mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ORM2
Gene summary
Basic gene Info.Gene symbolORM2
Gene nameorosomucoid 2
SynonymsAGP-B|AGP-B'|AGP2
CytomapUCSC genome browser: 9q32
Type of geneprotein-coding
RefGenesNM_000608.2,
DescriptionAGP 2OMD 2alpha-1-acid glycoprotein 2alpha-1-acid glycoprotein, type 2orosomucoid-2
Modification date20141207
dbXrefs MIM : 138610
HGNC : HGNC
Ensembl : ENSG00000228278
HPRD : 00725
Vega : OTTHUMG00000021014
ProteinUniProt: P19652
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ORM2
BioGPS: 5005
PathwayNCI Pathway Interaction Database: ORM2
KEGG: ORM2
REACTOME: ORM2
Pathway Commons: ORM2
ContextiHOP: ORM2
ligand binding site mutation search in PubMed: ORM2
UCL Cancer Institute: ORM2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for ORM2

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
S143S143YCOAD1
I62Q63HHNSC1
F130M129TUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for ORM2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
S143S143Y0.34992108
F130M129T-1.4042915
I62Q63H-0.7845008
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ORM2 from PDB

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Differential gene expression and gene-gene network for ORM2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ORM2 and the right PPI network was created from samples without mutations in the LBS of ORM2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for ORM2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for ORM2
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ORM2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of ORM2
Multiple alignments for P19652 in multiple species
LBSAA sequence# speciesSpecies


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