mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for FOXO4
Gene summary
Basic gene Info.Gene symbolFOXO4
Gene nameforkhead box O4
SynonymsAFX|AFX1|MLLT7
CytomapUCSC genome browser: Xq13.1
Type of geneprotein-coding
RefGenesNM_001170931.1,
NM_005938.3,
Descriptionfork head domain transcription factor AFX1forkhead box protein O4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7
Modification date20141222
dbXrefs MIM : 300033
HGNC : HGNC
Ensembl : ENSG00000184481
HPRD : 02070
Vega : OTTHUMG00000021789
ProteinUniProt: P98177
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_FOXO4
BioGPS: 4303
PathwayNCI Pathway Interaction Database: FOXO4
KEGG: FOXO4
REACTOME: FOXO4
Pathway Commons: FOXO4
ContextiHOP: FOXO4
ligand binding site mutation search in PubMed: FOXO4
UCL Cancer Institute: FOXO4
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006355regulation of transcription, DNA-templated15126506
GO:0007050cell cycle arrest10783894
GO:0008285negative regulation of cell proliferation10783894
GO:0008286insulin receptor signaling pathway10217147
GO:0016525negative regulation of angiogenesis12761217
GO:0051151negative regulation of smooth muscle cell differentiation16054032
GO:0070317negative regulation of G0 to G1 transition10783894


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Ligand binding site mutations for FOXO4
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R98R98WCOAD1
Y106E108KGBM1
N99A100SLUSC1
S176S176CLUSC1
R155,S153I154TSTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for FOXO4
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
S153I154T-1.4288178
R155I154T-1.4288178
N99A100S-1.3811998
Y106E108K-1.2604849
R98R98W-1.0449212
S176S176C-0.50237783
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for FOXO4 from PDB

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Differential gene expression and gene-gene network for FOXO4
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of FOXO4 and the right PPI network was created from samples without mutations in the LBS of FOXO4. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for FOXO4
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for FOXO4
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of FOXO4 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of FOXO4
Multiple alignments for P98177 in multiple species
LBSAA sequence# speciesSpecies


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