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mutLBSgeneDB |
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| Gene summary for MMP10 |
 Gene summary |
| Basic gene Info. | Gene symbol | MMP10 |
| Gene name | matrix metallopeptidase 10 (stromelysin 2) | |
| Synonyms | SL-2|STMY2 | |
| Cytomap | UCSC genome browser: 11q22.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002425.2, | |
| Description | MMP-10matrix metalloprotease 10matrix metalloproteinase 10 (stromelysin 2)matrix metalloproteinase-10stromelysin 2stromelysin-2transin 2transin-2 | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 185260 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000166670 | ||
| HPRD : 01704 | ||
| Vega : OTTHUMG00000168083 | ||
| Protein | UniProt: P09238 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MMP10 | |
| BioGPS: 4319 | ||
| Pathway | NCI Pathway Interaction Database: MMP10 | |
| KEGG: MMP10 | ||
| REACTOME: MMP10 | ||
| Pathway Commons: MMP10 | ||
| Context | iHOP: MMP10 | |
| ligand binding site mutation search in PubMed: MMP10 | ||
| UCL Cancer Institute: MMP10 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for MMP10 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | H227 | H227Y | HNSC | 1 | D193 | D193Y | LUAD | 1 | D174 | S172F | LUAD | 1 | G192 | G192R | LUAD | 1 | D174 | F173C | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for MMP10 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | D174 | F173C | -1.1327808 | D193 | D193Y | -0.64108083 | H227 | H227Y | -0.57572807 | G192 | G192R | -0.45673884 | D174 | S172F | -0.37642321 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for MMP10 from PDB |
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| Differential gene expression and gene-gene network for MMP10 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for MMP10 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0027627 | Neoplasm Metastasis | 5 | Biomarker |
| umls:C0024121 | Lung Neoplasms | 3 | AlteredExpression, Biomarker |
| umls:C0038356 | Stomach Neoplasms | 2 | AlteredExpression, Biomarker |
| umls:C0004096 | Asthma | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for MMP10 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved|investigational | DB00786 | Marimastat | Small molecule |  |
| Experimental | DB08271 | N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of MMP10 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | CA | CALCIUM(2+) | 1q3a | A | D174 | CA | CALCIUM(2+) | 1q3a | B | D174 | CA | CALCIUM(2+) | 1q3a | C | D174 | CA | CALCIUM(2+) | 3v96 | B | D174 | CA | CALCIUM(2+) | 4ilw | D | D174 | CA | CALCIUM(2+) | 4ilw | F | D174 | CA | CALCIUM(2+) | 1q3a | A | D193 | CA | CALCIUM(2+) | 1q3a | B | D193 | CA | CALCIUM(2+) | 3v96 | B | D193 | CA | CALCIUM(2+) | 4ilw | D | D193 | CA | CALCIUM(2+) | 4ilw | F | D193 | CA | CALCIUM(2+) | 1q3a | C | G192 D193 | ZN | ZINC(2+) | 1q3a | A | H227 | NGH | N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYLHYDROXAMIC ACID | 1q3a | A | H227 | ZN | ZINC(2+) | 1q3a | B | H227 | NGH | N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYLHYDROXAMIC ACID | 1q3a | B | H227 | ZN | ZINC(2+) | 1q3a | C | H227 | NGH | N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYLHYDROXAMIC ACID | 1q3a | C | H227 | ZN | ZINC(2+) | 3v96 | B | H227 | ZN | ZINC(2+) | 4ilw | D | H227 | ZN | ZINC(2+) | 4ilw | F | H227 |
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| Conservation information for LBS of MMP10 |
| Multiple alignments for P09238 in multiple species |
| LBS | AA sequence | # species | Species | A156 | ISEGEADIMIS | 2 | Mus musculus, Rattus norvegicus | A156 | LYEGEADIMIS | 1 | Homo sapiens | A181 | PGHSLAHAYPP | 1 | Homo sapiens | A181 | PGQSLAHAYPP | 1 | Mus musculus | A181 | VGQSLAHAYPP | 1 | Rattus norvegicus | D123 | VNYTPDLPRDA | 1 | Homo sapiens | D123 | VNYTPDLPRQS | 1 | Mus musculus | D123 | VNYTLDLPRES | 1 | Rattus norvegicus | D157 | SEGEADIMISF | 2 | Mus musculus, Rattus norvegicus | D157 | YEGEADIMISF | 1 | Homo sapiens | D174 | DFYSFDGPGHS | 1 | Homo sapiens | D174 | DFYPFDGPGQS | 1 | Mus musculus | D174 | DFYPFDGVGQS | 1 | Rattus norvegicus | D193 | PGLYGDIHFDD | 1 | Homo sapiens | D193 | PGFYGDVHFDD | 1 | Mus musculus | D193 | PGFYGDAHFDD | 1 | Rattus norvegicus | D197 | GDIHFDDDEKW | 1 | Homo sapiens | D197 | GDVHFDDDEKW | 1 | Mus musculus | D197 | GDAHFDDDEKW | 1 | Rattus norvegicus | D198 | DIHFDDDEKWT | 1 | Homo sapiens | D198 | DVHFDDDEKWT | 1 | Mus musculus | D198 | DAHFDDDEKWS | 1 | Rattus norvegicus | E200 | HFDDDEKWTED | 1 | Homo sapiens | E200 | HFDDDEKWTLA | 1 | Mus musculus | E200 | HFDDDEKWSLG | 1 | Rattus norvegicus | E218 | LVAAHELGHSL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F242 | PLYNSFTELAQ | 1 | Homo sapiens | F242 | PVYRFSTSPAN | 1 | Mus musculus | F242 | PVYRFSTSQAN | 1 | Rattus norvegicus | G175 | FYSFDGPGHSL | 1 | Homo sapiens | G175 | FYPFDGPGQSL | 1 | Mus musculus | G175 | FYPFDGVGQSL | 1 | Rattus norvegicus | G177 | SFDGPGHSLAH | 1 | Homo sapiens | G177 | PFDGPGQSLAH | 1 | Mus musculus | G177 | PFDGVGQSLAH | 1 | Rattus norvegicus | G189 | YPPGPGLYGDI | 1 | Homo sapiens | G189 | YPPGPGFYGDV | 1 | Mus musculus | G189 | YPPGPGFYGDA | 1 | Rattus norvegicus | G192 | GPGLYGDIHFD | 1 | Homo sapiens | G192 | GPGFYGDVHFD | 1 | Mus musculus | G192 | GPGFYGDAHFD | 1 | Rattus norvegicus | H178 | FDGPGHSLAHA | 1 | Homo sapiens | H178 | FDGPGQSLAHA | 1 | Mus musculus | H178 | FDGVGQSLAHA | 1 | Rattus norvegicus | H182 | GQSLAHAYPPG | 2 | Mus musculus, Rattus norvegicus | H182 | GHSLAHAYPPG | 1 | Homo sapiens | H195 | LYGDIHFDDDE | 1 | Homo sapiens | H195 | FYGDVHFDDDE | 1 | Mus musculus | H195 | FYGDAHFDDDE | 1 | Rattus norvegicus | H217 | FLVAAHELGHS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H221 | AHELGHSLGLF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H227 | SLGLFHSANTE | 1 | Homo sapiens | H227 | SLGLFHSDKKE | 1 | Mus musculus | H227 | SLGLFHSNNKE | 1 | Rattus norvegicus | K201 | FDDDEKWTEDA | 1 | Homo sapiens | K201 | FDDDEKWTLAP | 1 | Mus musculus | K201 | FDDDEKWSLGP | 1 | Rattus norvegicus | L180 | GPGHSLAHAYP | 1 | Homo sapiens | L180 | GPGQSLAHAYP | 1 | Mus musculus | L180 | GVGQSLAHAYP | 1 | Rattus norvegicus | L190 | PPGPGLYGDIH | 1 | Homo sapiens | L190 | PPGPGFYGDVH | 1 | Mus musculus | L190 | PPGPGFYGDAH | 1 | Rattus norvegicus | L213 | GTNLFLVAAHE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L234 | ANTEALMYPLY | 1 | Homo sapiens | L234 | DKKESLMYPVY | 1 | Mus musculus | L234 | NNKESLMYPVY | 1 | Rattus norvegicus | L238 | SLMYPVYRFST | 2 | Mus musculus, Rattus norvegicus | L238 | ALMYPLYNSFT | 1 | Homo sapiens | N240 | MYPLYNSFTEL | 1 | Homo sapiens | N240 | MYPVYRFSTSP | 1 | Mus musculus | N240 | MYPVYRFSTSQ | 1 | Rattus norvegicus | P176 | YSFDGPGHSLA | 1 | Homo sapiens | P176 | YPFDGPGQSLA | 1 | Mus musculus | P176 | YPFDGVGQSLA | 1 | Rattus norvegicus | P237 | ESLMYPVYRFS | 2 | Mus musculus, Rattus norvegicus | P237 | EALMYPLYNSF | 1 | Homo sapiens | S179 | DGPGHSLAHAY | 1 | Homo sapiens | S179 | DGPGQSLAHAY | 1 | Mus musculus | S179 | DGVGQSLAHAY | 1 | Rattus norvegicus | T121 | RIVNYTPDLPR | 2 | Homo sapiens, Mus musculus | T121 | RIVNYTLDLPR | 1 | Rattus norvegicus | V214 | TNLFLVAAHEL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | W202 | DDDEKWTEDAS | 1 | Homo sapiens | W202 | DDDEKWTLAPS | 1 | Mus musculus | W202 | DDDEKWSLGPS | 1 | Rattus norvegicus | Y191 | PGPGLYGDIHF | 1 | Homo sapiens | Y191 | PGPGFYGDVHF | 1 | Mus musculus | Y191 | PGPGFYGDAHF | 1 | Rattus norvegicus | Y239 | LMYPVYRFSTS | 2 | Mus musculus, Rattus norvegicus | Y239 | LMYPLYNSFTE | 1 | Homo sapiens |
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