mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for NOS2
Gene summary
Basic gene Info.Gene symbolNOS2
Gene namenitric oxide synthase 2, inducible
SynonymsHEP-NOS|INOS|NOS|NOS2A
CytomapUCSC genome browser: 17q11.2
Type of geneprotein-coding
RefGenesNM_000625.4,
NM_153292.1,
DescriptionNOS type IINOS, type IIhepatocyte NOSinducible NO synthaseinducible NOSnitric oxide synthase 2A (inducible, hepatocytes)nitric oxide synthase, induciblenitric oxide synthase, macrophagepeptidyl-cysteine S-nitrosylase NOS2
Modification date20141222
dbXrefs MIM : 163730
HGNC : HGNC
Ensembl : ENSG00000007171
HPRD : 01225
Vega : OTTHUMG00000132445
ProteinUniProt: P35228
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_NOS2
BioGPS: 4843
PathwayNCI Pathway Interaction Database: NOS2
KEGG: NOS2
REACTOME: NOS2
Pathway Commons: NOS2
ContextiHOP: NOS2
ligand binding site mutation search in PubMed: NOS2
UCL Cancer Institute: NOS2
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006527arginine catabolic process7504305
GO:0006809nitric oxide biosynthetic process7504305


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Ligand binding site mutations for NOS2
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
Y489F488VBRCA1
H477H477YBRCA1
W194R195HCOAD1
Y491Q492KHNSC1
C115C115GLUAD1
S550E551DLUAD1
W90G91CSKCM1
S242A243TSTAD1
M434T432ISTAD1
F593F593VSTAD1
Y347A348VUCEC1
E479E479DUCEC1
Q665E666KUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for NOS2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
C115C115G-1.3418068
Y489F488V-1.1144246
W194R195H-0.98937287
E479E479D-0.9696571
Q665E666K-0.91274455
S242A243T-0.80560515
M434T432I-0.8035653
W90G91C-0.78851227
F593F593V-0.68884697
Y347A348V-0.47638242
Y491Q492K-0.43931617
H477H477Y-0.17081147
S550E551D-0.13626518
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for NOS2 from PDB

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Differential gene expression and gene-gene network for NOS2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of NOS2 and the right PPI network was created from samples without mutations in the LBS of NOS2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for NOS2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0004096Asthma32AlteredExpression, Biomarker, GeneticVariation
umls:C0024530Malaria17AlteredExpression, Biomarker, GeneticVariation
umls:C0020538Hypertension10Biomarker, GeneticVariation
umls:C0011860Diabetes Mellitus, Type 29Biomarker, GeneticVariation
umls:C0004352Autistic Disorder9Biomarker, GeneticVariation
umls:C0038454Stroke8Biomarker, GeneticVariation
umls:C0243026Sepsis7Biomarker, GeneticVariation
umls:C0021368Inflammation7Biomarker, GeneticVariation
umls:C0018801Heart Failure7Biomarker, GeneticVariation
umls:C0027055Myocardial Reperfusion Injury6Biomarker, Therapeutic
umls:C0023895Liver Diseases6Biomarker, GeneticVariation
umls:C0024117Pulmonary Disease, Chronic Obstructive5AlteredExpression, Biomarker, GeneticVariation
umls:C1458155Breast Neoplasms5AlteredExpression, Biomarker
umls:C0004153Atherosclerosis5Biomarker
umls:C0035126Reperfusion Injury4Biomarker
umls:C0007786Brain Ischemia4Biomarker, GeneticVariation
umls:C0085580Hypertension, Essential4Biomarker, GeneticVariation
umls:C0033860Psoriasis4Biomarker, GeneticVariation
umls:C0038358Stomach Ulcer4Biomarker
umls:C0027051Myocardial Infarction4Biomarker
umls:C0009319Colitis3Biomarker
umls:C0011853Diabetes Mellitus, Experimental3Biomarker
umls:C0376618Endotoxemia3Biomarker
umls:C0023893Liver Cirrhosis, Experimental3Biomarker, Therapeutic
umls:C0022658Kidney Diseases3Biomarker, GeneticVariation
umls:C0520459Enterocolitis, Necrotizing3Biomarker
umls:C0008370Cholestasis3Biomarker
umls:C0003949Asbestosis2Biomarker
umls:C0036983Shock, Septic2Biomarker
umls:C0037116Silicosis2Biomarker, GeneticVariation
umls:C0014859Esophageal Neoplasms2Biomarker, GeneticVariation
umls:C0206698Cholangiocarcinoma2Biomarker
umls:C0036572Seizures2Biomarker
umls:C0038525Subarachnoid Hemorrhage2Biomarker
umls:C0009375Colonic Neoplasms2Biomarker
umls:C0013295Duodenal Ulcer2Biomarker
umls:C0020429Hyperalgesia2Biomarker
umls:C0024121Lung Neoplasms2Biomarker
umls:C0677050Manganese Poisoning2Biomarker
umls:C0027540Necrosis2Biomarker
umls:C0003872Arthritis, Psoriatic1Biomarker, GeneticVariation
umls:C2609414Acute Kidney Injury1Biomarker
umls:C1527311Brain Edema1Biomarker
umls:C0006261Bronchial Diseases1Biomarker
umls:C0006434Burns1Biomarker
umls:C0243050Cardiovascular Abnormalities1Biomarker
umls:C0007621Cell Transformation, Neoplastic1Biomarker
umls:C0008313Cholangitis, Sclerosing1Biomarker
umls:C0013990Emphysema1Biomarker
umls:C0017668Glomerulosclerosis, Focal Segmental1Biomarker
umls:C0020452Hyperemia1Biomarker
umls:C0021831Intestinal Diseases1Biomarker
umls:C0751651Mitochondrial Diseases1Therapeutic
umls:C0026936Mycoplasma Infections1Biomarker
umls:C0206146Myocardial Stunning1Biomarker
umls:C0032290Pneumonia, Aspiration1Biomarker
umls:C0036330Schistosomiasis mansoni1Therapeutic
umls:C0038220Status Epilepticus1Biomarker
umls:C0038325Stevens-Johnson Syndrome1Biomarker
umls:C0038587Substance Withdrawal Syndrome1Biomarker
umls:C0042029Urinary Tract Infections1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for NOS2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|nutraceuticalDB00125L-ArginineSmall molecule
Approved|nutraceuticalDB00155L-CitrullineSmall molecule
Approved|investigational|vet_approvedDB01110MiconazoleSmall molecule
Approved|investigational|vet_approvedDB01234DexamethasoneSmall molecule
ExperimentalDB01686N,N-dimethylarginineSmall molecule
ExperimentalDB018354r-Fluoro-N6-Ethanimidoyl-L-LysineSmall molecule
ExperimentalDB019973-Bromo-7-NitroindazoleSmall molecule
ExperimentalDB02044N-(3-(Aminomethyl)Benzyl)AcetamidineSmall molecule
ExperimentalDB022077-NitroindazoleSmall molecule
ExperimentalDB02234EthylisothioureaSmall molecule
ExperimentalDB02462ThiocoumarinSmall molecule
ExperimentalDB02533AminoguanidineSmall molecule
ExperimentalDB02539S-EthylisothioureaSmall molecule
ExperimentalDB02644N-Omega-Propyl-L-ArginineSmall molecule
ExperimentalDB02692(6r,1'r,2's)-5,6,7,8 TetrahydrobiopterinSmall molecule
ExperimentalDB031006-NitroindazoleSmall molecule
ExperimentalDB03144N-Omega-Hydroxy-L-ArginineSmall molecule
ExperimentalDB03449N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-ThiophecarboxamidineSmall molecule
ExperimentalDB03953L-ThiocitrullineSmall molecule
ExperimentalDB044007,8-DihydrobiopterinSmall molecule
ExperimentalDB045345-NitroindazoleSmall molecule
InvestigationalDB05214KD7040Small molecule
InvestigationalDB05252ACCLAIMSmall molecule
ExperimentalDB068795-(4'-AMINO-1'-ETHYL-5',8'-DIFLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLINE]-1-YLCARBONYL)PICOLINONITRILESmall molecule
ExperimentalDB06916N-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-1-[2-(1H-IMIDAZOL-1-YL)-6-METHYLPYRIMIDIN-4-YL]-D-PROLINAMIDESmall molecule
ExperimentalDB070024-({4-[(4-methoxypyridin-2-yl)amino]piperidin-1-yl}carbonyl)benzonitrileSmall molecule
ExperimentalDB07003(2S)-2-methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amineSmall molecule
ExperimentalDB07007(3R)-3-[(1,2,3,4-tetrahydroisoquinolin-7-yloxy)methyl]-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amineSmall molecule
ExperimentalDB070084-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PYRIMIDINESmall molecule
ExperimentalDB07011(3S)-1-(1,3-BENZODIOXOL-5-YLMETHYL)-3-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PIPERIDINESmall molecule
ExperimentalDB070294-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-6-METHYLPYRIMIDINESmall molecule
ExperimentalDB07306ETHYL 4-[(4-CHLOROPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATESmall molecule
ExperimentalDB07318N-[2-(4-AMINO-5,8-DIFLUORO-1,2-DIHYDROQUINAZOLIN-2-YL)ETHYL]-3-FURAMIDESmall molecule
ExperimentalDB07388ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATESmall molecule
ExperimentalDB07389N-[2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL]-4-CYANOBENZAMIDESmall molecule
ExperimentalDB074051-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[PIPERIDINE-4,2'(1'H)-QUINAZOLINE]-4'-AMINESmall molecule
ExperimentalDB082144-(1H-IMIDAZOL-1-YL)PHENOLSmall molecule
ExperimentalDB087501-[4-(AMINOMETHYL)BENZOYL]-5'-FLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLIN]-4'-AMINESmall molecule
ApprovedDB08814TriflusalSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of NOS2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ZNZINC(2+)1nsiAC115
ZNZINC(2+)1nsiBC115
ZNZINC(2+)1nsiCC115
ZNZINC(2+)1nsiDC115
ZNZINC(2+)3e7gAC115
ZNZINC(2+)3e7gBC115
ZNZINC(2+)3e7gCC115
ZNZINC(2+)3e7gDC115
ZNZINC(2+)3ej8AC115
ZNZINC(2+)3ej8BC115
ZNZINC(2+)3ej8CC115
ZNZINC(2+)3ej8DC115
ZNZINC(2+)4nosAC115
ZNZINC(2+)4nosBC115
ZNZINC(2+)4nosCC115
ZNZINC(2+)4nosDC115
H4B5,6,7,8-TETRAHYDROBIOPTERIN2nsiAH477
H4B5,6,7,8-TETRAHYDROBIOPTERIN2nsiCH477
H4B5,6,7,8-TETRAHYDROBIOPTERIN3e7gAH477
H4B5,6,7,8-TETRAHYDROBIOPTERIN3e7gBH477
H4B5,6,7,8-TETRAHYDROBIOPTERIN3ej8AH477
H4B5,6,7,8-TETRAHYDROBIOPTERIN3ej8BH477
H4B5,6,7,8-TETRAHYDROBIOPTERIN1nsiAH477 E479
H4B5,6,7,8-TETRAHYDROBIOPTERIN1nsiBH477 E479
H4B5,6,7,8-TETRAHYDROBIOPTERIN1nsiCH477 E479
H4B5,6,7,8-TETRAHYDROBIOPTERIN1nsiDH477 E479
H4B5,6,7,8-TETRAHYDROBIOPTERIN2nsiBH477 E479
H4B5,6,7,8-TETRAHYDROBIOPTERIN2nsiDH477 E479
H4B5,6,7,8-TETRAHYDROBIOPTERIN3e7gDH477 E479
H4B5,6,7,8-TETRAHYDROBIOPTERIN4nosAH477 E479
H2BQUINONOID 7,8-TETRAHYDROBIOPTERIN4nosBH477 E479
H4B5,6,7,8-TETRAHYDROBIOPTERIN4nosCH477 E479
H4B5,6,7,8-TETRAHYDROBIOPTERIN4nosDH477 E479
H4B5,6,7,8-TETRAHYDROBIOPTERIN4cx7AH477 E479
H4B5,6,7,8-TETRAHYDROBIOPTERIN4cx7BH477 E479
H4B5,6,7,8-TETRAHYDROBIOPTERIN4cx7CH477 E479
H4B5,6,7,8-TETRAHYDROBIOPTERIN4cx7DH477 E479
FMNFLAVIN MONONUCLEOTIDE3hr4AS550 F593 Q665
FMNFLAVIN MONONUCLEOTIDE3hr4CS550 F593 Q665
FMNFLAVIN MONONUCLEOTIDE3hr4ES550 F593 Q665
FMNFLAVIN MONONUCLEOTIDE3hr4GS550 F593 Q665
HECFERROHEME C(2-)3ej8BW194 S242 M434 Y489 Y491
HEMHEME B1nsiCW194 S242 Y489 Y491
HEMHEME B3e7gAW194 S242 Y489 Y491
HEMHEME B3e7gBW194 S242 Y489 Y491
HEMHEME B3e7gCW194 S242 Y489 Y491
HEMHEME B3e7gDW194 S242 Y489 Y491
HECFERROHEME C(2-)3ej8AW194 S242 Y489 Y491
HEMHEME B4nosAW194 S242 Y489 Y491
HEMHEME B4nosBW194 S242 Y489 Y491
HEMHEME B4nosCW194 S242 Y489 Y491
HEMHEME B4nosDW194 S242 Y489 Y491
HEMHEME B4cx7AW194 S242 Y489 Y491
HEMHEME B4cx7CW194 S242 Y489 Y491
HEMHEME B1nsiAW194 S242 Y491
HEMHEME B2nsiAW194 S242 Y491
HEMHEME B2nsiBW194 S242 Y491
HEMHEME B2nsiCW194 S242 Y491
HEMHEME B2nsiDW194 S242 Y491
HEMHEME B1nsiBW194 Y489 Y491
HECFERROHEME C(2-)3ej8CW194 Y489 Y491
HECFERROHEME C(2-)3ej8DW194 Y489 Y491
HEMHEME B4cx7BW194 Y489 Y491
HEMHEME B1nsiDW194 Y491
HEMHEME B4cx7DW194 Y491
H4B5,6,7,8-TETRAHYDROBIOPTERIN3ej8CW90 H477
H4B5,6,7,8-TETRAHYDROBIOPTERIN3e7gCW90 H477 E479
ARGARGININE1nsiAY347
ARGARGININE1nsiBY347
AT2ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE3e7gAY347
AT2ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE3e7gBY347
AT2ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE3e7gCY347
AT2ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE3e7gDY347
S71(R)-6-(3-AMINO-2-(5-(2-(6-AMINO-4- METHYLPYRIDIN-2-YL)ETHYL)PYRIDIN-3-YL)PROPYL)-4- METHYLPYRIDIN-2-AMINE4cx7AY491
S71(R)-6-(3-AMINO-2-(5-(2-(6-AMINO-4- METHYLPYRIDIN-2-YL)ETHYL)PYRIDIN-3-YL)PROPYL)-4- METHYLPYRIDIN-2-AMINE4cx7BY491
S71(R)-6-(3-AMINO-2-(5-(2-(6-AMINO-4- METHYLPYRIDIN-2-YL)ETHYL)PYRIDIN-3-YL)PROPYL)-4- METHYLPYRIDIN-2-AMINE4cx7CY491
S71(R)-6-(3-AMINO-2-(5-(2-(6-AMINO-4- METHYLPYRIDIN-2-YL)ETHYL)PYRIDIN-3-YL)PROPYL)-4- METHYLPYRIDIN-2-AMINE4cx7DY491


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Conservation information for LBS of NOS2
Multiple alignments for P35228 in multiple species
LBSAA sequence# speciesSpecies
A197QAWRNAPRCIG3Homo sapiens, Gallus gallus, Bos taurus
A197MAWRNAPRCIG2Mus musculus, Rattus norvegicus
C110KGILTCRSKSC1Homo sapiens
C110KEVINCRTRAC1Gallus gallus
C110TSDFTCKSKSC1Mus musculus
C110TSDISCKSKLC1Rattus norvegicus
C110KGDLSCKSKSC1Bos taurus
C115CRSKSCLGSIM1Homo sapiens
C115CRTRACQGALM1Gallus gallus
C115CKSKSCLGSIM1Mus musculus
C115CKSKLCMGSIM1Rattus norvegicus
C115CKSKSCLASIM1Bos taurus
C200RNAPRCIGRIQ5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
C635MYPQFCAFAHD3Mus musculus, Rattus norvegicus, Bos taurus
C635MYPRFCAFAHD1Homo sapiens
C635MYPEFCAFAHA1Gallus gallus
D382EIGVRDFCDVQ2Homo sapiens, Gallus gallus
D382EIGVRDFCDTQ2Mus musculus, Rattus norvegicus
D382EVGVRDFCDAQ1Bos taurus
E377WYMGTEIGVRD4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
E377WYMGTEVGVRD1Bos taurus
E479PVFHQEMLNYV5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
E546VLFATETGKSE2Mus musculus, Rattus norvegicus
E546ILFATETGKSE1Homo sapiens
E546VIYATETGKSE1Gallus gallus
E546ILFATETGRSE1Bos taurus
E661TGEGDELSGQE3Mus musculus, Rattus norvegicus, Bos taurus
E661MGEGDELSGQE1Homo sapiens
E661VGEGDELNGQE1Gallus gallus
F369FPGCPFNGWYM2Homo sapiens, Bos taurus
F369FPACPFNGWYM2Mus musculus, Rattus norvegicus
F369FTACPFNGWYM1Gallus gallus
F476SITPVFHQEML5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
F593VVTSTFGNGDC3Homo sapiens, Mus musculus, Rattus norvegicus
F593VVTSTFGNGDS2Gallus gallus, Bos taurus
F634SMYPQFCAFAH3Mus musculus, Rattus norvegicus, Bos taurus
F634SMYPRFCAFAH1Homo sapiens
F634TMYPEFCAFAH1Gallus gallus
G202APRCIGRIQWS5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
G371ACPFNGWYMGT3Gallus gallus, Mus musculus, Rattus norvegicus
G371GCPFNGWYMGT2Homo sapiens, Bos taurus
G548FATETGKSEAL3Homo sapiens, Mus musculus, Rattus norvegicus
G548YATETGKSETL1Gallus gallus
G548FATETGRSETL1Bos taurus
G594VTSTFGNGDCP3Homo sapiens, Mus musculus, Rattus norvegicus
G594VTSTFGNGDSP2Gallus gallus, Bos taurus
G596STFGNGDCPSN2Mus musculus, Rattus norvegicus
G596STFGNGDCPGN1Homo sapiens
G596STFGNGDSPNN1Gallus gallus
G596STFGNGDSPGN1Bos taurus
G627AVFGLGSSMYP4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G627AVFGLGSTMYP1Gallus gallus
H477ITPVFHQEMLN5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
I201NAPRCIGRIQW5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
I462CPADWIWLVPP4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
I462CPADWVWIVPP1Gallus gallus
K549ATETGKSEALA3Homo sapiens, Mus musculus, Rattus norvegicus
K549ATETGKSETLA1Gallus gallus
K549ATETGRSETLA1Bos taurus
L209IQWSNLQVFDA5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
L626YAVFGLGSSMY4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L626YAVFGLGSTMY1Gallus gallus
M120CLGSIMTPKSL1Homo sapiens
M120CQGALMTPKGL1Gallus gallus
M120CLGSIMNPKSL1Mus musculus
M120CMGSIMNSKSL1Rattus norvegicus
M120CLASIMNPKSL1Bos taurus
M355PAVANMLLEVG5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
M374FNGWYMGTEIG4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
M374FNGWYMGTEVG1Bos taurus
M434QNVTIMDHHSA3Homo sapiens, Gallus gallus, Bos taurus
M434QNVTIMDHHTA2Mus musculus, Rattus norvegicus
N370PGCPFNGWYMG2Homo sapiens, Bos taurus
N370PACPFNGWYMG2Mus musculus, Rattus norvegicus
N370TACPFNGWYMG1Gallus gallus
N595TSTFGNGDCPS2Mus musculus, Rattus norvegicus
N595TSTFGNGDCPG1Homo sapiens
N595TSTFGNGDSPN1Gallus gallus
N595TSTFGNGDSPG1Bos taurus
P350KWYALPAVANM5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
Q205CIGRIQWSNLQ5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
Q263RVWNAQLIRYA2Homo sapiens, Bos taurus
Q263RVWNSQLIRYA1Gallus gallus
Q263RLWNSQLIRYA1Mus musculus
Q263RIWNSQLIRYA1Rattus norvegicus
Q478TPVFHQEMLNY5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
Q665DELSGQEDAFR3Homo sapiens, Mus musculus, Rattus norvegicus
Q665DELNGQEEAFR1Gallus gallus
Q665DELSGQEEAFR1Bos taurus
R199WRNAPRCIGRI5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
R266NSQLIRYAGYQ3Gallus gallus, Mus musculus, Rattus norvegicus
R266NAQLIRYAGYQ2Homo sapiens, Bos taurus
R381TEIGVRDFCDV2Homo sapiens, Gallus gallus
R381TEIGVRDFCDT2Mus musculus, Rattus norvegicus
R381TEVGVRDFCDA1Bos taurus
R388FCDTQRYNILE2Mus musculus, Rattus norvegicus
R388FCDVQRYNILE1Homo sapiens
R388FCDVQRYNILK1Gallus gallus
R388FCDAQRYNILE1Bos taurus
R633SSMYPQFCAFA3Mus musculus, Rattus norvegicus, Bos taurus
R633SSMYPRFCAFA1Homo sapiens
R633STMYPEFCAFA1Gallus gallus
S118KSCLGSIMTPK1Homo sapiens
S118RACQGALMTPK1Gallus gallus
S118KSCLGSIMNPK1Mus musculus
S118KLCMGSIMNSK1Rattus norvegicus
S118KSCLASIMNPK1Bos taurus
S242NGNIRSAITVF3Homo sapiens, Mus musculus, Bos taurus
S242NGNIRSAITIF1Gallus gallus
S242SGNIRSAITVF1Rattus norvegicus
S550TETGKSEALAR2Mus musculus, Rattus norvegicus
S550TETGKSEALAW1Homo sapiens
S550TETGKSETLAN1Gallus gallus
S550TETGRSETLAQ1Bos taurus
S591LLVVTSTFGNG5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
S628VFGLGSSMYPQ3Mus musculus, Rattus norvegicus, Bos taurus
S628VFGLGSSMYPR1Homo sapiens
S628VFGLGSTMYPE1Gallus gallus
T121LGSIMTPKSLT1Homo sapiens
T121QGALMTPKGLV1Gallus gallus
T121LGSIMNPKSLT1Mus musculus
T121MGSIMNSKSLT1Rattus norvegicus
T121LASIMNPKSLT1Bos taurus
T545TVLFATETGKS2Mus musculus, Rattus norvegicus
T545TILFATETGKS1Homo sapiens
T545TVIYATETGKS1Gallus gallus
T545TILFATETGRS1Bos taurus
T547LFATETGKSEA3Homo sapiens, Mus musculus, Rattus norvegicus
T547IYATETGKSET1Gallus gallus
T547LFATETGRSET1Bos taurus
T592LVVTSTFGNGD5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
V352YALPAVANMLL5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
W194ATKQAWRNAPR2Homo sapiens, Bos taurus
W194ATKMAWRNAPR2Mus musculus, Rattus norvegicus
W194AAKQAWRNAPR1Gallus gallus
W372CPFNGWYMGTE5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
W461GCPADWIWLVP4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
W461GCPADWVWIVP1Gallus gallus
W463PADWIWLVPPV2Mus musculus, Rattus norvegicus
W463PADWIWLVPPM1Homo sapiens
W463PADWVWIVPPM1Gallus gallus
W463PADWIWLVPPI1Bos taurus
W90VRIKNWGSGMT1Homo sapiens
W90VKVRNMENGSS1Gallus gallus
W90VRIKNWGSGEI1Mus musculus
W90VRIKNWGNGEI1Rattus norvegicus
W90VRIKNWGSGVT1Bos taurus
Y347LELKWYALPAV2Homo sapiens, Bos taurus
Y347LGLKWYALPAV2Mus musculus, Rattus norvegicus
Y347LDLKWYALPAV1Gallus gallus
Y373PFNGWYMGTEI4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
Y373PFNGWYMGTEV1Bos taurus
Y489VLSPFYYYQVE2Homo sapiens, Bos taurus
Y489VLSPFYYYQIE2Mus musculus, Rattus norvegicus
Y489VLTPFFYYQVD1Gallus gallus
Y491SPFYYYQIEPW2Mus musculus, Rattus norvegicus
Y491SPFYYYQVEAW1Homo sapiens
Y491TPFFYYQVDAW1Gallus gallus
Y491SPFYYYQVEPW1Bos taurus
Y631LGSSMYPQFCA3Mus musculus, Rattus norvegicus, Bos taurus
Y631LGSSMYPRFCA1Homo sapiens
Y631LGSTMYPEFCA1Gallus gallus


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