mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ODC1
Gene summary
Basic gene Info.Gene symbolODC1
Gene nameornithine decarboxylase 1
SynonymsODC
CytomapUCSC genome browser: 2p25
Type of geneprotein-coding
RefGenesNM_001287188.1,
NM_001287189.1,NM_001287190.1,NM_002539.2,
Descriptionornithine decarboxylase
Modification date20141207
dbXrefs MIM : 165640
HGNC : HGNC
Ensembl : ENSG00000115758
HPRD : 01324
Vega : OTTHUMG00000090450
ProteinUniProt: P11926
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ODC1
BioGPS: 4953
PathwayNCI Pathway Interaction Database: ODC1
KEGG: ODC1
REACTOME: ODC1
Pathway Commons: ODC1
ContextiHOP: ODC1
ligand binding site mutation search in PubMed: ODC1
UCL Cancer Institute: ODC1
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for ODC1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
A67A67TCOAD1
K69N71KSKCM1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for ODC1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
K69N71K-0.89330587
A67A67T-0.69281026
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ODC1 from PDB

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Differential gene expression and gene-gene network for ODC1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ODC1 and the right PPI network was created from samples without mutations in the LBS of ODC1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for ODC1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0009404Colorectal Neoplasms6AlteredExpression, Biomarker, GeneticVariation
umls:C0009375Colonic Neoplasms4Biomarker
umls:C0019693HIV Infections3Biomarker
umls:C0030354Papilloma3Biomarker
umls:C0037286Skin Neoplasms3Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for ODC1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
NutraceuticalDB00114Pyridoxal PhosphateSmall molecule
Approved|nutraceuticalDB00127SpermineSmall molecule
ExperimentalDB01917PutrescineSmall molecule
ExperimentalDB02209Pyridoxine-5'-PhosphateSmall molecule
ExperimentalDB02824N-Pyridoxyl-Glycine-5-MonophosphateSmall molecule
ExperimentalDB03856Alpha-DifluoromethylornithineSmall molecule
ExperimentalDB04083N'-Pyridoxyl-Lysine-5'-MonophosphateSmall molecule
ExperimentalDB04263GeneticinSmall molecule
Approved|withdrawnDB06243EflornithineSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ODC1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
PLPPYRIDOXAL 5'-PHOSPHATE2oo0AA67 K69
PLPPYRIDOXAL 5'-PHOSPHATE2oo0BA67 K69
PLPPYRIDOXAL 5'-PHOSPHATE5bwaAA67 K69
PLPPYRIDOXAL 5'-PHOSPHATE4zgyAK69


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Conservation information for LBS of ODC1
Multiple alignments for P11926 in multiple species
LBSAA sequence# speciesSpecies
A111ERIIYANPCKQ4Homo sapiens, Gallus gallus, Rattus norvegicus, Bos taurus
A111ERIIFAHPCRP1Drosophila melanogaster
A111ERIIFANPCRP1Drosophila melanogaster
A111ERIIYANPCKT1Caenorhabditis elegans
A111DRIVYANPCKV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A111SRIIYAQPCKT1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
A111DRIVYANPCKA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A111ERVIYANPCKQ1Mus musculus
A67VTPFYAVKCND5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
A67IEPHYAVKCND1Drosophila melanogaster
A67IKPFYAVKCND1Drosophila melanogaster
A67IEPFYAVKCNT1Caenorhabditis elegans
A67IKPFYAVKCNP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A67VKPFYAVKCHP1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
A67VQPFYAVKCNP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C164DSKAVCRLSVK5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
C164AKKALCPLGDK1Drosophila melanogaster
C164AKEAQCPLGDK1Drosophila melanogaster
C164DPTATCPLNLK1Caenorhabditis elegans
C164DSTAQCRLSTK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C164DSSSLCRFSMK1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
C164DSNSLCRLSLK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C360IWGPTCDGLDR5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
C360IWGPSCDAMDK1Drosophila melanogaster
C360IWGPSCDALDK1Drosophila melanogaster
C360IWGPTCDSLDL1Caenorhabditis elegans
C360IWGPTCDGLDC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C360IWGPTCDGIDR1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
C360IWGPTCDSLDV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D332NCILYDHAHVK5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
D332AGMFYYPEEVA1Drosophila melanogaster
D332NCILYDHQVVI1Drosophila melanogaster
D332NCILFDHAHPI1Caenorhabditis elegans
D332NCILFDHQEPH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D332SSIMFDHQHPV1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
D332NCILFDHQHPV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D361WGPTCDGLDRI5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
D361WGPSCDAMDKI1Drosophila melanogaster
D361WGPSCDALDKI1Drosophila melanogaster
D361WGPTCDSLDLV1Caenorhabditis elegans
D361WGPTCDGLDCI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D361WGPTCDGIDRI1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
D361WGPTCDSLDVI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D88IGTGFDCASKT3Mus musculus, Rattus norvegicus, Bos taurus
D88TGTGFDCASKT1Homo sapiens
D88LGTGFDCASKN1Drosophila melanogaster
D88LGAGFDCASKN1Drosophila melanogaster
D88LGCGFDCASKD1Caenorhabditis elegans
D88LGVNFDCASKV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D88LGTGFDCASKA1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
D88FGTGFDCASKG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D88LGAGFDCASKT1Gallus gallus
E274VRIIAEPGRYY4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
E274IRIISEPGRFF1Drosophila melanogaster
E274VHIIAEPGRFF1Drosophila melanogaster
E274KRLIAEPGRFF1Caenorhabditis elegans
E274VDIIAEPGRYF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E274VNLIAEPGRYY1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
E274IRVISEPGRFF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E274VTIIAEPGRYY1Gallus gallus
F238DIGGGFPGSED5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
F238DVGGGFPGIDD1Drosophila melanogaster
F238DIGGGFPGSDD1Drosophila melanogaster
F238DMGGGFPGAEH1Caenorhabditis elegans
F238DVGGGFQFES-1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F238DVGGGFCSDDS1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
F238DIGGGFMNDS-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F397AAASTFNGFQR5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
F397PIASPFNGFDV1Drosophila melanogaster
F397PIASAFNGFEV1Drosophila melanogaster
F397AAATTFNGFSK1Caenorhabditis elegans
F397SAATQFNGFEQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F397CSATTFNGFSN1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
F397AAASCFNGFKT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G201FHVGSGCTDPE5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
G201FHVGSGCSEVE1Drosophila melanogaster
G201FHVGSGCSELQ1Drosophila melanogaster
G201FHVGSGCNDAS1Caenorhabditis elegans
G201FHVGSGASDFT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G201FHVGSGASDPT1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G201FHVGSGSYDPS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G236LLDIGGGFPGS5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
G236LLDVGGGFPGI1Drosophila melanogaster
G236FLDIGGGFPGS1Drosophila melanogaster
G236IIDMGGGFPGA1Caenorhabditis elegans
G236ILDVGGGFQFE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G236TLDVGGGFCSD1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G236LLDIGGGFMND1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G237LDIGGGFPGSE5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
G237LDVGGGFPGID1Drosophila melanogaster
G237LDIGGGFPGSD1Drosophila melanogaster
G237IDMGGGFPGAE1Caenorhabditis elegans
G237LDVGGGFQFES1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G237LDVGGGFCSDD1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G237LDIGGGFMNDS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G240GGGFPGSEDVK3Homo sapiens, Gallus gallus, Bos taurus
G240GGGFPGSEDTK2Mus musculus, Rattus norvegicus
G240GGGFPGIDDEM1Drosophila melanogaster
G240GGGFPGSDDVK1Drosophila melanogaster
G240GGGFPGAEHHN1Caenorhabditis elegans
G240GGGFQFES---1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G240GGGFCSDDS--1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G240GGGFMNDS---1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G276IIAEPGRYYVA5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
G276IISEPGRFFVE1Drosophila melanogaster
G276IIAEPGRFFVA1Drosophila melanogaster
G276LIAEPGRFFAA1Caenorhabditis elegans
G276IIAEPGRYFVA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G276LIAEPGRYYAS1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G276VISEPGRFFVS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H197IGVSFHVGSGC3Mus musculus, Rattus norvegicus, Bos taurus
H197VGVSFHVGSGC2Homo sapiens, Gallus gallus
H197TGTSFHVGSGC2Drosophila melanogaster, Drosophila melanogaster
H197VGISFHVGSGC1Caenorhabditis elegans
H197AGVSFHVGSGA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H197VGVSFHVGSGA1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
H197VGVSFHVGSGS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K245GSEDVKLKFEE3Homo sapiens, Gallus gallus, Bos taurus
K245GSEDTKLKFEE2Mus musculus, Rattus norvegicus
K245GIDDEM--FEE1Drosophila melanogaster
K245GSDDVK--FEK1Drosophila melanogaster
K245GAEHHN-PFEK1Caenorhabditis elegans
K245FES-----FKE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K245SDDS----FEQ1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K245NDS-----FDG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K69PFYAVKCNDSR3Mus musculus, Rattus norvegicus, Bos taurus
K69PFYAVKCNDSK1Homo sapiens
K69PHYAVKCNDDP1Drosophila melanogaster
K69PFYAVKCNDDP1Drosophila melanogaster
K69PFYAVKCNTDL1Caenorhabditis elegans
K69PFYAVKCNPDT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K69PFYAVKCHPDE1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K69PFYAVKCNPDP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K69PFYAVKCNDSE1Gallus gallus
L166KAVCRLSVKFG5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
L166KALCPLGDKYG1Drosophila melanogaster
L166EAQCPLGDKFG1Drosophila melanogaster
L166TATCPLNLKFG1Caenorhabditis elegans
L166TAQCRLSTKYG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L166SSLCRFSMKFG1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
L166NSLCRLSLKFG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L246SEDVKLKFEEI3Homo sapiens, Gallus gallus, Bos taurus
L246SEDTKLKFEEI2Mus musculus, Rattus norvegicus
L246IDDEM--FEEI1Drosophila melanogaster
L246SDDVK--FEKI1Drosophila melanogaster
L246AEHHN-PFEKI1Caenorhabditis elegans
L246ES-----FKES1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L246DDS----FEQM1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
L246DS-----FDGV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N385WMLFENMGAYT4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
N385LLGFRNMGAYT2Drosophila melanogaster, Drosophila melanogaster
N385WLYYPDMGAYT1Caenorhabditis elegans
N385WFYFPALGAYT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N385WLYFEDMGAYT1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
N385WIYFEDAGAYT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N385WILFENMGAYT1Gallus gallus
P239IGGGFPGSEDV3Homo sapiens, Gallus gallus, Bos taurus
P239IGGGFPGSEDT2Mus musculus, Rattus norvegicus
P239VGGGFPGIDDE1Drosophila melanogaster
P239IGGGFPGSDDV1Drosophila melanogaster
P239MGGGFPGAEHH1Caenorhabditis elegans
P239VGGGFQFES--1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P239VGGGFCSDDS-1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
P239IGGGFMNDS--1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P275RIIAEPGRYYV4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
P275RIISEPGRFFV1Drosophila melanogaster
P275HIIAEPGRFFV1Drosophila melanogaster
P275RLIAEPGRFFA1Caenorhabditis elegans
P275DIIAEPGRYFV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P275NLIAEPGRYYA1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
P275RVISEPGRFFV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P275TIIAEPGRYYV1Gallus gallus
R154AKLVLRIATDD4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
R154SNLIVRFKSEA2Drosophila melanogaster, Drosophila melanogaster
R154AEMILRIAVSD1Caenorhabditis elegans
R154SQLLLRIATDD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R154AELFLRILTDD1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R154SRLLLRISTDD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R154AKLLLRITTDD1Gallus gallus
R277IAEPGRYYVAS5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
R277ISEPGRFFVEA1Drosophila melanogaster
R277IAEPGRFFVAA1Drosophila melanogaster
R277IAEPGRFFAAG1Caenorhabditis elegans
R277IAEPGRYFVAT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R277IAEPGRYYASS1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R277ISEPGRFFVSS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S200SFHVGSGCTDP5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
S200SFHVGSGCSEV1Drosophila melanogaster
S200SFHVGSGCSEL1Drosophila melanogaster
S200SFHVGSGCNDA1Caenorhabditis elegans
S200SFHVGSGASDF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S200SFHVGSGASDP1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S200SFHVGSGSYDP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S241GGFPGSEDVKL3Homo sapiens, Gallus gallus, Bos taurus
S241GGFPGSEDTKL2Mus musculus, Rattus norvegicus
S241GGFPGIDDEM-1Drosophila melanogaster
S241GGFPGSDDVK-1Drosophila melanogaster
S241GGFPGAEHHN-1Caenorhabditis elegans
S241GGFQFES----1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S241GGFCSDDS---1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S241GGFMNDS----1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T203VGSGCTDPETF5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
T203VGSGCSEVEAY1Drosophila melanogaster
T203VGSGCSELQAY1Drosophila melanogaster
T203VGSGCNDASAY1Caenorhabditis elegans
T203VGSGASDFTSL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T203VGSGASDPTAF1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
T203VGSGSYDPSAF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V244PGSEDVKLKFE3Homo sapiens, Gallus gallus, Bos taurus
V244PGSEDTKLKFE2Mus musculus, Rattus norvegicus
V244PGIDDEM--FE1Drosophila melanogaster
V244PGSDDVK--FE1Drosophila melanogaster
V244PGAEHHN-PFE1Caenorhabditis elegans
V244QFES-----FK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V244CSDDS----FE1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
V244MNDS-----FD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y278AEPGRYYVASA5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
Y278SEPGRFFVEAA1Drosophila melanogaster
Y278AEPGRFFVAAA1Drosophila melanogaster
Y278AEPGRFFAAGP1Caenorhabditis elegans
Y278AEPGRYFVATA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y278AEPGRYYASSA1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Y278SEPGRFFVSSS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y331FNCILYDHAHV5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
Y331FAGMFYYPEEV1Drosophila melanogaster
Y331FNCILYDHQVV1Drosophila melanogaster
Y331FNCILFDHAHP1Caenorhabditis elegans
Y331MNCILFDHQEP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y331FSSIMFDHQHP1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Y331LNCILFDHQHP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y389ENMGAYTVAAA5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
Y389RNMGAYTMPIA2Drosophila melanogaster, Drosophila melanogaster
Y389PDMGAYTLAAA1Caenorhabditis elegans
Y389PALGAYTSSAA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y389EDMGAYTKCSA1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Y389EDAGAYTVAAA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)


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