mutLBSgeneDB |
Gene summary for MMP16 |
Gene summary |
Basic gene Info. | Gene symbol | MMP16 |
Gene name | matrix metallopeptidase 16 (membrane-inserted) | |
Synonyms | C8orf57|MMP-X2|MT-MMP2|MT-MMP3|MT3-MMP | |
Cytomap | UCSC genome browser: 8q21.3 | |
Type of gene | protein-coding | |
RefGenes | NM_005941.4, NM_022564.3,NM_032297.1, | |
Description | MMP-16MT-MMP 3MT3MMPMTMMP3Putative transmembrane protein C8orf57matrix metalloproteinase-16membrane-type matrix metalloproteinase 3membrane-type-3 matrix metalloproteinase | |
Modification date | 20141222 | |
dbXrefs | MIM : 602262 | |
HGNC : HGNC | ||
HPRD : 03776 | ||
Protein | UniProt: P51512 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MMP16 | |
BioGPS: 4325 | ||
Pathway | NCI Pathway Interaction Database: MMP16 | |
KEGG: MMP16 | ||
REACTOME: MMP16 | ||
Pathway Commons: MMP16 | ||
Context | iHOP: MMP16 | |
ligand binding site mutation search in PubMed: MMP16 | ||
UCL Cancer Institute: MMP16 | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for MMP16 |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | Y268 | Y270H | COAD | 1 | G215 | G215R | HNSC | 1 | H193 | H193N | LUAD | 1 | G217 | G217R | LUAD | 1 | D195,H193 | G194W | LUAD | 1 | H193 | H193L | LUAD | 1 | H246 | H246L | LUAD | 1 | D200 | P198H | LUSC | 1 | H246 | V245A | STAD | 1 | H256 | L254V | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for MMP16 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | H246 | H246L | 0.95624718 | H193 | H193L | 0.44952881 | H246 | V245A | -1.5179173 | Y268 | Y270H | -1.415366 | D200 | P198H | -0.93502104 | H256 | L254V | -0.83171412 | H193 | H193N | -0.24588171 | D195 | G194W | -0.05367235 | H193 | G194W | -0.05367235 | G217 | G217R | -0.051027518 | G215 | G215R | -0.034083954 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for MMP16 from PDB |
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Differential gene expression and gene-gene network for MMP16 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for MMP16 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for MMP16 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Approved|investigational | DB00786 | Marimastat | Small molecule | |
Experimental | DB03880 | Batimastat | Small molecule |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of MMP16 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | CA | CALCIUM(2+) | 1rm8 | A | D200 | CA | CALCIUM(2+) | 1rm8 | A | G215 G217 | ZN | ZINC(2+) | 1rm8 | A | H193 D195 | ZN | ZINC(2+) | 1rm8 | A | H246 H256 | BAT | BATIMASTAT | 1rm8 | A | H246 H256 Y268 |
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Conservation information for LBS of MMP16 |
Multiple alignments for P51512 in multiple species |
LBS | AA sequence | # species | Species | A207 | EGGFLAHAYFP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D183 | GKRDVDITIIF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D195 | SGFHGDSSPFD | 2 | Homo sapiens, Mus musculus | D195 | SGFHGDRSPFD | 1 | Rattus norvegicus | D200 | DSSPFDGEGGF | 2 | Homo sapiens, Mus musculus | D200 | DRSPFDGEGGF | 1 | Rattus norvegicus | D219 | PGIGGDTHFDS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D223 | GDTHFDSDEPW | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E202 | SPFDGEGGFLA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E226 | HFDSDEPWTLG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E247 | LVAVHELGHAL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F205 | DGEGGFLAHAY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F267 | AIMAPFYQYME | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G201 | SSPFDGEGGFL | 2 | Homo sapiens, Mus musculus | G201 | RSPFDGEGGFL | 1 | Rattus norvegicus | G203 | PFDGEGGFLAH | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G204 | FDGEGGFLAHA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G215 | YFPGPGIGGDT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G217 | PGPGIGGDTHF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H193 | FASGFHGDSSP | 2 | Homo sapiens, Mus musculus | H193 | FASGFHGDRSP | 1 | Rattus norvegicus | H208 | GGFLAHAYFPG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H221 | IGGDTHFDSDE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H246 | FLVAVHELGHA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H250 | VHELGHALGLE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H256 | ALGLEHSNDPT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I184 | KRDVDITIIFA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I216 | FPGPGIGGDTH | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L206 | GEGGFLAHAYF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P266 | TAIMAPFYQYM | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V243 | NDLFLVAVHEL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y268 | IMAPFYQYMET | 3 | Homo sapiens, Mus musculus, Rattus norvegicus |
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