mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ATIC
Gene summary
Basic gene Info.Gene symbolATIC
Gene name5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
SynonymsAICAR|AICARFT|HEL-S-70p|IMPCHASE|PURH
CytomapUCSC genome browser: 2q35
Type of geneprotein-coding
RefGenesNM_004044.6,
Description5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleotide transformylase/inosinicaseAICAR formyltransferase/IMP cyclohydrolase bifunctional enzymeAICARFT/IMPCHASEbifunctional purine biosynthesis protein PURHepididymis secretory sperm binding protein Li 7
Modification date20141207
dbXrefs MIM : 601731
HGNC : HGNC
Ensembl : ENSG00000138363
HPRD : 03434
Vega : OTTHUMG00000133023
ProteinUniProt: P31939
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ATIC
BioGPS: 471
PathwayNCI Pathway Interaction Database: ATIC
KEGG: ATIC
REACTOME: ATIC
Pathway Commons: ATIC
ContextiHOP: ATIC
ligand binding site mutation search in PubMed: ATIC
UCL Cancer Institute: ATIC
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for ATIC

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
S565G564SCOAD1
S34S34PCOAD1
R451R451HCOAD1
A566D568YLUAD1
G63L61FLUAD1
H267S269ILUAD1
S34S34FOV1
K66,R64V65ASTAD1
N489A490VSTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for ATIC
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
G63L61F-0.9341196
A566D568Y-0.84675879
R451R451H-0.81022074
S34S34P-0.71680534
R64V65A-0.65701022
K66V65A-0.65701022
S34S34F-0.58123741
H267S269I-0.454639
S565G564S-0.29395286
N489A490V-0.20094197
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ATIC from PDB

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Differential gene expression and gene-gene network for ATIC
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ATIC and the right PPI network was created from samples without mutations in the LBS of ATIC. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for ATIC
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C1837530AICAR Transformylase Inosine Monophosphate Cyclohydrolase Deficiency1Biomarker, GeneticVariation
umls:C0029456Osteoporosis1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for ATIC
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|nutraceuticalDB00116Tetrahydrofolic acidSmall molecule
Approved|investigationalDB00642PemetrexedSmall molecule
ExperimentalDB01700AicarSmall molecule
ExperimentalDB01972Guanosine-5'-MonophosphateSmall molecule
ExperimentalDB023095--Monophosphate-9-Beta-D-Ribofuranosyl XanthineSmall molecule
ExperimentalDB034422-[5-Hydroxy-3-Methyl-1-(2-Methyl-4-Sulfo-Phenyl)-1h-Pyrazol-4-Ylazo]-4-Sulfo-Benzoic AcidSmall molecule
ExperimentalDB04057Beta-Dadf, Msa, Multisubstrate Adduct InhibitorSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ATIC go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
AMZ5-AMINO-1-(5-PHOSPHO-D-RIBOSYL)IMIDAZOLE-4-CARBOXAMIDE1p4rAH267
AMZ5-AMINO-1-(5-PHOSPHO-D-RIBOSYL)IMIDAZOLE-4-CARBOXAMIDE1p4rBH267
AMZ5-AMINO-1-(5-PHOSPHO-D-RIBOSYL)IMIDAZOLE-4-CARBOXAMIDE1pl0AH267
AMZ5-AMINO-1-(5-PHOSPHO-D-RIBOSYL)IMIDAZOLE-4-CARBOXAMIDE1pl0CH267
AMZ5-AMINO-1-(5-PHOSPHO-D-RIBOSYL)IMIDAZOLE-4-CARBOXAMIDE1pl0DH267
354N-[(S)-(4-{[(2-AMINO-4-HYDROXYQUINAZOLIN-6-YL)(DIHYDROXY)-LAMBDA~4~-SULFANYL]AMINO}PHENYL)(HYDROXY)METHYL]-L-GLUTAMIC ACID1p4rAN489
354N-[(S)-(4-{[(2-AMINO-4-HYDROXYQUINAZOLIN-6-YL)(DIHYDROXY)-LAMBDA~4~-SULFANYL]AMINO}PHENYL)(HYDROXY)METHYL]-L-GLUTAMIC ACID1p4rBN489
BW2N-(4-{[(2-AMINO-4-OXO-3,4-DIHYDROQUINAZOLIN-6-YL)AMINO]SULFONYL}BENZOYL)GLUTAMIC ACID1pl0AN489
BW2N-(4-{[(2-AMINO-4-OXO-3,4-DIHYDROQUINAZOLIN-6-YL)AMINO]SULFONYL}BENZOYL)GLUTAMIC ACID1pl0CN489
AMZ5-AMINO-1-(5-PHOSPHO-D-RIBOSYL)IMIDAZOLE-4-CARBOXAMIDE1p4rAR451
AMZ5-AMINO-1-(5-PHOSPHO-D-RIBOSYL)IMIDAZOLE-4-CARBOXAMIDE1p4rBR451
AMZ5-AMINO-1-(5-PHOSPHO-D-RIBOSYL)IMIDAZOLE-4-CARBOXAMIDE1pl0BR451
BW2N-(4-{[(2-AMINO-4-OXO-3,4-DIHYDROQUINAZOLIN-6-YL)AMINO]SULFONYL}BENZOYL)GLUTAMIC ACID1pl0BR451
AMZ5-AMINO-1-(5-PHOSPHO-D-RIBOSYL)IMIDAZOLE-4-CARBOXAMIDE1pl0CR451
AMZ5-AMINO-1-(5-PHOSPHO-D-RIBOSYL)IMIDAZOLE-4-CARBOXAMIDE1pl0DR451
BW2N-(4-{[(2-AMINO-4-OXO-3,4-DIHYDROQUINAZOLIN-6-YL)AMINO]SULFONYL}BENZOYL)GLUTAMIC ACID1pl0DR451
354N-[(S)-(4-{[(2-AMINO-4-HYDROXYQUINAZOLIN-6-YL)(DIHYDROXY)-LAMBDA~4~-SULFANYL]AMINO}PHENYL)(HYDROXY)METHYL]-L-GLUTAMIC ACID1p4rAR451 S565 A566
354N-[(S)-(4-{[(2-AMINO-4-HYDROXYQUINAZOLIN-6-YL)(DIHYDROXY)-LAMBDA~4~-SULFANYL]AMINO}PHENYL)(HYDROXY)METHYL]-L-GLUTAMIC ACID1p4rBR451 S565 A566
XMPXANTHOSINE-5'-MONOPHOSPHATE1pl0CS34 G63 R64 K66
XMPXANTHOSINE-5'-MONOPHOSPHATE1p4rAS34 R64 K66
XMPXANTHOSINE-5'-MONOPHOSPHATE1pkxAS34 R64 K66
XMPXANTHOSINE-5'-MONOPHOSPHATE1pkxCS34 R64 K66
XMPXANTHOSINE-5'-MONOPHOSPHATE1pl0AS34 R64 K66


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Conservation information for LBS of ATIC
Multiple alignments for P31939 in multiple species
LBSAA sequence# speciesSpecies
A540SISSDAFFPFR2Homo sapiens, Bos taurus
A540SVSSDAFFPFR2Mus musculus, Rattus norvegicus
A540SLSSDAFFPFR1Gallus gallus
A540SLSSDAFFPFP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A540VCASDAFFPFP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A566APSGSAADKVV2Homo sapiens, Bos taurus
A566APSGSTADKVV2Mus musculus, Rattus norvegicus
A566APSGSAADEVV1Gallus gallus
A566APSGSVMDKVV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A566APGGSVMDQAV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C101VRVVVCNLYPF2Gallus gallus, Mus musculus
C101IRVVVCNLYPF2Rattus norvegicus, Bos taurus
C101IRVVACNLYPF1Homo sapiens
C101VDYVVCNLYPF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C101IDIVVCNLYPF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D125AVEQIDIGGVT3Homo sapiens, Mus musculus, Rattus norvegicus
D125AVEEIDIGGVT2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D125AVEKIDIGGVA1Gallus gallus
D125AVEHIDIGGVT1Bos taurus
D339SREVSDGIIAP2Homo sapiens, Bos taurus
D339SREVSDGIVAP2Mus musculus, Rattus norvegicus
D339SREVSDGVIAP2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D339SREVSDGVVAP1Gallus gallus
D546FFPFRDNVDRA5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
D546FFPFPDNVYRA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D546FFPFPDNIYRL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F315DRMSSFGDFVA4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
F315DRMSSFGDFIA2Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F315DRMSSFGDWIA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F541ISSDAFFPFRD2Homo sapiens, Bos taurus
F541VSSDAFFPFRD2Mus musculus, Rattus norvegicus
F541LSSDAFFPFRD1Gallus gallus
F541LSSDAFFPFPD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F541CASDAFFPFPD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F544DAFFPFRDNVD5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
F544DAFFPFPDNVY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F544DAFFPFPDNIY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F590TNLRLFHH3Homo sapiens, Gallus gallus, Bos taurus
F590TDLRLFHH2Mus musculus, Rattus norvegicus
F590NPIRLFHH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F590IPLRLFHH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G127EQIDIGGVTLL3Homo sapiens, Mus musculus, Rattus norvegicus
G127EEIDIGGVTLL2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G127EKIDIGGVALL1Gallus gallus
G127EHIDIGGVTLL1Bos taurus
G128QIDIGGVTLLR3Homo sapiens, Mus musculus, Rattus norvegicus
G128EIDIGGVTLLR2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G128KIDIGGVALLR1Gallus gallus
G128HIDIGGVTLLR1Bos taurus
G316RMSSFGDFVAL4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G316RMSSFGDFIAL2Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G316RMSSFGDWIAL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G35SLVASGGTAKA2Mus musculus, Rattus norvegicus
G35NLVASGGTAKA1Homo sapiens
G35GLIASGGTATA1Gallus gallus
G35NLIASGGTAKA1Bos taurus
G35RILASGGTARM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G35KLLGSGGTAKM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G36LVASGGTAKAI2Mus musculus, Rattus norvegicus
G36LVASGGTAKAL1Homo sapiens
G36LIASGGTATAL1Gallus gallus
G36LIASGGTAKAL1Bos taurus
G36ILASGGTARMI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G36LLGSGGTAKMI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G63PEMLGGRVKTL6Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G63PEILGGRVKTL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H267AASFKHVSPAG7Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I126VEQIDIGGVTL3Homo sapiens, Mus musculus, Rattus norvegicus
I126VEEIDIGGVTL2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I126VEKIDIGGVAL1Gallus gallus
I126VEHIDIGGVTL1Bos taurus
I238GAPGFINLCDA4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
I238GSPGFINLCDA1Gallus gallus
I238GSPGYINLLDA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I238GSPGYINLMDA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I452GQQSRIHCTRL6Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I452GQQSRIHCNRL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K14FSVSDKTGLVE3Homo sapiens, Mus musculus, Rattus norvegicus
K14LSVSEKAGLVE1Gallus gallus
K14FSVSDKNGLVE1Bos taurus
K14LSVYDKTGLLD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K14LSVYDKTGLLE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K266AAASFKHVSPA7Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K66LGGRVKTLHPA7Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L103VVVCNLYPFVK3Gallus gallus, Mus musculus, Rattus norvegicus
L103VVACNLYPFVK1Homo sapiens
L103VVVCNLYPFGK1Bos taurus
L103YVVCNLYPFKE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L103IVVCNLYPFRE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L68GRVKTLHPAVH7Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M312RGADRMSSFGD7Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N102RVVVCNLYPFV3Gallus gallus, Mus musculus, Rattus norvegicus
N102RVVACNLYPFV1Homo sapiens
N102RVVVCNLYPFG1Bos taurus
N102DYVVCNLYPFK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N102DIVVCNLYPFR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N431KYTQSNSVCYA7Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N489RAEISNAIDQY3Homo sapiens, Mus musculus, Bos taurus
N489RAEVSNAIDQY2Gallus gallus, Rattus norvegicus
N489RPEKSNAIDLF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N489RPEKSNAIDLY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N547FPFRDNVDRAK5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
N547FPFPDNVYRAV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N547FPFPDNIYRLA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P543SDAFFPFRDNV5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
P543SDAFFPFPDNV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P543SDAFFPFPDNI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q449IGAGQQSRIHC5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
Q449LGAGQQSRIHC2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R207SQMPLRYGMNP4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
R207SQLPLRYGMNP1Gallus gallus
R207AQITLRYGANP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R207DQLTLRYGANP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R451AGQQSRIHCTR6Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R451AGQQSRIHCNR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R588AHTNLRLFHH2Homo sapiens, Bos taurus
R588AHTDLRLFHH2Mus musculus, Rattus norvegicus
R588IHTNLRLFHH1Gallus gallus
R588VENPIRLFHH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R588SEIPLRLFHH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R64EMLGGRVKTLH6Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R64EILGGRVKTLH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S10QLALFSVSDKT3Homo sapiens, Mus musculus, Rattus norvegicus
S10QLALLSVSEKA1Gallus gallus
S10QLALFSVSDKN1Bos taurus
S10KTAILSVYDKT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S10MYALLSVYDKT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S12ALFSVSDKTGL3Homo sapiens, Mus musculus, Rattus norvegicus
S12ALLSVSEKAGL1Gallus gallus
S12ALFSVSDKNGL1Bos taurus
S12AILSVYDKTGL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S12ALLSVYDKTGL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S34LSLVASGGTAK2Mus musculus, Rattus norvegicus
S34LNLVASGGTAK1Homo sapiens
S34LGLIASGGTAT1Gallus gallus
S34LNLIASGGTAK1Bos taurus
S34VRILASGGTAR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S34VKLLGSGGTAK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S450GAGQQSRIHCT6Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S450GAGQQSRIHCN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S565AAPSGSAADKV2Homo sapiens, Bos taurus
S565VAPSGSTADKV2Mus musculus, Rattus norvegicus
S565VAPSGSAADEV1Gallus gallus
S565AAPSGSVMDKV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S565AAPGGSVMDQA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T37VASGGTAKAIR2Mus musculus, Rattus norvegicus
T37VASGGTAKALR1Homo sapiens
T37IASGGTATALR1Gallus gallus
T37IASGGTAKALR1Bos taurus
T37LASGGTARMIR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T37LGSGGTAKMIR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T67GGRVKTLHPAV7Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V11LALFSVSDKTG3Homo sapiens, Mus musculus, Rattus norvegicus
V11LALLSVSEKAG1Gallus gallus
V11LALFSVSDKNG1Bos taurus
V11TAILSVYDKTG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V11YALLSVYDKTG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y104VVCNLYPFVKT3Gallus gallus, Mus musculus, Rattus norvegicus
Y104VACNLYPFVKT1Homo sapiens
Y104VVCNLYPFGKT1Bos taurus
Y104VVCNLYPFKET1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y104VVCNLYPFRET1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y208QMPLRYGMNPH4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Y208QLPLRYGMNPH1Gallus gallus
Y208QITLRYGANPH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y208QLTLRYGANPH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)


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