mutated Ligand Binding Site gene DataBase





About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for OAS1
Gene summary
Basic gene Info.Gene symbolOAS1
Gene name2'-5'-oligoadenylate synthetase 1, 40/46kDa
CytomapUCSC genome browser: 12q24.2
Type of geneprotein-coding
Description(2-5')oligo(A) synthase 1(2-5')oligo(A) synthetase 12',5'-oligo A synthetase 12',5'-oligoadenylate synthetase 1, 40/46kDa2'-5' oligoadenylate synthetase 1 p48 isoform2'-5' oligoadenylate synthetase 1 p52 isoform2'-5'-oligoadenylate synthase 12'-5'-
Modification date20141207
dbXrefs MIM : 164350
Ensembl : ENSG00000089127
HPRD : 08879
Vega : OTTHUMG00000169792
ProteinUniProt: P00973
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_OAS1
BioGPS: 4938
PathwayNCI Pathway Interaction Database: OAS1
Pathway Commons: OAS1
ContextiHOP: OAS1
ligand binding site mutation search in PubMed: OAS1
UCL Cancer Institute: OAS1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0006164purine nucleotide biosynthetic process11682059
GO:0009615response to virus18931074
GO:0035457cellular response to interferon-alpha3753689
GO:0045071negative regulation of viral genome replication18931074
GO:0051259protein oligomerization11682059
GO:0051607defense response to virus19923450
GO:0060700regulation of ribonuclease activity19923450

Ligand binding site mutations for OAS1
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for OAS1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for OAS1 from PDB

Differential gene expression and gene-gene network for OAS1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of OAS1 and the right PPI network was created from samples without mutations in the LBS of OAS1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for OAS1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0011854Diabetes Mellitus, Type 16Biomarker, GeneticVariation
umls:C0042769Virus Diseases2Biomarker
umls:C0021400Influenza, Human1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for OAS1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB02987Cysteine-S-AcetamideSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of OAS1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids4ig8AD13 N31 K204
NUCNucleic Acids4ig8AR47

Conservation information for LBS of OAS1
Multiple alignments for P00973 in multiple species
LBSAA sequence# speciesSpecies
C38AIDIICGFLKE1Homo sapiens
C38AVNVVCDFLKE1Mus musculus
C38AINVLCDFLKE1Rattus norvegicus
C54SSYPVCVSKVV1Homo sapiens
C54AAHPVRVSKVV1Mus musculus
C54TVHPVRVSKVV1Rattus norvegicus
D13PAKSLDKFIED1Homo sapiens
D13PAWTLDKFIED1Mus musculus
D13PSWKLDKFIEV1Rattus norvegicus
D148EGVEFDVLPAF1Homo sapiens
D148QEVEFDVLPAF1Mus musculus
D148QEVEFDVLPAY1Rattus norvegicus
D35INHAIDIICGF1Homo sapiens
D35VKSAVNVVCDF1Mus musculus
D35VKSAINVLCDF1Rattus norvegicus
D75LKGKSDADLVV2Mus musculus, Rattus norvegicus
D75LRGRSDADLVV1Homo sapiens
D77GKSDADLVVFL2Mus musculus, Rattus norvegicus
D77GRSDADLVVFL1Homo sapiens
E17LDKFIEDYLLP2Homo sapiens, Mus musculus
E17LDKFIEVYLLP1Rattus norvegicus
E43CGFLKERCFRG1Homo sapiens
E43CDFLKERCFQG1Mus musculus
E43CDFLKERCFRD1Rattus norvegicus
G62KVVKGGSSGKG3Homo sapiens, Mus musculus, Rattus norvegicus
G67GSSGKGTTLKG2Mus musculus, Rattus norvegicus
G67GSSGKGTTLRG1Homo sapiens
H248GSMKTHFNTAQ1Homo sapiens
H248GNGCYEFNTAQ1Mus musculus
H248GNGITEFNTAQ1Rattus norvegicus
I34QINHAIDIICG1Homo sapiens
I34DVKSAVNVVCD1Mus musculus
I34DVKSAINVLCD1Rattus norvegicus
K14AKSLDKFIEDY1Homo sapiens
K14AWTLDKFIEDY1Mus musculus
K14SWKLDKFIEVY1Rattus norvegicus
K199QRNFLKQRPTK2Mus musculus, Rattus norvegicus
K199QRDFLKQRPTK1Homo sapiens
K204KQRPTKLKSLI3Homo sapiens, Mus musculus, Rattus norvegicus
K206RPTKLKSLIRL3Homo sapiens, Mus musculus, Rattus norvegicus
K213LIRLVKHWYQL2Mus musculus, Rattus norvegicus
K213LIRLVKHWYQN1Homo sapiens
K42ICGFLKERCFR1Homo sapiens
K42VCDFLKERCFQ1Mus musculus
K42LCDFLKERCFR1Rattus norvegicus
K57PVRVSKVVKGG2Mus musculus, Rattus norvegicus
K57PVCVSKVVKGG1Homo sapiens
K60VSKVVKGGSSG3Homo sapiens, Mus musculus, Rattus norvegicus
N31FRMQINHAIDI1Homo sapiens
N31FGADVKSAVNV1Mus musculus
N31FRDDVKSAINV1Rattus norvegicus
P22EDYLLPDTCFR1Homo sapiens
P22EDYLLPDTTFG1Mus musculus
P22EVYLLPNTSFR1Rattus norvegicus
Q158FDALGQLTGGY1Homo sapiens
Q158FDVLGHVNTSS1Mus musculus
Q158YDVLGHVSLYS1Rattus norvegicus
Q200RNFLKQRPTKL2Mus musculus, Rattus norvegicus
Q200RDFLKQRPTKL1Homo sapiens
Q229KPLPPQYALEL2Mus musculus, Rattus norvegicus
Q229K-LPPQYALEL1Homo sapiens
R27PDTCFRMQINH1Homo sapiens
R27PDTTFGADVKS1Mus musculus
R27PNTSFRDDVKS1Rattus norvegicus
R47KERCFRGSSYP1Homo sapiens
R47KERCFQGAAHP1Mus musculus
R47KERCFRDTVHP1Rattus norvegicus
S56HPVRVSKVVKG2Mus musculus, Rattus norvegicus
S56YPVCVSKVVKG1Homo sapiens
S63VVKGGSSGKGT3Homo sapiens, Mus musculus, Rattus norvegicus
T203LKQRPTKLKSL3Homo sapiens, Mus musculus, Rattus norvegicus
T24YLLPDTCFRMQ1Homo sapiens
T24YLLPDTTFGAD1Mus musculus
T24YLLPNTSFRDD1Rattus norvegicus
T247RGSMKTHFNTA1Homo sapiens
T247QGNGCYEFNTA1Mus musculus
T247RGNGITEFNTA1Rattus norvegicus
V55SYPVCVSKVVK1Homo sapiens
V55AHPVRVSKVVK1Mus musculus
V55VHPVRVSKVVK1Rattus norvegicus
V58VRVSKVVKGGS2Mus musculus, Rattus norvegicus
V58VCVSKVVKGGS1Homo sapiens

Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas