mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MAX
Gene summary
Basic gene Info.Gene symbolMAX
Gene nameMYC associated factor X
SynonymsbHLHd4
CytomapUCSC genome browser: 14q23
Type of geneprotein-coding
RefGenesNM_001271068.1,
NM_001271069.1,NM_002382.4,NM_145112.2,NM_145113.2,
NM_145114.2,NM_197957.3,NR_073137.1,NR_073138.1,
NM_145116.1,
Descriptionclass D basic helix-loop-helix protein 4protein max
Modification date20141219
dbXrefs MIM : 154950
HGNC : HGNC
Ensembl : ENSG00000125952
HPRD : 01113
Vega : OTTHUMG00000142809
ProteinUniProt: P61244
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MAX
BioGPS: 4149
PathwayNCI Pathway Interaction Database: MAX
KEGG: MAX
REACTOME: MAX
Pathway Commons: MAX
ContextiHOP: MAX
ligand binding site mutation search in PubMed: MAX
UCL Cancer Institute: MAX
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for MAX
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
H28H28RUCEC4
R60R60QUCEC3
E32E32KCOAD1
R60R60QLAML1
R35R35LLUAD1
R60R60QSTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for MAX
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
H28H28R0.31931916
E32E32K-0.78680892
R60R60Q-0.78659386
R35R35L-0.43592858
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MAX from PDB
PDB IDPDB titlePDB structure
1R05Solution Structure of Max B-HLH-LZ

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Differential gene expression and gene-gene network for MAX
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MAX and the right PPI network was created from samples without mutations in the LBS of MAX. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for MAX
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0031511Pheochromocytoma7Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for MAX
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MAX go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids1an2AE32 R60


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Conservation information for LBS of MAX
Multiple alignments for P61244 in multiple species
LBSAA sequence# speciesSpecies


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