mutLBSgeneDB |
Gene summary for MAOA |
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Basic gene Info. | Gene symbol | MAOA |
Gene name | monoamine oxidase A | |
Synonyms | MAO-A | |
Cytomap | UCSC genome browser: Xp11.3 | |
Type of gene | protein-coding | |
RefGenes | NM_000240.3, NM_001270458.1, | |
Description | amine oxidase [flavin-containing] Amonoamine oxidase type A | |
Modification date | 20141222 | |
dbXrefs | MIM : 309850 | |
HGNC : HGNC | ||
Ensembl : ENSG00000189221 | ||
HPRD : 02400 | ||
Protein | UniProt: P21397 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MAOA | |
BioGPS: 4128 | ||
Pathway | NCI Pathway Interaction Database: MAOA | |
KEGG: MAOA | ||
REACTOME: MAOA | ||
Pathway Commons: MAOA | ||
Context | iHOP: MAOA | |
ligand binding site mutation search in PubMed: MAOA | ||
UCL Cancer Institute: MAOA | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for MAOA |
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LBS | AAchange of nsSNV | Cancer type | # samples | L337 | D338N | COAD | 1 | V115 | P114T | GBM | 1 | R45 | R47K | SKCM | 1 | I19 | V17L | UCEC | 1 | F208 | R206W | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for MAOA |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | R45 | R47K | -1.2556168 | L337 | D338N | -1.0724438 | V115 | P114T | -0.80947485 | I19 | V17L | -0.76427654 | F208 | R206W | -0.75139595 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for MAOA |
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Phenotype information for MAOA |
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Disease ID | Disease name | # PubMed | Association type |
umls:C0003431 | Antisocial Personality Disorder | 18 | Biomarker, GeneticVariation |
umls:C0004936 | Mental Disorders | 15 | Biomarker, GeneticVariation |
umls:C0004352 | Autistic Disorder | 12 | Biomarker, GeneticVariation |
umls:C0030567 | Parkinson Disease | 7 | Biomarker, GeneticVariation |
umls:C0033054 | Prenatal Exposure Delayed Effects | 2 | Biomarker, GeneticVariation |
umls:C0796275 | Brunner Syndrome | 1 | Biomarker, GeneticVariation |
umls:C0031511 | Pheochromocytoma | 1 | Biomarker |
umls:C0014175 | Endometriosis | 1 | Biomarker |
umls:C1285261 | Fetal Nutrition Disorders | 1 | Biomarker |
umls:C0020649 | Hypotension | 1 | Biomarker |
umls:C1136249 | Mental Retardation, X-Linked | 1 | Biomarker |
umls:C0026848 | Muscular Diseases | 1 | Biomarker |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for MAOA |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
Approved|illicit | DB00191 | Phentermine | Small molecule | ![]() |
Approved|investigational|vet_approved | DB00721 | Procaine | Small molecule | ![]() |
Approved | DB00752 | Tranylcypromine | Small molecule | ![]() |
Approved | DB00780 | Phenelzine | Small molecule | ![]() |
Approved | DB00805 | Minaprine | Small molecule | ![]() |
Approved|investigational | DB00909 | Zonisamide | Small molecule | ![]() |
Approved|investigational|vet_approved | DB01037 | Selegiline | Small molecule | ![]() |
Approved | DB01171 | Moclobemide | Small molecule | ![]() |
Approved | DB01247 | Isocarboxazid | Small molecule | ![]() |
Approved|nutraceutical|withdrawn | DB01363 | Ephedra | Small molecule | ![]() |
Experimental|illicit | DB01442 | MMDA | Small molecule | ![]() |
Experimental|illicit | DB01472 | 4-Methoxyamphetamine | Small molecule | ![]() |
Approved|illicit | DB01577 | Methamphetamine | Small molecule | ![]() |
Approved | DB01626 | Pargyline | Small molecule | ![]() |
Approved | DB03147 | Flavin adenine dinucleotide | Small molecule | ![]() |
Experimental | DB04017 | N-Methyl-N-Propargyl-3-(2,4-Dichlorophenoxy)Propylamine | Small molecule | ![]() |
Withdrawn | DB04820 | Nialamide | Small molecule | ![]() |
Withdrawn | DB04821 | Nomifensine | Small molecule | ![]() |
Withdrawn | DB04832 | Zimelidine | Small molecule | ![]() |
Investigational | DB04850 | Posizolid | Small molecule | ![]() |
Investigational | DB05205 | CX157 | Small molecule | ![]() |
Experimental | DB07641 | DECYL(DIMETHYL)PHOSPHINE OXIDE | Small molecule | ![]() |
Experimental | DB07919 | 7-METHOXY-1-METHYL-9H-BETA-CARBOLINE | Small molecule | ![]() |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | HRM | HARMINE | 2z5x | A | F208 L337 | HRM | HARMINE | 2z5y | A | F208 L337 | FAD | FAD | 2bxs | A | I19 | FAD | FAD | 2bxs | B | I19 | FAD | FAD | 2bxr | A | I19 R45 | FAD | FAD | 2bxr | B | I19 R45 | FAD | FAD | 2z5x | A | I19 R45 | FAD | FAD | 2z5y | A | I19 R45 | MLG | N-METHYL-N-PROPARGYL-3-(2,4-DICHLOROPHENOXY)PROPYLAMINE | 2bxr | A | L337 | MLG | N-METHYL-N-PROPARGYL-3-(2,4-DICHLOROPHENOXY)PROPYLAMINE | 2bxr | B | L337 | MLG | N-METHYL-N-PROPARGYL-3-(2,4-DICHLOROPHENOXY)PROPYLAMINE | 2bxs | A | L337 | MLG | N-METHYL-N-PROPARGYL-3-(2,4-DICHLOROPHENOXY)PROPYLAMINE | 2bxs | B | L337 | DCX | DIMETHYLDECYLPHOSPHINE OXIDE | 2z5x | A | V115 |
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Conservation information for LBS of MAOA |
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LBS | AA sequence | # species | Species | A272 | KYVINAIPPTL | 1 | Homo sapiens | A272 | KYVISAIPPVL | 1 | Mus musculus | A272 | RYVISAIPPTL | 1 | Bos taurus | A272 | KYVISAIPPTL | 1 | Canis lupus familiaris | A44 | VLVLEARDRVG | 3 | Homo sapiens, Mus musculus, Canis lupus familiaris | A44 | VLVLEARERVG | 1 | Bos taurus | A448 | GYMEGAVEAGE | 4 | Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris | A68 | VDVGGAYVGPT | 4 | Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris | C323 | KDYCGCMIIED | 4 | Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris | C406 | QYSGGCYTAYF | 4 | Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris | E216 | TNGGQERKFVG | 4 | Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris | E43 | SVLVLEARDRV | 1 | Homo sapiens | E43 | NVLVLEARDRV | 1 | Mus musculus | E43 | NVLVLEARERV | 1 | Bos taurus | E43 | DVLVLEARDRV | 1 | Canis lupus familiaris | E492 | THTFWERNLPS | 2 | Homo sapiens, Canis lupus familiaris | E492 | THTFLERNLPS | 1 | Mus musculus | E492 | TPSFWERNLPS | 1 | Bos taurus | F208 | GTTRIFSVTNG | 2 | Homo sapiens, Canis lupus familiaris | F208 | GTSRIFSVTNG | 1 | Mus musculus | F208 | GTTRIFSITNG | 1 | Bos taurus | F352 | PAIMGFILARK | 4 | Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris | G20 | DVVVIGGGISG | 4 | Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris | G21 | VVVIGGGISGL | 4 | Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris | G22 | VVIGGGISGLS | 3 | Homo sapiens, Bos taurus, Canis lupus familiaris | G22 | VVIGGGISGLA | 1 | Mus musculus | G434 | RIYFAGTETAT | 3 | Mus musculus, Bos taurus, Canis lupus familiaris | G434 | RIFFAGTETAT | 1 | Homo sapiens | G443 | ATQWSGYMEGA | 2 | Mus musculus, Bos taurus | G443 | ATKWSGYMEGA | 1 | Homo sapiens | G443 | ATHWSGYMEGA | 1 | Canis lupus familiaris | G50 | RDRVGGRTYTV | 2 | Mus musculus, Canis lupus familiaris | G50 | RDRVGGRTYTI | 1 | Homo sapiens | G50 | RERVGGRTYTV | 1 | Bos taurus | G66 | DYVDVGGAYVG | 3 | Homo sapiens, Bos taurus, Canis lupus familiaris | G66 | KWVDVGGAYVG | 1 | Mus musculus | G67 | YVDVGGAYVGP | 3 | Homo sapiens, Bos taurus, Canis lupus familiaris | G67 | WVDVGGAYVGP | 1 | Mus musculus | H242 | QVKLNHPVTHV | 1 | Homo sapiens | H242 | KVKLSSPVTYI | 1 | Mus musculus | H242 | RVKLRSPVTYV | 1 | Bos taurus | H242 | RVKLKRPVTYV | 1 | Canis lupus familiaris | I180 | YLFVNINVTSE | 2 | Homo sapiens, Mus musculus | I180 | SLFVNINVTSE | 2 | Bos taurus, Canis lupus familiaris | I19 | FDVVVIGGGIS | 4 | Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris | I23 | VIGGGISGLSA | 3 | Homo sapiens, Bos taurus, Canis lupus familiaris | I23 | VIGGGISGLAA | 1 | Mus musculus | I273 | YVISAIPPTLT | 2 | Bos taurus, Canis lupus familiaris | I273 | YVINAIPPTLT | 1 | Homo sapiens | I273 | YVISAIPPVLT | 1 | Mus musculus | I335 | EAPISITLDDT | 3 | Mus musculus, Bos taurus, Canis lupus familiaris | I335 | DAPISITLDDT | 1 | Homo sapiens | K305 | MGAVIKCMMYY | 2 | Homo sapiens, Bos taurus | K305 | MGAVIKCMVYY | 1 | Mus musculus | K305 | MGAIIKCMMYY | 1 | Canis lupus familiaris | L122 | NPIAYLDYNNL | 3 | Homo sapiens, Bos taurus, Canis lupus familiaris | L122 | NPLAYLDYNNL | 1 | Mus musculus | L277 | AIPPTLTAKIH | 3 | Homo sapiens, Bos taurus, Canis lupus familiaris | L277 | AIPPVLTAKIH | 1 | Mus musculus | L337 | PISITLDDTKP | 4 | Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris | L42 | VSVLVLEARDR | 1 | Homo sapiens | L42 | INVLVLEARDR | 1 | Mus musculus | L42 | VNVLVLEARER | 1 | Bos taurus | L42 | VDVLVLEARDR | 1 | Canis lupus familiaris | M445 | QWSGYMEGAVE | 2 | Mus musculus, Bos taurus | M445 | KWSGYMEGAVE | 1 | Homo sapiens | M445 | HWSGYMEGAVE | 1 | Canis lupus familiaris | N181 | LFVNINVTSEP | 4 | Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris | P118 | PPVWNPIAYLD | 3 | Homo sapiens, Bos taurus, Canis lupus familiaris | P118 | PPVWNPLAYLD | 1 | Mus musculus | P243 | VKLNHPVTHVD | 1 | Homo sapiens | P243 | VKLSSPVTYID | 1 | Mus musculus | P243 | VKLRSPVTYVD | 1 | Bos taurus | P243 | VKLKRPVTYVD | 1 | Canis lupus familiaris | Q215 | VTNGGQERKFV | 3 | Homo sapiens, Mus musculus, Canis lupus familiaris | Q215 | ITNGGQERKFV | 1 | Bos taurus | R45 | LVLEARDRVGG | 3 | Homo sapiens, Mus musculus, Canis lupus familiaris | R45 | LVLEARERVGG | 1 | Bos taurus | R51 | DRVGGRTYTVR | 2 | Mus musculus, Canis lupus familiaris | R51 | DRVGGRTYTIR | 1 | Homo sapiens | R51 | ERVGGRTYTVR | 1 | Bos taurus | S24 | IGGGISGLSAA | 3 | Homo sapiens, Bos taurus, Canis lupus familiaris | S24 | IGGGISGLAAA | 1 | Mus musculus | T435 | IYFAGTETATQ | 2 | Mus musculus, Bos taurus | T435 | IFFAGTETATK | 1 | Homo sapiens | T435 | IYFAGTETATH | 1 | Canis lupus familiaris | T489 | VEITHTFWERN | 1 | Homo sapiens | T489 | LEITHTFLERN | 1 | Mus musculus | T489 | VEITPSFWERN | 1 | Bos taurus | T489 | MEITHTFWERN | 1 | Canis lupus familiaris | T52 | RVGGRTYTVRN | 3 | Mus musculus, Bos taurus, Canis lupus familiaris | T52 | RVGGRTYTIRN | 1 | Homo sapiens | V115 | GAFPPVWNPIA | 3 | Homo sapiens, Bos taurus, Canis lupus familiaris | V115 | GAFPPVWNPLA | 1 | Mus musculus | V244 | KLNHPVTHVDQ | 1 | Homo sapiens | V244 | KLSSPVTYIDQ | 1 | Mus musculus | V244 | KLRSPVTYVDQ | 1 | Bos taurus | V244 | KLKRPVTYVDQ | 1 | Canis lupus familiaris | V303 | LPMGAVIKCMM | 2 | Homo sapiens, Bos taurus | V303 | LPMGAVIKCMV | 1 | Mus musculus | V303 | LPMGAIIKCMM | 1 | Canis lupus familiaris | V65 | VDYVDVGGAYV | 3 | Homo sapiens, Bos taurus, Canis lupus familiaris | V65 | VKWVDVGGAYV | 1 | Mus musculus | W116 | AFPPVWNPIAY | 3 | Homo sapiens, Bos taurus, Canis lupus familiaris | W116 | AFPPVWNPLAY | 1 | Mus musculus | W397 | YEEKNWCEEQY | 3 | Homo sapiens, Mus musculus, Canis lupus familiaris | W397 | YEEKNWCQEQY | 1 | Bos taurus | W491 | ITHTFWERNLP | 2 | Homo sapiens, Canis lupus familiaris | W491 | ITHTFLERNLP | 1 | Mus musculus | W491 | ITPSFWERNLP | 1 | Bos taurus | Y121 | WNPIAYLDYNN | 3 | Homo sapiens, Bos taurus, Canis lupus familiaris | Y121 | WNPLAYLDYNN | 1 | Mus musculus | Y402 | WCEEQYSGGCY | 3 | Homo sapiens, Mus musculus, Canis lupus familiaris | Y402 | WCQEQYSGGCY | 1 | Bos taurus | Y407 | YSGGCYTAYFP | 4 | Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris | Y444 | TQWSGYMEGAV | 2 | Mus musculus, Bos taurus | Y444 | TKWSGYMEGAV | 1 | Homo sapiens | Y444 | THWSGYMEGAV | 1 | Canis lupus familiaris | Y69 | DVGGAYVGPTQ | 4 | Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris |
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