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mutLBSgeneDB |
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| Gene summary for MX1 |
 Gene summary |
| Basic gene Info. | Gene symbol | MX1 |
| Gene name | MX dynamin-like GTPase 1 | |
| Synonyms | IFI-78K|IFI78|MX|MxA | |
| Cytomap | UCSC genome browser: 21q22.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001144925.2, NM_001178046.2,NM_001282920.1,NM_002462.4, | |
| Description | interferon-induced GTP-binding protein Mx1interferon-induced protein p78interferon-inducible protein p78interferon-regulated resistance GTP-binding protein MxAmyxoma resistance protein 1myxovirus (influenza virus) resistance 1, interferon-inducible p | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 147150 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000157601 | ||
| HPRD : 00919 | ||
| Vega : OTTHUMG00000086755 | ||
| Protein | UniProt: P20591 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MX1 | |
| BioGPS: 4599 | ||
| Pathway | NCI Pathway Interaction Database: MX1 | |
| KEGG: MX1 | ||
| REACTOME: MX1 | ||
| Pathway Commons: MX1 | ||
| Context | iHOP: MX1 | |
| ligand binding site mutation search in PubMed: MX1 | ||
| UCL Cancer Institute: MX1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0045071 | negative regulation of viral genome replication | 14687945 |
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| Ligand binding site mutations for MX1 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | R281 | R281L | LUAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for MX1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | R281 | R281L | -0.34746768 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for MX1 from PDB |
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| Differential gene expression and gene-gene network for MX1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for MX1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0021400 | Influenza, Human | 14 | Biomarker |
| umls:C0015625 | Fanconi Anemia | 1 | Biomarker |
| umls:C0016627 | Influenza in Birds | 1 | Therapeutic |
| umls:C0023467 | Leukemia, Myeloid, Acute | 1 | Biomarker |
| umls:C0151744 | Myocardial Ischemia | 1 | Biomarker |
| umls:C0038356 | Stomach Neoplasms | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for MX1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of MX1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | GDP | GUANOSINE-5'-DIPHOSPHATE | 4p4t | A | R281 |
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| Conservation information for LBS of MX1 |
| Multiple alignments for P20591 in multiple species |
| LBS | AA sequence | # species | Species | C280 | YMIVKCRGQQE | 2 | Homo sapiens, Macaca mulatta | C280 | YMIVKCRGQQD | 2 | Bos taurus, Canis lupus familiaris | C280 | YVCVRNRIGEE | 1 | Arabidopsis thaliana | D250 | ILTKPDLVDKG | 3 | Homo sapiens, Bos taurus, Macaca mulatta | D250 | VVTKADMAPEG | 1 | Arabidopsis thaliana | D250 | ILTKPDLVDRG | 1 | Canis lupus familiaris | G282 | IVKCRGQQEIQ | 2 | Homo sapiens, Macaca mulatta | G282 | CVRNRIGEE-- | 1 | Arabidopsis thaliana | G282 | IVKCRGQQDIK | 1 | Bos taurus | G282 | IVKCRGQQDIQ | 1 | Canis lupus familiaris | G82 | GDQSSGKSSVL | 5 | Homo sapiens, Arabidopsis thaliana, Bos taurus, Canis lupus familiaris, Macaca mulatta | I286 | RGQQEIQDQLS | 2 | Homo sapiens, Macaca mulatta | I286 | RIGEE-----T | 1 | Arabidopsis thaliana | I286 | RGQQDIKHRMS | 1 | Bos taurus | I286 | RGQQDIQDQVS | 1 | Canis lupus familiaris | K248 | IGILTKPDLVD | 4 | Homo sapiens, Bos taurus, Canis lupus familiaris, Macaca mulatta | K248 | LAVVTKADMAP | 1 | Arabidopsis thaliana | K279 | GYMIVKCRGQQ | 4 | Homo sapiens, Bos taurus, Canis lupus familiaris, Macaca mulatta | K279 | GYVCVRNRIGE | 1 | Arabidopsis thaliana | K83 | DQSSGKSSVLE | 5 | Homo sapiens, Arabidopsis thaliana, Bos taurus, Canis lupus familiaris, Macaca mulatta | L251 | LTKPDLVDKGT | 3 | Homo sapiens, Bos taurus, Macaca mulatta | L251 | VTKADMAPEGL | 1 | Arabidopsis thaliana | L251 | LTKPDLVDRGT | 1 | Canis lupus familiaris | P96 | SGVALPRGSGI | 4 | Homo sapiens, Bos taurus, Canis lupus familiaris, Macaca mulatta | P96 | AGISLPRGQGI | 1 | Arabidopsis thaliana | Q283 | VKCRGQQEIQD | 2 | Homo sapiens, Macaca mulatta | Q283 | VRNRIGEE--- | 1 | Arabidopsis thaliana | Q283 | VKCRGQQDIKH | 1 | Bos taurus | Q283 | VKCRGQQDIQD | 1 | Canis lupus familiaris | R281 | MIVKCRGQQEI | 2 | Homo sapiens, Macaca mulatta | R281 | MIVKCRGQQDI | 2 | Bos taurus, Canis lupus familiaris | R281 | VCVRNRIGEE- | 1 | Arabidopsis thaliana | S80 | VIGDQSSGKSS | 4 | Homo sapiens, Bos taurus, Canis lupus familiaris, Macaca mulatta | S80 | VVGDQSSGKSS | 1 | Arabidopsis thaliana | S81 | IGDQSSGKSSV | 4 | Homo sapiens, Bos taurus, Canis lupus familiaris, Macaca mulatta | S81 | VGDQSSGKSSV | 1 | Arabidopsis thaliana | S84 | QSSGKSSVLEA | 4 | Homo sapiens, Bos taurus, Canis lupus familiaris, Macaca mulatta | S84 | QSSGKSSVLES | 1 | Arabidopsis thaliana | S85 | SSGKSSVLEAL | 4 | Homo sapiens, Bos taurus, Canis lupus familiaris, Macaca mulatta | S85 | SSGKSSVLESL | 1 | Arabidopsis thaliana | T103 | GSGIVTRCPLV | 4 | Homo sapiens, Bos taurus, Canis lupus familiaris, Macaca mulatta | T103 | GQGICTRVPLV | 1 | Arabidopsis thaliana |
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