mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for P2RY1
Gene summary
Basic gene Info.Gene symbolP2RY1
Gene namepurinergic receptor P2Y, G-protein coupled, 1
SynonymsP2Y1
CytomapUCSC genome browser: 3q25.2
Type of geneprotein-coding
RefGenesNM_002563.3,
DescriptionATP receptorP2 purinoceptor subtype Y1P2Y purinoceptor 1platelet ADP receptor
Modification date20141207
dbXrefs MIM : 601167
HGNC : HGNC
Ensembl : ENSG00000169860
HPRD : 03103
Vega : OTTHUMG00000159694
ProteinUniProt: P47900
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_P2RY1
BioGPS: 5028
PathwayNCI Pathway Interaction Database: P2RY1
KEGG: P2RY1
REACTOME: P2RY1
Pathway Commons: P2RY1
ContextiHOP: P2RY1
ligand binding site mutation search in PubMed: P2RY1
UCL Cancer Institute: P2RY1
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for P2RY1
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
I178V179ABLCA1
S213R212QBRCA1
Y217I216FBRCA1
C220T221MCOAD1
T143T143ACOAD1
M279M279ICOAD1
Q291P293QCOAD1
V181A182VCOAD1
R195R195HHNSC1
T305,Y303A304VHNSC1
V228P229HLUAD1
K46T47MLUAD1
A286A286VLUAD1
R195R195HLUSC1
P105P105LLUSC1
P185,Y189L187HSKCM1
T305T305RSTAD1
V181V180AUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for P2RY1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
Y303A304V0.079204266
T305A304V0.079204266
P185L187H-1.663923
Y189L187H-1.663923
V181V180A-1.5736049
T305T305R-1.4147418
Y217I216F-1.4049311
I178V179A-1.1951691
T143T143A-1.0184848
S213R212Q-0.89635403
R195R195H-0.84426301
M279M279I-0.7530239
V228P229H-0.7070263
K46T47M-0.53027116
Q291P293Q-0.46142031
A286A286V-0.35904479
C220T221M-0.35072745
P105P105L-0.30034796
V181A182V-0.043610058
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for P2RY1 from PDB

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Differential gene expression and gene-gene network for P2RY1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of P2RY1 and the right PPI network was created from samples without mutations in the LBS of P2RY1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for P2RY1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0040053Thrombosis1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for P2RY1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of P2RY1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
2ID[(1R,2S,4S,5S)-4-[2-IODO-6-(METHYLAMINO)-9H-PURIN-9- YL]-2-(PHOSPHONOOXY)BICYCLO[3.1.0]HEX-1-YL]METHYL DIHYDROGEN PHOSPHATE4xnwAK46 R195 A286 Q291 Y303
2ID[(1R,2S,4S,5S)-4-[2-IODO-6-(METHYLAMINO)-9H-PURIN-9- YL]-2-(PHOSPHONOOXY)BICYCLO[3.1.0]HEX-1-YL]METHYL DIHYDROGEN PHOSPHATE4xnwCK46 R195 A286 Q291 Y303
Y01CHOLESTEROL HYDROGEN SUCCINATE4xnvAM279 T305
BUR1-[2-(2-TERT-BUTYLPHENOXY)PYRIDIN-3-YL]-3-[4- (TRIFLUOROMETHOXY)PHENYL]UREA4xnvAP105
Y01CHOLESTEROL HYDROGEN SUCCINATE4xnvAT143 I178 V228
CLRCHOLESTEROL4xnvAV181 P185 Y189 S213 Y217 C220


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Conservation information for LBS of P2RY1
Multiple alignments for P47900 in multiple species
LBSAA sequence# speciesSpecies
A106VLTLPALIFYY5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
A147LTCISAHRYSG4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
A147LTCISVHRYTG1Gallus gallus
A224MCTTVAMFCVP2Homo sapiens, Bos taurus
A224MCTTVAMFCIP2Mus musculus, Rattus norvegicus
A224MCTTVFMFCIP1Gallus gallus
A270VLTVFAVSYIP4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
A270VLTVFAVSYLP1Gallus gallus
A286TMNLRARLDFQ4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
A286TLNLRARLDFQ1Gallus gallus
C144ILFLTCISAHR4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
C144ILFLTCISVHR1Gallus gallus
C220FIYSMCTTVAM4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
C220FVYSMCTTVFM1Gallus gallus
C42SSSFKCALTKT1Homo sapiens
C42----KCSLTKT1Gallus gallus
C42SSSFQCALTKT1Mus musculus
C42SSSFRCALIKT1Rattus norvegicus
C42ASPFKCALTKT1Bos taurus
D204TITCYDTTSDE2Homo sapiens, Bos taurus
D204TITCYDTTADE1Gallus gallus
D204TVTCYDTTSND1Mus musculus
D204TVTCYDSTSDE1Rattus norvegicus
F109LPALIFYYFNK5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
F112LIFYYFNKTDW5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
F119KTDWIFGDAMC3Homo sapiens, Mus musculus, Bos taurus
F119KTDWIFGDVMC2Gallus gallus, Rattus norvegicus
F62VYILVFIIGFL4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
F62VYILVFITGFL1Gallus gallus
F66VFIIGFLGNSV4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
F66VFITGFLGNSV1Gallus gallus
H148TCISAHRYSGV4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
H148TCISVHRYTGV1Gallus gallus
I108TLPALIFYYFN5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
I171KNAIYVSVLVW2Mus musculus, Rattus norvegicus
I171KNAICISVLVW1Homo sapiens
I171KNAVYVSSLVW1Gallus gallus
I171KNAVYISVLVW1Bos taurus
I178VLVWLIVVVAI3Homo sapiens, Mus musculus, Rattus norvegicus
I178SLVWALVVAVI1Gallus gallus
I178VLVWLIVVVGI1Bos taurus
I274FAVSYIPFHVM4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
I274FAVSYLPFHVM1Gallus gallus
I59LPAVYILVFII4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
I59LPTVYILVFIT1Gallus gallus
I63YILVFIIGFLG4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
I63YILVFITGFLG1Gallus gallus
K46KCALTKTGFQF2Homo sapiens, Bos taurus
K46KCSLTKTGFQF1Gallus gallus
K46QCALTKTGFQF1Mus musculus
K46RCALIKTGFQF1Rattus norvegicus
L102DFLYVLTLPAL5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
L126DAMCKLQRFIF3Homo sapiens, Mus musculus, Bos taurus
L126DVMCKLQRFIF2Gallus gallus, Rattus norvegicus
L232CVPLVLILGCY2Homo sapiens, Bos taurus
L232CIPLVLILGCY2Mus musculus, Rattus norvegicus
L232CIPFIVILGCY1Gallus gallus
L44SFKCALTKTGF1Homo sapiens
L44--KCSLTKTGF1Gallus gallus
L44SFQCALTKTGF1Mus musculus
L44SFRCALIKTGF1Rattus norvegicus
L44PFKCALTKTGF1Bos taurus
L67FIIGFLGNSVA4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L67FITGFLGNSVA1Gallus gallus
M123IFGDAMCKLQR3Homo sapiens, Mus musculus, Bos taurus
M123IFGDVMCKLQR2Gallus gallus, Rattus norvegicus
M279IPFHVMKTMNL4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
M279LPFHVMKTLNL1Gallus gallus
M282HVMKTMNLRAR4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
M282HVMKTLNLRAR1Gallus gallus
N113IFYYFNKTDWI5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
N283VMKTMNLRARL4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
N283VMKTLNLRARL1Gallus gallus
N299EMCDFNDRVYA2Mus musculus, Rattus norvegicus
N299AMCAFNDRVYA1Homo sapiens
N299QMCAFNDKVYA1Gallus gallus
N299EMCAFNDRVYA1Bos taurus
P105YVLTLPALIFY5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
P185VVAISPILFYS3Homo sapiens, Mus musculus, Rattus norvegicus
P185VAVIAPILFYS1Gallus gallus
P185VVGISPILFYS1Bos taurus
P275AVSYIPFHVMK4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
P275AVSYLPFHVMK1Gallus gallus
Q127AMCKLQRFIFH3Homo sapiens, Mus musculus, Bos taurus
Q127VMCKLQRFIFH2Gallus gallus, Rattus norvegicus
Q291ARLDFQTPEMC3Mus musculus, Rattus norvegicus, Bos taurus
Q291ARLDFQTPAMC1Homo sapiens
Q291ARLDFQTPQMC1Gallus gallus
R195SGTGVRKNKTI1Homo sapiens
R195SGTGVRRNKTI1Gallus gallus
R195SGTGTRKNKTV1Mus musculus
R195SGTGIRKNKTV1Rattus norvegicus
R195SGTGIRKNKTI1Bos taurus
R287MNLRARLDFQT4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
R287LNLRARLDFQT1Gallus gallus
R301CAFNDRVYATY2Homo sapiens, Bos taurus
R301CDFNDRVYATY2Mus musculus, Rattus norvegicus
R301CAFNDKVYATY1Gallus gallus
R310TYQVTRGLASL5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
S213DEYLRSYFIYS3Homo sapiens, Rattus norvegicus, Bos taurus
S213DEYLRSYFVYS1Gallus gallus
S213NDYLRSYFIYS1Mus musculus
T103FLYVLTLPALI5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
T143SILFLTCISAH4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
T143SILFLTCISVH1Gallus gallus
T201KNKTITCYDTT2Homo sapiens, Bos taurus
T201RNKTITCYDTT1Gallus gallus
T201KNKTVTCYDTT1Mus musculus
T201KNKTVTCYDST1Rattus norvegicus
T205ITCYDTTSDEY2Homo sapiens, Bos taurus
T205ITCYDTTADEY1Gallus gallus
T205VTCYDTTSNDY1Mus musculus
T205VTCYDSTSDEY1Rattus norvegicus
T305DRVYATYQVTR4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
T305DKVYATYQVTR1Gallus gallus
V181WLIVVVAISPI3Homo sapiens, Mus musculus, Rattus norvegicus
V181WALVVAVIAPI1Gallus gallus
V181WLIVVVGISPI1Bos taurus
V228VAMFCVPLVLI2Homo sapiens, Bos taurus
V228VAMFCIPLVLI2Mus musculus, Rattus norvegicus
V228VFMFCIPFIVI1Gallus gallus
V278YIPFHVMKTMN4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
V278YLPFHVMKTLN1Gallus gallus
Y110PALIFYYFNKT5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
Y189SPILFYSGTGI2Rattus norvegicus, Bos taurus
Y189SPILFYSGTGV1Homo sapiens
Y189APILFYSGTGV1Gallus gallus
Y189SPILFYSGTGT1Mus musculus
Y203KTITCYDTTSD2Homo sapiens, Bos taurus
Y203KTITCYDTTAD1Gallus gallus
Y203KTVTCYDTTSN1Mus musculus
Y203KTVTCYDSTSD1Rattus norvegicus
Y217RSYFIYSMCTT4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Y217RSYFVYSMCTT1Gallus gallus
Y303FNDRVYATYQV4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Y303FNDKVYATYQV1Gallus gallus
Y306RVYATYQVTRG4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Y306KVYATYQVTRG1Gallus gallus
Y89SGISVYMFNLA5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus


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