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mutLBSgeneDB |
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| Gene summary for NQO2 |
 Gene summary |
| Basic gene Info. | Gene symbol | NQO2 |
| Gene name | NAD(P)H dehydrogenase, quinone 2 | |
| Synonyms | DHQV|DIA6|NMOR2|QR2 | |
| Cytomap | UCSC genome browser: 6p25.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000904.4, NM_001290221.1,NM_001290222.1, | |
| Description | NAD(P)H menadione oxidoreductase-1, dioxin-inducible-2NRH:quinone oxidoreductase 2quinone reductase 2ribosyldihydronicotinamide dehydrogenaseribosyldihydronicotinamide dehydrogenase [quinone] | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 160998 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000124588 | ||
| HPRD : 01190 | ||
| Vega : OTTHUMG00000014130 | ||
| Protein | UniProt: P16083 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_NQO2 | |
| BioGPS: 4835 | ||
| Pathway | NCI Pathway Interaction Database: NQO2 | |
| KEGG: NQO2 | ||
| REACTOME: NQO2 | ||
| Pathway Commons: NQO2 | ||
| Context | iHOP: NQO2 | |
| ligand binding site mutation search in PubMed: NQO2 | ||
| UCL Cancer Institute: NQO2 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for NQO2 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | F107 | S108G | COAD | 2 | V161 | G160E | BRCA | 1 | T72 | E74G | COAD | 1 | F107 | S108C | OV | 1 | M155,G151 | A153G | STAD | 1 | S21,N19 | G20R | UCEC | 1 | P103 | Q101H | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for NQO2 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | N19 | G20R | 0.28036017 | S21 | G20R | 0.28036017 | P103 | Q101H | -0.92566731 | F107 | S108G | -0.82443482 | T72 | E74G | -0.78038547 | V161 | G160E | -0.63508668 | F107 | S108C | -0.41295332 | G151 | A153G | -0.23398345 | M155 | A153G | -0.23398345 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for NQO2 from PDB |
| PDB ID | PDB title | PDB structure | 1QR2 | HUMAN QUINONE REDUCTASE TYPE 2 |  |
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| Differential gene expression and gene-gene network for NQO2 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for NQO2 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0001824 | Agranulocytosis | 1 | Biomarker, GeneticVariation |
| umls:C0005956 | Bone Marrow Diseases | 1 | Biomarker |
| umls:C0025261 | Memory Disorders | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for NQO2 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Nutraceutical | DB00157 | NADH | Small molecule |  |
| Approved|nutraceutical | DB00170 | Menadione | Small molecule |  |
| Approved|nutraceutical|vet_approved | DB01065 | Melatonin | Small molecule |  |
| Approved | DB01087 | Primaquine | Small molecule |  |
| Experimental|investigational | DB02709 | Resveratrol | Small molecule |  |
| Approved | DB03147 | Flavin adenine dinucleotide | Small molecule |  |
| Experimental | DB03541 | 10-Propargyl-5,8-Dideazafolic Acid | Small molecule |  |
| Experimental | DB04253 | CB1954 | Small molecule |  |
| Experimental | DB07339 | (3S)-3-hydroxy-1-methyl-2,3-dihydro-1H-indole-5,6-dione | Small molecule |  |
| Experimental | DB08190 | N-[2-(2-iodo-5-methoxy-1H-indol-3-yl)ethyl]acetamide | Small molecule |  |
| Experimental | DB08228 | 5,8-dimethoxy-1,4-dimethylquinolin-2(1H)-one | Small molecule |  |
| Experimental | DB08744 | 6-methoxy-9-methyl[1,3]dioxolo[4,5-h]quinolin-8(9H)-one | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of NQO2 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of NQO2 |
| Multiple alignments for P16083 in multiple species |
| LBS | AA sequence | # species | Species | C122 | MDRVLCQGFAF | 2 | Homo sapiens, Rattus norvegicus | C122 | MDRVLCRGFAF | 1 | Mus musculus | C223 | EEPIPCTAHWH | 1 | Homo sapiens | C223 | EEPIHCTPPWY | 1 | Mus musculus | C223 | EEPIHCTPSWY | 1 | Rattus norvegicus | D118 | LKGWMDRVLCQ | 2 | Homo sapiens, Rattus norvegicus | D118 | LKGWMDRVLCR | 1 | Mus musculus | D128 | QGFAFDIPGFY | 1 | Homo sapiens | D128 | RGFAFDIPGFY | 1 | Mus musculus | D128 | QGFAFDVPGFY | 1 | Rattus norvegicus | D28 | KNVAVDELSRQ | 1 | Homo sapiens | D28 | KKVAVEELSKQ | 1 | Mus musculus | D28 | KQVAVEELSKQ | 1 | Rattus norvegicus | E194 | ISFAPEIASEE | 1 | Homo sapiens | E194 | ISFGLDVSSEE | 1 | Mus musculus | E194 | ISFGPEVSSEE | 1 | Rattus norvegicus | E198 | PEIASEEERKG | 1 | Homo sapiens | E198 | LDVSSEEERKV | 1 | Mus musculus | E198 | PEVSSEEQRKV | 1 | Rattus norvegicus | F107 | FPLYWFSVPAI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F127 | CQGFAFDIPGF | 1 | Homo sapiens | F127 | CRGFAFDIPGF | 1 | Mus musculus | F127 | CQGFAFDVPGF | 1 | Rattus norvegicus | F132 | FDIPGFYDSGL | 1 | Homo sapiens | F132 | FDIPGFYDSGF | 1 | Mus musculus | F132 | FDVPGFYDSGF | 1 | Rattus norvegicus | F179 | HGTLHFCGFKV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F18 | QEPKSFNGSLK | 2 | Homo sapiens, Mus musculus | F18 | QEPKSFNGSMK | 1 | Rattus norvegicus | G150 | LSVTTGGTAEM | 1 | Homo sapiens | G150 | LSLTTGGTAEM | 1 | Mus musculus | G150 | LSFTTGGTAEM | 1 | Rattus norvegicus | G151 | SVTTGGTAEMY | 1 | Homo sapiens | G151 | SLTTGGTAEMY | 1 | Mus musculus | G151 | SFTTGGTAEMY | 1 | Rattus norvegicus | G175 | WPLQHGTLHFC | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G69 | EVFNYGVETHE | 1 | Homo sapiens | G69 | DVFSYGIETHE | 1 | Mus musculus | G69 | EVFKYGIEAYE | 1 | Rattus norvegicus | H12 | LIVYAHQEPKS | 2 | Homo sapiens, Mus musculus | H12 | LLVYAHQEPKS | 1 | Rattus norvegicus | H174 | LWPLQHGTLHF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H178 | QHGTLHFCGFK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H228 | CTAHWHFGQ | 1 | Homo sapiens | H228 | CTPPWYFQE | 1 | Mus musculus | H228 | CTPSWYFQG | 1 | Rattus norvegicus | I129 | GFAFDIPGFYD | 2 | Homo sapiens, Mus musculus | I129 | GFAFDVPGFYD | 1 | Rattus norvegicus | I195 | SFAPEIASEEE | 1 | Homo sapiens | I195 | SFGLDVSSEEE | 1 | Mus musculus | I195 | SFGPEVSSEEQ | 1 | Rattus norvegicus | K16 | AHQEPKSFNGS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K202 | SEEERKGMVAA | 1 | Homo sapiens | K202 | SEEERKVMLAS | 1 | Mus musculus | K202 | SEEQRKVMLAS | 1 | Rattus norvegicus | K23 | FNGSLKNVAVD | 1 | Homo sapiens | K23 | FNGSLKKVAVE | 1 | Mus musculus | K23 | FNGSMKQVAVE | 1 | Rattus norvegicus | L104 | IFQFPLYWFSV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L121 | WMDRVLCQGFA | 2 | Homo sapiens, Rattus norvegicus | L121 | WMDRVLCRGFA | 1 | Mus musculus | M155 | GGTAEMYTKTG | 1 | Homo sapiens | M155 | GGTAEMYTKDG | 1 | Mus musculus | M155 | GGTAEMYTKAG | 1 | Rattus norvegicus | N162 | TKTGVNGDSRY | 1 | Homo sapiens | N162 | TKDGVSGDFRY | 1 | Mus musculus | N162 | TKAGVNGDFRY | 1 | Rattus norvegicus | N19 | EPKSFNGSLKN | 1 | Homo sapiens | N19 | EPKSFNGSLKK | 1 | Mus musculus | N19 | EPKSFNGSMKQ | 1 | Rattus norvegicus | N24 | NGSLKNVAVDE | 1 | Homo sapiens | N24 | NGSLKKVAVEE | 1 | Mus musculus | N24 | NGSMKQVAVEE | 1 | Rattus norvegicus | N67 | NPEVFNYGVET | 1 | Homo sapiens | N67 | NPDVFSYGIET | 1 | Mus musculus | N67 | NPEVFKYGIEA | 1 | Rattus norvegicus | P103 | VIFQFPLYWFS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P193 | QISFAPEIASE | 1 | Homo sapiens | P193 | QISFGLDVSSE | 1 | Mus musculus | P193 | QISFGPEVSSE | 1 | Rattus norvegicus | Q123 | DRVLCQGFAFD | 2 | Homo sapiens, Rattus norvegicus | Q123 | DRVLCRGFAFD | 1 | Mus musculus | R201 | ASEEERKGMVA | 1 | Homo sapiens | R201 | SSEEERKVMLA | 1 | Mus musculus | R201 | SSEEQRKVMLA | 1 | Rattus norvegicus | S17 | HQEPKSFNGSL | 2 | Homo sapiens, Mus musculus | S17 | HQEPKSFNGSM | 1 | Rattus norvegicus | S21 | KSFNGSLKNVA | 1 | Homo sapiens | S21 | KSFNGSLKKVA | 1 | Mus musculus | S21 | KSFNGSMKQVA | 1 | Rattus norvegicus | T148 | ALLSVTTGGTA | 1 | Homo sapiens | T148 | ALLSLTTGGTA | 1 | Mus musculus | T148 | ALLSFTTGGTA | 1 | Rattus norvegicus | T149 | LLSVTTGGTAE | 1 | Homo sapiens | T149 | LLSLTTGGTAE | 1 | Mus musculus | T149 | LLSFTTGGTAE | 1 | Rattus norvegicus | T224 | EPIPCTAHWHF | 1 | Homo sapiens | T224 | EPIHCTPPWYF | 1 | Mus musculus | T224 | EPIHCTPSWYF | 1 | Rattus norvegicus | T72 | NYGVETHEAYK | 1 | Homo sapiens | T72 | SYGIETHEAYK | 1 | Mus musculus | T72 | KYGIEAYEAYK | 1 | Rattus norvegicus | V161 | YTKTGVNGDSR | 1 | Homo sapiens | V161 | YTKDGVSGDFR | 1 | Mus musculus | V161 | YTKAGVNGDFR | 1 | Rattus norvegicus | V205 | ERKGMVAAWSQ | 1 | Homo sapiens | V205 | ERKVMLASWAQ | 1 | Mus musculus | V205 | QRKVMLASWVQ | 1 | Rattus norvegicus | V27 | LKNVAVDELSR | 1 | Homo sapiens | V27 | LKKVAVEELSK | 1 | Mus musculus | V27 | MKQVAVEELSK | 1 | Rattus norvegicus | V65 | LSNPEVFNYGV | 1 | Homo sapiens | V65 | PSNPDVFSYGI | 1 | Mus musculus | V65 | LSNPEVFKYGI | 1 | Rattus norvegicus | V70 | VFNYGVETHEA | 1 | Homo sapiens | V70 | VFSYGIETHEA | 1 | Mus musculus | V70 | VFKYGIEAYEA | 1 | Rattus norvegicus | W106 | QFPLYWFSVPA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | W170 | FRYFLWPLQHG | 2 | Mus musculus, Rattus norvegicus | W170 | SRYFLWPLQHG | 1 | Homo sapiens | Y105 | FQFPLYWFSVP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y133 | DIPGFYDSGLL | 1 | Homo sapiens | Y133 | DIPGFYDSGFL | 1 | Mus musculus | Y133 | DVPGFYDSGFL | 1 | Rattus norvegicus | Y156 | GTAEMYTKTGV | 1 | Homo sapiens | Y156 | GTAEMYTKDGV | 1 | Mus musculus | Y156 | GTAEMYTKAGV | 1 | Rattus norvegicus | Y68 | PEVFNYGVETH | 1 | Homo sapiens | Y68 | PDVFSYGIETH | 1 | Mus musculus | Y68 | PEVFKYGIEAY | 1 | Rattus norvegicus |
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