mutLBSgeneDB |
Gene summary for FOXO4 |
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Basic gene Info. | Gene symbol | FOXO4 |
Gene name | forkhead box O4 | |
Synonyms | AFX|AFX1|MLLT7 | |
Cytomap | UCSC genome browser: Xq13.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001170931.1, NM_005938.3, | |
Description | fork head domain transcription factor AFX1forkhead box protein O4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7 | |
Modification date | 20141222 | |
dbXrefs | MIM : 300033 | |
HGNC : HGNC | ||
Ensembl : ENSG00000184481 | ||
HPRD : 02070 | ||
Vega : OTTHUMG00000021789 | ||
Protein | UniProt: P98177 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FOXO4 | |
BioGPS: 4303 | ||
Pathway | NCI Pathway Interaction Database: FOXO4 | |
KEGG: FOXO4 | ||
REACTOME: FOXO4 | ||
Pathway Commons: FOXO4 | ||
Context | iHOP: FOXO4 | |
ligand binding site mutation search in PubMed: FOXO4 | ||
UCL Cancer Institute: FOXO4 | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
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GO ID | GO Term | PubMed ID | GO:0006355 | regulation of transcription, DNA-templated | 15126506 | GO:0007050 | cell cycle arrest | 10783894 | GO:0008285 | negative regulation of cell proliferation | 10783894 | GO:0008286 | insulin receptor signaling pathway | 10217147 | GO:0016525 | negative regulation of angiogenesis | 12761217 | GO:0051151 | negative regulation of smooth muscle cell differentiation | 16054032 | GO:0070317 | negative regulation of G0 to G1 transition | 10783894 |
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Ligand binding site mutations for FOXO4 |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | R98 | R98W | COAD | 1 | Y106 | E108K | GBM | 1 | N99 | A100S | LUSC | 1 | S176 | S176C | LUSC | 1 | R155,S153 | I154T | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for FOXO4 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | S153 | I154T | -1.4288178 | R155 | I154T | -1.4288178 | N99 | A100S | -1.3811998 | Y106 | E108K | -1.2604849 | R98 | R98W | -1.0449212 | S176 | S176C | -0.50237783 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for FOXO4 |
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Phenotype information for FOXO4 |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for FOXO4 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of FOXO4 |
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LBS | AA sequence | # species | Species |
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