mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for SERPINB2
Gene summary
Basic gene Info.Gene symbolSERPINB2
Gene nameserpin peptidase inhibitor, clade B (ovalbumin), member 2
SynonymsHsT1201|PAI|PAI-2|PAI2|PLANH2
CytomapUCSC genome browser: 18q21.3
Type of geneprotein-coding
RefGenesNM_001143818.1,
NM_002575.2,
Descriptionmonocyte Arg-serpinplacental plasminogen activator inhibitorplasminogen activator inhibitor 2plasminogen activator inhibitor, type II (arginine-serpin)serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2serpin B2urokinase inhibit
Modification date20141207
dbXrefs MIM : 173390
HGNC : HGNC
Ensembl : ENSG00000197632
HPRD : 01420
Vega : OTTHUMG00000060592
ProteinUniProt: P05120
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SERPINB2
BioGPS: 5055
PathwayNCI Pathway Interaction Database: SERPINB2
KEGG: SERPINB2
REACTOME: SERPINB2
Pathway Commons: SERPINB2
ContextiHOP: SERPINB2
ligand binding site mutation search in PubMed: SERPINB2
UCL Cancer Institute: SERPINB2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for SERPINB2

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
T194T194ICOAD2
N347R346KBLCA1
Y203Y203CCOAD1
K335K335QLUAD1
N363E365DLUAD1
F408F409ILUSC1
G206G206RSKCM1
T38M39ISKCM1
F350F350LSKCM1
G206G206ESKCM1
F204F204CSTAD1
M343S344LSTAD1
S34S34IUCEC1
I35S36AUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for SERPINB2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
M343S344L0.77810074
K335K335Q0.19327781
N363E365D-1.287479
N347R346K-1.1678855
F204F204C-1.0185705
F350F350L-0.71905389
I35S36A-0.66535036
Y203Y203C-0.63863272
T38M39I-0.59044478
G206G206E-0.41171111
F408F409I-0.41102965
G206G206R-0.37154003
S34S34I-0.22030073
T194T194I-0.19864496
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for SERPINB2 from PDB
PDB IDPDB titlePDB structure
1BY7HUMAN PLASMINOGEN ACTIVATOR INHIBITOR-2. LOOP (66-98) DELETION MUTANT

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Differential gene expression and gene-gene network for SERPINB2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of SERPINB2 and the right PPI network was created from samples without mutations in the LBS of SERPINB2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for SERPINB2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0031117Peripheral Nervous System Diseases2Biomarker
umls:C1458155Breast Neoplasms1Biomarker
umls:C0400966Non-alcoholic Fatty Liver Disease1Biomarker
umls:C0038356Stomach Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for SERPINB2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|investigational|withdrawnDB00013UrokinaseBiotech
ApprovedDB00031TenecteplaseBiotech

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of SERPINB2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (ACE,THR,GLU,ALA,ALA,ALA,GLY,THR,GLY,GLY,VAL,MET,THR,GLY,ARG)1jrrAS34 I35 T38 T194 Y203 F204 G206 K335 M343 N347 F350 N363 F408
IIIPeptide ligand (ACE,THR,GLU,ALA,ALA,ALA,GLY,ASP,GLY,GLY,VAL,MET,THR,GLY,ARG)2arqAS34 I35 T38 T194 Y203 F204 G206 K335 M343 N347 F350 N363 F408
IIIPeptide ligand (ACE,THR,GLU,ALA,ALA,ALA,GLY,MET,GLY,GLY,VAL,MET,THR,GLY,ARG)2arrAS34 I35 T38 T194 Y203 F204 G206 K335 M343 N347 F350 N363 F408


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Conservation information for LBS of SERPINB2
Multiple alignments for P05120 in multiple species
LBSAA sequence# speciesSpecies
A201MVLVNAVYFKG2Homo sapiens, Mus musculus
A201MVLVNTIYFKG1Rattus norvegicus
A338FNKGRANFSGM1Homo sapiens
A338FNKGKANFSGM1Mus musculus
A338FNKGKADFSGM1Rattus norvegicus
A358EVFHQAMVDVN1Homo sapiens
A358EVFHQASVDVT1Mus musculus
A358EVFHQATVDVN1Rattus norvegicus
D193GSVDEDTKMVL2Mus musculus, Rattus norvegicus
D193GSVDGDTRMVL1Homo sapiens
D348MSERNDLFLSE2Homo sapiens, Mus musculus
D348MSESNDLFLSE1Rattus norvegicus
D361HQAMVDVNEEG1Homo sapiens
D361HQASVDVTEEG1Mus musculus
D361HQATVDVNEEG1Rattus norvegicus
E353DLFLSEVFHQA3Homo sapiens, Mus musculus, Rattus norvegicus
F204VNAVYFKGKWK2Homo sapiens, Mus musculus
F204VNTIYFKGRWK1Rattus norvegicus
F340KGRANFSGMSE1Homo sapiens
F340KGKANFSGMSE1Mus musculus
F340KGKADFSGMSE1Rattus norvegicus
F350ERNDLFLSEVF2Homo sapiens, Mus musculus
F350ESNDLFLSEVF1Rattus norvegicus
F355FLSEVFHQAMV1Homo sapiens
F355FLSEVFHQASV1Mus musculus
F355FLSEVFHQATV1Rattus norvegicus
F408TNCILFFGRFS1Homo sapiens
F408THTILFVGRFS1Mus musculus
F408TRTILFVGRFS1Rattus norvegicus
G206AVYFKGKWKTP2Homo sapiens, Mus musculus
G206TIYFKGRWKTP1Rattus norvegicus
H356LSEVFHQAMVD1Homo sapiens
H356LSEVFHQASVD1Mus musculus
H356LSEVFHQATVD1Rattus norvegicus
I181QTKGEIPNLLP2Mus musculus, Rattus norvegicus
I181QTKGKIPNLLP1Homo sapiens
I35ISPWSISSTLA2Mus musculus, Rattus norvegicus
I35LSPWSISSTMA1Homo sapiens
K180TQTKGEIPNLL2Mus musculus, Rattus norvegicus
K180TQTKGKIPNLL1Homo sapiens
K205NAVYFKGKWKT2Homo sapiens, Mus musculus
K205NTIYFKGRWKT1Rattus norvegicus
K335EDAFNKGRANF1Homo sapiens
K335EDAFNKGKANF1Mus musculus
K335EDAFNKGKADF1Rattus norvegicus
L184GEIPNLLPEGS2Mus musculus, Rattus norvegicus
L184GKIPNLLPEGS1Homo sapiens
L198DTRMVLVNAVY1Homo sapiens
L198DTKMVLVNAVY1Mus musculus
L198DTKMVLVNTIY1Rattus norvegicus
L349SERNDLFLSEV2Homo sapiens, Mus musculus
L349SESNDLFLSEV1Rattus norvegicus
L351RNDLFLSEVFH2Homo sapiens, Mus musculus
L351SNDLFLSEVFH1Rattus norvegicus
M196DGDTRMVLVNA1Homo sapiens
M196DEDTKMVLVNA1Mus musculus
M196DEDTKMVLVNT1Rattus norvegicus
M343ANFSGMSERND2Homo sapiens, Mus musculus
M343ADFSGMSESND1Rattus norvegicus
M359VFHQAMVDVNE1Homo sapiens
M359VFHQASVDVTE1Mus musculus
M359VFHQATVDVNE1Rattus norvegicus
N200RMVLVNAVYFK1Homo sapiens
N200KMVLVNAVYFK1Mus musculus
N200KMVLVNTIYFK1Rattus norvegicus
N347GMSERNDLFLS2Homo sapiens, Mus musculus
N347GMSESNDLFLS1Rattus norvegicus
N363AMVDVNEEGTE1Homo sapiens
N363ASVDVTEEGTV1Mus musculus
N363ATVDVNEEGTV1Rattus norvegicus
Q357SEVFHQAMVDV1Homo sapiens
Q357SEVFHQASVDV1Mus musculus
Q357SEVFHQATVDV1Rattus norvegicus
R195VDEDTKMVLVN2Mus musculus, Rattus norvegicus
R195VDGDTRMVLVN1Homo sapiens
S31QNIFISPWSIS2Mus musculus, Rattus norvegicus
S31QNLFLSPWSIS1Homo sapiens
S34FISPWSISSTL2Mus musculus, Rattus norvegicus
S34FLSPWSISSTM1Homo sapiens
S352NDLFLSEVFHQ3Homo sapiens, Mus musculus, Rattus norvegicus
T194SVDEDTKMVLV2Mus musculus, Rattus norvegicus
T194SVDGDTRMVLV1Homo sapiens
T38WSISSTMAMVY1Homo sapiens
T38WSISSTLAIVL1Mus musculus
T38WSISSTLAIVF1Rattus norvegicus
V197GDTRMVLVNAV1Homo sapiens
V197EDTKMVLVNAV1Mus musculus
V197EDTKMVLVNTI1Rattus norvegicus
V199TRMVLVNAVYF1Homo sapiens
V199TKMVLVNAVYF1Mus musculus
V199TKMVLVNTIYF1Rattus norvegicus
V202VLVNAVYFKGK2Homo sapiens, Mus musculus
V202VLVNTIYFKGR1Rattus norvegicus
V354LFLSEVFHQAM1Homo sapiens
V354LFLSEVFHQAS1Mus musculus
V354LFLSEVFHQAT1Rattus norvegicus
V360FHQAMVDVNEE1Homo sapiens
V360FHQASVDVTEE1Mus musculus
V360FHQATVDVNEE1Rattus norvegicus
V362QAMVDVNEEGT1Homo sapiens
V362QASVDVTEEGT1Mus musculus
V362QATVDVNEEGT1Rattus norvegicus
W208YFKGKWKTPFE2Homo sapiens, Mus musculus
W208YFKGRWKTPFQ1Rattus norvegicus
Y203LVNAVYFKGKW2Homo sapiens, Mus musculus
Y203LVNTIYFKGRW1Rattus norvegicus
Y258ILELPYAGDVS1Homo sapiens
Y258ILELPHTGNIS1Mus musculus
Y258ILELPYIGNIS1Rattus norvegicus


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