mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for NFYB
Gene summary
Basic gene Info.Gene symbolNFYB
Gene namenuclear transcription factor Y, beta
SynonymsCBF-A|CBF-B|HAP3|NF-YB
CytomapUCSC genome browser: 12q22-q23
Type of geneprotein-coding
RefGenesNM_006166.3,
DescriptionCAAT box DNA-binding protein subunit BCCAAT-binding transcription factor subunit ATranscription factor NF-Y, B subunitnuclear transcription factor Y subunit Bnuclear transcription factor Y subunit beta
Modification date20141207
dbXrefs MIM : 189904
HGNC : HGNC
Ensembl : ENSG00000120837
HPRD : 01794
Vega : OTTHUMG00000170176
ProteinUniProt: P25208
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_NFYB
BioGPS: 4801
PathwayNCI Pathway Interaction Database: NFYB
KEGG: NFYB
REACTOME: NFYB
Pathway Commons: NFYB
ContextiHOP: NFYB
ligand binding site mutation search in PubMed: NFYB
UCL Cancer Institute: NFYB
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006355regulation of transcription, DNA-templated15243141


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Ligand binding site mutations for NFYB
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
K69M68ISKCM1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for NFYB
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
K69M68I-0.87055866
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for NFYB from PDB

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Differential gene expression and gene-gene network for NFYB
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of NFYB and the right PPI network was created from samples without mutations in the LBS of NFYB. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for NFYB
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for NFYB
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of NFYB go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of NFYB
Multiple alignments for P25208 in multiple species
LBSAA sequence# speciesSpecies
A62IYLPIANVARI5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
A62RWLPINNVARL2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
A62RFLPIANISRI2Arabidopsis thaliana, Arabidopsis thaliana
A62RFLPIANIGRI1Oryza sativa subsp. japonica
A79QTGKIAKDAKE5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
A79PSAKVSKDAKE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A79ATTKVSKDAKE1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
A79ENGKIAKDSKE1Oryza sativa subsp. japonica
A79ANGKIAKDAKE1Arabidopsis thaliana
A79LNGKIAKDAKE1Arabidopsis thaliana
I61DIYLPIANVAR5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
I61DRWLPINNVAR2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
I61DRFLPIANISR2Arabidopsis thaliana, Arabidopsis thaliana
I61DRFLPIANIGR1Oryza sativa subsp. japonica
I78PQTGKIAKDAK5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
I78PPSAKVSKDAK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I78PATTKVSKDAK1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
I78PENGKIAKDSK1Oryza sativa subsp. japonica
I78PANGKIAKDAK1Arabidopsis thaliana
I78PLNGKIAKDAK1Arabidopsis thaliana
K69VARIMKNAIPQ5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
K69VARLMKNTLPP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K69VARLMKNTLPA1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
K69IGRIMRRAVPE1Oryza sativa subsp. japonica
K69ISRIMKRGLPA1Arabidopsis thaliana
K69ISRIMKRGLPL1Arabidopsis thaliana
K77IPQTGKIAKDA5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
K77LPPSAKVSKDA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K77LPATTKVSKDA1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
K77VPENGKIAKDS1Oryza sativa subsp. japonica
K77LPANGKIAKDA1Arabidopsis thaliana
K77LPLNGKIAKDA1Arabidopsis thaliana
K80TGKIAKDAKEC5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
K80SAKVSKDAKEC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K80TTKVSKDAKEC1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
K80NGKIAKDSKES1Oryza sativa subsp. japonica
K80NGKIAKDAKEI1Arabidopsis thaliana
K80NGKIAKDAKET1Arabidopsis thaliana
K83IAKDAKECVQE5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
K83VSKDAKECMQE2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
K83IAKDSKESVQE1Oryza sativa subsp. japonica
K83IAKDAKEIVQE1Arabidopsis thaliana
K83IAKDAKETMQE1Arabidopsis thaliana
N63YLPIANVARIM5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
N63WLPINNVARLM2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
N63FLPIANISRIM2Arabidopsis thaliana, Arabidopsis thaliana
N63FLPIANIGRIM1Oryza sativa subsp. japonica
P60QDIYLPIANVA5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
P60QDRWLPINNVA2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
P60QDRFLPIANIS2Arabidopsis thaliana, Arabidopsis thaliana
P60QDRFLPIANIG1Oryza sativa subsp. japonica
Q55ESFREQDIYLP5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
Q55STLREQDRWLP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q55NELAEQDRWLP1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Q55---KEQDRFLP1Oryza sativa subsp. japonica
Q55LHVREQDRFLP1Arabidopsis thaliana
Q55LNVREQDRFLP1Arabidopsis thaliana
R66IANVARIMKNA5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
R66INNVARLMKNT2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
R66IANISRIMKRG2Arabidopsis thaliana, Arabidopsis thaliana
R66IANIGRIMRRA1Oryza sativa subsp. japonica
T112QEKRKTINGED5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
T112REKRKTINGDD2Arabidopsis thaliana, Arabidopsis thaliana
T112ADKRKTINGED1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T112SGKRKTINGED1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
T112KEKRKTINGDD1Oryza sativa subsp. japonica


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