mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for NQO2
Gene summary
Basic gene Info.Gene symbolNQO2
Gene nameNAD(P)H dehydrogenase, quinone 2
CytomapUCSC genome browser: 6p25.2
Type of geneprotein-coding
DescriptionNAD(P)H menadione oxidoreductase-1, dioxin-inducible-2NRH:quinone oxidoreductase 2quinone reductase 2ribosyldihydronicotinamide dehydrogenaseribosyldihydronicotinamide dehydrogenase [quinone]
Modification date20141207
dbXrefs MIM : 160998
Ensembl : ENSG00000124588
HPRD : 01190
Vega : OTTHUMG00000014130
ProteinUniProt: P16083
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_NQO2
BioGPS: 4835
PathwayNCI Pathway Interaction Database: NQO2
Pathway Commons: NQO2
ContextiHOP: NQO2
ligand binding site mutation search in PubMed: NQO2
UCL Cancer Institute: NQO2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for NQO2
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for NQO2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for NQO2 from PDB
PDB IDPDB titlePDB structure

Differential gene expression and gene-gene network for NQO2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of NQO2 and the right PPI network was created from samples without mutations in the LBS of NQO2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for NQO2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0001824Agranulocytosis1Biomarker, GeneticVariation
umls:C0005956Bone Marrow Diseases1Biomarker
umls:C0025261Memory Disorders1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for NQO2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
NutraceuticalDB00157NADHSmall molecule
Approved|nutraceuticalDB00170MenadioneSmall molecule
Approved|nutraceutical|vet_approvedDB01065MelatoninSmall molecule
ApprovedDB01087PrimaquineSmall molecule
Experimental|investigationalDB02709ResveratrolSmall molecule
ApprovedDB03147Flavin adenine dinucleotideSmall molecule
ExperimentalDB0354110-Propargyl-5,8-Dideazafolic AcidSmall molecule
ExperimentalDB04253CB1954Small molecule
ExperimentalDB07339(3S)-3-hydroxy-1-methyl-2,3-dihydro-1H-indole-5,6-dioneSmall molecule
ExperimentalDB08190N-[2-(2-iodo-5-methoxy-1H-indol-3-yl)ethyl]acetamideSmall molecule
ExperimentalDB082285,8-dimethoxy-1,4-dimethylquinolin-2(1H)-oneSmall molecule
ExperimentalDB087446-methoxy-9-methyl[1,3]dioxolo[4,5-h]quinolin-8(9H)-oneSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of NQO2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of NQO2
Multiple alignments for P16083 in multiple species
LBSAA sequence# speciesSpecies
C122MDRVLCQGFAF2Homo sapiens, Rattus norvegicus
C122MDRVLCRGFAF1Mus musculus
C223EEPIPCTAHWH1Homo sapiens
C223EEPIHCTPPWY1Mus musculus
C223EEPIHCTPSWY1Rattus norvegicus
D118LKGWMDRVLCQ2Homo sapiens, Rattus norvegicus
D118LKGWMDRVLCR1Mus musculus
D128QGFAFDIPGFY1Homo sapiens
D128RGFAFDIPGFY1Mus musculus
D128QGFAFDVPGFY1Rattus norvegicus
D28KNVAVDELSRQ1Homo sapiens
D28KKVAVEELSKQ1Mus musculus
D28KQVAVEELSKQ1Rattus norvegicus
E194ISFAPEIASEE1Homo sapiens
E194ISFGLDVSSEE1Mus musculus
E194ISFGPEVSSEE1Rattus norvegicus
E198PEIASEEERKG1Homo sapiens
E198LDVSSEEERKV1Mus musculus
E198PEVSSEEQRKV1Rattus norvegicus
F107FPLYWFSVPAI3Homo sapiens, Mus musculus, Rattus norvegicus
F127CQGFAFDIPGF1Homo sapiens
F127CRGFAFDIPGF1Mus musculus
F127CQGFAFDVPGF1Rattus norvegicus
F132FDIPGFYDSGL1Homo sapiens
F132FDIPGFYDSGF1Mus musculus
F132FDVPGFYDSGF1Rattus norvegicus
F179HGTLHFCGFKV3Homo sapiens, Mus musculus, Rattus norvegicus
F18QEPKSFNGSLK2Homo sapiens, Mus musculus
F18QEPKSFNGSMK1Rattus norvegicus
G150LSVTTGGTAEM1Homo sapiens
G150LSLTTGGTAEM1Mus musculus
G150LSFTTGGTAEM1Rattus norvegicus
G151SVTTGGTAEMY1Homo sapiens
G151SLTTGGTAEMY1Mus musculus
G151SFTTGGTAEMY1Rattus norvegicus
G175WPLQHGTLHFC3Homo sapiens, Mus musculus, Rattus norvegicus
G69EVFNYGVETHE1Homo sapiens
G69DVFSYGIETHE1Mus musculus
G69EVFKYGIEAYE1Rattus norvegicus
H12LIVYAHQEPKS2Homo sapiens, Mus musculus
H12LLVYAHQEPKS1Rattus norvegicus
H174LWPLQHGTLHF3Homo sapiens, Mus musculus, Rattus norvegicus
H178QHGTLHFCGFK3Homo sapiens, Mus musculus, Rattus norvegicus
H228CTAHWHFGQ1Homo sapiens
H228CTPPWYFQE1Mus musculus
H228CTPSWYFQG1Rattus norvegicus
I129GFAFDIPGFYD2Homo sapiens, Mus musculus
I129GFAFDVPGFYD1Rattus norvegicus
I195SFAPEIASEEE1Homo sapiens
I195SFGLDVSSEEE1Mus musculus
I195SFGPEVSSEEQ1Rattus norvegicus
K16AHQEPKSFNGS3Homo sapiens, Mus musculus, Rattus norvegicus
K202SEEERKGMVAA1Homo sapiens
K202SEEERKVMLAS1Mus musculus
K202SEEQRKVMLAS1Rattus norvegicus
K23FNGSLKNVAVD1Homo sapiens
K23FNGSLKKVAVE1Mus musculus
K23FNGSMKQVAVE1Rattus norvegicus
L104IFQFPLYWFSV3Homo sapiens, Mus musculus, Rattus norvegicus
L121WMDRVLCQGFA2Homo sapiens, Rattus norvegicus
L121WMDRVLCRGFA1Mus musculus
M155GGTAEMYTKTG1Homo sapiens
M155GGTAEMYTKDG1Mus musculus
M155GGTAEMYTKAG1Rattus norvegicus
N162TKTGVNGDSRY1Homo sapiens
N162TKDGVSGDFRY1Mus musculus
N162TKAGVNGDFRY1Rattus norvegicus
N19EPKSFNGSLKN1Homo sapiens
N19EPKSFNGSLKK1Mus musculus
N19EPKSFNGSMKQ1Rattus norvegicus
N24NGSLKNVAVDE1Homo sapiens
N24NGSLKKVAVEE1Mus musculus
N24NGSMKQVAVEE1Rattus norvegicus
N67NPEVFNYGVET1Homo sapiens
N67NPDVFSYGIET1Mus musculus
N67NPEVFKYGIEA1Rattus norvegicus
P103VIFQFPLYWFS3Homo sapiens, Mus musculus, Rattus norvegicus
P193QISFAPEIASE1Homo sapiens
P193QISFGLDVSSE1Mus musculus
P193QISFGPEVSSE1Rattus norvegicus
Q123DRVLCQGFAFD2Homo sapiens, Rattus norvegicus
Q123DRVLCRGFAFD1Mus musculus
R201ASEEERKGMVA1Homo sapiens
R201SSEEERKVMLA1Mus musculus
R201SSEEQRKVMLA1Rattus norvegicus
S17HQEPKSFNGSL2Homo sapiens, Mus musculus
S17HQEPKSFNGSM1Rattus norvegicus
S21KSFNGSLKNVA1Homo sapiens
S21KSFNGSLKKVA1Mus musculus
S21KSFNGSMKQVA1Rattus norvegicus
T148ALLSVTTGGTA1Homo sapiens
T148ALLSLTTGGTA1Mus musculus
T148ALLSFTTGGTA1Rattus norvegicus
T149LLSVTTGGTAE1Homo sapiens
T149LLSLTTGGTAE1Mus musculus
T149LLSFTTGGTAE1Rattus norvegicus
T224EPIPCTAHWHF1Homo sapiens
T224EPIHCTPPWYF1Mus musculus
T224EPIHCTPSWYF1Rattus norvegicus
T72NYGVETHEAYK1Homo sapiens
T72SYGIETHEAYK1Mus musculus
T72KYGIEAYEAYK1Rattus norvegicus
V161YTKTGVNGDSR1Homo sapiens
V161YTKDGVSGDFR1Mus musculus
V161YTKAGVNGDFR1Rattus norvegicus
V205ERKGMVAAWSQ1Homo sapiens
V205ERKVMLASWAQ1Mus musculus
V205QRKVMLASWVQ1Rattus norvegicus
V27LKNVAVDELSR1Homo sapiens
V27LKKVAVEELSK1Mus musculus
V27MKQVAVEELSK1Rattus norvegicus
V65LSNPEVFNYGV1Homo sapiens
V65PSNPDVFSYGI1Mus musculus
V65LSNPEVFKYGI1Rattus norvegicus
V70VFNYGVETHEA1Homo sapiens
V70VFSYGIETHEA1Mus musculus
V70VFKYGIEAYEA1Rattus norvegicus
W106QFPLYWFSVPA3Homo sapiens, Mus musculus, Rattus norvegicus
W170FRYFLWPLQHG2Mus musculus, Rattus norvegicus
W170SRYFLWPLQHG1Homo sapiens
Y105FQFPLYWFSVP3Homo sapiens, Mus musculus, Rattus norvegicus
Y133DIPGFYDSGLL1Homo sapiens
Y133DIPGFYDSGFL1Mus musculus
Y133DVPGFYDSGFL1Rattus norvegicus
Y156GTAEMYTKTGV1Homo sapiens
Y156GTAEMYTKDGV1Mus musculus
Y156GTAEMYTKAGV1Rattus norvegicus
Y68PEVFNYGVETH1Homo sapiens
Y68PDVFSYGIETH1Mus musculus
Y68PEVFKYGIEAY1Rattus norvegicus

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