mutLBSgeneDB |
Gene summary for MPO |
Gene summary |
Basic gene Info. | Gene symbol | MPO |
Gene name | myeloperoxidase | |
Synonyms | - | |
Cytomap | UCSC genome browser: 17q23.1 | |
Type of gene | protein-coding | |
RefGenes | NM_000250.1, | |
Description | - | |
Modification date | 20141221 | |
dbXrefs | MIM : 606989 | |
HGNC : HGNC | ||
Ensembl : ENSG00000005381 | ||
HPRD : 06102 | ||
Vega : OTTHUMG00000178922 | ||
Protein | UniProt: P05164 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MPO | |
BioGPS: 4353 | ||
Pathway | NCI Pathway Interaction Database: MPO | |
KEGG: MPO | ||
REACTOME: MPO | ||
Pathway Commons: MPO | ||
Context | iHOP: MPO | |
ligand binding site mutation search in PubMed: MPO | ||
UCL Cancer Institute: MPO | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0034374 | low-density lipoprotein particle remodeling | 10772654 | GO:0042744 | hydrogen peroxide catabolic process | 10772654 | GO:0055114 | oxidation-reduction process | 10772654 |
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Ligand binding site mutations for MPO |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | L583,L581 | D582H | BLCA | 1 | R548 | I546V | BRCA | 1 | G501 | G501S | COAD | 1 | L586 | A585D | COAD | 1 | M409 | E411K | COAD | 1 | R590 | R590H | COAD | 1 | L596 | L596F | COAD | 1 | Y462 | D461G | KIRC | 1 | F532 | F532V | KIRC | 1 | R548 | L547P | KIRC | 1 | P386 | P386R | LUAD | 1 | M577 | M577K | LUSC | 1 | K671 | K671N | LUSC | 1 | K671 | R673W | LUSC | 1 | S340 | S340T | LUSC | 1 | Y462 | R460Q | SKCM | 1 | N514 | R515W | SKCM | 1 | P597 | G598E | SKCM | 1 | R548 | L547F | STAD | 1 | R590 | R590C | STAD | 1 | T334 | A332T | UCEC | 1 | F605 | F605L | UCEC | 1 | F313,P311 | F312L | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for MPO |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | L596 | L596F | -1.5260608 | S340 | S340T | -1.4782562 | R590 | R590H | -1.4444861 | N514 | R515W | -1.4435436 | K671 | R673W | -1.3852086 | R548 | L547P | -1.3613308 | R548 | L547F | -1.350209 | R590 | R590C | -1.1722552 | T334 | A332T | -1.1701989 | M409 | E411K | -1.1485931 | Y462 | R460Q | -1.0027872 | R548 | I546V | -0.92094887 | G501 | G501S | -0.92002935 | Y462 | D461G | -0.89864606 | K671 | K671N | -0.8701109 | L586 | A585D | -0.84123588 | P386 | P386R | -0.76825634 | M577 | M577K | -0.73100464 | F313 | F312L | -0.68567411 | P311 | F312L | -0.68567411 | P597 | G598E | -0.56768438 | F532 | F532V | -0.5395256 | F605 | F605L | -0.3070946 | L583 | D582H | -0.21696534 | L581 | D582H | -0.21696534 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for MPO from PDB |
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Differential gene expression and gene-gene network for MPO |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for MPO |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0002395 | Alzheimer Disease | 10 | AlteredExpression, Biomarker, GeneticVariation |
umls:C0007222 | Cardiovascular Diseases | 10 | Biomarker, GeneticVariation |
umls:C0024121 | Lung Neoplasms | 9 | Biomarker, GeneticVariation |
umls:C0021368 | Inflammation | 9 | Biomarker, GeneticVariation |
umls:C0009319 | Colitis | 9 | Biomarker |
umls:C0398595 | Myeloperoxidase Deficiency | 7 | Biomarker, GeneticVariation |
umls:C0035126 | Reperfusion Injury | 7 | Biomarker |
umls:C0024115 | Lung Diseases | 6 | Biomarker, GeneticVariation |
umls:C0022658 | Kidney Diseases | 6 | Biomarker, GeneticVariation |
umls:C2239176 | Carcinoma, Hepatocellular | 4 | Biomarker, GeneticVariation |
umls:C0009324 | Colitis, Ulcerative | 4 | Biomarker |
umls:C0028797 | Occupational Diseases | 3 | Biomarker, GeneticVariation |
umls:C2609414 | Acute Kidney Injury | 2 | Biomarker |
umls:C0006434 | Burns | 2 | Biomarker |
umls:C0011853 | Diabetes Mellitus, Experimental | 2 | Biomarker |
umls:C0023891 | Liver Cirrhosis, Alcoholic | 2 | Biomarker, GeneticVariation |
umls:C0032927 | Precancerous Conditions | 2 | Biomarker, GeneticVariation |
umls:C0033578 | Prostatic Neoplasms | 2 | Biomarker, GeneticVariation |
umls:C0005695 | Urinary Bladder Neoplasms | 2 | Biomarker, GeneticVariation |
umls:C0003873 | Arthritis, Rheumatoid | 2 | Biomarker |
umls:C0003130 | Anoxia | 1 | Biomarker |
umls:C0993582 | Arthritis, Experimental | 1 | Biomarker |
umls:C0270611 | Brain Injuries | 1 | Biomarker |
umls:C0007786 | Brain Ischemia | 1 | Biomarker |
umls:C0011609 | Drug Eruptions | 1 | Biomarker |
umls:C0022593 | Keratosis | 1 | Biomarker |
umls:C0030305 | Pancreatitis | 1 | Biomarker |
umls:C0036982 | Shock, Hemorrhagic | 1 | Biomarker |
umls:C0040954 | Trichuriasis | 1 | Biomarker |
umls:C0042109 | Urticaria | 1 | Biomarker |
umls:C0043251 | Wounds and Injuries | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
18673 | G501S | Pathogenic | Germline | MedGen:C0398595 OMIM:254600 SNOMED CT:129644003 SNOMED CT:234433009 |
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Pharmacological information for MPO |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Approved | DB00244 | Mesalazine | Small molecule | |
Approved | DB00535 | Cefdinir | Small molecule | |
Approved | DB00583 | L-Carnitine | Small molecule | |
Approved|nutraceutical|vet_approved | DB01065 | Melatonin | Small molecule | |
Withdrawn | DB04821 | Nomifensine | Small molecule |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of MPO go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of MPO |
Multiple alignments for P05164 in multiple species |
LBS | AA sequence | # species | Species |
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