mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MST1R
Gene summary
Basic gene Info.Gene symbolMST1R
Gene namemacrophage stimulating 1 receptor (c-met-related tyrosine kinase)
CytomapUCSC genome browser: 3p21.3
Type of geneprotein-coding
DescriptionMSP receptorMST1R variant RON30MST1R variant RON62PTK8 protein tyrosine kinase 8RON variant 21RON variant E2E3c-met-related tyrosine kinasemacrophage-stimulating protein receptorp185-Ronsoluble RON variant 1soluble RON variant 2soluble RON vari
Modification date20141222
dbXrefs MIM : 600168
Ensembl : ENSG00000164078
HPRD : 02545
Vega : OTTHUMG00000156709
ProteinUniProt: Q04912
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MST1R
BioGPS: 4486
PathwayNCI Pathway Interaction Database: MST1R
Pathway Commons: MST1R
ContextiHOP: MST1R
ligand binding site mutation search in PubMed: MST1R
UCL Cancer Institute: MST1R
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0009615response to virus12676986
GO:0043406positive regulation of MAP kinase activity12676986
GO:0051897positive regulation of protein kinase B signaling12676986

Ligand binding site mutations for MST1R

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for MST1R
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MST1R from PDB

Differential gene expression and gene-gene network for MST1R
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MST1R and the right PPI network was created from samples without mutations in the LBS of MST1R. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for MST1R
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0860207Drug-Induced Liver Injury1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for MST1R
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MST1R go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ANPAMP-PNP3plsAV1096 R1212

Conservation information for LBS of MST1R
Multiple alignments for Q04912 in multiple species
LBSAA sequence# speciesSpecies

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