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mutLBSgeneDB |
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| Gene summary for OPRK1 |
 Gene summary |
| Basic gene Info. | Gene symbol | OPRK1 |
| Gene name | opioid receptor, kappa 1 | |
| Synonyms | K-OR-1|KOR|KOR-1|OPRK | |
| Cytomap | UCSC genome browser: 8q11.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000912.3, NM_001282904.1, | |
| Description | Opiate receptor, kappa-1kappa opioid receptorkappa-type opioid receptor | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 165196 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000082556 | ||
| HPRD : 01309 | ||
| Vega : OTTHUMG00000164276 | ||
| Protein | UniProt: P41145 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_OPRK1 | |
| BioGPS: 4986 | ||
| Pathway | NCI Pathway Interaction Database: OPRK1 | |
| KEGG: OPRK1 | ||
| REACTOME: OPRK1 | ||
| Pathway Commons: OPRK1 | ||
| Context | iHOP: OPRK1 | |
| ligand binding site mutation search in PubMed: OPRK1 | ||
| UCL Cancer Institute: OPRK1 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006955 | immune response | 8755601 | GO:0031635 | adenylate cyclase-inhibiting opioid receptor signaling pathway | 22437504 | GO:0038003 | opioid receptor signaling pathway | 8755601 | GO:0051607 | defense response to virus | 8755601 |
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| Ligand binding site mutations for OPRK1 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | W287 | V285I | BRCA | 1 | M142 | F143L | COAD | 1 | I290,I294 | I292V | LUAD | 1 | G319 | G319D | LUAD | 1 | I290 | P289L | SKCM | 1 | D138 | S136F | SKCM | 1 | W124 | S123F | SKCM | 1 | V230 | V230I | STAD | 1 | I316 | A317T | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for OPRK1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | I316 | A317T | -1.0745259 | V230 | V230I | -0.8881768 | G319 | G319D | -0.84915852 | W287 | V285I | -0.81993224 | I290 | I292V | -0.80756207 | I294 | I292V | -0.80756207 | W124 | S123F | -0.60954774 | I290 | P289L | -0.57528713 | M142 | F143L | -0.56069294 | D138 | S136F | -0.43868419 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for OPRK1 from PDB |
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| Differential gene expression and gene-gene network for OPRK1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for OPRK1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0236736 | Cocaine-Related Disorders | 3 | Biomarker, GeneticVariation |
| umls:C0038587 | Substance Withdrawal Syndrome | 3 | Biomarker |
| umls:C0030193 | Pain | 2 | Biomarker, GeneticVariation |
| umls:C0036572 | Seizures | 2 | Biomarker, Therapeutic |
| umls:C0003811 | Arrhythmias, Cardiac | 1 | Therapeutic |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for OPRK1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved|investigational | DB00193 | Tramadol | Small molecule |  |
| Approved|investigational | DB00295 | Morphine | Small molecule |  |
| Approved|illicit | DB00318 | Codeine | Small molecule |  |
| Approved | DB00321 | Amitriptyline | Small molecule |  |
| Approved|illicit | DB00327 | Hydromorphone | Small molecule |  |
| Approved | DB00370 | Mirtazapine | Small molecule |  |
| Approved|vet_approved | DB00396 | Progesterone | Small molecule |  |
| Approved | DB00454 | Pethidine | Small molecule |  |
| Approved|illicit|investigational | DB00497 | Oxycodone | Small molecule |  |
| Approved | DB00514 | Dextromethorphan | Small molecule |  |
| Approved|illicit|vet_approved | DB00611 | Butorphanol | Small molecule |  |
| Approved|illicit|withdrawn | DB00647 | Dextropropoxyphene | Small molecule |  |
| Approved|vet_approved | DB00652 | Pentazocine | Small molecule |  |
| Approved|investigational|vet_approved | DB00704 | Naltrexone | Small molecule |  |
| Approved|investigational | DB00708 | Sufentanil | Small molecule |  |
| Approved|illicit|investigational|vet_approved | DB00813 | Fentanyl | Small molecule |  |
| Approved | DB00825 | Menthol | Small molecule |  |
| Approved | DB00836 | Loperamide | Small molecule |  |
| Approved | DB00844 | Nalbuphine | Small molecule |  |
| Approved | DB00854 | Levorphanol | Small molecule |  |
| Approved | DB00899 | Remifentanil | Small molecule |  |
| Approved|illicit|investigational|vet_approved | DB00921 | Buprenorphine | Small molecule |  |
| Approved|vet_approved | DB01183 | Naloxone | Small molecule |  |
| Approved | DB01209 | Dezocine | Small molecule |  |
| Approved|vet_approved | DB01221 | Ketamine | Small molecule |  |
| Experimental|illicit | DB01439 | 3-Methylthiofentanyl | Small molecule |  |
| Approved|illicit | DB01452 | Heroin | Small molecule |  |
| Illicit|vet_approved | DB01497 | Etorphine | Small molecule |  |
| Illicit|vet_approved | DB01535 | Carfentanil | Small molecule |  |
| Illicit|vet_approved | DB01548 | Diprenorphine | Small molecule |  |
| Experimental|illicit | DB01565 | Dihydromorphine | Small molecule |  |
| Illicit | DB01571 | 3-Methylfentanyl | Small molecule |  |
| Investigational | DB05046 | V1003 | Small molecule |  |
| Investigational | DB05104 | Asimadoline | Small molecule |  |
| Investigational | DB05155 | CR665 | Small molecule |  |
| Investigational | DB05443 | ADL 10-0101 | Small molecule |  |
| Approved | DB06148 | Mianserin | Small molecule |  |
| Approved | DB06204 | Tapentadol | Small molecule |  |
| Approved | DB06274 | Alvimopan | Small molecule |  |
| Approved | DB06738 | Ketobemidone | Small molecule |  |
| Approved | DB06800 | Methylnaltrexone | Small molecule |  |
| Approved | DB09272 | Eluxadoline | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of OPRK1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | JDC | (3R)-7-HYDROXY-N-{(2S)-1-[(3R,4R)-4-(3-HYDROXYPHENYL)-3,4-DIMETHYLPIPERIDIN-1-YL]-3-METHYLBUTAN-2-YL}-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXAMIDE | 4djh | B | D138 M142 V230 W287 I290 I294 I316 G319 | JDC | (3R)-7-HYDROXY-N-{(2S)-1-[(3R,4R)-4-(3-HYDROXYPHENYL)-3,4-DIMETHYLPIPERIDIN-1-YL]-3-METHYLBUTAN-2-YL}-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXAMIDE | 4djh | A | W124 D138 M142 V230 W287 I290 I294 I316 G319 |
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| Conservation information for LBS of OPRK1 |
| Multiple alignments for P41145 in multiple species |
| LBS | AA sequence | # species | Species | C210 | VDVIECSLQFP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C210 | MEVIECSLQFP | 1 | Bos taurus | D138 | IVISIDYYNMF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D138 | VVISIDYYNMF | 1 | Bos taurus | G319 | FCIALGYTNSS | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | I290 | VCWTPIHIFIL | 2 | Homo sapiens, Bos taurus | I290 | ICWTPIHIFIL | 2 | Mus musculus, Rattus norvegicus | I294 | PIHIFILVEAL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | I316 | SYYFCIALGYT | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | K227 | WDLFMKICVFV | 2 | Mus musculus, Rattus norvegicus | K227 | WDLFMKICVFI | 1 | Homo sapiens | K227 | WDLFMKVCVFV | 1 | Bos taurus | M142 | IDYYNMFTSIF | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | Q115 | TTMPFQSTVYL | 2 | Homo sapiens, Bos taurus | Q115 | TTMPFQSAVYL | 2 | Mus musculus, Rattus norvegicus | T111 | ALVTTTMPFQS | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | V108 | LADALVTTTMP | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | V230 | FMKICVFVFAF | 2 | Mus musculus, Rattus norvegicus | V230 | FMKICVFIFAF | 1 | Homo sapiens | V230 | FMKVCVFVFAF | 1 | Bos taurus | W124 | YLMNSWPFGDV | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | W287 | VFVVCWTPIHI | 2 | Homo sapiens, Bos taurus | W287 | VFIICWTPIHI | 2 | Mus musculus, Rattus norvegicus | Y139 | VISIDYYNMFT | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | Y320 | CIALGYTNSSL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus |
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