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mutLBSgeneDB |
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| Gene summary for OPRD1 |
 Gene summary |
| Basic gene Info. | Gene symbol | OPRD1 |
| Gene name | opioid receptor, delta 1 | |
| Synonyms | OPRD | |
| Cytomap | UCSC genome browser: 1p36.1-p34.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000911.3, | |
| Description | D-OR-1DOR-1delta opioid receptor 1delta-type opioid receptor | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 165195 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000116329 | ||
| HPRD : 01308 | ||
| Vega : OTTHUMG00000003646 | ||
| Protein | UniProt: P41143 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_OPRD1 | |
| BioGPS: 4985 | ||
| Pathway | NCI Pathway Interaction Database: OPRD1 | |
| KEGG: OPRD1 | ||
| REACTOME: OPRD1 | ||
| Pathway Commons: OPRD1 | ||
| Context | iHOP: OPRD1 | |
| ligand binding site mutation search in PubMed: OPRD1 | ||
| UCL Cancer Institute: OPRD1 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0000060 | protein import into nucleus, translocation | 16325578 | GO:0007186 | G-protein coupled receptor signaling pathway | 16325578 | GO:0010629 | negative regulation of gene expression | 24613828 | GO:0032460 | negative regulation of protein oligomerization | 24613828 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 24613828 | GO:0051881 | regulation of mitochondrial membrane potential | 24613828 | GO:0071456 | cellular response to hypoxia | 24613828 | GO:0097237 | cellular response to toxic substance | 24613828 |
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| Ligand binding site mutations for OPRD1 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | I148 | V150F | BLCA | 1 | G268 | A269T | BRCA | 1 | V272 | V271M | COAD | 1 | F320 | A319T | COAD | 1 | D128 | D128N | COAD | 1 | V316 | V316M | COAD | 1 | I304 | A305T | COAD | 1 | W274 | A275V | GBM | 1 | V272,W274 | C273Y | KICH | 1 | I148 | A149T | KIRC | 1 | M199 | C198F | LUAD | 1 | D293 | D293H | LUSC | 1 | L313 | N314S | SKCM | 1 | Y87 | I88T | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for OPRD1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | D128 | D128N | -1.5743475 | Y87 | I88T | -1.4649109 | I304 | A305T | -1.3145211 | I148 | V150F | -1.1561666 | G268 | A269T | -1.1300054 | V316 | V316M | -0.89471134 | I148 | A149T | -0.88524834 | V272 | V271M | -0.85330875 | L313 | N314S | -0.8176953 | F320 | A319T | -0.78933038 | V272 | C273Y | -0.73940806 | W274 | C273Y | -0.73940806 | D293 | D293H | -0.44087765 | W274 | A275V | -0.42558673 | M199 | C198F | -0.014124277 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for OPRD1 from PDB |
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| Differential gene expression and gene-gene network for OPRD1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for OPRD1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0236969 | Substance-Related Disorders | 3 | Biomarker, GeneticVariation |
| umls:C0014544 | Epilepsy | 1 | Biomarker |
| umls:C0020651 | Hypotension, Orthostatic | 1 | Biomarker |
| umls:C0038587 | Substance Withdrawal Syndrome | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for OPRD1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved|investigational | DB00193 | Tramadol | Small molecule |  |
| Approved|investigational | DB00295 | Morphine | Small molecule |  |
| Approved|illicit | DB00318 | Codeine | Small molecule |  |
| Approved | DB00321 | Amitriptyline | Small molecule |  |
| Approved|illicit | DB00327 | Hydromorphone | Small molecule |  |
| Approved | DB00333 | Methadone | Small molecule |  |
| Approved|illicit|investigational | DB00497 | Oxycodone | Small molecule |  |
| Approved | DB00514 | Dextromethorphan | Small molecule |  |
| Approved|illicit|vet_approved | DB00611 | Butorphanol | Small molecule |  |
| Approved|illicit|withdrawn | DB00647 | Dextropropoxyphene | Small molecule |  |
| Approved|investigational|vet_approved | DB00704 | Naltrexone | Small molecule |  |
| Approved|investigational | DB00708 | Sufentanil | Small molecule |  |
| Approved|illicit|investigational|vet_approved | DB00813 | Fentanyl | Small molecule |  |
| Approved | DB00836 | Loperamide | Small molecule |  |
| Approved | DB00844 | Nalbuphine | Small molecule |  |
| Approved | DB00854 | Levorphanol | Small molecule |  |
| Approved | DB00899 | Remifentanil | Small molecule |  |
| Approved|illicit|investigational|vet_approved | DB00921 | Buprenorphine | Small molecule |  |
| Approved|illicit | DB00956 | Hydrocodone | Small molecule |  |
| Approved|illicit | DB01081 | Diphenoxylate | Small molecule |  |
| Approved|vet_approved | DB01183 | Naloxone | Small molecule |  |
| Approved|investigational|vet_approved | DB01192 | Oxymorphone | Small molecule |  |
| Approved|vet_approved | DB01221 | Ketamine | Small molecule |  |
| Experimental|illicit | DB01439 | 3-Methylthiofentanyl | Small molecule |  |
| Experimental|illicit | DB01444 | Dimethylthiambutene | Small molecule |  |
| Approved|illicit | DB01452 | Heroin | Small molecule |  |
| Illicit|vet_approved | DB01497 | Etorphine | Small molecule |  |
| Illicit|vet_approved | DB01535 | Carfentanil | Small molecule |  |
| Illicit|vet_approved | DB01548 | Diprenorphine | Small molecule |  |
| Experimental|illicit | DB01565 | Dihydromorphine | Small molecule |  |
| Illicit | DB01571 | 3-Methylfentanyl | Small molecule |  |
| Investigational | DB05050 | ADL5859 | Small molecule |  |
| Approved | DB06204 | Tapentadol | Small molecule |  |
| Approved | DB06274 | Alvimopan | Small molecule |  |
| Approved | DB06738 | Ketobemidone | Small molecule |  |
| Approved | DB09272 | Eluxadoline | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of OPRD1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (TYR,DI8,PHE,PHE,NH2) | 4rwa | B | D128 I304 | III | Peptide ligand (TYR,DI8,PHE,PHE,NH2) | 4rwa | A | D128 M199 I304 | III | Peptide ligand (TYR,DI8,PHE,PHE,NH2) | 4rwd | A | D128 M199 I304 | III | Peptide ligand (TYR,DI8,PHE,PHE,NH2) | 4rwd | B | D128 M199 I304 | EJ4 | NALTRINDOLE | 4n6h | A | D128 W274 I304 | OLA | OLEIC ACID | 4n6h | A | D293 | OLA | OLEIC ACID | 4n6h | A | G268 V272 | OLA | OLEIC ACID | 4n6h | A | L313 V316 F320 | OLA | OLEIC ACID | 4n6h | A | Y87 I148 |
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| Conservation information for LBS of OPRD1 |
| Multiple alignments for P41143 in multiple species |
| LBS | AA sequence | # species | Species | A51 | LALAIAITALY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A54 | AIAITALYSAV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A58 | TALYSAVCAVG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D128 | AVLSIDYYNMF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D145 | TMMSVDRYIAV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D290 | TLVDINRRDPL | 2 | Mus musculus, Rattus norvegicus | D290 | TLVDIDRRDPL | 1 | Homo sapiens | D293 | DINRRDPLVVA | 2 | Mus musculus, Rattus norvegicus | D293 | DIDRRDPLVVA | 1 | Homo sapiens | F116 | METWPFGELLC | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F137 | MFTSIFTLTMM | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F159 | VKALDFRTPAK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F320 | PVLYAFLDENF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G268 | VLVVVGAFVVC | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G307 | LCIALGYANSS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I148 | SVDRYIAVCHP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I168 | AKAKLINICIW | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I277 | VCWAPIHIFVI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I279 | WAPIHIFVIVW | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I289 | WTLVDINRRDP | 2 | Mus musculus, Rattus norvegicus | I289 | WTLVDIDRRDP | 1 | Homo sapiens | I304 | ALHLCIALGYA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K214 | WDTVTKICVFL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L125 | LCKAVLSIDYY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L175 | ICIWVLASGVG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L200 | AVVCMLQFPSP | 2 | Homo sapiens, Mus musculus | L200 | AVVCTLQFPSP | 1 | Rattus norvegicus | L295 | NRRDPLVVAAL | 2 | Mus musculus, Rattus norvegicus | L295 | DRRDPLVVAAL | 1 | Homo sapiens | L300 | LVVAALHLCIA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L313 | YANSSLNPVLY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L48 | ASSLALAIAIT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L55 | IAITALYSAVC | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | M132 | IDYYNMFTSIF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | M141 | IFTLTMMSVDR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | M199 | GAVVCMLQFPS | 2 | Homo sapiens, Mus musculus | M199 | GAVVCTLQFPS | 1 | Rattus norvegicus | P103 | ATSTLPFQSAK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P115 | LMETWPFGELL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P294 | INRRDPLVVAA | 2 | Mus musculus, Rattus norvegicus | P294 | IDRRDPLVVAA | 1 | Homo sapiens | R261 | LRRITRMVLVV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S44 | GARSASSLALA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V217 | VTKICVFLFAF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V272 | VGAFVVCWAPI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V281 | PIHIFVIVWTL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V296 | RRDPLVVAALH | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V316 | SSLNPVLYAFL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | W274 | AFVVCWAPIHI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | W284 | IFVIVWTLVDI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y129 | VLSIDYYNMFT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y233 | IITVCYGLMLL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y308 | CIALGYANSSL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y87 | TATNIYIFNLA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus |
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