mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MLLT3
Gene summary
Basic gene Info.Gene symbolMLLT3
Gene namemyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
SynonymsAF9|YEATS3
CytomapUCSC genome browser: 9p22
Type of geneprotein-coding
RefGenesNM_001286691.1,
NM_004529.3,
DescriptionALL1-fused gene from chromosome 9 proteinYEATS domain-containing protein 3myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 3myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 proteinprotein AF-9
Modification date20141207
dbXrefs MIM : 159558
HGNC : HGNC
Ensembl : ENSG00000171843
HPRD : 01163
Vega : OTTHUMG00000019650
ProteinUniProt: P42568
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MLLT3
BioGPS: 4300
PathwayNCI Pathway Interaction Database: MLLT3
KEGG: MLLT3
REACTOME: MLLT3
Pathway Commons: MLLT3
ContextiHOP: MLLT3
ligand binding site mutation search in PubMed: MLLT3
UCL Cancer Institute: MLLT3
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0090090negative regulation of canonical Wnt signaling pathway19591803


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Ligand binding site mutations for MLLT3

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
F59P60SBRCA1
V527V527MSTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for MLLT3
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
F59P60S-1.1237405
V527V527M-0.69176431
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MLLT3 from PDB

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Differential gene expression and gene-gene network for MLLT3
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MLLT3 and the right PPI network was created from samples without mutations in the LBS of MLLT3. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for MLLT3
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for MLLT3
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MLLT3 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (THR,LYS,GLN,THR,ALA,ARG,LYS,SER)4tmpAF59
IIIPeptide ligand (THR,LYS,GLN,THR,ALA,ARG,LYS,SER)4tmpCF59
IIIPeptide ligand (THR,ASN,LYS,LEU,PRO,VAL,SER,ILE,PRO,LEU,ALA,SER,VAL,VAL,LEU,PRO,SER,ARG,ALA,GLU,ARG,ALA,ARG,SER,THR)2mv7AV527


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Conservation information for LBS of MLLT3
Multiple alignments for P42568 in multiple species
LBSAA sequence# speciesSpecies


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