mutLBSgeneDB |
Gene summary for MMP7 |
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Basic gene Info. | Gene symbol | MMP7 |
Gene name | matrix metallopeptidase 7 (matrilysin, uterine) | |
Synonyms | MMP-7|MPSL1|PUMP-1 | |
Cytomap | UCSC genome browser: 11q21-q22 | |
Type of gene | protein-coding | |
RefGenes | NM_002423.3, | |
Description | matrilysinmatrinmatrix metalloproteinase 7 (matrilysin, uterine)matrix metalloproteinase-7pump-1 proteaseuterine matrilysinuterine metalloproteinase | |
Modification date | 20141222 | |
dbXrefs | MIM : 178990 | |
HGNC : HGNC | ||
Ensembl : ENSG00000137673 | ||
HPRD : 01525 | ||
Vega : OTTHUMG00000048193 | ||
Protein | UniProt: P09237 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MMP7 | |
BioGPS: 4316 | ||
Pathway | NCI Pathway Interaction Database: MMP7 | |
KEGG: MMP7 | ||
REACTOME: MMP7 | ||
Pathway Commons: MMP7 | ||
Context | iHOP: MMP7 | |
ligand binding site mutation search in PubMed: MMP7 | ||
UCL Cancer Institute: MMP7 | ||
Assigned class in mutLBSgeneDB | A: This gene has a literature evidence and it belongs to targetable_mutLBSgenes. | |
References showing study about ligand binding site mutation for MMP7. | 1. Yoshioka, S., King, M. L., Ran, S., Okuda, H., MacLean, J. A., McAsey, M. E., ... & Hayashi, K. (2012). WNT7A regulates tumor growth and progression in ovarian cancer through the WNT/β-catenin pathway. Molecular Cancer Research, 10(3), 469-482. 25084196 |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for MMP7 |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | G171 | G171E | GBM | 1 | T175 | T175M | GBM | 1 | Y210 | Y210C | LUAD | 1 | Y167 | P168S | SKCM | 1 | D165 | D165N | SKCM | 1 | G187 | G187E | SKCM | 1 | W198,E196 | R197L | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for MMP7 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | G187 | G187E | 0.20122621 | T175 | T175M | 0.002958772 | E196 | R197L | -1.5445244 | W198 | R197L | -1.5445244 | Y167 | P168S | -1.0768526 | G171 | G171E | -0.81689822 | D165 | D165N | -0.73246761 | Y210 | Y210C | -0.65172307 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for MMP7 |
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Phenotype information for MMP7 |
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Disease ID | Disease name | # PubMed | Association type |
umls:C0009375 | Colonic Neoplasms | 4 | AlteredExpression, Biomarker |
umls:C0000786 | Abortion, Spontaneous | 1 | Biomarker |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for MMP7 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
Approved|investigational | DB00786 | Marimastat | Small molecule | ![]() |
Experimental | DB08170 | (1R)-N,6-DIHYDROXY-7-METHOXY-2-[(4-METHOXYPHENYL)SULFONYL]-1,2,3,4-TETRAHYDROISOQUINOLINE-1-CARBOXAMIDE | Small molecule | ![]() |
Experimental | DB08489 | N4-HYDROXY-2-ISOBUTYL-N1-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YL)-SUCCINAMIDE | Small molecule | ![]() |
Experimental | DB08493 | 5-METHYL-3-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YLCARBAMOYL)-HEXANOIC ACID | Small molecule | ![]() |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of MMP7 |
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LBS | AA sequence | # species | Species | A152 | -VWGTADIMIG | 1 | Homo sapiens | A152 | -SWGTADIIIG | 1 | Rattus norvegicus | A152 | DDFTTADLKIG | 1 | Arabidopsis thaliana | A177 | PGNTLAHAFAP | 1 | Homo sapiens | A177 | PGNTLGHAFAP | 1 | Rattus norvegicus | A177 | VLGTLAHAFAP | 1 | Arabidopsis thaliana | A179 | NTLAHAFAPGT | 1 | Homo sapiens | A179 | NTLGHAFAPGP | 1 | Rattus norvegicus | A179 | GTLAHAFAPE- | 1 | Arabidopsis thaliana | A211 | INFLYAATHEL | 1 | Homo sapiens | A211 | VNFLFVATHEL | 1 | Rattus norvegicus | A211 | VDLESVATHEI | 1 | Arabidopsis thaliana | C87 | MQKPRCGVPD- | 2 | Homo sapiens, Rattus norvegicus | C87 | MSLPRCGVSDT | 1 | Arabidopsis thaliana | D153 | VWGTADIMIGF | 1 | Homo sapiens | D153 | SWGTADIIIGF | 1 | Rattus norvegicus | D153 | DFTTADLKIGF | 1 | Arabidopsis thaliana | D165 | RGAHGDSYPFD | 1 | Homo sapiens | D165 | RGDHGDNFPFD | 1 | Rattus norvegicus | D165 | AGDHGDGLPFD | 1 | Arabidopsis thaliana | D170 | DSYPFDGPGNT | 1 | Homo sapiens | D170 | DNFPFDGPGNT | 1 | Rattus norvegicus | D170 | DGLPFDGVLGT | 1 | Arabidopsis thaliana | D189 | TGLGGDAHFDE | 1 | Homo sapiens | D189 | PGLGGDAHFDK | 1 | Rattus norvegicus | D189 | ---NGRLHLDA | 1 | Arabidopsis thaliana | D193 | GDAHFDEDERW | 1 | Homo sapiens | D193 | GDAHFDKDEYW | 1 | Rattus norvegicus | D193 | GRLHLDAAETW | 1 | Arabidopsis thaliana | E196 | HFDEDERWTDG | 1 | Homo sapiens | E196 | HFDKDEYWTDG | 1 | Rattus norvegicus | E196 | HLDAAETWIVD | 1 | Arabidopsis thaliana | E215 | YAATHELGHSL | 1 | Homo sapiens | E215 | FVATHELGHSL | 1 | Rattus norvegicus | E215 | SVATHEIGHLL | 1 | Arabidopsis thaliana | F180 | TLAHAFAPGTG | 1 | Homo sapiens | F180 | TLGHAFAPGPG | 1 | Rattus norvegicus | F180 | TLAHAFAPE-- | 1 | Arabidopsis thaliana | F244 | GDPQNFKLSQD | 1 | Homo sapiens | F244 | DHSEDFSLTKD | 1 | Rattus norvegicus | F244 | PRTKKVDLTVD | 1 | Arabidopsis thaliana | F98 | AEYSLFPNSPK | 1 | Homo sapiens | F98 | AEFSLMPNSPK | 1 | Rattus norvegicus | F98 | AHYTYFNGKPK | 1 | Arabidopsis thaliana | G171 | SYPFDGPGNTL | 1 | Homo sapiens | G171 | NFPFDGPGNTL | 1 | Rattus norvegicus | G171 | GLPFDGVLGTL | 1 | Arabidopsis thaliana | G173 | PFDGPGNTLAH | 1 | Homo sapiens | G173 | PFDGPGNTLGH | 1 | Rattus norvegicus | G173 | PFDGVLGTLAH | 1 | Arabidopsis thaliana | G185 | FAPGTGLGGDA | 1 | Homo sapiens | G185 | FAPGPGLGGDA | 1 | Rattus norvegicus | G185 | FAPE---NGRL | 1 | Arabidopsis thaliana | G187 | PGTGLGGDAHF | 1 | Homo sapiens | G187 | PGPGLGGDAHF | 1 | Rattus norvegicus | G187 | PE---NGRLHL | 1 | Arabidopsis thaliana | G188 | GTGLGGDAHFD | 1 | Homo sapiens | G188 | GPGLGGDAHFD | 1 | Rattus norvegicus | G188 | E---NGRLHLD | 1 | Arabidopsis thaliana | H163 | FARGAHGDSYP | 1 | Homo sapiens | H163 | FARGDHGDNFP | 1 | Rattus norvegicus | H163 | FYAGDHGDGLP | 1 | Arabidopsis thaliana | H178 | GNTLAHAFAPG | 1 | Homo sapiens | H178 | GNTLGHAFAPG | 1 | Rattus norvegicus | H178 | LGTLAHAFAPE | 1 | Arabidopsis thaliana | H191 | LGGDAHFDEDE | 1 | Homo sapiens | H191 | LGGDAHFDKDE | 1 | Rattus norvegicus | H191 | -NGRLHLDAAE | 1 | Arabidopsis thaliana | H214 | LYAATHELGHS | 1 | Homo sapiens | H214 | LFVATHELGHS | 1 | Rattus norvegicus | H214 | ESVATHEIGHL | 1 | Arabidopsis thaliana | H218 | THELGHSLGMG | 1 | Homo sapiens | H218 | THELGHSLGLG | 1 | Rattus norvegicus | H218 | THEIGHLLGLG | 1 | Arabidopsis thaliana | H224 | SLGMGHSSDPN | 1 | Homo sapiens | H224 | SLGLGHSSVPS | 1 | Rattus norvegicus | H224 | LLGLGHSSQES | 1 | Arabidopsis thaliana | I206 | ----GINFLYA | 1 | Homo sapiens | I206 | ----GVNFLFV | 1 | Rattus norvegicus | I206 | SSEVAVDLESV | 1 | Arabidopsis thaliana | L176 | GPGNTLAHAFA | 1 | Homo sapiens | L176 | GPGNTLGHAFA | 1 | Rattus norvegicus | L176 | GVLGTLAHAFA | 1 | Arabidopsis thaliana | L186 | APGTGLGGDAH | 1 | Homo sapiens | L186 | APGPGLGGDAH | 1 | Rattus norvegicus | L186 | APE---NGRLH | 1 | Arabidopsis thaliana | N174 | FDGPGNTLAHA | 1 | Homo sapiens | N174 | FDGPGNTLGHA | 1 | Rattus norvegicus | N174 | FDGVLGTLAHA | 1 | Arabidopsis thaliana | N207 | ---GINFLYAA | 1 | Homo sapiens | N207 | ---GVNFLFVA | 1 | Rattus norvegicus | N207 | SEVAVDLESVA | 1 | Arabidopsis thaliana | P172 | YPFDGPGNTLA | 1 | Homo sapiens | P172 | FPFDGPGNTLG | 1 | Rattus norvegicus | P172 | LPFDGVLGTLA | 1 | Arabidopsis thaliana | P234 | NAVMYPTYGNG | 1 | Homo sapiens | P234 | SSVMYPTYQGD | 1 | Rattus norvegicus | P234 | SAVMYPSLR-P | 1 | Arabidopsis thaliana | T175 | DGPGNTLAHAF | 1 | Homo sapiens | T175 | DGPGNTLGHAF | 1 | Rattus norvegicus | T175 | DGVLGTLAHAF | 1 | Arabidopsis thaliana | T235 | AVMYPTYGNGD | 1 | Homo sapiens | T235 | SVMYPTYQGDH | 1 | Rattus norvegicus | T235 | AVMYPSLR-PR | 1 | Arabidopsis thaliana | V231 | SDPNAVMYPTY | 1 | Homo sapiens | V231 | SVPSSVMYPTY | 1 | Rattus norvegicus | V231 | SQESAVMYPSL | 1 | Arabidopsis thaliana | W198 | DEDERWTDGSS | 1 | Homo sapiens | W198 | DKDEYWTDGED | 1 | Rattus norvegicus | W198 | DAAETWIVDDD | 1 | Arabidopsis thaliana | Y167 | AHGDSYPFDGP | 1 | Homo sapiens | Y167 | DHGDNFPFDGP | 1 | Rattus norvegicus | Y167 | DHGDGLPFDGV | 1 | Arabidopsis thaliana | Y210 | GINFLYAATHE | 1 | Homo sapiens | Y210 | GVNFLFVATHE | 1 | Rattus norvegicus | Y210 | AVDLESVATHE | 1 | Arabidopsis thaliana | Y236 | VMYPTYGNGDP | 1 | Homo sapiens | Y236 | VMYPTYQGDHS | 1 | Rattus norvegicus | Y236 | VMYPSLR-PRT | 1 | Arabidopsis thaliana |
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