mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MAOA
Gene summary
Basic gene Info.Gene symbolMAOA
Gene namemonoamine oxidase A
SynonymsMAO-A
CytomapUCSC genome browser: Xp11.3
Type of geneprotein-coding
RefGenesNM_000240.3,
NM_001270458.1,
Descriptionamine oxidase [flavin-containing] Amonoamine oxidase type A
Modification date20141222
dbXrefs MIM : 309850
HGNC : HGNC
Ensembl : ENSG00000189221
HPRD : 02400
ProteinUniProt: P21397
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MAOA
BioGPS: 4128
PathwayNCI Pathway Interaction Database: MAOA
KEGG: MAOA
REACTOME: MAOA
Pathway Commons: MAOA
ContextiHOP: MAOA
ligand binding site mutation search in PubMed: MAOA
UCL Cancer Institute: MAOA
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for MAOA

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
L337D338NCOAD1
V115P114TGBM1
R45R47KSKCM1
I19V17LUCEC1
F208R206WUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for MAOA
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
R45R47K-1.2556168
L337D338N-1.0724438
V115P114T-0.80947485
I19V17L-0.76427654
F208R206W-0.75139595
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MAOA from PDB

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Differential gene expression and gene-gene network for MAOA
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MAOA and the right PPI network was created from samples without mutations in the LBS of MAOA. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for MAOA
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0003431Antisocial Personality Disorder18Biomarker, GeneticVariation
umls:C0004936Mental Disorders15Biomarker, GeneticVariation
umls:C0004352Autistic Disorder12Biomarker, GeneticVariation
umls:C0030567Parkinson Disease7Biomarker, GeneticVariation
umls:C0033054Prenatal Exposure Delayed Effects2Biomarker, GeneticVariation
umls:C0796275Brunner Syndrome1Biomarker, GeneticVariation
umls:C0031511Pheochromocytoma1Biomarker
umls:C0014175Endometriosis1Biomarker
umls:C1285261Fetal Nutrition Disorders1Biomarker
umls:C0020649Hypotension1Biomarker
umls:C1136249Mental Retardation, X-Linked1Biomarker
umls:C0026848Muscular Diseases1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for MAOA
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|illicitDB00191PhentermineSmall molecule
Approved|investigational|vet_approvedDB00721ProcaineSmall molecule
ApprovedDB00752TranylcypromineSmall molecule
ApprovedDB00780PhenelzineSmall molecule
ApprovedDB00805MinaprineSmall molecule
Approved|investigationalDB00909ZonisamideSmall molecule
Approved|investigational|vet_approvedDB01037SelegilineSmall molecule
ApprovedDB01171MoclobemideSmall molecule
ApprovedDB01247IsocarboxazidSmall molecule
Approved|nutraceutical|withdrawnDB01363EphedraSmall molecule
Experimental|illicitDB01442MMDASmall molecule
Experimental|illicitDB014724-MethoxyamphetamineSmall molecule
Approved|illicitDB01577MethamphetamineSmall molecule
ApprovedDB01626PargylineSmall molecule
ApprovedDB03147Flavin adenine dinucleotideSmall molecule
ExperimentalDB04017N-Methyl-N-Propargyl-3-(2,4-Dichlorophenoxy)PropylamineSmall molecule
WithdrawnDB04820NialamideSmall molecule
WithdrawnDB04821NomifensineSmall molecule
WithdrawnDB04832ZimelidineSmall molecule
InvestigationalDB04850PosizolidSmall molecule
InvestigationalDB05205CX157Small molecule
ExperimentalDB07641DECYL(DIMETHYL)PHOSPHINE OXIDESmall molecule
ExperimentalDB079197-METHOXY-1-METHYL-9H-BETA-CARBOLINESmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MAOA go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
HRMHARMINE2z5xAF208 L337
HRMHARMINE2z5yAF208 L337
FADFAD2bxsAI19
FADFAD2bxsBI19
FADFAD2bxrAI19 R45
FADFAD2bxrBI19 R45
FADFAD2z5xAI19 R45
FADFAD2z5yAI19 R45
MLGN-METHYL-N-PROPARGYL-3-(2,4-DICHLOROPHENOXY)PROPYLAMINE2bxrAL337
MLGN-METHYL-N-PROPARGYL-3-(2,4-DICHLOROPHENOXY)PROPYLAMINE2bxrBL337
MLGN-METHYL-N-PROPARGYL-3-(2,4-DICHLOROPHENOXY)PROPYLAMINE2bxsAL337
MLGN-METHYL-N-PROPARGYL-3-(2,4-DICHLOROPHENOXY)PROPYLAMINE2bxsBL337
DCXDIMETHYLDECYLPHOSPHINE OXIDE2z5xAV115


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Conservation information for LBS of MAOA
Multiple alignments for P21397 in multiple species
LBSAA sequence# speciesSpecies
A272KYVINAIPPTL1Homo sapiens
A272KYVISAIPPVL1Mus musculus
A272RYVISAIPPTL1Bos taurus
A272KYVISAIPPTL1Canis lupus familiaris
A44VLVLEARDRVG3Homo sapiens, Mus musculus, Canis lupus familiaris
A44VLVLEARERVG1Bos taurus
A448GYMEGAVEAGE4Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
A68VDVGGAYVGPT4Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
C323KDYCGCMIIED4Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
C406QYSGGCYTAYF4Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
E216TNGGQERKFVG4Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
E43SVLVLEARDRV1Homo sapiens
E43NVLVLEARDRV1Mus musculus
E43NVLVLEARERV1Bos taurus
E43DVLVLEARDRV1Canis lupus familiaris
E492THTFWERNLPS2Homo sapiens, Canis lupus familiaris
E492THTFLERNLPS1Mus musculus
E492TPSFWERNLPS1Bos taurus
F208GTTRIFSVTNG2Homo sapiens, Canis lupus familiaris
F208GTSRIFSVTNG1Mus musculus
F208GTTRIFSITNG1Bos taurus
F352PAIMGFILARK4Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
G20DVVVIGGGISG4Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
G21VVVIGGGISGL4Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
G22VVIGGGISGLS3Homo sapiens, Bos taurus, Canis lupus familiaris
G22VVIGGGISGLA1Mus musculus
G434RIYFAGTETAT3Mus musculus, Bos taurus, Canis lupus familiaris
G434RIFFAGTETAT1Homo sapiens
G443ATQWSGYMEGA2Mus musculus, Bos taurus
G443ATKWSGYMEGA1Homo sapiens
G443ATHWSGYMEGA1Canis lupus familiaris
G50RDRVGGRTYTV2Mus musculus, Canis lupus familiaris
G50RDRVGGRTYTI1Homo sapiens
G50RERVGGRTYTV1Bos taurus
G66DYVDVGGAYVG3Homo sapiens, Bos taurus, Canis lupus familiaris
G66KWVDVGGAYVG1Mus musculus
G67YVDVGGAYVGP3Homo sapiens, Bos taurus, Canis lupus familiaris
G67WVDVGGAYVGP1Mus musculus
H242QVKLNHPVTHV1Homo sapiens
H242KVKLSSPVTYI1Mus musculus
H242RVKLRSPVTYV1Bos taurus
H242RVKLKRPVTYV1Canis lupus familiaris
I180YLFVNINVTSE2Homo sapiens, Mus musculus
I180SLFVNINVTSE2Bos taurus, Canis lupus familiaris
I19FDVVVIGGGIS4Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
I23VIGGGISGLSA3Homo sapiens, Bos taurus, Canis lupus familiaris
I23VIGGGISGLAA1Mus musculus
I273YVISAIPPTLT2Bos taurus, Canis lupus familiaris
I273YVINAIPPTLT1Homo sapiens
I273YVISAIPPVLT1Mus musculus
I335EAPISITLDDT3Mus musculus, Bos taurus, Canis lupus familiaris
I335DAPISITLDDT1Homo sapiens
K305MGAVIKCMMYY2Homo sapiens, Bos taurus
K305MGAVIKCMVYY1Mus musculus
K305MGAIIKCMMYY1Canis lupus familiaris
L122NPIAYLDYNNL3Homo sapiens, Bos taurus, Canis lupus familiaris
L122NPLAYLDYNNL1Mus musculus
L277AIPPTLTAKIH3Homo sapiens, Bos taurus, Canis lupus familiaris
L277AIPPVLTAKIH1Mus musculus
L337PISITLDDTKP4Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
L42VSVLVLEARDR1Homo sapiens
L42INVLVLEARDR1Mus musculus
L42VNVLVLEARER1Bos taurus
L42VDVLVLEARDR1Canis lupus familiaris
M445QWSGYMEGAVE2Mus musculus, Bos taurus
M445KWSGYMEGAVE1Homo sapiens
M445HWSGYMEGAVE1Canis lupus familiaris
N181LFVNINVTSEP4Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
P118PPVWNPIAYLD3Homo sapiens, Bos taurus, Canis lupus familiaris
P118PPVWNPLAYLD1Mus musculus
P243VKLNHPVTHVD1Homo sapiens
P243VKLSSPVTYID1Mus musculus
P243VKLRSPVTYVD1Bos taurus
P243VKLKRPVTYVD1Canis lupus familiaris
Q215VTNGGQERKFV3Homo sapiens, Mus musculus, Canis lupus familiaris
Q215ITNGGQERKFV1Bos taurus
R45LVLEARDRVGG3Homo sapiens, Mus musculus, Canis lupus familiaris
R45LVLEARERVGG1Bos taurus
R51DRVGGRTYTVR2Mus musculus, Canis lupus familiaris
R51DRVGGRTYTIR1Homo sapiens
R51ERVGGRTYTVR1Bos taurus
S24IGGGISGLSAA3Homo sapiens, Bos taurus, Canis lupus familiaris
S24IGGGISGLAAA1Mus musculus
T435IYFAGTETATQ2Mus musculus, Bos taurus
T435IFFAGTETATK1Homo sapiens
T435IYFAGTETATH1Canis lupus familiaris
T489VEITHTFWERN1Homo sapiens
T489LEITHTFLERN1Mus musculus
T489VEITPSFWERN1Bos taurus
T489MEITHTFWERN1Canis lupus familiaris
T52RVGGRTYTVRN3Mus musculus, Bos taurus, Canis lupus familiaris
T52RVGGRTYTIRN1Homo sapiens
V115GAFPPVWNPIA3Homo sapiens, Bos taurus, Canis lupus familiaris
V115GAFPPVWNPLA1Mus musculus
V244KLNHPVTHVDQ1Homo sapiens
V244KLSSPVTYIDQ1Mus musculus
V244KLRSPVTYVDQ1Bos taurus
V244KLKRPVTYVDQ1Canis lupus familiaris
V303LPMGAVIKCMM2Homo sapiens, Bos taurus
V303LPMGAVIKCMV1Mus musculus
V303LPMGAIIKCMM1Canis lupus familiaris
V65VDYVDVGGAYV3Homo sapiens, Bos taurus, Canis lupus familiaris
V65VKWVDVGGAYV1Mus musculus
W116AFPPVWNPIAY3Homo sapiens, Bos taurus, Canis lupus familiaris
W116AFPPVWNPLAY1Mus musculus
W397YEEKNWCEEQY3Homo sapiens, Mus musculus, Canis lupus familiaris
W397YEEKNWCQEQY1Bos taurus
W491ITHTFWERNLP2Homo sapiens, Canis lupus familiaris
W491ITHTFLERNLP1Mus musculus
W491ITPSFWERNLP1Bos taurus
Y121WNPIAYLDYNN3Homo sapiens, Bos taurus, Canis lupus familiaris
Y121WNPLAYLDYNN1Mus musculus
Y402WCEEQYSGGCY3Homo sapiens, Mus musculus, Canis lupus familiaris
Y402WCQEQYSGGCY1Bos taurus
Y407YSGGCYTAYFP4Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
Y444TQWSGYMEGAV2Mus musculus, Bos taurus
Y444TKWSGYMEGAV1Homo sapiens
Y444THWSGYMEGAV1Canis lupus familiaris
Y69DVGGAYVGPTQ4Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris


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