mutLBSgeneDB |
Gene summary for MPG |
Gene summary |
Basic gene Info. | Gene symbol | MPG |
Gene name | N-methylpurine-DNA glycosylase | |
Synonyms | AAG|ADPG|APNG|CRA36.1|MDG|Mid1|PIG11|PIG16|anpg | |
Cytomap | UCSC genome browser: 16p13.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001015052.2, NM_001015054.2,NM_002434.3, | |
Description | 3' end of the Mid1 gene, localized 68 kb upstream the humanzeta globin gene on 16p3-alkyladenine DNA glycosylase3-methyladenine DNA glycosidaseCRA36.1 (3-methyl-adenine DNA glycosylase)DNA-3-methyladenine glycosylaseN-methylpurine-DNA glycosylase, MP | |
Modification date | 20141207 | |
dbXrefs | MIM : 156565 | |
HGNC : HGNC | ||
Ensembl : ENSG00000103152 | ||
HPRD : 06766 | ||
Vega : OTTHUMG00000047887 | ||
Protein | UniProt: P29372 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MPG | |
BioGPS: 4350 | ||
Pathway | NCI Pathway Interaction Database: MPG | |
KEGG: MPG | ||
REACTOME: MPG | ||
Pathway Commons: MPG | ||
Context | iHOP: MPG | |
ligand binding site mutation search in PubMed: MPG | ||
UCL Cancer Institute: MPG | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for MPG |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | V262 | R261Q | BLCA | 1 | Y157,Y159 | V158M | KIRC | 1 | R145 | R145H | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for MPG |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | Y157 | V158M | -1.5589293 | Y159 | V158M | -1.5589293 | R145 | R145H | -1.0734853 | V262 | R261Q | -0.99428337 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for MPG from PDB |
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Differential gene expression and gene-gene network for MPG |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for MPG |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for MPG |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of MPG go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 1bnk | A | R145 | NUC | Nucleic Acids | 1ewn | A | R145 | NUC | Nucleic Acids | 1f4r | A | R145 | NUC | Nucleic Acids | 1f6o | A | R145 | NUC | Nucleic Acids | 3qi5 | A | R145 | NUC | Nucleic Acids | 3qi5 | B | R145 | NUC | Nucleic Acids | 3uby | A | R145 | NUC | Nucleic Acids | 3qi5 | A | Y157 Y159 V262 | NUC | Nucleic Acids | 3uby | A | Y157 Y159 V262 | NUC | Nucleic Acids | 1ewn | A | Y159 | NUC | Nucleic Acids | 1bnk | A | Y159 V262 | NUC | Nucleic Acids | 1f4r | A | Y159 V262 | NUC | Nucleic Acids | 1f6o | A | Y159 V262 | NUC | Nucleic Acids | 3qi5 | B | Y159 V262 |
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Conservation information for LBS of MPG |
Multiple alignments for P29372 in multiple species |
LBS | AA sequence | # species | Species |
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