mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for RNF165
Gene summary
Basic gene Info.Gene symbolRNF165
Gene namering finger protein 165
SynonymsARKL2|RNF111L2
CytomapUCSC genome browser: 18q21.1
Type of geneprotein-coding
RefGenesNM_001256758.1,
NM_152470.2,NR_046357.1,
DescriptionRING finger protein 165
Modification date20141207
dbXrefs HGNC : HGNC
Ensembl : ENSG00000141622
ProteinUniProt: Q6ZSG1
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_RNF165
BioGPS: 494470
PathwayNCI Pathway Interaction Database: RNF165
KEGG: RNF165
REACTOME: RNF165
Pathway Commons: RNF165
ContextiHOP: RNF165
ligand binding site mutation search in PubMed: RNF165
UCL Cancer Institute: RNF165
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for RNF165

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
C331P332LCOAD1
C297S299PCOAD1
C297C297FLUAD1
C331K329TSTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for RNF165
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
C331K329T-0.87802172
C331P332L-0.87528101
C297C297F-0.76555556
C297S299P-0.20951715
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for RNF165 from PDB

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Differential gene expression and gene-gene network for RNF165
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of RNF165 and the right PPI network was created from samples without mutations in the LBS of RNF165. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for RNF165
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for RNF165
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of RNF165 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ZNZINC(2+)5d0iAC297
ZNZINC(2+)5d0iBC297
ZNZINC(2+)5d0kCC297
ZNZINC(2+)5d0kFC297
ZNZINC(2+)5d0kIC297
ZNZINC(2+)5d0kLC297
ZNZINC(2+)5d0mCC297
ZNZINC(2+)5d0iAC331
ZNZINC(2+)5d0iBC331
ZNZINC(2+)5d0kCC331
ZNZINC(2+)5d0kFC331
ZNZINC(2+)5d0kIC331
ZNZINC(2+)5d0kLC331
ZNZINC(2+)5d0mCC331


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Conservation information for LBS of RNF165
Multiple alignments for Q6ZSG1 in multiple species
LBSAA sequence# speciesSpecies


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