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mutLBSgeneDB |
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| Gene summary for NEK2 |
 Gene summary |
| Basic gene Info. | Gene symbol | NEK2 |
| Gene name | NIMA-related kinase 2 | |
| Synonyms | HsPK21|NEK2A|NLK1|PPP1R111|RP67 | |
| Cytomap | UCSC genome browser: 1q32.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001204182.1, NM_001204183.1,NM_002497.3, | |
| Description | NIMA (never in mitosis gene a)-related kinase 2nimA-like protein kinase 1nimA-related protein kinase 2protein phosphatase 1, regulatory subunit 111serine/threonine-protein kinase Nek2 | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 604043 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000117650 | ||
| HPRD : 04953 | ||
| Vega : OTTHUMG00000037121 | ||
| Protein | UniProt: P51955 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_NEK2 | |
| BioGPS: 4751 | ||
| Pathway | NCI Pathway Interaction Database: NEK2 | |
| KEGG: NEK2 | ||
| REACTOME: NEK2 | ||
| Pathway Commons: NEK2 | ||
| Context | iHOP: NEK2 | |
| ligand binding site mutation search in PubMed: NEK2 | ||
| UCL Cancer Institute: NEK2 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006468 | protein phosphorylation | 21076410 | GO:0007059 | chromosome segregation | 14978040 | GO:0046777 | protein autophosphorylation | 17626005 | GO:0051299 | centrosome separation | 18086858 |
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| Ligand binding site mutations for NEK2 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | Y12 | Y12C | BRCA | 1 | G92 | G92V | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for NEK2 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | Y12 | Y12C | -0.61953003 | G92 | G92V | -0.23782219 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for NEK2 from PDB |
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| Differential gene expression and gene-gene network for NEK2 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for NEK2 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for NEK2 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB07180 | 5-[(Z)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of NEK2 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | 5Z5 | 5-[(Z)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE | 2jav | A | G92 | VGK | 4-[2-AMINO-5-(3,4,5-TRIMETHOXYPHENYL)PYRIDIN-3-YL]BENZOIC ACID | 2wqo | A | G92 | XK3 | 4-[3-AMINO-6-(3-ETHYLTHIOPHEN-2-YL)PYRAZIN-2-YL]CYCLOHEXANE-1-CARBOXYLIC ACID | 2xk3 | A | G92 | OL2 | 4-[3-AMINO-6-(3,4,5-TRIMETHOXYPHENYL)PYRAZIN-2-YL]-2-ETHOXYBENZOIC ACID | 2xk4 | A | G92 | EQH | CIS-4-[3-AMINO-6-(3-CYCLOPROPYLTHIOPHEN-2-YL)PYRAZIN-2-YL]CYCLOHEXANECARBOXYLIC ACID | 2xk6 | A | G92 | 30E | (3R,4R)-1-[3-AMINO-6-(3,4,5-TRIMETHOXYPHENYL)PYRAZIN-2-YL]-3-ETHYLPIPERIDINE-4-CARBOXYLICACID | 2xk7 | A | G92 | 5R1 | 4-[3-AMINO-6-(3,4,5-TRIMETHOXYPHENYL)PYRAZIN-2-YL]-2-METHOXYBENZOIC ACID | 2xk8 | A | G92 | 4VQ | 4-[3-AMINO-6-(3,4,5-TRIMETHOXYPHENYL)PYRAZIN-2-YL]-2-METHYLBENZOIC ACID | 2xkc | A | G92 | T3M | 4-[3-AMINO-6-(3,4,5-TRIMETHOXYPHENYL)PYRAZIN-2-YL]BENZOIC ACID | 2xkd | A | G92 | WI2 | 1-[3-AMINO-6-(3-METHOXYPHENYL)PYRAZIN-2-YL]PIPERIDINE-4-CARBOXYLIC ACID | 2xke | A | G92 | BX1 | 1-[3-AMINO-6-(3,4,5-TRIMETHOXYPHENYL)PYRAZIN-2-YL]PIPERIDINE-4-CARBOXYLIC ACID | 2xkf | A | G92 | WGZ | 5-{6-[(1-METHYLPIPERIDIN-4-YL)OXY]-1H-BENZIMIDAZOL-1-YL}-3-{(1R)-1-[2-(TRIFLUOROMETHYL)PHENYL]ETHOXY}THIOPHENE-2-CARBOXAMIDE | 2xnm | A | G92 | 430 | 5-(1H-BENZIMIDAZOL-1-YL)-3-{(1R)-1-[2-(TRIFLUOROMETHYL)PHENYL]ETHOXY}THIOPHENE-2-CARBOXAMIDE | 2xnn | A | G92 | WCX | 4-{5-[(1-METHYLPIPERIDIN-4-YL)OXY]-1H-BENZIMIDAZOL-1-YL}-2-{(1R)-1-[2-(TRIFLUOROMETHYL)PHENYL]ETHOXY}BENZAMIDE | 2xnp | A | G92 | GGY | 4-(2-AMINO-5-{4-[(DIMETHYLAMINO)METHYL]THIOPHEN-2-YL}PYRIDIN-3-YL)-2-{[(1R,2Z)-4,4,4-TRIFLUORO-1-METHYLBUT-2-EN-1-YL]OXY}BENZAMIDE | 4afe | A | Y12 G92 |
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| Conservation information for LBS of NEK2 |
| Multiple alignments for P51955 in multiple species |
| LBS | AA sequence | # species | Species | A145 | RDLKPANVFLD | 2 | Homo sapiens, Mus musculus | A145 | RDIKPANIFLD | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | C22 | GSYGRCQKIRR | 2 | Homo sapiens, Mus musculus | C22 | GSFGRIYKVQR | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | C89 | IVMEYCEGGDL | 2 | Homo sapiens, Mus musculus | C89 | LYMEYCGHGDL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D159 | NVKLGDFGLAR | 2 | Homo sapiens, Mus musculus | D159 | SVKLGDFGLSK | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D93 | YCEGGDLASVI | 2 | Homo sapiens, Mus musculus | D93 | YCGHGDLANLI | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | E87 | LYIVMEYCEGG | 2 | Homo sapiens, Mus musculus | E87 | INLYMEYCGHG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | E90 | VMEYCEGGDLA | 2 | Homo sapiens, Mus musculus | E90 | YMEYCGHGDLA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F148 | KPANVFLDGKQ | 1 | Homo sapiens | F148 | KPANIFLDENN | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F148 | KPANVFLDSKH | 1 | Mus musculus | G15 | VLYTIGTGSYG | 1 | Homo sapiens | G15 | ILECIGHGSFG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G15 | VLHSIGTGSYG | 1 | Mus musculus | G158 | QNVKLGDFGLA | 1 | Homo sapiens | G158 | NSVKLGDFGLS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G158 | HNVKLGDFGLA | 1 | Mus musculus | G17 | YTIGTGSYGRC | 1 | Homo sapiens | G17 | ECIGHGSFGRI | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G17 | HSIGTGSYGRC | 1 | Mus musculus | G92 | EYCEGGDLASV | 2 | Homo sapiens, Mus musculus | G92 | EYCGHGDLANL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I14 | EVLYTIGTGSY | 1 | Homo sapiens | I14 | KILECIGHGSF | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I14 | EVLHSIGTGSY | 1 | Mus musculus | K37 | KILVWKELDYG | 2 | Homo sapiens, Mus musculus | K37 | ALLAQKEIHFG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L162 | LGDFGLARILN | 2 | Homo sapiens, Mus musculus | L162 | LGDFGLSKLLD | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | M86 | TLYIVMEYCEG | 2 | Homo sapiens, Mus musculus | M86 | VINLYMEYCGH | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | N146 | DLKPANVFLDG | 1 | Homo sapiens | N146 | DIKPANIFLDE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | N146 | DLKPANVFLDS | 1 | Mus musculus | S18 | TIGTGSYGRCQ | 1 | Homo sapiens | S18 | CIGHGSFGRIY | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S18 | SIGTGSYGRCQ | 1 | Mus musculus | S96 | GGDLASVITKG | 1 | Homo sapiens | S96 | HGDLANLIQRY | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S96 | GGDLASVISKG | 1 | Mus musculus | V35 | DGKILVWKELD | 2 | Homo sapiens, Mus musculus | V35 | DGALLAQKEIH | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | V68 | KHPNIVRYYDR | 1 | Homo sapiens | V68 | KHPNIVQYCGE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | V68 | KHPNIVSYYDR | 1 | Mus musculus | Y12 | DYEVLYTIGTG | 1 | Homo sapiens | Y12 | KYKILECIGHG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y12 | DYEVLHSIGTG | 1 | Mus musculus | Y19 | IGTGSYGRCQK | 2 | Homo sapiens, Mus musculus | Y19 | IGHGSFGRIYK | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y70 | PNIVRYYDRII | 1 | Homo sapiens | Y70 | PNIVQYCGEEL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y70 | PNIVSYYDRII | 1 | Mus musculus | Y88 | YIVMEYCEGGD | 2 | Homo sapiens, Mus musculus | Y88 | NLYMEYCGHGD | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) |
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