | D120 | R119C | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for LYZ |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | E53 | E53K | -0.97062038 | D120 | R119C | -0.56009825 | A129 | R131I | -0.2904051 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for LYZ from PDB |
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| Differential gene expression and gene-gene network for LYZ |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for LYZ |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0268389 | Amyloidosis, familial visceral | 1 | Biomarker, GeneticVariation |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for LYZ |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved|nutraceutical | DB00128 | L-Aspartic Acid | Small molecule |  |
| Experimental | DB02250 | Cu-Bicyclam | Small molecule |  |
| Experimental | DB02759 | 4-Methylumbelliferyl Chitobiose | Small molecule |  |
| Experimental | DB02772 | Sucrose | Small molecule |  |
| Experimental|vet_approved | DB03006 | Arsanilic acid | Small molecule |  |
| Experimental | DB03013 | Di(N-Acetyl-D-Glucosamine) | Small molecule |  |
| Experimental | DB03120 | Para-Toluene Sulfonate | Small molecule |  |
| Experimental | DB03175 | 1-Proponol | Small molecule |  |
| Experimental | DB03189 | Cu-Cyclam | Small molecule |  |
| Experimental | DB03487 | 3-Aminosuccinimide | Small molecule |  |
| Experimental | DB03967 | Dodecyl Sulfate | Small molecule |  |
| Experimental | DB04194 | Chitotriose | Small molecule |  |
| Experimental | DB04268 | Methylumbelliferyl Chitotriose | Small molecule |  |
| Experimental | DB06912 | UNDECA-3,7-DIENE-1,3,7,11-TETRACARBALDEHYDE | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of LYZ go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of LYZ |
| Multiple alignments for P61626 in multiple species |
| LBS | AA sequence | # species | Species | A126 | PQGIRAWVAWR | 6 | Homo sapiens, Bos taurus, Pan troglodytes, Macaca mulatta, Mus musculus, Mus musculus | A126 | GNGMNAWVAWR | 1 | Gallus gallus | A129 | IRAWVAWRNRC | 2 | Homo sapiens, Pan troglodytes | A129 | MNAWVAWRNRC | 1 | Gallus gallus | A129 | IRAWVAWRSHC | 1 | Bos taurus | A129 | IRAWVAWRNHC | 1 | Macaca mulatta | A129 | IRAWVAWRAHC | 1 | Mus musculus | A129 | IRAWVAWRTQC | 1 | Mus musculus | C113 | ADAVACAKRVV | 2 | Homo sapiens, Pan troglodytes | C113 | TAAIQCAKRVV | 2 | Mus musculus, Mus musculus | C113 | TASVNCAKKIV | 1 | Gallus gallus | C113 | TQAVACAKRVV | 1 | Bos taurus | C113 | ADAVTCAKRVV | 1 | Macaca mulatta | D120 | KRVVRDPQGIR | 4 | Homo sapiens, Pan troglodytes, Mus musculus, Mus musculus | D120 | KRVVSDPQGIR | 2 | Bos taurus, Macaca mulatta | D120 | KKIVSDGNGMN | 1 | Gallus gallus | D71 | GDRSTDYGIFQ | 3 | Homo sapiens, Pan troglodytes, Mus musculus | D71 | GDQSTDYGIFQ | 3 | Bos taurus, Macaca mulatta, Mus musculus | D71 | -DGSTDYGILQ | 1 | Gallus gallus | E53 | CLAKWESGYNT | 2 | Homo sapiens, Pan troglodytes | E53 | CLAQHESNYNT | 2 | Mus musculus, Mus musculus | E53 | CAAKFESNFNT | 1 | Gallus gallus | E53 | CLARWESNYNT | 1 | Bos taurus | E53 | CLAKWESNYNT | 1 | Macaca mulatta | H96 | AVNACHLSCSA | 2 | Homo sapiens, Pan troglodytes | H96 | SRNLCNIPCSA | 1 | Gallus gallus | H96 | AVNACHLPCGA | 1 | Bos taurus | H96 | AVNACHISCNA | 1 | Macaca mulatta | H96 | AVNACGINCSA | 1 | Mus musculus | H96 | SKNACGINCSA | 1 | Mus musculus | I77 | YGIFQINSRYW | 4 | Homo sapiens, Pan troglodytes, Mus musculus, Mus musculus | I77 | YGILQINSRWW | 1 | Gallus gallus | I77 | YGIFQINSHWW | 1 | Bos taurus | I77 | YGIFQINSHYW | 1 | Macaca mulatta | L97 | VNACHLSCSAL | 2 | Homo sapiens, Pan troglodytes | L97 | RNLCNIPCSAL | 1 | Gallus gallus | L97 | VNACHLPCGAL | 1 | Bos taurus | L97 | VNACHISCNAL | 1 | Macaca mulatta | L97 | VNACGINCSAL | 1 | Mus musculus | L97 | KNACGINCSAL | 1 | Mus musculus | N62 | NTRATNYNAGD | 2 | Homo sapiens, Pan troglodytes | N62 | NTRATNYNRGD | 2 | Mus musculus, Mus musculus | N62 | NTQATNRNT-D | 1 | Gallus gallus | N62 | NTQATNYNAGD | 1 | Bos taurus | N62 | NTQATNYNPGD | 1 | Macaca mulatta | N64 | RATNYNAGDRS | 2 | Homo sapiens, Pan troglodytes | N64 | QATNRNT-DGS | 1 | Gallus gallus | N64 | QATNYNAGDQS | 1 | Bos taurus | N64 | QATNYNPGDQS | 1 | Macaca mulatta | N64 | RATNYNRGDQS | 1 | Mus musculus | N64 | RATNYNRGDRS | 1 | Mus musculus | N78 | GIFQINSRYWC | 4 | Homo sapiens, Pan troglodytes, Mus musculus, Mus musculus | N78 | GILQINSRWWC | 1 | Gallus gallus | N78 | GIFQINSHWWC | 1 | Bos taurus | N78 | GIFQINSHYWC | 1 | Macaca mulatta | P121 | RVVRDPQGIRA | 4 | Homo sapiens, Pan troglodytes, Mus musculus, Mus musculus | P121 | RVVSDPQGIRA | 2 | Bos taurus, Macaca mulatta | P121 | KIVSDGNGMNA | 1 | Gallus gallus | Q122 | VVRDPQGIRAW | 4 | Homo sapiens, Pan troglodytes, Mus musculus, Mus musculus | Q122 | VVSDPQGIRAW | 2 | Bos taurus, Macaca mulatta | Q122 | IVSDGNGMNAW | 1 | Gallus gallus | Q76 | DYGIFQINSRY | 4 | Homo sapiens, Pan troglodytes, Mus musculus, Mus musculus | Q76 | DYGILQINSRW | 1 | Gallus gallus | Q76 | DYGIFQINSHW | 1 | Bos taurus | Q76 | DYGIFQINSHY | 1 | Macaca mulatta | R116 | VACAKRVVRDP | 2 | Homo sapiens, Pan troglodytes | R116 | IQCAKRVVRDP | 2 | Mus musculus, Mus musculus | R116 | VNCAKKIVSDG | 1 | Gallus gallus | R116 | VACAKRVVSDP | 1 | Bos taurus | R116 | VTCAKRVVSDP | 1 | Macaca mulatta | T61 | YNTRATNYNAG | 2 | Homo sapiens, Pan troglodytes | T61 | YNTRATNYNRG | 2 | Mus musculus, Mus musculus | T61 | FNTQATNRNT- | 1 | Gallus gallus | T61 | YNTQATNYNAG | 1 | Bos taurus | T61 | YNTQATNYNPG | 1 | Macaca mulatta | V128 | GIRAWVAWRNR | 2 | Homo sapiens, Pan troglodytes | V128 | GMNAWVAWRNR | 1 | Gallus gallus | V128 | GIRAWVAWRSH | 1 | Bos taurus | V128 | GIRAWVAWRNH | 1 | Macaca mulatta | V128 | GIRAWVAWRAH | 1 | Mus musculus | V128 | GIRAWVAWRTQ | 1 | Mus musculus | W127 | QGIRAWVAWRN | 3 | Homo sapiens, Pan troglodytes, Macaca mulatta | W127 | NGMNAWVAWRN | 1 | Gallus gallus | W127 | QGIRAWVAWRS | 1 | Bos taurus | W127 | QGIRAWVAWRA | 1 | Mus musculus | W127 | QGIRAWVAWRT | 1 | Mus musculus | W52 | MCLAKWESGYN | 2 | Homo sapiens, Pan troglodytes | W52 | VCLAQHESNYN | 2 | Mus musculus, Mus musculus | W52 | VCAAKFESNFN | 1 | Gallus gallus | W52 | MCLARWESNYN | 1 | Bos taurus | W52 | VCLAKWESNYN | 1 | Macaca mulatta | W82 | INSRYWCNDGK | 4 | Homo sapiens, Pan troglodytes, Mus musculus, Mus musculus | W82 | INSRWWCNDGR | 1 | Gallus gallus | W82 | INSHWWCNDGK | 1 | Bos taurus | W82 | INSHYWCNNGK | 1 | Macaca mulatta | Y81 | QINSRYWCNDG | 4 | Homo sapiens, Pan troglodytes, Mus musculus, Mus musculus | Y81 | QINSRWWCNDG | 1 | Gallus gallus | Y81 | QINSHWWCNDG | 1 | Bos taurus | Y81 | QINSHYWCNNG | 1 | Macaca mulatta |
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