mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

Home

Download

 Statistics

Help

About Us
Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MMP13
Gene summary
Basic gene Info.Gene symbolMMP13
Gene namematrix metallopeptidase 13 (collagenase 3)
SynonymsCLG3|MANDP1|MMP-13
CytomapUCSC genome browser: 11q22.3
Type of geneprotein-coding
RefGenesNM_002427.3,
Descriptioncollagenase 3matrix metalloproteinase 13 (collagenase 3)
Modification date20141222
dbXrefs MIM : 600108
HGNC : HGNC
Ensembl : ENSG00000137745
HPRD : 02522
Vega : OTTHUMG00000165850
ProteinUniProt: P45452
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MMP13
BioGPS: 4322
PathwayNCI Pathway Interaction Database: MMP13
KEGG: MMP13
REACTOME: MMP13
Pathway Commons: MMP13
ContextiHOP: MMP13
ligand binding site mutation search in PubMed: MMP13
UCL Cancer Institute: MMP13
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0030574collagen catabolic process8576151
GO:0060349bone morphogenesis16167086


Top
Ligand binding site mutations for MMP13
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
L111L111RCOAD1
T149P150SGBM1
H222A221VGBM1
G248G248DGBM1
D432D432YGBM1
H226G225DGBM1
D128D128HHNSC1
P127P127SHNSC1
G248G248DKIRC1
P242P242RLUAD1
H172K170NLUSC1
H226G225VLUSC1
A385A385SOV1
G237G237RSKCM1
D198,G196G197ASKCM1
A384A384GSKCM1
D204D204YSKCM1
N194N194DUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


Top
Protein structure related information for MMP13
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
G237G237R0.033910654
L111L111R-1.3476719
P127P127S-1.2938811
A385A385S-1.0430939
D198G197A-1.0330372
G196G197A-1.0330372
D128D128H-1.0043713
T149P150S-0.95847863
P242P242R-0.92200569
A384A384G-0.89947949
D204D204Y-0.70936986
N194N194D-0.69972981
H226G225D-0.69339913
G248G248D-0.62175755
H222A221V-0.61686183
D432D432Y-0.45516697
H226G225V-0.37300076
H172K170N-0.34663391
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MMP13 from PDB

Top
Differential gene expression and gene-gene network for MMP13
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MMP13 and the right PPI network was created from samples without mutations in the LBS of MMP13. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Top

Top
Phenotype information for MMP13
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C1865832Spondyloepimetaphyseal Dysplasia, Missouri Type2Biomarker, GeneticVariation
umls:C0023893Liver Cirrhosis, Experimental2Biomarker, Therapeutic
umls:C0376634Craniofacial Abnormalities1Biomarker
umls:C0033578Prostatic Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Top
Pharmacological information for MMP13
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|investigationalDB00786MarimastatSmall molecule
ExperimentalDB019963-MethylpyridineSmall molecule
ExperimentalDB020492-{4-[4-(4-Chloro-Phenoxy)-Benzenesulfonyl]-Tetrahydro-Pyran-4-Yl}-N-Hydroxy-AcetamideSmall molecule
ExperimentalDB02071WAY-151693Small molecule
ExperimentalDB02697HydroxyaminovalineSmall molecule
ExperimentalDB030331-Methyloxy-4-Sulfone-BenzeneSmall molecule
ExperimentalDB04759PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-(3-METHYL-BENZYLAMIDE)Small molecule
ExperimentalDB04760PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-(4-FLUORO-3-METHYL-BENZYLAMIDE)Small molecule
ExperimentalDB04761PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-[(PYRIDIN-3-YLMETHYL)-AMIDE]Small molecule
ExperimentalDB07013TERT-BUTYL 4-({[4-(BUT-2-YN-1-YLAMINO)PHENYL]SULFONYL}METHYL)-4-[(HYDROXYAMINO)CARBONYL]PIPERIDINE-1-CARBOXYLATESmall molecule
ExperimentalDB078274-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACIDSmall molecule
ExperimentalDB083885-(2-ETHOXYETHYL)-5-[4-(4-FLUOROPHENOXY)PHENOXY]PYRIMIDINE-2,4,6(1H,3H,5H)-TRIONESmall molecule
ExperimentalDB084904-[4-(4-CHLORO-PHENOXY)-BENZENESULFONYLMETHYL]-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HYDROXYAMIDESmall molecule
ExperimentalDB08561BENZYL 6-BENZYL-5,7-DIOXO-6,7-DIHYDRO-5H-[1,3]THIAZOLO[3,2-C]PYRIMIDINE-2-CARBOXYLATESmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MMP13 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
CACALCIUM(2+)4fu4AA385
CACALCIUM(2+)4fu4BA385
CACALCIUM(2+)4fvlAA385
CACALCIUM(2+)4fvlBA385
CACALCIUM(2+)4g0dAA385
CACALCIUM(2+)4g0dBA385
CACALCIUM(2+)4g0dCA385
CACALCIUM(2+)4g0dDA385
CACALCIUM(2+)2d1nAD128
CACALCIUM(2+)2d1nBD128
CACALCIUM(2+)3elmAD128
CACALCIUM(2+)3elmBD128
CACALCIUM(2+)3i7gAD128
CACALCIUM(2+)3i7iBD128
CACALCIUM(2+)3kecAD128
CACALCIUM(2+)3kecBD128
CACALCIUM(2+)3kejBD128
CACALCIUM(2+)3kekAD128
CACALCIUM(2+)3kekBD128
CACALCIUM(2+)3tvcAD128
CACALCIUM(2+)3zxhAD128
CACALCIUM(2+)3zxhBD128
CACALCIUM(2+)4fvlBD128
CACALCIUM(2+)4g0dAD128
CACALCIUM(2+)4g0dBD128
CACALCIUM(2+)4g0dCD128
CACALCIUM(2+)4g0dDD128
NASODIUM(1+)3wv1AD128
CACALCIUM(2+)5botAD128
CACALCIUM(2+)5botBD128
CACALCIUM(2+)5bpaBD128
CACALCIUM(2+)4fvlAD128 D204
NASODIUM(1+)3wv1BD128 D204
CACALCIUM(2+)4fu4AD432
CACALCIUM(2+)4fu4BD432
CACALCIUM(2+)4fvlAD432
CACALCIUM(2+)4fvlBD432
CACALCIUM(2+)4g0dAD432
CACALCIUM(2+)4g0dBD432
CACALCIUM(2+)4g0dCD432
CACALCIUM(2+)4g0dDD432
ZNZINC(2+)1eubAH172
ZNZINC(2+)1xucAH172
ZNZINC(2+)1xucBH172
ZNZINC(2+)1xudAH172
ZNZINC(2+)1xudBH172
ZNZINC(2+)1xurAH172
ZNZINC(2+)1xurBH172
ZNZINC(2+)1youAH172
ZNZINC(2+)1youBH172
ZNZINC(2+)2d1nAH172
ZNZINC(2+)2d1nBH172
ZNZINC(2+)2e2dAH172
ZNZINC(2+)2yigAH172
ZNZINC(2+)2yigBH172
ZNZINC(2+)3elmAH172
ZNZINC(2+)3elmBH172
ZNZINC(2+)3i7gAH172
ZNZINC(2+)3i7gBH172
ZNZINC(2+)3i7iAH172
ZNZINC(2+)3i7iBH172
ZNZINC(2+)3kecAH172
ZNZINC(2+)3kecBH172
ZNZINC(2+)3kejAH172
ZNZINC(2+)3kejBH172
ZNZINC(2+)3kekAH172
ZNZINC(2+)3kekBH172
ZNZINC(2+)3kryAH172
ZNZINC(2+)3kryBH172
ZNZINC(2+)3kryCH172
ZNZINC(2+)3kryDH172
ZNZINC(2+)3ljzAH172
ZNZINC(2+)3ljzBH172
ZNZINC(2+)3ljzCH172
ZNZINC(2+)3ljzDH172
ZNZINC(2+)3tvcAH172
ZNZINC(2+)3zxhAH172
ZNZINC(2+)3zxhBH172
ZNZINC(2+)456cAH172
ZNZINC(2+)456cBH172
ZNZINC(2+)4a7bAH172
ZNZINC(2+)4a7bBH172
ZNZINC(2+)830cAH172
ZNZINC(2+)830cBH172
ZNZINC(2+)4fu4AH172
ZNZINC(2+)4fu4BH172
ZNZINC(2+)4fvlAH172
ZNZINC(2+)4fvlBH172
ZNZINC(2+)4g0dAH172
ZNZINC(2+)4g0dBH172
ZNZINC(2+)4g0dCH172
ZNZINC(2+)4g0dDH172
ZNZINC(2+)4jp4AH172
ZNZINC(2+)4jp4BH172
ZNZINC(2+)4jpaAH172
ZNZINC(2+)4jpaBH172
ZNZINC(2+)3wv2AH172
ZNZINC(2+)3wv2BH172
ZNZINC(2+)3wv3AH172
ZNZINC(2+)3wv3BH172
ZNZINC(2+)4l19AH172
ZNZINC(2+)4l19BH172
ZNZINC(2+)3wv1AH172
ZNZINC(2+)3wv1BH172
ZNZINC(2+)5botAH172
ZNZINC(2+)5botBH172
ZNZINC(2+)5boyAH172
ZNZINC(2+)5boyBH172
ZNZINC(2+)5bpaAH172
ZNZINC(2+)5bpaBH172
PB5N,N'-BIS(PYRIDIN-3-YLMETHYL)PYRIMIDINE-4,6-DICARBOXAMIDE1xurAH222
PB5N,N'-BIS(PYRIDIN-3-YLMETHYL)PYRIMIDINE-4,6-DICARBOXAMIDE1xurBH222
WGGN-(3-METHOXYBENZYL)-4-OXO-3,4-DIHYDROQUINAZOLINE-2- CARBOXAMIDE3wv2AH222
WLLN-(3-METHOXYBENZYL)-4-OXO-3,4-DIHYDROTHIENO[2,3- D]PYRIMIDINE-2-CARBOXAMIDE3wv3AH222
WLLN-(3-METHOXYBENZYL)-4-OXO-3,4-DIHYDROTHIENO[2,3- D]PYRIMIDINE-2-CARBOXAMIDE3wv3BH222
WHH4-[2-({6-FLUORO-2-[(3-METHOXYBENZYL)CARBAMOYL]-4-OXO-3, 4-DIHYDROQUINAZOLIN-5-YL}OXY)ETHYL]BENZOIC ACID3wv1AH222
FMTFORMIC ACID3wv1BH222
WHH4-[2-({6-FLUORO-2-[(3-METHOXYBENZYL)CARBAMOYL]-4-OXO-3, 4-DIHYDROQUINAZOLIN-5-YL}OXY)ETHYL]BENZOIC ACID3wv1BH222
4UF4-{[({5-[2-(ETHOXYCARBONYL)-1H-INDOL-5-YL]-1-METHYL-1H- PYRAZOL-3-YL}CARBONYL)AMINO]METHYL}BENZOIC ACID5bpaBH222
WGGN-(3-METHOXYBENZYL)-4-OXO-3,4-DIHYDROQUINAZOLINE-2- CARBOXAMIDE3wv2BH222 G237
5EL4-(4-{[(3S)-3-HYDROXY-1-AZABICYCLO[2.2.2]OCT-3-YL]ETHYNYL}PHENOXY)-N-(PYRIDIN-4-YLMETHYL)BENZAMIDE2yigAH222 G237 P242
5EL4-(4-{[(3S)-3-HYDROXY-1-AZABICYCLO[2.2.2]OCT-3-YL]ETHYNYL}PHENOXY)-N-(PYRIDIN-4-YLMETHYL)BENZAMIDE2yigBH222 G237 P242
518N-[4-(5-{[(1S)-1-CYCLOHEXYL-2-(METHYLAMINO)-2-OXOETHYL]CARBAMOYL}FURAN-2-YL)PHENYL]-1-BENZOFURAN-2-CARBOXAMIDE3i7iAH222 G237 P242
3W5N-[(3S)-1,1-DIOXIDOTETRAHYDRO-2H-THIOPYRAN-3-YL]-4-(4-{[(3S)-3-HYDROXY-1-AZABICYCLO[2.2.2]OCT-3-YL]ETHYNYL}PHENOXY)BENZAMIDE4a7bAH222 G237 P242
3W4N-[(3R)-1,1-DIOXIDOTETRAHYDRO-2H-THIOPYRAN-3-YL]-4-(4-{[(3S)-3-HYDROXY-1-AZABICYCLO[2.2.2]OCT-3-YL]ETHYNYL}PHENOXY)BENZAMIDE4a7bBH222 G237 P242
1UA2-[(4-METHYLBENZYL)SULFANYL]-3,5,6,7-TETRAHYDRO-4H- CYCLOPENTA[D]PYRIMIDIN-4-ONE4l19BH222 G237 P242
ZNZINC(2+)1eubAH222 H226
HAVHYDROXYAMINOVALINE1eubAH222 H226
ZNZINC(2+)1xucAH222 H226
ZNZINC(2+)1xucBH222 H226
ZNZINC(2+)1xudAH222 H226
ZNZINC(2+)1xudBH222 H226
ZNZINC(2+)1xurAH222 H226
ZNZINC(2+)1xurBH222 H226
ZNZINC(2+)1youAH222 H226
ZNZINC(2+)1youBH222 H226
ZNZINC(2+)2d1nAH222 H226
ZNZINC(2+)2d1nBH222 H226
ZNZINC(2+)2e2dAH222 H226
ZNZINC(2+)2yigAH222 H226
ZNZINC(2+)2yigBH222 H226
ZNZINC(2+)3elmAH222 H226
ZNZINC(2+)3elmBH222 H226
ZNZINC(2+)3i7gAH222 H226
ZNZINC(2+)3i7gBH222 H226
ZNZINC(2+)3i7iAH222 H226
ZNZINC(2+)3i7iBH222 H226
ZNZINC(2+)3kecAH222 H226
ZNZINC(2+)3kecBH222 H226
ZNZINC(2+)3kejAH222 H226
ZNZINC(2+)3kejBH222 H226
ZNZINC(2+)3kekAH222 H226
ZNZINC(2+)3kekBH222 H226
ZNZINC(2+)3kryAH222 H226
ZNZINC(2+)3kryBH222 H226
ZNZINC(2+)3kryCH222 H226
ZNZINC(2+)3kryDH222 H226
ZNZINC(2+)3ljzAH222 H226
ZNZINC(2+)3ljzBH222 H226
ZNZINC(2+)3ljzCH222 H226
ZNZINC(2+)3ljzDH222 H226
ZNZINC(2+)3tvcAH222 H226
ZNZINC(2+)3zxhAH222 H226
ZNZINC(2+)3zxhBH222 H226
ZNZINC(2+)456cAH222 H226
ZNZINC(2+)456cBH222 H226
ZNZINC(2+)4a7bAH222 H226
ZNZINC(2+)4a7bBH222 H226
ZNZINC(2+)830cAH222 H226
ZNZINC(2+)830cBH222 H226
ZNZINC(2+)4fu4AH222 H226
ZNZINC(2+)4fu4BH222 H226
ZNZINC(2+)4fvlAH222 H226
ZNZINC(2+)4fvlBH222 H226
ZNZINC(2+)4g0dAH222 H226
ZNZINC(2+)4g0dBH222 H226
ZNZINC(2+)4g0dCH222 H226
ZNZINC(2+)4g0dDH222 H226
ZNZINC(2+)4jp4AH222 H226
ZNZINC(2+)4jp4BH222 H226
ZNZINC(2+)4jpaAH222 H226
ZNZINC(2+)4jpaBH222 H226
ZNZINC(2+)3wv2AH222 H226
ZNZINC(2+)3wv2BH222 H226
ZNZINC(2+)3wv3AH222 H226
ZNZINC(2+)3wv3BH222 H226
ZNZINC(2+)4l19AH222 H226
ZNZINC(2+)4l19BH222 H226
ZNZINC(2+)3wv1AH222 H226
FMTFORMIC ACID3wv1AH222 H226
ZNZINC(2+)3wv1BH222 H226
ZNZINC(2+)5botAH222 H226
ZNZINC(2+)5botBH222 H226
ZNZINC(2+)5boyAH222 H226
ZNZINC(2+)5boyBH222 H226
ZNZINC(2+)5bpaAH222 H226
ZNZINC(2+)5bpaBH222 H226
AZ63-[({2-[4-({[(4S)-4-METHYL-2,5-DIOXOIMIDAZOLIDIN-4- YL]METHYL}SULFONYL)PIPERAZIN-1-YL]PYRIMIDIN-5-YL}OXY) METHYL]BENZONITRILE4jpaAH222 H226 G237 P242
PFD5-(2-ETHOXYETHYL)-5-[4-(4-FLUOROPHENOXY)PHENOXY]BARBITURIC ACID1youAH222 H226 P242
PFD5-(2-ETHOXYETHYL)-5-[4-(4-FLUOROPHENOXY)PHENOXY]BARBITURIC ACID1youBH222 H226 P242
FA4SM-254532d1nAH222 H226 P242
FA4SM-254532d1nBH222 H226 P242
24F(2R)-({[5-(4-ETHOXYPHENYL)THIOPHEN-2-YL]SULFONYL}AMINO){1-[(1-METHYLETHOXY)CARBONYL]PIPERIDIN-4-YL}ETHANOIC ACID3elmAH222 H226 P242
24F(2R)-({[5-(4-ETHOXYPHENYL)THIOPHEN-2-YL]SULFONYL}AMINO){1-[(1-METHYLETHOXY)CARBONYL]PIPERIDIN-4-YL}ETHANOIC ACID3elmBH222 H226 P242
3KR1-(2-METHOXYETHYL)-N-OXO-4-({4-[4-(TRIFLUOROMETHOXY)PHENOXY]PHENYL}SULFONYL)PIPERIDINE-4-CARBOXAMIDE3kryAH222 H226 P242
3KR1-(2-METHOXYETHYL)-N-OXO-4-({4-[4-(TRIFLUOROMETHOXY)PHENOXY]PHENYL}SULFONYL)PIPERIDINE-4-CARBOXAMIDE3kryBH222 H226 P242
3KR1-(2-METHOXYETHYL)-N-OXO-4-({4-[4-(TRIFLUOROMETHOXY)PHENOXY]PHENYL}SULFONYL)PIPERIDINE-4-CARBOXAMIDE3kryCH222 H226 P242
3KR1-(2-METHOXYETHYL)-N-OXO-4-({4-[4-(TRIFLUOROMETHOXY)PHENOXY]PHENYL}SULFONYL)PIPERIDINE-4-CARBOXAMIDE3kryDH222 H226 P242
LA3(R)-2-(4-(BENZO[D][1,3]DIOXOL-5-YL)BENZYL)-N4-HYDROXY-N1-((1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL)SUCCINAMIDE3ljzAH222 H226 P242
LA3(R)-2-(4-(BENZO[D][1,3]DIOXOL-5-YL)BENZYL)-N4-HYDROXY-N1-((1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL)SUCCINAMIDE3ljzBH222 H226 P242
LA3(R)-2-(4-(BENZO[D][1,3]DIOXOL-5-YL)BENZYL)-N4-HYDROXY-N1-((1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL)SUCCINAMIDE3ljzCH222 H226 P242
LA3(R)-2-(4-(BENZO[D][1,3]DIOXOL-5-YL)BENZYL)-N4-HYDROXY-N1-((1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL)SUCCINAMIDE3ljzDH222 H226 P242
E3PN~2~-[3-(1,1':4',1''-TERPHENYL-4-YL)PROPANOYL]-L-ALPHA- GLUTAMINE3tvcAH222 H226 P242
E41N-HYDROXY-N^2^-(3-METHYLBUTYL)-N^2^-(NAPHTHALEN-2-YLSULFONYL)-D-VALINAMIDE3zxhAH222 H226 P242
E41N-HYDROXY-N^2^-(3-METHYLBUTYL)-N^2^-(NAPHTHALEN-2-YLSULFONYL)-D-VALINAMIDE3zxhBH222 H226 P242
CBP2-[4-[4-(4-CHLOROPHENOXY)PHENYL]SULFONYLOXAN-4-YL]-N-HYDROXYACETAMIDE456cAH222 H226 P242
CBP2-[4-[4-(4-CHLOROPHENOXY)PHENYL]SULFONYLOXAN-4-YL]-N-HYDROXYACETAMIDE456cBH222 H226 P242
RS14-[[4-(4-CHLOROPHENOXY)PHENYL]SULFONYLMETHYL]-N-HYDROXYOXANE-4-CARBOXAMIDE830cAH222 H226 P242
RS14-[[4-(4-CHLOROPHENOXY)PHENYL]SULFONYLMETHYL]-N-HYDROXYOXANE-4-CARBOXAMIDE830cBH222 H226 P242
IIIPeptide ligand (GLY,GLY,ASP,GLU,ASP,ASP,LEU,SER,GLU,GLU,ASP,LEU,GLN,PHE,ALA,GLU,ARG,TYR,LEU,ARG,SER,TYR,TYR,HIS,PRO,THR)4fu4AH222 H226 P242
IIIPeptide ligand (GLN,PHE,ALA,GLU,ARG,TYR,LEU,ARG,SER,TYR,TYR,HIS,PRO,THR)4fvlAH222 H226 P242
AZ4N-[(2S)-4-(5-FLUOROPYRIMIDIN-2-YL)-1-({4-[5-(2,2,2- TRIFLUOROETHOXY)PYRIMIDIN-2-YL]PIPERAZIN-1- YL}SULFONYL)BUTAN-2-YL]-N-HYDROXYFORMAMIDE4jp4AH222 H226 P242
AZ4N-[(2S)-4-(5-FLUOROPYRIMIDIN-2-YL)-1-({4-[5-(2,2,2- TRIFLUOROETHOXY)PYRIMIDIN-2-YL]PIPERAZIN-1- YL}SULFONYL)BUTAN-2-YL]-N-HYDROXYFORMAMIDE4jp4BH222 H226 P242
AZ63-[({2-[4-({[(4S)-4-METHYL-2,5-DIOXOIMIDAZOLIDIN-4- YL]METHYL}SULFONYL)PIPERAZIN-1-YL]PYRIMIDIN-5-YL}OXY) METHYL]BENZONITRILE4jpaBH222 H226 P242
MSB4-METHOXYBENZENESULFINATE1eubAH222 P242
PB3N,N'-BIS(3-METHYLBENZYL)PYRIMIDINE-4,6-DICARBOXAMIDE1xucAH222 P242
PB3N,N'-BIS(3-METHYLBENZYL)PYRIMIDINE-4,6-DICARBOXAMIDE1xucBH222 P242
PB4N,N'-BIS(4-FLUORO-3-METHYLBENZYL)PYRIMIDINE-4,6-DICARBOXAMIDE1xudAH222 P242
PB4N,N'-BIS(4-FLUORO-3-METHYLBENZYL)PYRIMIDINE-4,6-DICARBOXAMIDE1xudBH222 P242
7325-(4-CHLOROPHENYL)-N-[(1S)-1-CYCLOHEXYL-2-(METHYLAMINO)-2-OXOETHYL]FURAN-2-CARBOXAMIDE3i7gAH222 P242
3KE4-((3-(2-(4-METHOXYBENZYL)-2H-TETRAZOL-5-YL)BENZAMIDO)METHYL)BENZOIC ACID3kecAH222 P242
3KE4-((3-(2-(4-METHOXYBENZYL)-2H-TETRAZOL-5-YL)BENZAMIDO)METHYL)BENZOIC ACID3kecBH222 P242
3EJ4-[(5-{2-[(3-FLUOROBENZYL)CARBAMOYL]PYRIDIN-4-YL}-2H-TETRAZOL-2-YL)METHYL]BENZOIC ACID3kejBH222 P242
3EK(1R,4R)-4-((3-(2((4-FLUOROBENZYL)CARBAMOYL)-6-METHYLPYRIDIN-4-YL)-1H-1,2,4-TRIAZOL-1-YL)METHYL]CYCLOHEXANECARBOXYLIC ACID3kekAH222 P242
3EK(1R,4R)-4-((3-(2((4-FLUOROBENZYL)CARBAMOYL)-6-METHYLPYRIDIN-4-YL)-1H-1,2,4-TRIAZOL-1-YL)METHYL]CYCLOHEXANECARBOXYLIC ACID3kekBH222 P242
1UA2-[(4-METHYLBENZYL)SULFANYL]-3,5,6,7-TETRAHYDRO-4H- CYCLOPENTA[D]PYRIMIDIN-4-ONE4l19AH222 P242
4UMETHYL 5-CARBAMOYL-1H-INDOLE-2-CARBOXYLATE5botAH222 P242
4UMETHYL 5-CARBAMOYL-1H-INDOLE-2-CARBOXYLATE5botBH222 P242
4UEETHYL 5-(1-METHYL-1H-IMIDAZOL-5-YL)-1H-INDOLE-2- CARBOXYLATE5boyAH222 P242
4UEETHYL 5-(1-METHYL-1H-IMIDAZOL-5-YL)-1H-INDOLE-2- CARBOXYLATE5boyBH222 P242
4UF4-{[({5-[2-(ETHOXYCARBONYL)-1H-INDOL-5-YL]-1-METHYL-1H- PYRAZOL-3-YL}CARBONYL)AMINO]METHYL}BENZOIC ACID5bpaAH222 P242
3EJ4-[(5-{2-[(3-FLUOROBENZYL)CARBAMOYL]PYRIDIN-4-YL}-2H-TETRAZOL-2-YL)METHYL]BENZOIC ACID3kejAH222 P242 G248
1UA2-[(4-METHYLBENZYL)SULFANYL]-3,5,6,7-TETRAHYDRO-4H- CYCLOPENTA[D]PYRIMIDIN-4-ONE4l19AH226
IIIPeptide ligand (GLY,GLY,ASP,GLU,ASP,ASP,LEU,SER,GLU,GLU,ASP,LEU,GLN,PHE,ALA,GLU,ARG,TYR,LEU,ARG,SER,TYR,TYR,HIS,PRO,THR)4fu4BL111 H172 G196 H222 H226 P242
IIIPeptide ligand (LEU,SER,GLU,GLU,ASP,LEU,GLN,PHE,ALA,GLU,ARG,TYR,LEU,ARG,SER,TYR,TYR,HIS,PRO,THR)4fvlBL111 H222 H226 P242
IIIPeptide ligand (SER,GLU,GLU,ASP,LEU,GLN,PHE,ALA,GLU,ARG,TYR,LEU,ARG,SER,TYR,TYR,HIS,PRO,THR)4g0dAL111 H222 H226 P242
IIIPeptide ligand (GLY,GLY,ASP,GLU,ASP,ASP,LEU,SER,GLU,GLU,ASP,LEU,GLN,PHE,ALA,GLU,ARG,TYR,LEU,ARG,SER,TYR,TYR,HIS,PRO,THR)4g0dBL111 H222 H226 P242
IIIPeptide ligand (GLU,ASP,ASP,LEU,SER,GLU,GLU,ASP,LEU,GLN,PHE,ALA,GLU,ARG,TYR,LEU,ARG,SER,TYR,TYR,HIS,PRO,THR)4g0dCL111 H222 H226 P242
IIIPeptide ligand (GLU,ASP,ASP,LEU,SER,GLU,GLU,ASP,LEU,GLN,PHE,ALA,GLU,ARG,TYR,LEU,ARG,SER,TYR,TYR,HIS,PRO,THR)4g0dDL111 H222 H226 P242
GG14-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACID2ozrAN194
GG14-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACID2ozrBN194
GG14-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACID2ozrCN194
GG14-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACID2ozrDN194
GG14-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACID2ozrEN194
GG14-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACID2ozrFN194
GG14-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACID2ozrGN194
GG14-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACID2ozrHN194
CACALCIUM(2+)1eubAN194 G196 D198
CACALCIUM(2+)1xucAN194 G196 D198
CACALCIUM(2+)1xucBN194 G196 D198
CACALCIUM(2+)1xudAN194 G196 D198
CACALCIUM(2+)1xudBN194 G196 D198
CACALCIUM(2+)1xurAN194 G196 D198
CACALCIUM(2+)1xurBN194 G196 D198
CACALCIUM(2+)2d1nAN194 G196 D198
CACALCIUM(2+)2d1nBN194 G196 D198
CACALCIUM(2+)2e2dAN194 G196 D198
CACALCIUM(2+)2yigAN194 G196 D198
CACALCIUM(2+)2yigBN194 G196 D198
CACALCIUM(2+)3elmAN194 G196 D198
CACALCIUM(2+)3elmBN194 G196 D198
CACALCIUM(2+)3i7gAN194 G196 D198
CACALCIUM(2+)3i7gBN194 G196 D198
CACALCIUM(2+)3i7iAN194 G196 D198
CACALCIUM(2+)3i7iBN194 G196 D198
CACALCIUM(2+)3kecAN194 G196 D198
CACALCIUM(2+)3kecBN194 G196 D198
CACALCIUM(2+)3kejAN194 G196 D198
CACALCIUM(2+)3kejBN194 G196 D198
CACALCIUM(2+)3kekAN194 G196 D198
CACALCIUM(2+)3kekBN194 G196 D198
CACALCIUM(2+)3kryAN194 G196 D198
CACALCIUM(2+)3kryBN194 G196 D198
CACALCIUM(2+)3kryCN194 G196 D198
CACALCIUM(2+)3kryDN194 G196 D198
CACALCIUM(2+)3ljzAN194 G196 D198
CACALCIUM(2+)3ljzBN194 G196 D198
CACALCIUM(2+)3ljzCN194 G196 D198
CACALCIUM(2+)3ljzDN194 G196 D198
CACALCIUM(2+)3tvcAN194 G196 D198
CACALCIUM(2+)3zxhAN194 G196 D198
CACALCIUM(2+)3zxhBN194 G196 D198
CACALCIUM(2+)4a7bAN194 G196 D198
CACALCIUM(2+)4a7bBN194 G196 D198
CACALCIUM(2+)4fu4AN194 G196 D198
CACALCIUM(2+)4fu4BN194 G196 D198
CACALCIUM(2+)4fvlAN194 G196 D198
CACALCIUM(2+)4fvlBN194 G196 D198
CACALCIUM(2+)4g0dAN194 G196 D198
CACALCIUM(2+)4g0dBN194 G196 D198
CACALCIUM(2+)4g0dCN194 G196 D198
CACALCIUM(2+)4g0dDN194 G196 D198
CACALCIUM(2+)4jp4AN194 G196 D198
CACALCIUM(2+)4jp4BN194 G196 D198
CACALCIUM(2+)4jpaAN194 G196 D198
CACALCIUM(2+)4jpaBN194 G196 D198
CACALCIUM(2+)3wv2AN194 G196 D198
CACALCIUM(2+)3wv2BN194 G196 D198
CACALCIUM(2+)3wv3AN194 G196 D198
CACALCIUM(2+)3wv3BN194 G196 D198
CACALCIUM(2+)4l19AN194 G196 D198
CACALCIUM(2+)4l19BN194 G196 D198
CACALCIUM(2+)3wv1AN194 G196 D198
CACALCIUM(2+)3wv1BN194 G196 D198
CACALCIUM(2+)5botAN194 G196 D198
CACALCIUM(2+)5botBN194 G196 D198
CACALCIUM(2+)5boyAN194 G196 D198
CACALCIUM(2+)5boyBN194 G196 D198
CACALCIUM(2+)5bpaAN194 G196 D198
CACALCIUM(2+)5bpaBN194 G196 D198
CACALCIUM(2+)3i7gBP127 D128
CACALCIUM(2+)3i7iAP127 D128
CACALCIUM(2+)3kejAP127 D128
CACALCIUM(2+)5boyAP127 D128
CACALCIUM(2+)5boyBP127 D128
CACALCIUM(2+)5bpaAP127 D128
3MP3-METHYLPYRIDINE1eubAP242
CACALCIUM(2+)3elmAT149
CACALCIUM(2+)3zxhAT149
CACALCIUM(2+)4g0dBT149
CACALCIUM(2+)4g0dCT149


Top
Conservation information for LBS of MMP13
Multiple alignments for P45452 in multiple species
LBSAA sequence# speciesSpecies
A161LHDGIADIMIS1Homo sapiens
A161IYDGTADIMIS1Mus musculus
A161IHNGTADIMIS1Bos taurus
A186PSGLLAHAFPP3Homo sapiens, Mus musculus, Bos taurus
A188GLLAHAFPPGP3Homo sapiens, Mus musculus, Bos taurus
A238SKDPGALMFPI3Homo sapiens, Mus musculus, Bos taurus
A336PNRIDAAYEHP2Homo sapiens, Bos taurus
A336PNHVDAAYEHP1Mus musculus
A337NRIDAAYEHPS2Homo sapiens, Bos taurus
A337NHVDAAYEHPS1Mus musculus
A384VKKISAAVHFE1Homo sapiens
A384VKRLSAAVHFE1Mus musculus
A384VKKISAALHFE1Bos taurus
A385KKISAAVHFED1Homo sapiens
A385KRLSAAVHFEN1Mus musculus
A385KKISAALHFED1Bos taurus
D128VNYTPDMTHSE1Homo sapiens
D128VNYTPDMSHSE1Mus musculus
D128VNYTPDLTHSE1Bos taurus
D162HDGIADIMISF1Homo sapiens
D162YDGTADIMISF1Mus musculus
D162HNGTADIMISF1Bos taurus
D174TKEHGDFYPFD2Mus musculus, Bos taurus
D174IKEHGDFYPFD1Homo sapiens
D179DFYPFDGPSGL3Homo sapiens, Mus musculus, Bos taurus
D198PNYGGDAHFDD3Homo sapiens, Mus musculus, Bos taurus
D202GDAHFDDDETW3Homo sapiens, Mus musculus, Bos taurus
D203DAHFDDDETWT3Homo sapiens, Mus musculus, Bos taurus
D204AHFDDDETWTS3Homo sapiens, Mus musculus, Bos taurus
D231HSLGLDHSKDP3Homo sapiens, Mus musculus, Bos taurus
D291PSLSLDAITSL2Homo sapiens, Bos taurus
D291PALSLDAITSL1Mus musculus
D335LPNRIDAAYEH2Homo sapiens, Bos taurus
D335LPNHVDAAYEH1Mus musculus
D361ALNGYDILEGY2Homo sapiens, Mus musculus
D361ALSGYDILEDY1Bos taurus
D432IGDKVDAVYEK1Homo sapiens
D432IGNKVDAVYEK1Mus musculus
D432IGDKVDAVYQK1Bos taurus
E205HFDDDETWTSS3Homo sapiens, Mus musculus, Bos taurus
E223LVAAHEFGHSL2Homo sapiens, Bos taurus
E223IVAAHELGHSL1Mus musculus
F107GEYNVFPRTLK3Homo sapiens, Mus musculus, Bos taurus
F175KEHGDFYPFDG3Homo sapiens, Mus musculus, Bos taurus
F189LLAHAFPPGPN3Homo sapiens, Mus musculus, Bos taurus
F217KGYNLFLVAAH2Homo sapiens, Bos taurus
F217KGYNLFIVAAH1Mus musculus
F241PGALMFPIYTY3Homo sapiens, Mus musculus, Bos taurus
F252TGKSHFMLPDD3Homo sapiens, Mus musculus, Bos taurus
G173GTKEHGDFYPF2Mus musculus, Bos taurus
G173GIKEHGDFYPF1Homo sapiens
G180FYPFDGPSGLL3Homo sapiens, Mus musculus, Bos taurus
G183FDGPSGLLAHA3Homo sapiens, Mus musculus, Bos taurus
G196PGPNYGGDAHF3Homo sapiens, Mus musculus, Bos taurus
G237HSKDPGALMFP3Homo sapiens, Mus musculus, Bos taurus
G248IYTYTGKSHFM3Homo sapiens, Mus musculus, Bos taurus
G269SLYGPGDEDPN1Homo sapiens
G269FLYGPGDEDPN1Mus musculus
G269SLYGPGDEDPY1Bos taurus
H131TPDMTHSEVEK1Homo sapiens
H131TPDMSHSEVEK1Mus musculus
H131TPDLTHSEVEK1Bos taurus
H172FGTKEHGDFYP2Mus musculus, Bos taurus
H172FGIKEHGDFYP1Homo sapiens
H187SGLLAHAFPPG3Homo sapiens, Mus musculus, Bos taurus
H200YGGDAHFDDDE3Homo sapiens, Mus musculus, Bos taurus
H222FLVAAHEFGHS2Homo sapiens, Bos taurus
H222FIVAAHELGHS1Mus musculus
H226AHEFGHSLGLD2Homo sapiens, Bos taurus
H226AHELGHSLGLD1Mus musculus
H232SLGLDHSKDPG3Homo sapiens, Mus musculus, Bos taurus
H251YTGKSHFMLPD3Homo sapiens, Mus musculus, Bos taurus
I243ALMFPIYTYTG3Homo sapiens, Mus musculus, Bos taurus
I293LSLDAITSLRG3Homo sapiens, Mus musculus, Bos taurus
K140EKAFRKAFKVW2Mus musculus, Bos taurus
K140EKAFKKAFKVW1Homo sapiens
K249YTYTGKSHFML3Homo sapiens, Mus musculus, Bos taurus
L111VFPRTLKWSKM2Homo sapiens, Bos taurus
L111VFPRTLKWSQT1Mus musculus
L184DGPSGLLAHAF3Homo sapiens, Mus musculus, Bos taurus
L185GPSGLLAHAFP3Homo sapiens, Mus musculus, Bos taurus
L218GYNLFLVAAHE2Homo sapiens, Bos taurus
L218GYNLFIVAAHE1Mus musculus
L239KDPGALMFPIY3Homo sapiens, Mus musculus, Bos taurus
L322DAELFLTKSFW1Homo sapiens
L322EAELFLTKSFW1Mus musculus
L322EAELFLTKSFG1Bos taurus
M164GTADIMISFGT2Mus musculus, Bos taurus
M164GIADIMISFGI1Homo sapiens
M240DPGALMFPIYT3Homo sapiens, Mus musculus, Bos taurus
M253GKSHFMLPDDD3Homo sapiens, Mus musculus, Bos taurus
N194FPPGPNYGGDA3Homo sapiens, Mus musculus, Bos taurus
N215SSKGYNLFLVA2Homo sapiens, Bos taurus
N215SSKGYNLFIVA1Mus musculus
N358KFWALNGYDIL2Homo sapiens, Mus musculus
N358KFWALSGYDIL1Bos taurus
P108EYNVFPRTLKW3Homo sapiens, Mus musculus, Bos taurus
P127IVNYTPDMTHS1Homo sapiens
P127IVNYTPDMSHS1Mus musculus
P127IVNYTPDLTHS1Bos taurus
P181YPFDGPSGLLA3Homo sapiens, Mus musculus, Bos taurus
P190LAHAFPPGPNY3Homo sapiens, Mus musculus, Bos taurus
P193AFPPGPNYGGD3Homo sapiens, Mus musculus, Bos taurus
P236DHSKDPGALMF3Homo sapiens, Mus musculus, Bos taurus
P242GALMFPIYTYT3Homo sapiens, Mus musculus, Bos taurus
P255SHFMLPDDDVQ3Homo sapiens, Mus musculus, Bos taurus
P328TKSFWPELPNR1Homo sapiens
P328TKSFWPELPNH1Mus musculus
P328TKSFGPELPNR1Bos taurus
R109YNVFPRTLKWS3Homo sapiens, Mus musculus, Bos taurus
S146AFKVWSDVTPL3Homo sapiens, Mus musculus, Bos taurus
S182PFDGPSGLLAH3Homo sapiens, Mus musculus, Bos taurus
S250TYTGKSHFMLP3Homo sapiens, Mus musculus, Bos taurus
S383EVKKISAAVHF1Homo sapiens
S383EVKRLSAAVHF1Mus musculus
S383HVKKISAALHF1Bos taurus
T126RIVNYTPDMTH1Homo sapiens
T126RIVNYTPDMSH1Mus musculus
T126RIVNYTPDLTH1Bos taurus
T130YTPDMTHSEVE1Homo sapiens
T130YTPDMSHSEVE1Mus musculus
T130YTPDLTHSEVE1Bos taurus
T149VWSDVTPLNFT3Homo sapiens, Mus musculus, Bos taurus
T206FDDDETWTSSS3Homo sapiens, Mus musculus, Bos taurus
T245MFPIYTYTGKS3Homo sapiens, Mus musculus, Bos taurus
T247PIYTYTGKSHF3Homo sapiens, Mus musculus, Bos taurus
T294SLDAITSLRGE3Homo sapiens, Mus musculus, Bos taurus
V219YNLFLVAAHEF2Homo sapiens, Bos taurus
V219YNLFIVAAHEL1Mus musculus
V386KISAAVHFEDT1Homo sapiens
V386RLSAAVHFENT1Mus musculus
V386KISAALHFEDS1Bos taurus
V434DKVDAVYEKNG1Homo sapiens
V434NKVDAVYEKNG1Mus musculus
V434DKVDAVYQKNG1Bos taurus
W207DDDETWTSSSK3Homo sapiens, Mus musculus, Bos taurus
Y176EHGDFYPFDGP3Homo sapiens, Mus musculus, Bos taurus
Y195PPGPNYGGDAH3Homo sapiens, Mus musculus, Bos taurus
Y214SSSKGYNLFLV2Homo sapiens, Bos taurus
Y214SSSKGYNLFIV1Mus musculus
Y244LMFPIYTYTGK3Homo sapiens, Mus musculus, Bos taurus
Y246FPIYTYTGKSH3Homo sapiens, Mus musculus, Bos taurus
Y338RIDAAYEHPSH2Homo sapiens, Bos taurus
Y338HVDAAYEHPSR1Mus musculus
Y360WALNGYDILEG2Homo sapiens, Mus musculus
Y360WALSGYDILED1Bos taurus
Y435KVDAVYEKNGY2Homo sapiens, Mus musculus
Y435KVDAVYQKNGY1Bos taurus


Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas