mutLBSgeneDB |
Gene summary for OCRL |
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Basic gene Info. | Gene symbol | OCRL |
Gene name | oculocerebrorenal syndrome of Lowe | |
Synonyms | INPP5F|LOCR|NPHL2|OCRL-1|OCRL1 | |
Cytomap | UCSC genome browser: Xq25 | |
Type of gene | protein-coding | |
RefGenes | NM_000276.3, NM_001587.3, | |
Description | Lowe oculocerebrorenal syndrome proteininositol polyphosphate 5-phosphatase OCRL-1phosphatidylinositol polyphosphate 5-phosphatase | |
Modification date | 20141219 | |
dbXrefs | MIM : 300535 | |
HGNC : HGNC | ||
Ensembl : ENSG00000122126 | ||
HPRD : 02395 | ||
Vega : OTTHUMG00000022706 | ||
Protein | UniProt: Q01968 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_OCRL | |
BioGPS: 4952 | ||
Pathway | NCI Pathway Interaction Database: OCRL | |
KEGG: OCRL | ||
REACTOME: OCRL | ||
Pathway Commons: OCRL | ||
Context | iHOP: OCRL | |
ligand binding site mutation search in PubMed: OCRL | ||
UCL Cancer Institute: OCRL | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID | GO:0032314 | regulation of Rac GTPase activity | 12915445 | GO:0032855 | positive regulation of Rac GTPase activity | 12915445 |
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Ligand binding site mutations for OCRL |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | K691 | R689C | COAD | 1 | Y838 | R837H | LUAD | 1 | K736 | E737K | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for OCRL |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | K691 | R689C | -1.325108 | Y838 | R837H | -1.2107858 | K736 | E737K | -0.9730685 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for OCRL |
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Phenotype information for OCRL |
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Disease ID | Disease name | # PubMed | Association type |
umls:C0028860 | Oculocerebrorenal Syndrome | 65 | Biomarker, GeneticVariation |
umls:C1845167 | Dent Disease 2 | 3 | Biomarker, GeneticVariation |
umls:C1848336 | Dent disease 1 | 2 | Biomarker |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for OCRL |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (PRO,PHE,ALA,ARG,LEU,HIS,GLU,CYS,TYR,GLY,GLN,GLU,ILE) | 3qis | A | K691 K736 Y838 |
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Conservation information for LBS of OCRL |
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LBS | AA sequence | # species | Species |
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