mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MMP16
Gene summary
Basic gene Info.Gene symbolMMP16
Gene namematrix metallopeptidase 16 (membrane-inserted)
SynonymsC8orf57|MMP-X2|MT-MMP2|MT-MMP3|MT3-MMP
CytomapUCSC genome browser: 8q21.3
Type of geneprotein-coding
RefGenesNM_005941.4,
NM_022564.3,NM_032297.1,
DescriptionMMP-16MT-MMP 3MT3MMPMTMMP3Putative transmembrane protein C8orf57matrix metalloproteinase-16membrane-type matrix metalloproteinase 3membrane-type-3 matrix metalloproteinase
Modification date20141222
dbXrefs MIM : 602262
HGNC : HGNC
HPRD : 03776
ProteinUniProt: P51512
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MMP16
BioGPS: 4325
PathwayNCI Pathway Interaction Database: MMP16
KEGG: MMP16
REACTOME: MMP16
Pathway Commons: MMP16
ContextiHOP: MMP16
ligand binding site mutation search in PubMed: MMP16
UCL Cancer Institute: MMP16
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for MMP16
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
Y268Y270HCOAD1
G215G215RHNSC1
H193H193NLUAD1
G217G217RLUAD1
D195,H193G194WLUAD1
H193H193LLUAD1
H246H246LLUAD1
D200P198HLUSC1
H246V245ASTAD1
H256L254VUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for MMP16
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
H246H246L0.95624718
H193H193L0.44952881
H246V245A-1.5179173
Y268Y270H-1.415366
D200P198H-0.93502104
H256L254V-0.83171412
H193H193N-0.24588171
D195G194W-0.05367235
H193G194W-0.05367235
G217G217R-0.051027518
G215G215R-0.034083954
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MMP16 from PDB

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Differential gene expression and gene-gene network for MMP16
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MMP16 and the right PPI network was created from samples without mutations in the LBS of MMP16. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for MMP16
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for MMP16
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|investigationalDB00786MarimastatSmall molecule
ExperimentalDB03880BatimastatSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MMP16 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
CACALCIUM(2+)1rm8AD200
CACALCIUM(2+)1rm8AG215 G217
ZNZINC(2+)1rm8AH193 D195
ZNZINC(2+)1rm8AH246 H256
BATBATIMASTAT1rm8AH246 H256 Y268


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Conservation information for LBS of MMP16
Multiple alignments for P51512 in multiple species
LBSAA sequence# speciesSpecies
A207EGGFLAHAYFP3Homo sapiens, Mus musculus, Rattus norvegicus
D183GKRDVDITIIF3Homo sapiens, Mus musculus, Rattus norvegicus
D195SGFHGDSSPFD2Homo sapiens, Mus musculus
D195SGFHGDRSPFD1Rattus norvegicus
D200DSSPFDGEGGF2Homo sapiens, Mus musculus
D200DRSPFDGEGGF1Rattus norvegicus
D219PGIGGDTHFDS3Homo sapiens, Mus musculus, Rattus norvegicus
D223GDTHFDSDEPW3Homo sapiens, Mus musculus, Rattus norvegicus
E202SPFDGEGGFLA3Homo sapiens, Mus musculus, Rattus norvegicus
E226HFDSDEPWTLG3Homo sapiens, Mus musculus, Rattus norvegicus
E247LVAVHELGHAL3Homo sapiens, Mus musculus, Rattus norvegicus
F205DGEGGFLAHAY3Homo sapiens, Mus musculus, Rattus norvegicus
F267AIMAPFYQYME3Homo sapiens, Mus musculus, Rattus norvegicus
G201SSPFDGEGGFL2Homo sapiens, Mus musculus
G201RSPFDGEGGFL1Rattus norvegicus
G203PFDGEGGFLAH3Homo sapiens, Mus musculus, Rattus norvegicus
G204FDGEGGFLAHA3Homo sapiens, Mus musculus, Rattus norvegicus
G215YFPGPGIGGDT3Homo sapiens, Mus musculus, Rattus norvegicus
G217PGPGIGGDTHF3Homo sapiens, Mus musculus, Rattus norvegicus
H193FASGFHGDSSP2Homo sapiens, Mus musculus
H193FASGFHGDRSP1Rattus norvegicus
H208GGFLAHAYFPG3Homo sapiens, Mus musculus, Rattus norvegicus
H221IGGDTHFDSDE3Homo sapiens, Mus musculus, Rattus norvegicus
H246FLVAVHELGHA3Homo sapiens, Mus musculus, Rattus norvegicus
H250VHELGHALGLE3Homo sapiens, Mus musculus, Rattus norvegicus
H256ALGLEHSNDPT3Homo sapiens, Mus musculus, Rattus norvegicus
I184KRDVDITIIFA3Homo sapiens, Mus musculus, Rattus norvegicus
I216FPGPGIGGDTH3Homo sapiens, Mus musculus, Rattus norvegicus
L206GEGGFLAHAYF3Homo sapiens, Mus musculus, Rattus norvegicus
P266TAIMAPFYQYM3Homo sapiens, Mus musculus, Rattus norvegicus
V243NDLFLVAVHEL3Homo sapiens, Mus musculus, Rattus norvegicus
Y268IMAPFYQYMET3Homo sapiens, Mus musculus, Rattus norvegicus


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