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mutLBSgeneDB |
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| Gene summary for PEBP1 |
 Gene summary |
| Basic gene Info. | Gene symbol | PEBP1 |
| Gene name | phosphatidylethanolamine binding protein 1 | |
| Synonyms | HCNP|HCNPpp|HEL-210|HEL-S-34|PBP|PEBP|PEBP-1|RKIP | |
| Cytomap | UCSC genome browser: 12q24.23 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002567.2, | |
| Description | Raf kinase inhibitory proteinepididymis luminal protein 210epididymis secretory protein Li 34hippocampal cholinergic neurostimulating peptideneuropolypeptide h3phosphatidylethanolamine-binding protein 1prostatic binding proteinprostatic-binding pro | |
| Modification date | 20141211 | |
| dbXrefs | MIM : 604591 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000089220 | ||
| HPRD : 06850 | ||
| Vega : OTTHUMG00000168860 | ||
| Protein | UniProt: P30086 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PEBP1 | |
| BioGPS: 5037 | ||
| Pathway | NCI Pathway Interaction Database: PEBP1 | |
| KEGG: PEBP1 | ||
| REACTOME: PEBP1 | ||
| Pathway Commons: PEBP1 | ||
| Context | iHOP: PEBP1 | |
| ligand binding site mutation search in PubMed: PEBP1 | ||
| UCL Cancer Institute: PEBP1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for PEBP1 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | G110 | G110W | LUAD | 1 | H118 | G116D | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for PEBP1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | H118 | G116D | -0.25819047 | G110 | G110W | -0.010568451 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PEBP1 from PDB |
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| Differential gene expression and gene-gene network for PEBP1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for PEBP1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0007097 | Carcinoma | 4 | Biomarker |
| umls:C0024667 | Mammary Neoplasms, Animal | 1 | Biomarker |
| umls:C0024668 | Mammary Neoplasms, Experimental | 1 | Biomarker |
| umls:C0151744 | Myocardial Ischemia | 1 | Biomarker |
| umls:C0032927 | Precancerous Conditions | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for PEBP1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of PEBP1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | CAC | DIMETHYLARSINATE | 1beh | A | G110 | CAC | DIMETHYLARSINATE | 1beh | B | G110 H118 | PTR | O(4)-PHOSPHO-L-TYROSINE | 2qyq | A | G110 H118 |
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| Conservation information for LBS of PEBP1 |
| Multiple alignments for P30086 in multiple species |
| LBS | AA sequence | # species | Species | A73 | LTDPDAPSRKD | 5 | Homo sapiens, Canis lupus familiaris, Bos taurus, Mus musculus, Rattus norvegicus | D70 | TLVLTDPDAPS | 5 | Homo sapiens, Canis lupus familiaris, Bos taurus, Mus musculus, Rattus norvegicus | G110 | DYVGSGPPKGT | 3 | Homo sapiens, Canis lupus familiaris, Bos taurus | G110 | DYVGSGPPSGT | 1 | Mus musculus | G110 | EYVGSGPPKDT | 1 | Rattus norvegicus | H118 | KGTGLHRYVWL | 3 | Homo sapiens, Canis lupus familiaris, Bos taurus | H118 | SGTGLHRYVWL | 1 | Mus musculus | H118 | KDTGLHRYVWL | 1 | Rattus norvegicus | H86 | YREWHHFLVVN | 3 | Homo sapiens, Canis lupus familiaris, Bos taurus | H86 | FREWHHFLVVN | 2 | Mus musculus, Rattus norvegicus | L184 | KLYEQLSGK | 3 | Homo sapiens, Bos taurus, Mus musculus | L184 | KLCEQLSGK | 1 | Canis lupus familiaris | L184 | KLHDQLAGK | 1 | Rattus norvegicus | P111 | YVGSGPPKGTG | 3 | Homo sapiens, Canis lupus familiaris, Bos taurus | P111 | YVGSGPPSGTG | 1 | Mus musculus | P111 | YVGSGPPKDTG | 1 | Rattus norvegicus | S109 | SDYVGSGPPKG | 3 | Homo sapiens, Canis lupus familiaris, Bos taurus | S109 | SDYVGSGPPSG | 1 | Mus musculus | S109 | SEYVGSGPPKD | 1 | Rattus norvegicus | W84 | PKYREWHHFLV | 3 | Homo sapiens, Canis lupus familiaris, Bos taurus | W84 | PKFREWHHFLV | 2 | Mus musculus, Rattus norvegicus | Y120 | TGLHRYVWLVY | 5 | Homo sapiens, Canis lupus familiaris, Bos taurus, Mus musculus, Rattus norvegicus | Y181 | YVPKLYEQLSG | 3 | Homo sapiens, Bos taurus, Mus musculus | Y181 | YVPKLCEQLSG | 1 | Canis lupus familiaris | Y181 | SVPKLHDQLAG | 1 | Rattus norvegicus |
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