mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ACHE
Gene summary
Basic gene Info.Gene symbolACHE
Gene nameacetylcholinesterase (Yt blood group)
SynonymsACEE|ARACHE|N-ACHE|YT
CytomapUCSC genome browser: 7q22
Type of geneprotein-coding
RefGenesNM_000665.4,
NM_001282449.1,NM_001302621.1,NM_001302622.1,NM_015831.2,
DescriptionYt blood groupacetylcholinesteraseapoptosis-related acetylcholinesterase
Modification date20141207
dbXrefs MIM : 100740
HGNC : HGNC
Ensembl : ENSG00000087085
HPRD : 00010
Vega : OTTHUMG00000157033
ProteinUniProt: P22303
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ACHE
BioGPS: 43
PathwayNCI Pathway Interaction Database: ACHE
KEGG: ACHE
REACTOME: ACHE
Pathway Commons: ACHE
ContextiHOP: ACHE
ligand binding site mutation search in PubMed: ACHE
UCL Cancer Institute: ACHE
Assigned class in mutLBSgeneDBA: This gene has a literature evidence and it belongs to targetable_mutLBSgenes.
References showing study about ligand binding site mutation for ACHE.1. "Mallender WD, Szegletes T, Rosenberry TL. Acetylthiocholine binds to asp74 at the peripheral site of human acetylcholinesterase as the first step in the catalytic pathway. Biochemistry. 2000 Jul 4;39(26):7753-63. PubMed PMID: 10869180." 10869180
2. "Lokeshwari D, Krishna Kumar NK, Manjunatha H. Multiple Mutations on the Second Acetylcholinesterase Gene Associated With Dimethoate Resistance in the Melon Aphid, Aphis gossypii (Hemiptera: Aphididae). J Econ Entomol. 2016 Jan 21. pii:tov403. [Epub ahead of print] PubMed PMID: 26797869." 26797869

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006581acetylcholine catabolic process1517212
GO:0007155cell adhesion15454088


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Ligand binding site mutations for ACHE
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
Y103D105YBLCA1
Y480E481KCOAD1
S234A235ELUAD1
Y372G373RLUSC1
Y480E481KSKCM1
Y480I482VSTAD1
N381E382AUCEC1
Y605K607NUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for ACHE
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
S234A235E0.15452215
Y103D105Y0.074696286
Y480I482V-1.332003
N381E382A-1.0194022
Y605K607N-0.55754745
Y480E481K-0.43691519
Y372G373R-0.33060296
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ACHE from PDB

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Differential gene expression and gene-gene network for ACHE
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ACHE and the right PPI network was created from samples without mutations in the LBS of ACHE. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for ACHE
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0002395Alzheimer Disease17Biomarker, GeneticVariation
umls:C0700359Organophosphate Poisoning3Biomarker, Therapeutic
umls:C0032343Poisoning2Biomarker
umls:C0002726Amyloidosis2Biomarker
umls:C0027765Nervous System Diseases2Biomarker
umls:C0236733Amphetamine-Related Disorders1Biomarker
umls:C1458155Breast Neoplasms1Biomarker
umls:C0007134Carcinoma, Renal Cell1Biomarker
umls:C0018273Growth Disorders1Biomarker
umls:C0023186Learning Disorders1Biomarker
umls:C0023893Liver Cirrhosis, Experimental1Biomarker
umls:C0025261Memory Disorders1Biomarker
umls:C0026650Movement Disorders1Biomarker
umls:C0026850Muscular Dystrophies1Biomarker
umls:C0086468Prenatal Injuries1Biomarker
umls:C0033578Prostatic Neoplasms1Biomarker
umls:C0036572Seizures1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for ACHE
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|nutraceuticalDB00122CholineSmall molecule
WithdrawnDB00382TacrineSmall molecule
ApprovedDB00449DipivefrinSmall molecule
ApprovedDB00483Gallamine TriethiodideSmall molecule
ApprovedDB00545PyridostigmineSmall molecule
ApprovedDB00674GalantamineSmall molecule
Approved|withdrawnDB00677IsoflurophateSmall molecule
Approved|vet_approvedDB00733PralidoximeSmall molecule
ApprovedDB00805MinaprineSmall molecule
ApprovedDB00843DonepezilSmall molecule
ApprovedDB00944DemecariumSmall molecule
ApprovedDB00981PhysostigmineSmall molecule
Approved|investigationalDB00989RivastigmineSmall molecule
ApprovedDB01010EdrophoniumSmall molecule
ApprovedDB01122AmbenoniumSmall molecule
ApprovedDB01199TubocurarineSmall molecule
ApprovedDB01245DecamethoniumSmall molecule
ApprovedDB01364EphedrineSmall molecule
Approved|vet_approvedDB01400NeostigmineSmall molecule
ExperimentalDB01805MonoisopropylphosphorylserineSmall molecule
ExperimentalDB02166PropidiumSmall molecule
ExperimentalDB022263,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-4-Yl]Hexyl]-PhenanthridiniumSmall molecule
ExperimentalDB023433,6,9,12,15-PentaoxaheptadecaneSmall molecule
ExperimentalDB024041-Deoxy-1-Thio-Heptaethylene GlycolSmall molecule
ExperimentalDB02673(4ar,6s,8ar)-11-[8-(1,3-Dioxo-1,3-Dihydro-2h-Isoindol-2-Yl)Octyl]-6-Hydroxy-3-Methoxy-5,6,9,10-Tetrahydro-4ah-[1]Benzofuro[3a,3,2-Ef][2]Benzazepin-11-IumSmall molecule
ExperimentalDB02825Methylphosphonic Acid Ester GroupSmall molecule
ExperimentalDB02845Methylphosphinic AcidSmall molecule
ExperimentalDB030053,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-5-Yl]Hexyl]-PhenanthridiniumSmall molecule
ApprovedDB03128AcetylcholineSmall molecule
ExperimentalDB03283beta-L-fucoseSmall molecule
InvestigationalDB03348Huperzine BSmall molecule
ExperimentalDB03359M-(N,N,N-Trimethylammonio)-2,2,2-Trifluoro-1,1-DihydroxyethylbenzeneSmall molecule
ExperimentalDB037402-(Acetylamino)-2-Deoxy-a-D-GlucopyranoseSmall molecule
ExperimentalDB038142-(N-Morpholino)-Ethanesulfonic AcidSmall molecule
ExperimentalDB04021MF268Small molecule
ExperimentalDB041143-Chloro-9-Ethyl-6,7,8,9,10,11-Hexahydro-7,11-Methanocycloocta[B]Quinolin-12-AmineSmall molecule
ExperimentalDB045563-[(1s)-1-(Dimethylamino)Ethyl]PhenolSmall molecule
ExperimentalDB04614(R)-tacrine(10)-hupyridoneSmall molecule
ExperimentalDB04615(S)-tacrine(10)-hupyridoneSmall molecule
ExperimentalDB04616TACRINE(8)-4-AMINOQUINOLINESmall molecule
ExperimentalDB04617(9S)-9-[(8-AMMONIOOCTYL)AMINO]-1,2,3,4,9,10-HEXAHYDROACRIDINIUMSmall molecule
InvestigationalDB04859ZanapezilSmall molecule
InvestigationalDB04864Huperzine ASmall molecule
InvestigationalDB04864Huperzine ASmall molecule
InvestigationalDB04892PhenserineSmall molecule
InvestigationalDB05510Huperzine-ASmall molecule
ExperimentalDB075551-(2-nitrophenyl)-2,2,2-trifluoroethyl]-arsenocholineSmall molecule
ExperimentalDB077011-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINESmall molecule
ExperimentalDB077561-[3-({[(4-AMINO-5-FLUORO-2-METHYLQUINOLIN-3-YL)METHYL]THIO}METHYL)PHENYL]-2,2,2-TRIFLUOROETHANE-1,1-DIOLSmall molecule
ExperimentalDB07822(1R)-1,2,2-TRIMETHYLPROPYL (S)-METHYLPHOSPHINATESmall molecule
ExperimentalDB078461S,3AS,8AS-TRIMETHYL-1-OXIDO-1,2,3,3A,8,8A-HEXAHYDROPYRROLO[2,3-B]INDOL-5-YL 2-ETHYLPHENYLCARBAMATESmall molecule
ExperimentalDB081673,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-IUMSmall molecule
ExperimentalDB083571-ETHOXY-2-(2-ETHOXYETHOXY)ETHANESmall molecule
ExperimentalDB086152-[4-(DIMETHYLAMINO)PHENYL]-6-HYDROXY-3-METHYL-1,3-BENZOTHIAZOL-3-IUMSmall molecule
Approved|withdrawnDB08996DimetacrineSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ACHE go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of ACHE
Multiple alignments for P22303 in multiple species
LBSAA sequence# speciesSpecies
A559GLRAQACAFWN2Homo sapiens, Bos taurus
A559GLRAQTCAFWN2Mus musculus, Rattus norvegicus
A559GLRTQFCALWN1Danio rerio
A559GPRLRQCAFWK1Anopheles gambiae
A559GPRRKECAFWK1Caenorhabditis elegans
A580DTLDEAER---4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
A580DNIDDVER---1Danio rerio
A580SNLPGPAPPSE1Anopheles gambiae
A580ADVGDPYL---1Caenorhabditis elegans
D380--FSKDNESLI5Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus, Bos taurus
D380--LRKEEGVTV1Anopheles gambiae
D380ADFFTKTDFIK1Caenorhabditis elegans
E233VTLFGESAGAA4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
E233VTIFGESAGAA1Danio rerio
E233VTLFGESAGAV1Anopheles gambiae
E233ITLFGESAGAA1Caenorhabditis elegans
E581TLDEAER----4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
E581NIDDVER----1Danio rerio
E581NLPGPAPPSEP1Anopheles gambiae
E581DVGDPYL----1Caenorhabditis elegans
E587-QWKAEFHRW-4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
E587-QWKVEFHRW-1Danio rerio
E587CESSAFFYR--1Anopheles gambiae
E587-VWKQQMDKWQ1Caenorhabditis elegans
F326PQESVFRFSFV2Homo sapiens, Bos taurus
F326PQESIFRFSFV2Mus musculus, Rattus norvegicus
F326PWSSLFRFSFV1Danio rerio
F326---GICEFPFV1Anopheles gambiae
F326PVREFGDFPWV1Caenorhabditis elegans
F328ESVFRFSFVPV2Homo sapiens, Bos taurus
F328ESIFRFSFVPV2Mus musculus, Rattus norvegicus
F328SSLFRFSFVPV1Danio rerio
F328-GICEFPFVPV1Anopheles gambiae
F328REFGDFPWVPV1Caenorhabditis elegans
F369DEGSYFLVYGA2Homo sapiens, Bos taurus
F369DEGSYFLVYGV2Mus musculus, Rattus norvegicus
F369DEGSYFLLYGA1Danio rerio
F369EEGYYFIIYYL1Anopheles gambiae
F369DESIYFLTYQL1Caenorhabditis elegans
F588QWKAEFHRW-S4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
F588QWKVEFHRW-S1Danio rerio
F588ESSAFFYR--P1Anopheles gambiae
F588VWKQQMDKWQN1Caenorhabditis elegans
F602HWKNQFDHYSK4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
F602HWKSQFDHYSK1Danio rerio
F602LLVSLLTATVR1Anopheles gambiae
F602DWQYHFEQYKR1Caenorhabditis elegans
G151LVWIYGGGFYS2Homo sapiens, Bos taurus
G151LIWIYGGGFYS2Mus musculus, Rattus norvegicus
G151MVWIYGGGFYS1Danio rerio
G151MLWIFGGGFYS1Anopheles gambiae
G151MVWVYGGGFWS1Caenorhabditis elegans
G152VWIYGGGFYSG3Homo sapiens, Danio rerio, Bos taurus
G152IWIYGGGFYSG2Mus musculus, Rattus norvegicus
G152LWIFGGGFYSG1Anopheles gambiae
G152VWVYGGGFWSG1Caenorhabditis elegans
G153WIYGGGFYSGA4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G153WIYGGGFYSGS1Danio rerio
G153WIFGGGFYSGT1Anopheles gambiae
G153WVYGGGFWSGT1Caenorhabditis elegans
G157GGFYSGASSLD3Homo sapiens, Rattus norvegicus, Bos taurus
G157GGFYSGSSSLD1Danio rerio
G157GGFYSGAASLD1Mus musculus
G157GGFYSGTATLD1Anopheles gambiae
G157GGFWSGTATLD1Caenorhabditis elegans
G479MGVPHGYEIEF4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G479MGVIHGYEIEF1Danio rerio
G479TGVMHGDEINY1Anopheles gambiae
G479MGVLHGYEINF1Caenorhabditis elegans
H478WMGVPHGYEIE4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
H478WMGVIHGYEIE1Danio rerio
H478WTGVMHGDEIN1Anopheles gambiae
H478WMGVLHGYEIN1Caenorhabditis elegans
K585---QWKAEFHR4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
K585---QWKVEFHR1Danio rerio
K585EPCESSAFFYR1Anopheles gambiae
K585---VWKQQMDK1Caenorhabditis elegans
K599YMVHWKNQFDH4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
K599YMMHWKSQFDH1Danio rerio
K599LIVLLVSLLTA1Anopheles gambiae
K599YITDWQYHFEQ1Caenorhabditis elegans
L577SATDTLDEAER4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L577NITDNIDDVER1Danio rerio
L577AATSNLPGPAP1Anopheles gambiae
L577AAVADVGDPYL1Caenorhabditis elegans
M595W-SSYMVHWKN4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
M595W-SSYMMHWKS1Danio rerio
M595--PDLIVLLVS1Anopheles gambiae
M595WQNEYITDWQY1Caenorhabditis elegans
N381-FSKDNESLIS5Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus, Bos taurus
N381-LRKEEGVTVT1Anopheles gambiae
N381DFFTKTDFIKD1Caenorhabditis elegans
Q558RGLRAQACAFW2Homo sapiens, Bos taurus
Q558RGLRAQTCAFW2Mus musculus, Rattus norvegicus
Q558KGLRTQFCALW1Danio rerio
Q558RGPRLRQCAFW1Anopheles gambiae
Q558HGPRRKECAFW1Caenorhabditis elegans
Q601VHWKNQFDHYS4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Q601MHWKSQFDHYS1Danio rerio
Q601VLLVSLLTATV1Anopheles gambiae
Q601TDWQYHFEQYK1Caenorhabditis elegans
R556VRRGLRAQACA2Homo sapiens, Bos taurus
R556VRRGLRAQTCA2Mus musculus, Rattus norvegicus
R556VHKGLRTQFCA1Danio rerio
R556VGRGPRLRQCA1Anopheles gambiae
R556IGHGPRRKECA1Caenorhabditis elegans
S156GGGFYSGASSL3Homo sapiens, Rattus norvegicus, Bos taurus
S156GGGFYSGSSSL1Danio rerio
S156GGGFYSGAASL1Mus musculus
S156GGGFYSGTATL1Anopheles gambiae
S156GGGFWSGTATL1Caenorhabditis elegans
S234TLFGESAGAAS5Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Caenorhabditis elegans
S234TIFGESAGAAS1Danio rerio
S234TLFGESAGAVS1Anopheles gambiae
S324VLPQESVFRFS2Homo sapiens, Bos taurus
S324VLPQESIFRFS2Mus musculus, Rattus norvegicus
S324VLPWSSLFRFS1Danio rerio
S324TL---GICEFP1Anopheles gambiae
S324--PVREFGDFP1Caenorhabditis elegans
S378----FSKDNES5Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus, Bos taurus
S378----LRKEEGV1Anopheles gambiae
S378PVADFFTKTDF1Caenorhabditis elegans
V325LPQESVFRFSF2Homo sapiens, Bos taurus
V325LPQESIFRFSF2Mus musculus, Rattus norvegicus
V325LPWSSLFRFSF1Danio rerio
V325L---GICEFPF1Anopheles gambiae
V325-PVREFGDFPW1Caenorhabditis elegans
W117EGTEMWNPNRE4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
W117PGIEMWNPNRV1Danio rerio
W117PGATMWNPNTP1Anopheles gambiae
W117YGSTMWNANTK1Caenorhabditis elegans
W317LVDHEWHVLPQ2Mus musculus, Rattus norvegicus
W317LVNHEWHVLPQ1Homo sapiens
W317LIDQEWQVLPW1Danio rerio
W317LVDHEWRVLPQ1Bos taurus
W317LVNNEWGTL--1Anopheles gambiae
W317LRENEWA--PV1Caenorhabditis elegans
W470ASTLSWPLWMG2Homo sapiens, Bos taurus
W470ASTLTWPLWMG2Mus musculus, Rattus norvegicus
W470ASNLAWPEWMG1Danio rerio
W470SKGNPWPRWTG1Anopheles gambiae
W470ASQQTWPEWMG1Caenorhabditis elegans
W584----QWKAEFH4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
W584----QWKVEFH1Danio rerio
W584SEPCESSAFFY1Anopheles gambiae
W584----VWKQQMD1Caenorhabditis elegans
W591AEFHRW-SSYM4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
W591VEFHRW-SSYM1Danio rerio
W591AFFYR--PDLI1Anopheles gambiae
W591QQMDKWQNEYI1Caenorhabditis elegans
W598SYMVHWKNQFD4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
W598SYMMHWKSQFD1Danio rerio
W598DLIVLLVSLLT1Anopheles gambiae
W598EYITDWQYHFE1Caenorhabditis elegans
Y103SVCYQYVDTLY2Homo sapiens, Bos taurus
Y103NVCYQYVDTLY2Mus musculus, Rattus norvegicus
Y103NACYQFVDTSY1Danio rerio
Y103NSCVQIVDTVF1Anopheles gambiae
Y103NSCIQSEDTYF1Caenorhabditis elegans
Y150VLVWIYGGGFY2Homo sapiens, Bos taurus
Y150VLIWIYGGGFY2Mus musculus, Rattus norvegicus
Y150VMVWIYGGGFY1Danio rerio
Y150VMLWIFGGGFY1Anopheles gambiae
Y150VMVWVYGGGFW1Caenorhabditis elegans
Y155YGGGFYSGASS3Homo sapiens, Rattus norvegicus, Bos taurus
Y155YGGGFYSGSSS1Danio rerio
Y155YGGGFYSGAAS1Mus musculus
Y155FGGGFYSGTAT1Anopheles gambiae
Y155YGGGFWSGTAT1Caenorhabditis elegans
Y164SSLDVYDGRFL3Homo sapiens, Rattus norvegicus, Bos taurus
Y164SSLDVYDGRYL1Danio rerio
Y164ASLDVYDGRFL1Mus musculus
Y164ATLDVYDHRAL1Anopheles gambiae
Y164ATLDVYDGRIL1Caenorhabditis elegans
Y368KDEGSYFLVYG4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Y368QDEGSYFLLYG1Danio rerio
Y368TEEGYYFIIYY1Anopheles gambiae
Y368RDESIYFLTYQ1Caenorhabditis elegans
Y372SYFLVYGAPG-2Homo sapiens, Bos taurus
Y372SYFLVYGVPG-2Mus musculus, Rattus norvegicus
Y372SYFLLYGAPG-1Danio rerio
Y372YYFIIYYLTEL1Anopheles gambiae
Y372IYFLTYQLPDI1Caenorhabditis elegans
Y480GVPHGYEIEFI4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Y480GVIHGYEIEFV1Danio rerio
Y480GVMHGDEINYV1Anopheles gambiae
Y480GVLHGYEINFI1Caenorhabditis elegans
Y594RW-SSYMVHWK4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Y594RW-SSYMMHWK1Danio rerio
Y594R--PDLIVLLV1Anopheles gambiae
Y594KWQNEYITDWQ1Caenorhabditis elegans
Y605NQFDHYSKQDR2Homo sapiens, Bos taurus
Y605NQFDHYSKQER2Mus musculus, Rattus norvegicus
Y605SQFDHYSKQER1Danio rerio
Y605SLLTATVRFIQ1Anopheles gambiae
Y605YHFEQYKRYQT1Caenorhabditis elegans


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