mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for OLR1
Gene summary
Basic gene Info.Gene symbolOLR1
Gene nameoxidized low density lipoprotein (lectin-like) receptor 1
CytomapUCSC genome browser: 12p13.2-p12.3
Type of geneprotein-coding
DescriptionC-type lectin domain family 8 member AhLOX-1lectin-type oxidized LDL receptor 1ox LDL receptor 1oxidized low-density lipoprotein receptor 1oxidized low-density lipoprotein receptor 1, soluble formscavenger receptor class E, member 1
Modification date20141222
dbXrefs MIM : 602601
Ensembl : ENSG00000173391
HPRD : 04003
Vega : OTTHUMG00000168527
ProteinUniProt: P78380
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_OLR1
BioGPS: 4973
PathwayNCI Pathway Interaction Database: OLR1
Pathway Commons: OLR1
ContextiHOP: OLR1
ligand binding site mutation search in PubMed: OLR1
UCL Cancer Institute: OLR1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for OLR1
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for OLR1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for OLR1 from PDB

Differential gene expression and gene-gene network for OLR1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of OLR1 and the right PPI network was created from samples without mutations in the LBS of OLR1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for OLR1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0027051Myocardial Infarction10Biomarker, GeneticVariation
umls:C0020538Hypertension5Biomarker, GeneticVariation
umls:C0017661Glomerulonephritis, IGA1Biomarker
umls:C0018801Heart Failure1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for OLR1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of OLR1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of OLR1
Multiple alignments for P78380 in multiple species
LBSAA sequence# speciesSpecies
D147APCPQDWIWHG1Homo sapiens
D147GPCPQDWLWHK1Mus musculus
D147GPCPQDWIWHK1Rattus norvegicus
D147GPCPQDWLWHE1Bos taurus
F158ENCYLF-HGPF2Mus musculus, Rattus norvegicus
F158ENCYLFSSGSF1Homo sapiens
F158ENCYQFSSGSF1Bos taurus
I149CPQDWIWHGEN1Homo sapiens
I149CPQDWLWHKEN1Mus musculus
I149CPQDWIWHKEN1Rattus norvegicus
I149CPQDWLWHEEN1Bos taurus
L157KENCYLF-HGP2Mus musculus, Rattus norvegicus
L157GENCYLFSSGS1Homo sapiens
L157EENCYQFSSGS1Bos taurus
Y197QQAISYSSFPF1Homo sapiens
Y197LQAISHTTSPF1Mus musculus
Y197LQATSHSTSPF1Rattus norvegicus
Y197QQMIAHSSFPF1Bos taurus

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