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mutLBSgeneDB |
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| Gene summary for MYO1C |
 Gene summary |
| Basic gene Info. | Gene symbol | MYO1C |
| Gene name | myosin IC | |
| Synonyms | MMI-beta|MMIb|NMI|myr2 | |
| Cytomap | UCSC genome browser: 17p13.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001080779.1, NM_001080950.1,NM_033375.4, | |
| Description | myosin I betamyosin-I betamyosin-Icnuclear myosin Iunconventional myosin-Ic | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 606538 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000197879 | ||
| HPRD : 09411 | ||
| Vega : OTTHUMG00000090323 | ||
| Protein | UniProt: O00159 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MYO1C | |
| BioGPS: 4641 | ||
| Pathway | NCI Pathway Interaction Database: MYO1C | |
| KEGG: MYO1C | ||
| REACTOME: MYO1C | ||
| Pathway Commons: MYO1C | ||
| Context | iHOP: MYO1C | |
| ligand binding site mutation search in PubMed: MYO1C | ||
| UCL Cancer Institute: MYO1C | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006605 | protein targeting | 21402783 | GO:0006612 | protein targeting to membrane | 21402783 |
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| Ligand binding site mutations for MYO1C |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | S196 | S196C | LUAD | 1 | E148 | A149V | SKCM | 1 | E141 | S139Y | SKCM | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for MYO1C |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | E148 | A149V | -0.83345926 | S196 | S196C | -0.61756643 | E141 | S139Y | -0.61195486 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for MYO1C from PDB |
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| Differential gene expression and gene-gene network for MYO1C |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for MYO1C |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for MYO1C |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of MYO1C go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of MYO1C |
| Multiple alignments for O00159 in multiple species |
| LBS | AA sequence | # species | Species | A144 | SGESGAGKTEA | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | A144 | SGESGSGKTEA | 1 | Drosophila melanogaster | E141 | VMISGESGAGK | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | E141 | VLISGESGSGK | 1 | Drosophila melanogaster | E141 | ILISGESGAGK | 1 | Gallus gallus | E148 | GAGKTEATKRL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | E148 | GSGKTEASKKV | 1 | Drosophila melanogaster | E148 | GAGKTEATKKI | 1 | Gallus gallus | G143 | ISGESGAGKTE | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | G143 | ISGESGSGKTE | 1 | Drosophila melanogaster | G145 | GESGAGKTEAT | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | G145 | GESGSGKTEAS | 1 | Drosophila melanogaster | G424 | LLDIYGFEVFQ | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | G424 | ILDIYGFEIFQ | 1 | Drosophila melanogaster | K146 | ESGAGKTEATK | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | K146 | ESGSGKTEASK | 1 | Drosophila melanogaster | N192 | AKTLRNDNSSR | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | N192 | AKTNRNDNSSR | 1 | Drosophila melanogaster | N192 | TKTLRNDNSSR | 1 | Gallus gallus | N194 | TLRNDNSSRFG | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | N194 | TNRNDNSSRFG | 1 | Drosophila melanogaster | N88 | VLVSVNPYRDL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | N88 | VLISVNPYKQL | 1 | Drosophila melanogaster | N88 | VLVSVNPYKEL | 1 | Gallus gallus | P89 | LVSVNPYRDLQ | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | P89 | LISVNPYKQLP | 1 | Drosophila melanogaster | P89 | LVSVNPYKELE | 1 | Gallus gallus | R91 | SVNPYRDLQIY | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | R91 | SVNPYKQLPIY | 1 | Drosophila melanogaster | R91 | SVNPYKELEIY | 1 | Gallus gallus | S142 | MISGESGAGKT | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | S142 | LISGESGSGKT | 1 | Drosophila melanogaster | S142 | LISGESGAGKT | 1 | Gallus gallus | S195 | LRNDNSSRFGK | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | S195 | NRNDNSSRFGK | 1 | Drosophila melanogaster | S196 | RNDNSSRFGKY | 6 | Homo sapiens, Drosophila melanogaster, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | T147 | SGAGKTEATKR | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | T147 | SGSGKTEASKK | 1 | Drosophila melanogaster | T147 | SGAGKTEATKK | 1 | Gallus gallus | Y423 | GLLDIYGFEVF | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | Y423 | GILDIYGFEIF | 1 | Drosophila melanogaster | Y96 | RDLQIYSRQHM | 3 | Homo sapiens, Bos taurus, Mus musculus | Y96 | KQLPIYTDDHV | 1 | Drosophila melanogaster | Y96 | KELEIYSKQNM | 1 | Gallus gallus | Y96 | RDLQIYTRQHM | 1 | Rattus norvegicus |
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