mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PEBP1
Gene summary
Basic gene Info.Gene symbolPEBP1
Gene namephosphatidylethanolamine binding protein 1
CytomapUCSC genome browser: 12q24.23
Type of geneprotein-coding
DescriptionRaf kinase inhibitory proteinepididymis luminal protein 210epididymis secretory protein Li 34hippocampal cholinergic neurostimulating peptideneuropolypeptide h3phosphatidylethanolamine-binding protein 1prostatic binding proteinprostatic-binding pro
Modification date20141211
dbXrefs MIM : 604591
Ensembl : ENSG00000089220
HPRD : 06850
Vega : OTTHUMG00000168860
ProteinUniProt: P30086
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PEBP1
BioGPS: 5037
PathwayNCI Pathway Interaction Database: PEBP1
Pathway Commons: PEBP1
ContextiHOP: PEBP1
ligand binding site mutation search in PubMed: PEBP1
UCL Cancer Institute: PEBP1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for PEBP1
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for PEBP1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PEBP1 from PDB

Differential gene expression and gene-gene network for PEBP1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PEBP1 and the right PPI network was created from samples without mutations in the LBS of PEBP1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for PEBP1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0024667Mammary Neoplasms, Animal1Biomarker
umls:C0024668Mammary Neoplasms, Experimental1Biomarker
umls:C0151744Myocardial Ischemia1Biomarker
umls:C0032927Precancerous Conditions1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for PEBP1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PEBP1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of PEBP1
Multiple alignments for P30086 in multiple species
LBSAA sequence# speciesSpecies
A73LTDPDAPSRKD5Homo sapiens, Canis lupus familiaris, Bos taurus, Mus musculus, Rattus norvegicus
D70TLVLTDPDAPS5Homo sapiens, Canis lupus familiaris, Bos taurus, Mus musculus, Rattus norvegicus
G110DYVGSGPPKGT3Homo sapiens, Canis lupus familiaris, Bos taurus
G110DYVGSGPPSGT1Mus musculus
G110EYVGSGPPKDT1Rattus norvegicus
H118KGTGLHRYVWL3Homo sapiens, Canis lupus familiaris, Bos taurus
H118SGTGLHRYVWL1Mus musculus
H118KDTGLHRYVWL1Rattus norvegicus
H86YREWHHFLVVN3Homo sapiens, Canis lupus familiaris, Bos taurus
H86FREWHHFLVVN2Mus musculus, Rattus norvegicus
L184KLYEQLSGK3Homo sapiens, Bos taurus, Mus musculus
L184KLCEQLSGK1Canis lupus familiaris
L184KLHDQLAGK1Rattus norvegicus
P111YVGSGPPKGTG3Homo sapiens, Canis lupus familiaris, Bos taurus
P111YVGSGPPSGTG1Mus musculus
P111YVGSGPPKDTG1Rattus norvegicus
S109SDYVGSGPPKG3Homo sapiens, Canis lupus familiaris, Bos taurus
S109SDYVGSGPPSG1Mus musculus
S109SEYVGSGPPKD1Rattus norvegicus
W84PKYREWHHFLV3Homo sapiens, Canis lupus familiaris, Bos taurus
W84PKFREWHHFLV2Mus musculus, Rattus norvegicus
Y120TGLHRYVWLVY5Homo sapiens, Canis lupus familiaris, Bos taurus, Mus musculus, Rattus norvegicus
Y181YVPKLYEQLSG3Homo sapiens, Bos taurus, Mus musculus
Y181YVPKLCEQLSG1Canis lupus familiaris
Y181SVPKLHDQLAG1Rattus norvegicus

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