mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

Home

Download

 Statistics

Help

About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MPO
Gene summary
Basic gene Info.Gene symbolMPO
Gene namemyeloperoxidase
Synonyms-
CytomapUCSC genome browser: 17q23.1
Type of geneprotein-coding
RefGenesNM_000250.1,
Description-
Modification date20141221
dbXrefs MIM : 606989
HGNC : HGNC
Ensembl : ENSG00000005381
HPRD : 06102
Vega : OTTHUMG00000178922
ProteinUniProt: P05164
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MPO
BioGPS: 4353
PathwayNCI Pathway Interaction Database: MPO
KEGG: MPO
REACTOME: MPO
Pathway Commons: MPO
ContextiHOP: MPO
ligand binding site mutation search in PubMed: MPO
UCL Cancer Institute: MPO
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0034374low-density lipoprotein particle remodeling10772654
GO:0042744hydrogen peroxide catabolic process10772654
GO:0055114oxidation-reduction process10772654


Top
Ligand binding site mutations for MPO

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
L583,L581D582HBLCA1
R548I546VBRCA1
G501G501SCOAD1
L586A585DCOAD1
M409E411KCOAD1
R590R590HCOAD1
L596L596FCOAD1
Y462D461GKIRC1
F532F532VKIRC1
R548L547PKIRC1
P386P386RLUAD1
M577M577KLUSC1
K671K671NLUSC1
K671R673WLUSC1
S340S340TLUSC1
Y462R460QSKCM1
N514R515WSKCM1
P597G598ESKCM1
R548L547FSTAD1
R590R590CSTAD1
T334A332TUCEC1
F605F605LUCEC1
F313,P311F312LUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


Top
Protein structure related information for MPO
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
L596L596F-1.5260608
S340S340T-1.4782562
R590R590H-1.4444861
N514R515W-1.4435436
K671R673W-1.3852086
R548L547P-1.3613308
R548L547F-1.350209
R590R590C-1.1722552
T334A332T-1.1701989
M409E411K-1.1485931
Y462R460Q-1.0027872
R548I546V-0.92094887
G501G501S-0.92002935
Y462D461G-0.89864606
K671K671N-0.8701109
L586A585D-0.84123588
P386P386R-0.76825634
M577M577K-0.73100464
F313F312L-0.68567411
P311F312L-0.68567411
P597G598E-0.56768438
F532F532V-0.5395256
F605F605L-0.3070946
L583D582H-0.21696534
L581D582H-0.21696534
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MPO from PDB

Top
Differential gene expression and gene-gene network for MPO
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MPO and the right PPI network was created from samples without mutations in the LBS of MPO. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Top

Top
Phenotype information for MPO
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0002395Alzheimer Disease10AlteredExpression, Biomarker, GeneticVariation
umls:C0007222Cardiovascular Diseases10Biomarker, GeneticVariation
umls:C0024121Lung Neoplasms9Biomarker, GeneticVariation
umls:C0021368Inflammation9Biomarker, GeneticVariation
umls:C0009319Colitis9Biomarker
umls:C0398595Myeloperoxidase Deficiency7Biomarker, GeneticVariation
umls:C0035126Reperfusion Injury7Biomarker
umls:C0024115Lung Diseases6Biomarker, GeneticVariation
umls:C0022658Kidney Diseases6Biomarker, GeneticVariation
umls:C2239176Carcinoma, Hepatocellular4Biomarker, GeneticVariation
umls:C0009324Colitis, Ulcerative4Biomarker
umls:C0028797Occupational Diseases3Biomarker, GeneticVariation
umls:C2609414Acute Kidney Injury2Biomarker
umls:C0006434Burns2Biomarker
umls:C0011853Diabetes Mellitus, Experimental2Biomarker
umls:C0023891Liver Cirrhosis, Alcoholic2Biomarker, GeneticVariation
umls:C0032927Precancerous Conditions2Biomarker, GeneticVariation
umls:C0033578Prostatic Neoplasms2Biomarker, GeneticVariation
umls:C0005695Urinary Bladder Neoplasms2Biomarker, GeneticVariation
umls:C0003873Arthritis, Rheumatoid2Biomarker
umls:C0003130Anoxia1Biomarker
umls:C0993582Arthritis, Experimental1Biomarker
umls:C0270611Brain Injuries1Biomarker
umls:C0007786Brain Ischemia1Biomarker
umls:C0011609Drug Eruptions1Biomarker
umls:C0022593Keratosis1Biomarker
umls:C0030305Pancreatitis1Biomarker
umls:C0036982Shock, Hemorrhagic1Biomarker
umls:C0040954Trichuriasis1Biomarker
umls:C0042109Urticaria1Biomarker
umls:C0043251Wounds and Injuries1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs
18673G501SPathogenicGermlineMedGen:C0398595
OMIM:254600
SNOMED CT:129644003
SNOMED CT:234433009

Top
Pharmacological information for MPO
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ApprovedDB00244MesalazineSmall molecule
ApprovedDB00535CefdinirSmall molecule
ApprovedDB00583L-CarnitineSmall molecule
Approved|nutraceutical|vet_approvedDB01065MelatoninSmall molecule
WithdrawnDB04821NomifensineSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MPO go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


Top
Conservation information for LBS of MPO
Multiple alignments for P05164 in multiple species
LBSAA sequence# speciesSpecies


Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas