mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MMP9
Gene summary
Basic gene Info.Gene symbolMMP9
Gene namematrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
SynonymsCLG4B|GELB|MANDP2|MMP-9
CytomapUCSC genome browser: 20q11.2-q13.1
Type of geneprotein-coding
RefGenesNM_004994.2,
Description92 kDa gelatinase92 kDa type IV collagenasemacrophage gelatinasematrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)matrix metalloproteinase-9type V collagenase
Modification date20141222
dbXrefs MIM : 120361
HGNC : HGNC
Ensembl : ENSG00000100985
HPRD : 00387
Vega : OTTHUMG00000033044
ProteinUniProt: P14780
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MMP9
BioGPS: 4318
PathwayNCI Pathway Interaction Database: MMP9
KEGG: MMP9
REACTOME: MMP9
Pathway Commons: MMP9
ContextiHOP: MMP9
ligand binding site mutation search in PubMed: MMP9
UCL Cancer Institute: MMP9
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006508proteolysis15863497
GO:1900122positive regulation of receptor binding24164424
GO:2001258negative regulation of cation channel activity24164424


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Ligand binding site mutations for MMP9
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
Q108Q108ECOAD1
T152T152MCOAD1
H405G404SCOAD1
V398V398MGBM1
Q391P389LLUSC1
R424R424LLUSC1
H405A406TSTAD1
A164A164TSTAD1
P133R134WSTAD1
H405G404DSTAD1
H203,D201A202TUCEC1
L188L188MUCEC1
M422M422IUCEC1
G195G195DUCEC1
G195,P193P194TUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for MMP9
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
T152T152M0.22143545
A164A164T-1.335802
D201A202T-1.1990255
H203A202T-1.1990255
G195G195D-1.1722559
P133R134W-0.90626067
H405G404S-0.80840694
H405G404D-0.79742745
M422M422I-0.65608462
R424R424L-0.63213578
V398V398M-0.56137818
Q108Q108E-0.51454538
Q391P389L-0.4418087
P193P194T-0.33298447
G195P194T-0.33298447
H405A406T-0.2252591
L188L188M-0.11308126
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MMP9 from PDB

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Differential gene expression and gene-gene network for MMP9
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MMP9 and the right PPI network was created from samples without mutations in the LBS of MMP9. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for MMP9
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0027627Neoplasm Metastasis230AlteredExpression, Biomarker, GeneticVariation
umls:C2239176Carcinoma, Hepatocellular54AlteredExpression, Biomarker, GeneticVariation
umls:C0007137Carcinoma, Squamous Cell32AlteredExpression, Biomarker, GeneticVariation
umls:C0004096Asthma28Biomarker, GeneticVariation
umls:C1458155Breast Neoplasms27AlteredExpression, Biomarker, GeneticVariation
umls:C0007131Carcinoma, Non-Small-Cell Lung26Biomarker, GeneticVariation
umls:C0024117Pulmonary Disease, Chronic Obstructive25AlteredExpression, Biomarker, GeneticVariation
umls:C0017636Glioblastoma24AlteredExpression, Biomarker
umls:C0162871Aortic Aneurysm, Abdominal21AlteredExpression, Biomarker, GeneticVariation
umls:C0027051Myocardial Infarction17AlteredExpression, Biomarker, GeneticVariation
umls:C0003486Aortic Aneurysm17Biomarker, GeneticVariation
umls:C0033578Prostatic Neoplasms13AlteredExpression, Biomarker, GeneticVariation
umls:C0028754Obesity12Biomarker, GeneticVariation
umls:C0004114Astrocytoma11Biomarker, GeneticVariation
umls:C0021368Inflammation9Biomarker, GeneticVariation
umls:C0948089Acute Coronary Syndrome9Biomarker, GeneticVariation
umls:C0031099Periodontitis9Biomarker, GeneticVariation
umls:C0023895Liver Diseases8Biomarker, GeneticVariation
umls:C0027626Neoplasm Invasiveness8AlteredExpression, Biomarker
umls:C0009375Colonic Neoplasms7AlteredExpression, Biomarker
umls:C0030297Pancreatic Neoplasms7AlteredExpression, Biomarker
umls:C0007786Brain Ischemia6Biomarker, GeneticVariation
umls:C0243026Sepsis6Biomarker, Therapeutic
umls:C0034069Pulmonary Fibrosis5Biomarker, GeneticVariation
umls:C0011853Diabetes Mellitus, Experimental5Biomarker, Therapeutic
umls:C2937358Cerebral Hemorrhage5Biomarker, Therapeutic
umls:C0162872Aortic Aneurysm, Thoracic4Biomarker, GeneticVariation
umls:C0029172Oral Submucous Fibrosis4Biomarker, GeneticVariation
umls:C0038358Stomach Ulcer3Biomarker, GeneticVariation
umls:C0270611Brain Injuries3AlteredExpression, Biomarker
umls:C0037286Skin Neoplasms3Biomarker, GeneticVariation
umls:C0017661Glomerulonephritis, IGA3AlteredExpression, Biomarker
umls:C0340288Angina, Stable3Biomarker, GeneticVariation
umls:C0005967Bone Neoplasms3Biomarker
umls:C0009324Colitis, Ulcerative3Biomarker
umls:C0007621Cell Transformation, Neoplastic3Biomarker
umls:C1527311Brain Edema2Biomarker, Therapeutic
umls:C0024668Mammary Neoplasms, Experimental2Biomarker
umls:C0026766Multiple Organ Failure2Biomarker
umls:C0020507Hyperplasia2Biomarker
umls:C0006663Calcinosis2Biomarker
umls:C0432291Mandibuloacral dysplasia with type A lipodystrophy1Biomarker
umls:C0003493Aortic Diseases1Biomarker
umls:C0003496Aortic Rupture1Biomarker
umls:C0011882Diabetic Neuropathies1Biomarker
umls:C0740392Infarction, Middle Cerebral Artery1Biomarker
umls:C0023176Lead Poisoning1Biomarker
umls:C0023893Liver Cirrhosis, Experimental1Biomarker
umls:C0024143Lupus Nephritis1Biomarker
umls:C0024796Marfan Syndrome1Biomarker
umls:C0026552Morphine Dependence1Biomarker
umls:C2936380Neointima1Biomarker
umls:C0038587Substance Withdrawal Syndrome1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for MMP9
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|investigationalDB00786MarimastatSmall molecule
Approved|investigationalDB01017MinocyclineSmall molecule
ApprovedDB01197CaptoprilSmall molecule
ApprovedDB01296GlucosamineSmall molecule
ExperimentalDB019492-Amino-N,3,3-TrimethylbutanamideSmall molecule
ExperimentalDB036832-{[Formyl(Hydroxy)Amino]Methyl}-4-Methylpentanoic AcidSmall molecule
InvestigationalDB05387AE-941Small molecule
InvestigationalDB05495PG-530742Small molecule
ExperimentalDB071175-(4-PHENOXYPHENYL)-5-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PYRIMIDINE-2,4,6(2H,3H)-TRIONESmall molecule
ExperimentalDB07246(2R)-2-AMINO-3,3,3-TRIFLUORO-N-HYDROXY-2-{[(4-PHENOXYPHENYL)SULFONYL]METHYL}PROPANAMIDESmall molecule
ExperimentalDB07285(3R)-4,4-DIFLUORO-3-[(4-METHOXYPHENYL)SULFONYL]BUTANOIC ACIDSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MMP9 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
CACALCIUM(2+)1l6jAA164 D201
CACALCIUM(2+)2ovzBA164 D201
CACALCIUM(2+)2ow0BA164 D201
CACALCIUM(2+)4h2eBA164 D201
CACALCIUM(2+)4wzvBA164 D201
CACALCIUM(2+)1gkcAD201
CACALCIUM(2+)1gkcBD201
CACALCIUM(2+)1gkdAD201
CACALCIUM(2+)1gkdBD201
CACALCIUM(2+)2ovxAD201
CACALCIUM(2+)2ovxBD201
CACALCIUM(2+)2ovzAD201
CACALCIUM(2+)2ow0AD201
CACALCIUM(2+)2ow1AD201
CACALCIUM(2+)2ow1BD201
CACALCIUM(2+)4h1qAD201
CACALCIUM(2+)4h1qBD201
CACALCIUM(2+)4h3xAD201
CACALCIUM(2+)4h3xBD201
CACALCIUM(2+)4hmaAD201
CACALCIUM(2+)4hmaBD201
CACALCIUM(2+)4h82AD201
CACALCIUM(2+)4h82BD201
CACALCIUM(2+)4h82CD201
CACALCIUM(2+)4h82DD201
CACALCIUM(2+)4xctAD201
CACALCIUM(2+)4wzvAD201
CACALCIUM(2+)4h2eAG195 D201
ZNZINC(2+)1gkcAH203
ZNZINC(2+)1gkcBH203
ZNZINC(2+)1gkdAH203
ZNZINC(2+)1gkdBH203
ZNZINC(2+)1l6jAH203
ZNZINC(2+)2ovxAH203
ZNZINC(2+)2ovxBH203
ZNZINC(2+)2ovzAH203
ZNZINC(2+)2ovzBH203
ZNZINC(2+)2ow0AH203
ZNZINC(2+)2ow0BH203
ZNZINC(2+)2ow1AH203
ZNZINC(2+)2ow1BH203
ZNZINC(2+)2ow2AH203
ZNZINC(2+)2ow2BH203
ZNZINC(2+)4h1qAH203
ZNZINC(2+)4h1qBH203
ZNZINC(2+)4h2eAH203
ZNZINC(2+)4h2eBH203
ZNZINC(2+)4h3xAH203
ZNZINC(2+)4h3xBH203
ZNZINC(2+)4hmaAH203
ZNZINC(2+)4hmaBH203
ZNZINC(2+)4h82AH203
ZNZINC(2+)4h82BH203
ZNZINC(2+)4h82CH203
ZNZINC(2+)4h82DH203
ZNZINC(2+)4jijAH203
ZNZINC(2+)4jijBH203
ZNZINC(2+)4jqgAH203
ZNZINC(2+)4jqgBH203
ZNZINC(2+)4xctAH203
ZNZINC(2+)4wzvAH203
ZNZINC(2+)4wzvBH203
ZNZINC(2+)1gkcAH405
ZNZINC(2+)1gkcBH405
ZNZINC(2+)1gkdAH405
ZNZINC(2+)1gkdBH405
ZNZINC(2+)1l6jAH405
ZNZINC(2+)2ovxAH405
ZNZINC(2+)2ovxBH405
ZNZINC(2+)2ovzAH405
ZNZINC(2+)2ovzBH405
ZNZINC(2+)2ow0AH405
ZNZINC(2+)2ow0BH405
ZNZINC(2+)2ow1AH405
ZNZINC(2+)2ow1BH405
ZNZINC(2+)2ow2AH405
ZNZINC(2+)2ow2BH405
0Y3N,N'-BIS(4-{[(3R)-3-[(BIPHENYL-4-YLSULFONYL)(PROPAN-2- YLOXY)AMINO]-4-(HYDROXYAMINO)-4-OXOBUTYL]AMINO}-4- OXOBUTYL)BENZENE-1,3-DICARBOXAMIDE4h2eBL188
10BN-2-(BIPHENYL-4-YLSULFONYL)-N-2-(ISOPROPYLOXY)- ACETOHYDROXAMIC ACIDN~2~-(BIPHENYL-4-YLSULFONYL)-N-HYDROXY-N~2~-(PROPAN-2- YLOXY)GLYCINAMIDE4h3xAL188
10BN-2-(BIPHENYL-4-YLSULFONYL)-N-2-(ISOPROPYLOXY)- ACETOHYDROXAMIC ACIDN~2~-(BIPHENYL-4-YLSULFONYL)-N-HYDROXY-N~2~-(PROPAN-2- YLOXY)GLYCINAMIDE4h3xBL188
0ZDN,N'-BIS(2-[(BIPHENYL-4YLSULFONYL)[(2R)-1-HYDROXY-3- METHYL-1-OXOBUTAN-2-YL]-AMINO]ETHYL)BENZENE-1,3- DICARBOXAMIDE4hmaAL188
0ZDN,N'-BIS(2-[(BIPHENYL-4YLSULFONYL)[(2R)-1-HYDROXY-3- METHYL-1-OXOBUTAN-2-YL]-AMINO]ETHYL)BENZENE-1,3- DICARBOXAMIDE4hmaBL188
L29N,N'-BIS(2-{(BIPHENYL-4-YLSULFONYL)[(2R)-1- (HYDROXYAMINO)-3-METHYL-1-OXOBUTAN-2-YL]AMINO}ETHYL) BENZENE-1,3-DICARBOXAMIDE (NON-PREFERRED NAME)4h82AL188
L29N,N'-BIS(2-{(BIPHENYL-4-YLSULFONYL)[(2R)-1- (HYDROXYAMINO)-3-METHYL-1-OXOBUTAN-2-YL]AMINO}ETHYL) BENZENE-1,3-DICARBOXAMIDE (NON-PREFERRED NAME)4h82BL188
L29N,N'-BIS(2-{(BIPHENYL-4-YLSULFONYL)[(2R)-1- (HYDROXYAMINO)-3-METHYL-1-OXOBUTAN-2-YL]AMINO}ETHYL) BENZENE-1,3-DICARBOXAMIDE (NON-PREFERRED NAME)4h82CL188
L29N,N'-BIS(2-{(BIPHENYL-4-YLSULFONYL)[(2R)-1- (HYDROXYAMINO)-3-METHYL-1-OXOBUTAN-2-YL]AMINO}ETHYL) BENZENE-1,3-DICARBOXAMIDE (NON-PREFERRED NAME)4h82DL188
N73N~2~-[BIPHENYL-4-YL(DIHYDROXY)-LAMBDA~4~-SULFANYL]-N- OXO-N~2~-(PROPAN-2-YLOXY)-D-VALINAMIDE4xctAL188
E40EN140(2R)-4-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)-N- HYDROXY-2-{[(4'-METHOXYBIPHENYL-4-YL)SULFONYL](PROPAN- 2-YLOXY)AMINO}BUTANAMIDE4wzvAL188
E40EN140(2R)-4-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)-N- HYDROXY-2-{[(4'-METHOXYBIPHENYL-4-YL)SULFONYL](PROPAN- 2-YLOXY)AMINO}BUTANAMIDE4wzvBL188
NFHN~2~-[(2R)-2-{[FORMYL(HYDROXY)AMINO]METHYL}-4-METHYLPENTANOYL]-N,3-DIMETHYL-L-VALINAMIDE1gkcBL188 H405 M422
STN2-{[FORMYL(HYDROXY)AMINO]METHYL}-4-METHYLPENTANOIC ACID1gkdBL188 H405 M422
6MRN-[(4'-IODOBIPHENYL-4-YL)SULFONYL]-D-TRYPTOPHAN2ow0AL188 H405 M422
6MRN-[(4'-IODOBIPHENYL-4-YL)SULFONYL]-D-TRYPTOPHAN2ow0BL188 H405 M422
8MR(3R)-4,4-DIFLUORO-3-[(4-METHOXYPHENYL)SULFONYL]BUTANOICACID2ow2BL188 H405 M422
7MR(2R)-2-AMINO-3,3,3-TRIFLUORO-N-HYDROXY-2-{[(4-PHENOXYPHENYL)SULFONYL]METHYL}PROPANAMIDE2ow1AL188 H405 M422 R424
7MR(2R)-2-AMINO-3,3,3-TRIFLUORO-N-HYDROXY-2-{[(4-PHENOXYPHENYL)SULFONYL]METHYL}PROPANAMIDE2ow1BL188 H405 M422 R424
0XXN-(4-{[(3R)-3-[(BIPHENYL-4-YLSULFONYL)(PROPAN-2-YLOXY) AMINO]-4-(HYDROXYAMINO)-4-OXOBUTYL]AMINO}-4-OXOBUTYL)- N'-(4-{[(3S)-3-[(BIPHENYL-4-YLSULFONYL)(PROPAN-2- YLOXY)AMINO]-4-(HYDROXYAMINO)-4-OXOBUTYL]AMINO}-4- OXOBUTYL)BENZENE-1,3-DICARBOXAMIDE4h1qAL188 P193
0XXN-(4-{[(3R)-3-[(BIPHENYL-4-YLSULFONYL)(PROPAN-2-YLOXY) AMINO]-4-(HYDROXYAMINO)-4-OXOBUTYL]AMINO}-4-OXOBUTYL)- N'-(4-{[(3S)-3-[(BIPHENYL-4-YLSULFONYL)(PROPAN-2- YLOXY)AMINO]-4-(HYDROXYAMINO)-4-OXOBUTYL]AMINO}-4- OXOBUTYL)BENZENE-1,3-DICARBOXAMIDE4h1qBL188 P193
8MR(3R)-4,4-DIFLUORO-3-[(4-METHOXYPHENYL)SULFONYL]BUTANOICACID2ow2AL188 V398
NFHN~2~-[(2R)-2-{[FORMYL(HYDROXY)AMINO]METHYL}-4-METHYLPENTANOYL]-N,3-DIMETHYL-L-VALINAMIDE1gkcAL188 V398 H405 M422
STN2-{[FORMYL(HYDROXY)AMINO]METHYL}-4-METHYLPENTANOIC ACID1gkdAL188 V398 H405 M422
5MRNALPHA-{(2S)-3-[(S)-HYDROXY(PHENYL)PHOSPHORYL]-2-[(3-PHENYLISOXAZOL-5-YL)METHYL]PROPANOYL}-L-TRYPTOPHANAMIDE2ovzAL188 V398 H405 M422
5MRNALPHA-{(2S)-3-[(S)-HYDROXY(PHENYL)PHOSPHORYL]-2-[(3-PHENYLISOXAZOL-5-YL)METHYL]PROPANOYL}-L-TRYPTOPHANAMIDE2ovzBL188 V398 H405 M422
4MR5-(4-PHENOXYPHENYL)-5-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PYRIMIDINE-2,4,6(2H,3H)-TRIONE2ovxAL188 V398 H405 M422 R424
4MR5-(4-PHENOXYPHENYL)-5-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PYRIMIDINE-2,4,6(2H,3H)-TRIONE2ovxBL188 V398 H405 M422 R424
BUM2-AMINO-N,3,3-TRIMETHYLBUTANAMIDE1gkdBM422
BUD(S,S)-BUTANE-2,3-DIOL4xctAP133
IIIPeptide ligand (8MC,PRO,LEU,GLY,PHE,ALA,ALA,ARG,NH2)4jijAQ108 L188
IIIPeptide ligand (8MC,PRO,LEU,GLY,PHE,ALA,ALA,ARG,NH2)4jijBQ108 L188
IIIPeptide ligand (8MC,PRO,LEU,GLY,PHE,ALA,ALA,ARG,NH2)4jqgAQ108 L188
IIIPeptide ligand (8MC,PRO,LEU,GLY,PHE,ALA,ALA,ARG,NH2)4jqgBQ108 L188
CACALCIUM(2+)1gkcAQ391
CACALCIUM(2+)1gkcBQ391
CACALCIUM(2+)1gkdAQ391
CACALCIUM(2+)1gkdBQ391
CACALCIUM(2+)2ovxAQ391
CACALCIUM(2+)2ovxBQ391
CACALCIUM(2+)2ovzAQ391
CACALCIUM(2+)2ovzBQ391
CACALCIUM(2+)2ow2AQ391
CACALCIUM(2+)2ow2BQ391
CACALCIUM(2+)1gkcBT152
CACALCIUM(2+)2ovxAT152
CACALCIUM(2+)2ovxBT152
CACALCIUM(2+)2ovzAT152
CACALCIUM(2+)2ovzBT152
CACALCIUM(2+)2ow0AT152
CACALCIUM(2+)2ow0BT152
CACALCIUM(2+)2ow1AT152
CACALCIUM(2+)2ow1BT152
CACALCIUM(2+)4h1qAT152


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Conservation information for LBS of MMP9
Multiple alignments for P14780 in multiple species
LBSAA sequence# speciesSpecies
A150FALWSAVTPLT2Homo sapiens, Bos taurus
A150FGKWASVIPVS1Arabidopsis thaliana
A150FAVWGEVAPLT1Mus musculus
A150FAVWSAVTPLT1Rattus norvegicus
A164YG-PEADIVIQ2Mus musculus, Bos taurus
A164YS-RDADIVIQ1Homo sapiens
A164EDYVIADIKIG1Arabidopsis thaliana
A164YG-LEADIVIQ1Rattus norvegicus
A189KDGLLAHAFPP3Homo sapiens, Mus musculus, Rattus norvegicus
A189VLGVLAHTFSP1Arabidopsis thaliana
A189KNGLLAHAFPP1Bos taurus
A191GLLAHAFPPGP2Homo sapiens, Rattus norvegicus
A191GVLAHTFSPE-1Arabidopsis thaliana
A191GLLAHAFPPGA1Mus musculus
A191GLLAHAFPPGK1Bos taurus
C99MRTPRCGVPD-1Homo sapiens
C99ILLPRCGFPDD1Arabidopsis thaliana
C99IRTPRCGVPD-1Mus musculus
C99IRSPRCGVPD-1Rattus norvegicus
C99MRAPRCGVPD-1Bos taurus
D131QNYSEDLPRAV2Homo sapiens, Bos taurus
D131ENLTPYLAPTD1Arabidopsis thaliana
D131QNYSEDLPRDM1Mus musculus
D131QSYTEDLPRDV1Rattus norvegicus
D165G-PEADIVIQF2Mus musculus, Bos taurus
D165S-RDADIVIQF1Homo sapiens
D165DYVIADIKIGF1Arabidopsis thaliana
D165G-LEADIVIQF1Rattus norvegicus
D177VAEHGDGYPFD3Homo sapiens, Mus musculus, Rattus norvegicus
D177NGDHGDGEPFD1Arabidopsis thaliana
D177VREHGDGYPFD1Bos taurus
D182DGYPFDGKDGL3Homo sapiens, Mus musculus, Rattus norvegicus
D182DGEPFDGVLGV1Arabidopsis thaliana
D182DGYPFDGKNGL1Bos taurus
D185PFDGKDGLLAH3Homo sapiens, Mus musculus, Rattus norvegicus
D185PFDGVLGVLAH1Arabidopsis thaliana
D185PFDGKNGLLAH1Bos taurus
D201PGIQGDAHFDD2Homo sapiens, Rattus norvegicus
D201---NGRLHLDK1Arabidopsis thaliana
D201AGVQGDAHFDD1Mus musculus
D201KGIQGDAHFDD1Bos taurus
D205GDAHFDDDELW3Homo sapiens, Mus musculus, Rattus norvegicus
D205GRLHLDKAETW1Arabidopsis thaliana
D205GDAHFDDEELW1Bos taurus
D206DAHFDDDELWS3Homo sapiens, Mus musculus, Rattus norvegicus
D206RLHLDKAETWA1Arabidopsis thaliana
D206DAHFDDEELWS1Bos taurus
D410HALGLDHSSVP3Homo sapiens, Mus musculus, Rattus norvegicus
D410HVLGLGHSSVK1Arabidopsis thaliana
D410HALGLDHTSVP1Bos taurus
E111----FEGDLKW1Homo sapiens
E111KYVYFPGRPRW1Arabidopsis thaliana
E111----FKG-LKW1Mus musculus
E111----FDGDLKW1Rattus norvegicus
E111----FEGELKW1Bos taurus
E130-QNYSEDLPRA2Homo sapiens, Bos taurus
E130QENLTPYLAPT1Arabidopsis thaliana
E130-QNYSEDLPRD1Mus musculus
E130-QSYTEDLPRD1Rattus norvegicus
E208HFDDDELWSLG3Homo sapiens, Mus musculus, Rattus norvegicus
E208HLDKAETWAVD1Arabidopsis thaliana
E208HFDDEELWSLG1Bos taurus
E402LVAAHEFGHAL4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
E402-VAVHEIGHVL1Arabidopsis thaliana
F107--VGRFQT---2Mus musculus, Bos taurus
F107--LGRFQT---1Homo sapiens
F107PKTAPFHTGKK1Arabidopsis thaliana
F107--VGKFQT---1Rattus norvegicus
F110-----FEGDLK1Homo sapiens
F110KKYVYFPGRPR1Arabidopsis thaliana
F110-----FKG-LK1Mus musculus
F110-----FDGDLK1Rattus norvegicus
F110-----FEGELK1Bos taurus
F181GDGYPFDGKDG3Homo sapiens, Mus musculus, Rattus norvegicus
F181GDGEPFDGVLG1Arabidopsis thaliana
F181GDGYPFDGKNG1Bos taurus
F192LLAHAFPPGPG2Homo sapiens, Rattus norvegicus
F192VLAHTFSPE--1Arabidopsis thaliana
F192LLAHAFPPGAG1Mus musculus
F192LLAHAFPPGKG1Bos taurus
G112---FEGDLKWH1Homo sapiens
G112YVYFPGRPRWT1Arabidopsis thaliana
G112---FKG-LKWD1Mus musculus
G112---FDGDLKWH1Rattus norvegicus
G112---FEGELKWH1Bos taurus
G183GYPFDGKDGLL3Homo sapiens, Mus musculus, Rattus norvegicus
G183GEPFDGVLGVL1Arabidopsis thaliana
G183GYPFDGKNGLL1Bos taurus
G186FDGKDGLLAHA3Homo sapiens, Mus musculus, Rattus norvegicus
G186FDGVLGVLAHT1Arabidopsis thaliana
G186FDGKNGLLAHA1Bos taurus
G195HAFPPGPGIQG2Homo sapiens, Rattus norvegicus
G195HTFSPE---NG1Arabidopsis thaliana
G195HAFPPGAGVQG1Mus musculus
G195HAFPPGKGIQG1Bos taurus
G197FPPGPGIQGDA2Homo sapiens, Rattus norvegicus
G197FSPE---NGRL1Arabidopsis thaliana
G197FPPGAGVQGDA1Mus musculus
G197FPPGKGIQGDA1Bos taurus
G200GPGIQGDAHFD2Homo sapiens, Rattus norvegicus
G200E---NGRLHLD1Arabidopsis thaliana
G200GAGVQGDAHFD1Mus musculus
G200GKGIQGDAHFD1Bos taurus
G392FCPDQGYSLFL4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G392-----------1Arabidopsis thaliana
G408FGHALGLDHSS3Homo sapiens, Mus musculus, Rattus norvegicus
G408IGHVLGLGHSS1Arabidopsis thaliana
G408FGHALGLDHTS1Bos taurus
H175FGVAEHGDGYP3Homo sapiens, Mus musculus, Rattus norvegicus
H175FFNGDHGDGEP1Arabidopsis thaliana
H175FGVREHGDGYP1Bos taurus
H190DGLLAHAFPPG3Homo sapiens, Mus musculus, Rattus norvegicus
H190LGVLAHTFSPE1Arabidopsis thaliana
H190NGLLAHAFPPG1Bos taurus
H203IQGDAHFDDDE2Homo sapiens, Rattus norvegicus
H203-NGRLHLDKAE1Arabidopsis thaliana
H203VQGDAHFDDDE1Mus musculus
H203IQGDAHFDDEE1Bos taurus
H401FLVAAHEFGHA4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
H401--VAVHEIGHV1Arabidopsis thaliana
H405AHEFGHALGLD4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
H405VHEIGHVLGLG1Arabidopsis thaliana
H411ALGLDHSSVPE3Homo sapiens, Mus musculus, Rattus norvegicus
H411VLGLGHSSVKD1Arabidopsis thaliana
H411ALGLDHTSVPE1Bos taurus
H441VNGIRHLYGPR1Homo sapiens
H441VVGVQSLYGTN1Arabidopsis thaliana
H441IDGIQYLYGRG1Mus musculus
H441IKGIHHLYGRG1Rattus norvegicus
H441VQGIQHLYGPR1Bos taurus
I198PPGPGIQGDAH2Homo sapiens, Rattus norvegicus
I198SPE---NGRLH1Arabidopsis thaliana
I198PPGAGVQGDAH1Mus musculus
I198PPGKGIQGDAH1Bos taurus
K184YPFDGKDGLLA3Homo sapiens, Mus musculus, Rattus norvegicus
K184EPFDGVLGVLA1Arabidopsis thaliana
K184YPFDGKNGLLA1Bos taurus
L132NYSEDLPRAVI2Homo sapiens, Bos taurus
L132NLTPYLAPTDI1Arabidopsis thaliana
L132NYSEDLPRDMI1Mus musculus
L132SYTEDLPRDVI1Rattus norvegicus
L154SAVTPLTFTRV3Homo sapiens, Rattus norvegicus, Bos taurus
L154ASVIPVSFIET1Arabidopsis thaliana
L154GEVAPLTFTRV1Mus musculus
L187DGKDGLLAHAF3Homo sapiens, Mus musculus, Rattus norvegicus
L187DGVLGVLAHTF1Arabidopsis thaliana
L187DGKNGLLAHAF1Bos taurus
L188GKDGLLAHAFP3Homo sapiens, Mus musculus, Rattus norvegicus
L188GVLGVLAHTFS1Arabidopsis thaliana
L188GKNGLLAHAFP1Bos taurus
L209FDDDELWSLGK3Homo sapiens, Mus musculus, Rattus norvegicus
L209LDKAETWAVD-1Arabidopsis thaliana
L209FDDEELWSLGK1Bos taurus
L397GYSLFLVAAHE4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L397------VAVHE1Arabidopsis thaliana
L409GHALGLDHSSV3Homo sapiens, Mus musculus, Rattus norvegicus
L409GHVLGLGHSSV1Arabidopsis thaliana
L409GHALGLDHTSV1Bos taurus
L418SVPEALMYPMY3Homo sapiens, Rattus norvegicus, Bos taurus
L418SVKDAAMYPTL1Arabidopsis thaliana
L418SVPEALMYPLY1Mus musculus
M422ALMYPMYR-FT2Homo sapiens, Bos taurus
M422AAMYPTLKPRS1Arabidopsis thaliana
M422ALMYPLYS-YL1Mus musculus
M422ALMYPMYH-YH1Rattus norvegicus
P133YSEDLPRAVID2Homo sapiens, Bos taurus
P133LTPYLAPTDIR1Arabidopsis thaliana
P133YSEDLPRDMID1Mus musculus
P133YTEDLPRDVID1Rattus norvegicus
P153WSAVTPLTFTR3Homo sapiens, Rattus norvegicus, Bos taurus
P153WASVIPVSFIE1Arabidopsis thaliana
P153WGEVAPLTFTR1Mus musculus
P180HGDGYPFDGKD3Homo sapiens, Mus musculus, Rattus norvegicus
P180HGDGEPFDGVL1Arabidopsis thaliana
P180HGDGYPFDGKN1Bos taurus
P193LAHAFPPGPGI2Homo sapiens, Rattus norvegicus
P193LAHTFSPE---1Arabidopsis thaliana
P193LAHAFPPGAGV1Mus musculus
P193LAHAFPPGKGI1Bos taurus
P421EALMYPMYR-F2Homo sapiens, Bos taurus
P421DAAMYPTLKPR1Arabidopsis thaliana
P421EALMYPLYS-Y1Mus musculus
P421EALMYPMYH-Y1Rattus norvegicus
Q108-VGRFQT----2Mus musculus, Bos taurus
Q108-LGRFQT----1Homo sapiens
Q108KTAPFHTGKKY1Arabidopsis thaliana
Q108-VGKFQT----1Rattus norvegicus
Q199PGPGIQGDAHF2Homo sapiens, Rattus norvegicus
Q199PE---NGRLHL1Arabidopsis thaliana
Q199PGAGVQGDAHF1Mus musculus
Q199PGKGIQGDAHF1Bos taurus
Q391GFCPDQGYSLF4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Q391-----------1Arabidopsis thaliana
R424MYPMYR-FTEG1Homo sapiens
R424MYPTLKPRSKK1Arabidopsis thaliana
R424MYPLYS-YLEG1Mus musculus
R424MYPMYH-YHED1Rattus norvegicus
R424MYPMYR-FTEE1Bos taurus
S129--QNYSEDLPR3Homo sapiens, Mus musculus, Bos taurus
S129SQENLTPYLAP1Arabidopsis thaliana
S129--QSYTEDLPR1Rattus norvegicus
S149AFALWSAVTPL2Homo sapiens, Bos taurus
S149AFGKWASVIPV1Arabidopsis thaliana
S149AFAVWGEVAPL1Mus musculus
S149AFAVWSAVTPL1Rattus norvegicus
S211DDELWSLGKGV2Homo sapiens, Mus musculus
S211KAETWAVD---1Arabidopsis thaliana
S211DDELWSLGKGA1Rattus norvegicus
S211DEELWSLGKGV1Bos taurus
T109VGRFQT-----2Mus musculus, Bos taurus
T109LGRFQT-----1Homo sapiens
T109TAPFHTGKKYV1Arabidopsis thaliana
T109VGKFQT-----1Rattus norvegicus
T152LWSAVTPLTFT2Homo sapiens, Bos taurus
T152KWASVIPVSFI1Arabidopsis thaliana
T152VWGEVAPLTFT1Mus musculus
T152VWSAVTPLTFT1Rattus norvegicus
V398YSLFLVAAHEF4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
V398-----VAVHEI1Arabidopsis thaliana
W210DDDELWSLGKG3Homo sapiens, Mus musculus, Rattus norvegicus
W210DKAETWAVD--1Arabidopsis thaliana
W210DDEELWSLGKG1Bos taurus
Y179EHGDGYPFDGK4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Y179DHGDGEPFDGV1Arabidopsis thaliana
Y393CPDQGYSLFLV4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Y393----------V1Arabidopsis thaliana
Y420PEALMYPMYR-2Homo sapiens, Bos taurus
Y420KDAAMYPTLKP1Arabidopsis thaliana
Y420PEALMYPLYS-1Mus musculus
Y420PEALMYPMYH-1Rattus norvegicus
Y423LMYPMYR-FTE2Homo sapiens, Bos taurus
Y423AMYPTLKPRSK1Arabidopsis thaliana
Y423LMYPLYS-YLE1Mus musculus
Y423LMYPMYH-YHE1Rattus norvegicus


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