mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for OGG1
Gene summary
Basic gene Info.Gene symbolOGG1
Gene name8-oxoguanine DNA glycosylase
SynonymsHMMH|HOGG1|MUTM|OGH1
CytomapUCSC genome browser: 3p26.2
Type of geneprotein-coding
RefGenesNM_002542.5,
NM_016819.3,NM_016820.3,NM_016821.2,NM_016826.2,
NM_016827.2,NM_016828.2,NM_016829.2,
Description8-hydroxyguanine DNA glycosylaseAP lyaseDNA-apurinic or apyrimidinic site lyaseN-glycosylase/DNA lyaseOGG1 type 1f
Modification date20141207
dbXrefs MIM : 601982
HGNC : HGNC
Ensembl : ENSG00000114026
HPRD : 03582
Vega : OTTHUMG00000097091
ProteinUniProt: O15527
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_OGG1
BioGPS: 4968
PathwayNCI Pathway Interaction Database: OGG1
KEGG: OGG1
REACTOME: OGG1
Pathway Commons: OGG1
ContextiHOP: OGG1
ligand binding site mutation search in PubMed: OGG1
UCL Cancer Institute: OGG1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006979response to oxidative stress17148573
GO:0009314response to radiation17148573
GO:0033158regulation of protein import into nucleus, translocation17148573


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Ligand binding site mutations for OGG1
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
F144F142LCOAD1
Q287T285MCOAD1
F45W47LLUAD1
L133R131GSKCM1
S292P291QSKCM1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for OGG1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
S292P291Q-0.91439604
F144F142L-0.81209443
Q287T285M-0.44237183
L133R131G-0.43671411
F45W47L-0.015322738
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for OGG1 from PDB

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Differential gene expression and gene-gene network for OGG1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of OGG1 and the right PPI network was created from samples without mutations in the LBS of OGG1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for OGG1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0024121Lung Neoplasms12Biomarker, GeneticVariation, Therapeutic
umls:C0001418Adenocarcinoma10Biomarker, GeneticVariation
umls:C0011860Diabetes Mellitus, Type 27Biomarker, GeneticVariation
umls:C0152013Adenocarcinoma of lung7Biomarker, GeneticVariation
umls:C0007134Carcinoma, Renal Cell3AlteredExpression, Biomarker, GeneticVariation
umls:C0020179Huntington Disease3Biomarker, GeneticVariation
umls:C0279702Hypernephroma3Biomarker, GeneticVariation
umls:C0020507Hyperplasia2Biomarker, GeneticVariation
umls:C0033578Prostatic Neoplasms2Biomarker, GeneticVariation
umls:C0024299Lymphoma2Biomarker, Therapeutic
umls:C0021364Infertility, Male1Biomarker, GeneticVariation
umls:C0006111Brain Diseases1Biomarker
umls:C0018799Heart Diseases1Therapeutic
umls:C0026613Motor Skills Disorders1Biomarker
umls:C0033054Prenatal Exposure Delayed Effects1Biomarker
umls:C0086468Prenatal Injuries1Biomarker
umls:C0037274Skin Diseases1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for OGG1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of OGG1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids1yqlAF144
NUCNucleic Acids1yqmAF144
NUCNucleic Acids1yqrAF144
NUCNucleic Acids2nolAF144
NUCNucleic Acids2nozAF144
BRG8-BROMOGUANINE1lwwAF45
NUCNucleic Acids1n3cAF45
NUCNucleic Acids2xhiAF45
OXG8-OXOGUANINE1hu0AF45 F144
ANG8-AMINOGUANINE1lwvAF45 F144
ANG8-AMINOGUANINE1m3qAF45 F144
NUCNucleic Acids2noeAF45 F144
NUCNucleic Acids1ebmAQ287
NUCNucleic Acids1fn7AQ287
NUCNucleic Acids1hu0AQ287
NUCNucleic Acids1lwvAQ287
NUCNucleic Acids1lwwAQ287
NUCNucleic Acids1lwyAQ287
NUCNucleic Acids1m3hAQ287
NUCNucleic Acids1n39AQ287
NUCNucleic Acids1n3aAQ287
NUCNucleic Acids1n3cAQ287
NUCNucleic Acids1yqlAQ287
NUCNucleic Acids1yqrAQ287
NUCNucleic Acids2nolAQ287
NUCNucleic Acids2xhiAQ287
NUCNucleic Acids3ih7AQ287
NUCNucleic Acids3ktuAQ287
NUCNucleic Acids1m3qAQ287 S292
NUCNucleic Acids1yqmAQ287 S292
NUCNucleic Acids1yqkAS292
NUCNucleic Acids2i5wAS292
NUCNucleic Acids2noiAS292


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Conservation information for LBS of OGG1
Multiple alignments for O15527 in multiple species
LBSAA sequence# speciesSpecies
A288PTTSQAK----1Homo sapiens
A288PHLTGQK----1Drosophila melanogaster
A288PDLAGAK----1Arabidopsis thaliana
A288ANKNHLKELRT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A288PKTSQAK----1Mus musculus
A288PKTSQTK----1Rattus norvegicus
C241AHKALCTLPGV2Mus musculus, Rattus norvegicus
C241AHKALCILPGV1Homo sapiens
C241AREELTLLPGI1Drosophila melanogaster
C241AVAALCTLPGV1Arabidopsis thaliana
C241VREHLMSYNGV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C253TKVADCICLMA2Homo sapiens, Rattus norvegicus
C253YKVADCICLMS1Drosophila melanogaster
C253PKVAACIALFS1Arabidopsis thaliana
C253PKVADCVCLMG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C253AKVADCICLMA1Mus musculus
D268QAVPVDVHMWH1Homo sapiens
D268ESVPVDIHIYR1Drosophila melanogaster
D268SAIPVDTHVWQ1Arabidopsis thaliana
D268GIVPVDVHVSR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D268QAVPVDVHVWQ1Mus musculus
D268QAVPVDIHVWQ1Rattus norvegicus
F144ECLFSFICSSN3Homo sapiens, Mus musculus, Rattus norvegicus
F144ENIFSFLCSQN1Drosophila melanogaster
F144ECLIQFLCSSN1Arabidopsis thaliana
F144ETLISFICSSN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F319AQAVLFSADL-3Homo sapiens, Mus musculus, Rattus norvegicus
F319AQAILFSADL-1Drosophila melanogaster
F319AQTLLFIAELP1Arabidopsis thaliana
F319AQGVLFSKEI-1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F45PSGQSFRWR--1Homo sapiens
F45LGGQSFRWRSI1Drosophila melanogaster
F45PTGQTFRWK--1Arabidopsis thaliana
F45QAGQSFRW---1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F45ASGQSFRWK--1Mus musculus
F45ASGQSFRWR--1Rattus norvegicus
G200HLRKLGLGYRA3Homo sapiens, Mus musculus, Rattus norvegicus
G200QLRAAKFGYRA1Drosophila melanogaster
G200EFRKAGFGYRA1Arabidopsis thaliana
G200KLRELGFGYRA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G202RKLGLGYRARY3Homo sapiens, Mus musculus, Rattus norvegicus
G202RAAKFGYRAKF1Drosophila melanogaster
G202RKAGFGYRAKY1Arabidopsis thaliana
G202RELGFGYRAKY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G245LCILPGVGTKV1Homo sapiens
G245LTLLPGIGYKV1Drosophila melanogaster
G245LCTLPGVGPKV1Arabidopsis thaliana
G245LMSYNGVGPKV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G245LCTLPGVGAKV1Mus musculus
G245LCTLPGVGTKV1Rattus norvegicus
G247ILPGVGTKVAD1Homo sapiens
G247LLPGIGYKVAD1Drosophila melanogaster
G247TLPGVGPKVAA1Arabidopsis thaliana
G247SYNGVGPKVAD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G247TLPGVGAKVAD1Mus musculus
G247TLPGVGTKVAD1Rattus norvegicus
G42LVLASGQSFRW2Mus musculus, Rattus norvegicus
G42LVLPSGQSFRW1Homo sapiens
G42RTLLGGQSFRW1Drosophila melanogaster
G42LTFPTGQTFRW1Arabidopsis thaliana
G42NVLQAGQSFRW1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H270VPVDVHMWHIA1Homo sapiens
H270VPVDIHIYRIA1Drosophila melanogaster
H270IPVDTHVWQIA1Arabidopsis thaliana
H270VPVDVHVSRIA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H270VPVDVHVWQIA1Mus musculus
H270VPVDIHVWQIA1Rattus norvegicus
I152SSNNNIARITG3Homo sapiens, Mus musculus, Rattus norvegicus
I152SQNNNIKRISS1Drosophila melanogaster
I152SSNNNIARITK1Arabidopsis thaliana
I152SSNNNISRITR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I155NNIARITGMVE3Homo sapiens, Mus musculus, Rattus norvegicus
I155NNIKRISSMIE1Drosophila melanogaster
I155NNIARITKMVD1Arabidopsis thaliana
I155NNISRITRMCN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I242HKALCTLPGVG2Mus musculus, Rattus norvegicus
I242HKALCILPGVG1Homo sapiens
I242REELTLLPGIG1Drosophila melanogaster
I242VAALCTLPGVG1Arabidopsis thaliana
I242REHLMSYNGVG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K249PGVGTKVADCI2Homo sapiens, Rattus norvegicus
K249PGIGYKVADCI1Drosophila melanogaster
K249PGVGPKVAACI1Arabidopsis thaliana
K249NGVGPKVADCV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K249PGVGAKVADCI1Mus musculus
L133QGVRLLRQDPT2Mus musculus, Rattus norvegicus
L133QGVRLLRQDPI1Homo sapiens
L133-PVRLLSQEPF1Drosophila melanogaster
L133RGARVLRQDPL1Arabidopsis thaliana
L133QGIRILAQEPW1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L243KALCILPGVGT1Homo sapiens
L243EELTLLPGIGY1Drosophila melanogaster
L243AALCTLPGVGP1Arabidopsis thaliana
L243EHLMSYNGVGP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L243KALCTLPGVGA1Mus musculus
L243KALCTLPGVGT1Rattus norvegicus
M257DCICLMALDKP3Homo sapiens, Mus musculus, Rattus norvegicus
M257DCICLMSMGHL1Drosophila melanogaster
M257ACIALFSLDQH1Arabidopsis thaliana
M257DCVCLMGLHMD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M271PVDVHMWHIAQ1Homo sapiens
M271PVDIHIYRIAQ1Drosophila melanogaster
M271PVDTHVWQIAT1Arabidopsis thaliana
M271PVDVHVSRIAK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M271PVDVHVWQIAH1Mus musculus
M271PVDIHVWQIAH1Rattus norvegicus
N149FICSSNNNIAR3Homo sapiens, Mus musculus, Rattus norvegicus
N149FLCSQNNNIKR1Drosophila melanogaster
N149FLCSSNNNIAR1Arabidopsis thaliana
N149FICSSNNNISR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N150ICSSNNNIARI3Homo sapiens, Mus musculus, Rattus norvegicus
N150LCSQNNNIKRI1Drosophila melanogaster
N150LCSSNNNIARI1Arabidopsis thaliana
N150ICSSNNNISRI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N151CSSNNNIARIT4Homo sapiens, Arabidopsis thaliana, Mus musculus, Rattus norvegicus
N151CSQNNNIKRIS1Drosophila melanogaster
N151CSSNNNISRIT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P244ALCILPGVGTK1Homo sapiens
P244ELTLLPGIGYK1Drosophila melanogaster
P244ALCTLPGVGPK1Arabidopsis thaliana
P244HLMSYNGVGPK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P244ALCTLPGVGAK1Mus musculus
P244ALCTLPGVGTK1Rattus norvegicus
P266KPQAVPVDVHM1Homo sapiens
P266HLESVPVDIHI1Drosophila melanogaster
P266QHSAIPVDTHV1Arabidopsis thaliana
P266MDGIVPVDVHV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P266KPQAVPVDVHV1Mus musculus
P266KPQAVPVDIHV1Rattus norvegicus
P293--GPSPLANKE2Mus musculus, Rattus norvegicus
P293--GPSPQTNKE1Homo sapiens
P293--NVTKKIYEE1Drosophila melanogaster
P293---LTPKLHGR1Arabidopsis thaliana
P293KYNALPISRKK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q287HPTTSQAK---1Homo sapiens
Q287LPHLTGQK---1Drosophila melanogaster
Q287LPDLAGAK---1Arabidopsis thaliana
Q287SANKNHLKELR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q287HPKTSQAK---1Mus musculus
Q287QPKTSQTK---1Rattus norvegicus
Q294-GPSPLANKEL2Mus musculus, Rattus norvegicus
Q294-GPSPQTNKEL1Homo sapiens
Q294-NVTKKIYEEV1Drosophila melanogaster
Q294--LTPKLHGRV1Arabidopsis thaliana
Q294YNALPISRKKI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q315YAGWAQAVLFS3Homo sapiens, Mus musculus, Rattus norvegicus
Q315YAGWAQAILFS1Drosophila melanogaster
Q315YAGWAQTLLFI1Arabidopsis thaliana
Q315YAGWAQGVLFS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q43VLPSGQSFRWR1Homo sapiens
Q43TLLGGQSFRWR1Drosophila melanogaster
Q43TFPTGQTFRWK1Arabidopsis thaliana
Q43VLQAGQSFRW-1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q43VLASGQSFRWK1Mus musculus
Q43VLASGQSFRWR1Rattus norvegicus
R154NNNIARITGMV3Homo sapiens, Mus musculus, Rattus norvegicus
R154NNNIKRISSMI1Drosophila melanogaster
R154NNNIARITKMV1Arabidopsis thaliana
R154NNNISRITRMC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R197VEAHLRKLGLG1Homo sapiens
R197LNAQLRAAKFG1Drosophila melanogaster
R197SEEEFRKAGFG1Arabidopsis thaliana
R197TEAKLRELGFG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R197AETHLRKLGLG1Mus musculus
R197VETHLRKLGLG1Rattus norvegicus
R204LGLGYRARYVS1Homo sapiens
R204AKFGYRAKFIA1Drosophila melanogaster
R204AGFGYRAKYIT1Arabidopsis thaliana
R204LGFGYRAKYII1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R204LGLGYRARYVR1Mus musculus
R204LGLGYRARYVC1Rattus norvegicus
S147FSFICSSNNNI3Homo sapiens, Mus musculus, Rattus norvegicus
S147FSFLCSQNNNI1Drosophila melanogaster
S147IQFLCSSNNNI1Arabidopsis thaliana
S147ISFICSSNNNI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S148SFICSSNNNIA3Homo sapiens, Mus musculus, Rattus norvegicus
S148SFLCSQNNNIK1Drosophila melanogaster
S148QFLCSSNNNIA1Arabidopsis thaliana
S148SFICSSNNNIS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S292---GPSPLANK2Mus musculus, Rattus norvegicus
S292---GPSPQTNK1Homo sapiens
S292---NVTKKIYE1Drosophila melanogaster
S292----LTPKLHG1Arabidopsis thaliana
S292TKYNALPISRK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T248LPGVGTKVADC2Homo sapiens, Rattus norvegicus
T248LPGIGYKVADC1Drosophila melanogaster
T248LPGVGPKVAAC1Arabidopsis thaliana
T248YNGVGPKVADC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T248LPGVGAKVADC1Mus musculus
V246CILPGVGTKVA1Homo sapiens
V246TLLPGIGYKVA1Drosophila melanogaster
V246CTLPGVGPKVA1Arabidopsis thaliana
V246MSYNGVGPKVA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V246CTLPGVGAKVA1Mus musculus
V246CTLPGVGTKVA1Rattus norvegicus
V250GVGTKVADCIC2Homo sapiens, Rattus norvegicus
V250GIGYKVADCIC1Drosophila melanogaster
V250GVGPKVAACIA1Arabidopsis thaliana
V250GVGPKVADCVC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V250GVGAKVADCIC1Mus musculus
V269AVPVDVHMWHI1Homo sapiens
V269SVPVDIHIYRI1Drosophila melanogaster
V269AIPVDTHVWQI1Arabidopsis thaliana
V269IVPVDVHVSRI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V269AVPVDVHVWQI1Mus musculus
V269AVPVDIHVWQI1Rattus norvegicus
Y203KLGLGYRARYV3Homo sapiens, Mus musculus, Rattus norvegicus
Y203AAKFGYRAKFI1Drosophila melanogaster
Y203KAGFGYRAKYI1Arabidopsis thaliana
Y203ELGFGYRAKYI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y207GYRARYVSASA1Homo sapiens
Y207GYRAKFIAQTL1Drosophila melanogaster
Y207GYRAKYITGTV1Arabidopsis thaliana
Y207GYRAKYIIETA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y207GYRARYVRASA1Mus musculus
Y207GYRARYVCASA1Rattus norvegicus


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